Hotels in Lake Nona Medical City, Orlando

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17 Dec - 18 Dec
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18 Dec - 19 Dec
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19 Dec - 21 Dec
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26 Dec - 28 Dec

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Our top choices for Lake Nona Medical City hotels

Lounge
Aloft Orlando Lake Nona

Aloft Orlando Lake Nona

Aloft Orlando Lake Nona
3.0 star property
Lake Nona Medical City
9.8 out of 10, Exceptional, (269)
"Great staff and nice amenities. "
United States
David
The price is RM466
RM524 total
includes taxes & fees
24 Dec - 25 Dec
Aloft Orlando Lake Nona
Outdoor pool
Courtyard Orlando Lake Nona

Courtyard Orlando Lake Nona

Courtyard Orlando Lake Nona
3.0 star property
Lake Nona Medical City
9.6 out of 10, Exceptional, (592)
"Great stay"
United States
Romulo
The price is RM588
RM668 total
includes taxes & fees
24 Dec - 25 Dec
Courtyard Orlando Lake Nona
Outdoor pool
Residence Inn Orlando Lake Nona

Residence Inn Orlando Lake Nona

Residence Inn Orlando Lake Nona
3.0 star property
Lake Nona Medical City
9.6 out of 10, Exceptional, (326)
"Very clean hotel and spacious room with comfortable seating and kitchen area. The location was great for me as I was there visiting someone in an area hospital. There are also restaurants and coffee shops right outside the entrance. "
United States
Sharon
The price is RM731
RM831 total
includes taxes & fees
21 Dec - 22 Dec
Residence Inn Orlando Lake Nona
Business centre
Spark by Hilton Orlando near Universal

Spark by Hilton Orlando near Universal

Spark by Hilton Orlando near Universal
2.5 star property
Florida Center, 22.1 km from Lake Nona Medical City
9.0 out of 10, Wonderful, (440)
"The rooms and breakfast were lovely"
United States
MacKenzie Rose
The price is RM352
RM396 total
includes taxes & fees
4 Jan - 5 Jan 2026
Spark by Hilton Orlando near Universal
4 outdoor pools, open 5:30 AM to midnight, pool cabanas (surcharge)
Rosen Shingle Creek

Rosen Shingle Creek

Rosen Shingle Creek
4.5 star property
16.9 km from Lake Nona Medical City
9.4 out of 10, Exceptional, (4353)
"Great resort "
United States
Camille
The price is RM454
RM511 total
includes taxes & fees
21 Dec - 22 Dec
Rosen Shingle Creek
Outdoor pool, pool umbrellas, pool loungers
Kompose Boutique Resort at Theme Parks

Kompose Boutique Resort at Theme Parks

Kompose Boutique Resort at Theme Parks
3.0 star property
30.8 km from Lake Nona Medical City
9.4 out of 10, Exceptional, (1994)
"Great stay! Beautiful hotel with amazing rooms and an awesome location."
United States
Andrew
The price is RM165
RM349 total
includes taxes & fees
18 Dec - 19 Dec
Kompose Boutique Resort at Theme Parks
Free daily buffet breakfast
La Quinta Inn & Suites by Wyndham Orlando Airport North

La Quinta Inn & Suites by Wyndham Orlando Airport North

La Quinta Inn & Suites by Wyndham Orlando Airport North
3.0 star property
Airport North, 10.9 km from Lake Nona Medical City
7.4 out of 10, Good, (863)
"nice and clean staff was great also"
United States
sumatran
The price is RM356
RM401 total
includes taxes & fees
12 Jan - 13 Jan 2026
La Quinta Inn & Suites by Wyndham Orlando Airport North
Lobby
Hyatt House Orlando Airport

Hyatt House Orlando Airport

Hyatt House Orlando Airport
3.5 star property
Airport North, 10.6 km from Lake Nona Medical City
9.6 out of 10, Exceptional, (2802)
"Great location, friendly staff, great breakfast"
United States
Gabriel
The price is RM466
RM524 total
includes taxes & fees
24 Dec - 25 Dec
Hyatt House Orlando Airport
Exterior
Hampton Inn & Suites Orlando Airport @ Gateway Village

