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Our top choices for Perry County hotels

Exterior
Holiday Inn Express & Suites Perryville by IHG

Holiday Inn Express & Suites Perryville by IHG

Holiday Inn Express & Suites Perryville by IHG
2.5 star property
Perryville
9.2 out of 10, Wonderful, (543)
"lean, updated rooms, friendly staff and great breakfast."
United States
Linda
The price is RM353
RM404 total
includes taxes & fees
28 Dec - 29 Dec
Holiday Inn Express & Suites Perryville by IHG
In-room safe, desk, laptop workspace, blackout curtains
Super 8 by Wyndham Perryville

Super 8 by Wyndham Perryville

Super 8 by Wyndham Perryville
2.0 star property
Perryville
8.4 out of 10, Very good, (942)
"My girlfriend found hair and leaves in the tub of our room. This is after we checked in and it was only for one night."
United States
Timothy
The price is RM269
RM308 total
includes taxes & fees
31 Dec - 1 Jan 2026
Super 8 by Wyndham Perryville
Lobby
Quality Inn Perryville I-55

Quality Inn Perryville I-55

Quality Inn Perryville I-55
2.5 star property
Perryville
6.6 out of 10, (124)
"Nice place would recommend Mary Jane’s if you’re looking for good food "
United States
Andrew
The price is RM282
RM322 total
includes taxes & fees
31 Dec - 1 Jan 2026
Quality Inn Perryville I-55
Jetted bathtub
Days Inn by Wyndham Perryville

Days Inn by Wyndham Perryville

Days Inn by Wyndham Perryville
2.0 star property
Perryville
6.8 out of 10, (415)
"Was a nice place."
United States
Lesliee
The price is RM252
RM288 total
includes taxes & fees
28 Dec - 29 Dec
Days Inn by Wyndham Perryville
Interior
Missouri Castle w/ Private Lake, Pool & 100 Acres!

Missouri Castle w/ Private Lake, Pool & 100 Acres!

Missouri Castle w/ Private Lake, Pool & 100 Acres!
3.0 star property
St Mary
Missouri Castle w/ Private Lake, Pool & 100 Acres!
Full-sized fridge, microwave, oven, stovetop
Urban Lofts

Urban Lofts

Urban Lofts
3.0 star property
Perryville
9.2 out of 10, Wonderful, (17)
"Great place to stay! "
United States
Eric
Urban Lofts
Interior
Hot Tub & Creek Views: Secluded Perryville Cabin

Hot Tub & Creek Views: Secluded Perryville Cabin

Hot Tub & Creek Views: Secluded Perryville Cabin
3.0 star property
Perryville
Hot Tub & Creek Views: Secluded Perryville Cabin
Interior
'the Brewer Guesthouse' Tiny Home w/ Patio & Yard!

'the Brewer Guesthouse' Tiny Home w/ Patio & Yard!

'the Brewer Guesthouse' Tiny Home w/ Patio & Yard!
3.0 star property
Perryville
10.0 out of 10, Exceptional, (2)
"The house and host were just awesome, enjoyed our stay Toni even helped me Extend!! Would def stay again:)"
United States
Shandese
'the Brewer Guesthouse' Tiny Home w/ Patio & Yard!
Lobby
Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
3.0 star property
Jackson
9.6 out of 10, Exceptional, (1002)
"Breakfast was great- staff was welcoming. Will stay there again."
United States
Laura
The price is RM336
RM355 total
includes taxes & fees
5 Jan - 6 Jan 2026
Drury Inn & Suites Jackson MO
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Perry County Hotel Reviews

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

10/10 Excellent
"The room was great. Very clean and the bed was comfortable. "
Josh 1-night trip
Posted 4 days ago
Drury Plaza Hotel Cape Girardeau Conference Center

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