Hampton Inn & Suites Orlando Airport @ Gateway Village

Hampton Inn & Suites Orlando Airport @ Gateway Village
3.0 star property
Airport North, 10.6 km from Lake Nona Medical City
9.4 out of 10, Exceptional, (2457)
"Great location to airport and food choices. "
United States
Aliza
The price is RM405
RM456 total
includes taxes & fees
23 Dec - 24 Dec
Hampton Inn & Suites Orlando Airport @ Gateway Village
Property grounds
Seasons Florida Resort

Seasons Florida Resort

Seasons Florida Resort
2.0 star property
19.8 km from Lake Nona Medical City
8.8 out of 10, Excellent, (3291)
"Excellent location and value, very clean and friendly check in"
United States
Jason
The price is RM257
RM292 total
includes taxes & fees
4 Jan - 5 Jan 2026
Seasons Florida Resort
Outdoor pool
DoubleTree by Hilton at the Entrance to Universal Orlando

DoubleTree by Hilton at the Entrance to Universal Orlando

DoubleTree by Hilton at the Entrance to Universal Orlando
4.0 star property
Florida Center, 21.7 km from Lake Nona Medical City
8.4 out of 10, Very good, (6913)
"Wonderful stay. Great location!"
United States
Charmaine
The price is RM432
RM486 total
includes taxes & fees
3 Jan - 4 Jan 2026
DoubleTree by Hilton at the Entrance to Universal Orlando
Exterior
Cambria Hotel Orlando Airport

Cambria Hotel Orlando Airport

Cambria Hotel Orlando Airport
3.0 star property
11.1 km from Lake Nona Medical City
8.8 out of 10, Excellent, (1941)
"The room was clean and the staff was welcoming and friendly!"
United States
Otthoniel
The price is RM396
RM445 total
includes taxes & fees
24 Dec - 25 Dec
Cambria Hotel Orlando Airport
Pillow-top beds, in-room safe, desk, blackout curtains
Wingate by Wyndham - Orlando International Airport

Wingate by Wyndham - Orlando International Airport

Wingate by Wyndham - Orlando International Airport
3.0 star property
Airport North, 11 km from Lake Nona Medical City
8.8 out of 10, Excellent, (3758)
"Beautiful property, excellent staff and love the shuttle service to the airport!"
United States
Robert
The price is RM382
RM430 total
includes taxes & fees
22 Dec - 23 Dec
Wingate by Wyndham - Orlando International Airport
Exterior
avid hotel Orlando International Airport by IHG

avid hotel Orlando International Airport by IHG

avid hotel Orlando International Airport by IHG
2.5 star property
11.2 km from Lake Nona Medical City
9.2 out of 10, Wonderful, (2017)
"Easy check in, great people service, clean room, great location. "
United States
Tiffany
The price is RM449
RM506 total
includes taxes & fees
12 Jan - 13 Jan 2026
avid hotel Orlando International Airport by IHG
Lobby
La Quinta Inn & Suites by Wyndham Orlando UCF

La Quinta Inn & Suites by Wyndham Orlando UCF

La Quinta Inn & Suites by Wyndham Orlando UCF
3.0 star property
25.4 km from Lake Nona Medical City
8.6 out of 10, Excellent, (2693)
"This hotel is very clean and breakfast is great!"
United States
Teresita
The price is RM361
RM406 total
includes taxes & fees
21 Dec - 22 Dec
La Quinta Inn & Suites by Wyndham Orlando UCF
In-room safe, desk, iron/ironing board, free WiFi
Fairfield Inn By Marriott Orlando Airport

Fairfield Inn By Marriott Orlando Airport

Fairfield Inn By Marriott Orlando Airport
3.5 star property
Airport North, 10.8 km from Lake Nona Medical City
9.2 out of 10, Wonderful, (2352)
"Great location and nice staff"
United States
Francisco
The price is RM379
RM426 total
includes taxes & fees
22 Dec - 23 Dec
Fairfield Inn By Marriott Orlando Airport
Exterior
Caribe Royale Orlando

Caribe Royale Orlando

Caribe Royale Orlando
4.5 star property
21.2 km from Lake Nona Medical City
9.2 out of 10, Wonderful, (4512)
"Excellent hotel I will be booking again"
United States
Wilshaundra
The price is RM650
RM905 total
includes taxes & fees
18 Dec - 19 Dec
Caribe Royale Orlando
Free daily buffet breakfast
Hyatt House Orlando International Drive

Hyatt House Orlando International Drive

Hyatt House Orlando International Drive
4.0 star property
International Drive District, 20.2 km from Lake Nona Medical City
9.4 out of 10, Exceptional, (1372)
"The staff was really friendly and the property was nice and cozy "
United States
curtis
The price is RM445
RM501 total
includes taxes & fees
18 Dec - 19 Dec
Hyatt House Orlando International Drive
Exterior
Holiday Inn Express Orlando International Airport by IHG

Holiday Inn Express Orlando International Airport by IHG

Holiday Inn Express Orlando International Airport by IHG
2.5 star property
11.1 km from Lake Nona Medical City
9.0 out of 10, Wonderful, (1881)
" Nice hotel"
United States
Shalanda
The price is RM409
RM460 total
includes taxes & fees
23 Dec - 24 Dec
Holiday Inn Express Orlando International Airport by IHG
Lobby
DASKK Orlando Hotel near Universal Blvd, an Ascend Collection Hotel

DASKK Orlando Hotel near Universal Blvd, an Ascend Collection Hotel

DASKK Orlando Hotel near Universal Blvd, an Ascend Collection Hotel
3.0 star property
International Drive District, 21.3 km from Lake Nona Medical City
8.6 out of 10, Excellent, (700)
"Clean rooms, friendly staff, delicious breakfast "
United States
Katherin
The price is RM309
RM348 total
includes taxes & fees
7 Jan - 8 Jan 2026
DASKK Orlando Hotel near Universal Blvd, an Ascend Collection Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Lake Nona Medical City

Find the best Lake Nona Medical City areas for the activities you enjoy most.

International Drive District

Adventure activities, iconic attractions, shopping and world-class dining destinations make this famous street one of Orlando’s most popular tourist attractions.

Magic Kingdom® Theme Park featuring rides and interior views as well as a couple
Photo by ©Disney
Open Photo by ©Disney

Bay Lake

Exciting theme parks plentiful wildlife and top sights from Epcot® to Walt Disney World® Resort – discover Bay Lake, a destination also famous for its entertainment.

Champions Gate

Ample dining options and top golf courses are well-reviewed features of Champions Gate. Make a stop by top sights like ChampionsGate Golf Club while you're exploring the area.

Universal Studios Florida® featuring night scenes, a city and signage

Florida Center

If you're spending some time in Florida Center, Universal Orlando Resort and Universal Studios Florida are top sights worth seeing.

Downtown Orlando

One of the most popular neighborhoods in Florida, this bustling area is full of art galleries, shops, bars and restaurants.

Top Lake Nona Medical City Hotel Reviews

Rosen Inn Lake Buena Vista

Rosen Inn Lake Buena Vista

10/10 Excellent
"Always a great experience!"
Megan 1-night trip
Posted 2 days ago
Rosen Inn Lake Buena Vista

Frequently asked questions

What's it like in Lake Nona Medical City?
Lake Nona Medical City is a neighbourhood that travellers like for its restaurants.
What's the best accommodation in Lake Nona Medical City?
Based on Expedia customer reviews, Aloft Orlando Lake Nona is the highest ranked property in Lake Nona Medical City. This hotel offers a restaurant and an outdoor pool. Other favourite options in the area include Residence Inn Orlando Lake Nona and Courtyard Orlando Lake Nona.
How many hotels will I find in Lake Nona Medical City?
Expedia has 5 Lake Nona Medical City hotels and other accommodation options, and one might make a good home base for venturing out into the greater Orlando area.
If I need to cancel my hotel reservation in Lake Nona Medical City, will I receive a refund?
Yes, the majority of hotel bookings are fully refundable as long as you cancel prior to the hotel's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If you have a reservation that's non-refundable, you might be able to still cancel and get a refund within a 24-hour period of your booking. Enter dates in and click on "Search", then you can use the "fully refundable" filter to view the best deals available in Lake Nona Medical City.
What is there to do around this Orlando neighbourhood?
Eagle Creek Golf Club, USTA National Campus and Austin-Tindall Regional Park are just a few of the places to visit in and around Lake Nona Medical City. When you're sightseeing around the area, Lake Hart and Kissimmee Bay Country Club are a couple of other sights to visit.

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