A beach with palm trees, people relaxing on chairs, and colorful kayaks.

Five Star Hotels in Florida Keys

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Check availability on Florida Keys 5 Star Hotels

Tonight
17 Oct - 18 Oct
Tomorrow
18 Oct - 19 Oct
Next weekend
23 Oct - 25 Oct
In two weeks
30 Oct - 1 Nov

Our top choices for Florida Keys 5-star hotels

A bathroom with a large bathtub, a window with curtains, and a view of palm trees and the sea.
A bar area with a thatched roof, wooden chairs, and a view of the ocean.
A hotel room with a large bed, a television, a dining area with chairs, a table, and a view of the ocean.
A spacious lobby with a seating area, a bar, and a large window providing a view of the outdoors.

1. Cheeca Lodge & Spa

Cheeca Lodge & Spa
Matecumbe
United States
James
RM812
RM1,212 total
includes taxes & fees
19 Oct - 20 Oct
Cheeca Lodge & Spa
An aerial view of a resort with a central pool, multiple buildings, and a beach area with sun loungers.
A beach scene with two white chairs, a hammock, and palm trees.
A beach with white chairs and kayaks, palm trees, and a clear view of the ocean.
A bar area with wooden chairs, a bar counter, and a variety of bottles and glasses.

2. Isla Bella Beach Resort & Spa

Isla Bella Beach Resort & Spa
Marathon
United States
Clinton
RM838
RM1,186 total
includes taxes & fees
20 Oct - 21 Oct
Isla Bella Beach Resort & Spa
A balcony with a wooden table, two chairs, and a view of the ocean and palm trees.
A gated entrance to a resort with palm trees and a clear sky.
A pool area with clear blue water, white lounge chairs, and palm trees.
A beachside patio with a thatched roof, two lounge chairs, and a view of the ocean.

3. The Islands of Islamorada

The Islands of Islamorada
Matecumbe
United States
Christian
RM2,131
RM2,664 total
includes taxes & fees
19 Oct - 20 Oct
The Islands of Islamorada
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Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Florida Keys.
Reefhouse Resort & Marina

Reefhouse Resort & Marina

103800 Overseas Hwy Key Largo FL
RM812
RM1,077 total
19 Oct - 20 Oct
includes taxes & fees
9.2/10 Wonderful! (1,548 reviews)
Reefhouse Resort & Marina
Baker's Cay Resort Key Largo, Curio Collection by Hilton

Baker's Cay Resort Key Largo, Curio Collection by Hilton

97000 Overseas Hwy Key Largo FL
RM1,101
RM1,464 total
28 Oct - 29 Oct
includes taxes & fees
Baker's Cay Resort Key Largo, Curio Collection by Hilton
Hawks Cay Resort

Hawks Cay Resort

61 Hawks Cay Blvd Marathon FL
RM823
RM1,240 total
25 Oct - 26 Oct
includes taxes & fees
8.2/10 Very good! (1,005 reviews)
Hawks Cay Resort
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Florida Keys

Snorkel crystal-clear waters teeming with colourful fish, then feast on fresh-caught lobster at a laid-back waterfront shack. Drive the scenic Overseas Highway, stopping at Key West's Ernest Hemingway Home and Dry Tortugas National Park for island adventures.

See all hotels in Florida Keys
A beach with a historic brick fort, a small seaplane, and a group of people walking along the shore.

Top Florida Keys Hotel Reviews

Find out more about Florida Keys

Stay in Luxury: 5 Star Hotels in Florida Keys

There's nothing wrong with enjoying the finer things in life. Indulge your every desire on your upcoming leisure time. Treat yourself with a stay in a 5-star hotel during your Florida Keys trip. You'll join the multitudes of holidaymakers who have made Florida Keys so fashionable recently. You can also expect excellent customer service from these hotels, so get ready to kick back and indulge. Don't wait any longer. Reserve one of our 5-star hotels in Florida Keys and indulge in the finer things in life for a while.

5-Star Hotels in Florida Keys

You'll have a wonderful time at one of these 5-star hotels. Exceptional customer care, luxurious bedding, and deeply relaxing spa offerings are waiting for you. You're sure to find exactly the accommodation you need. You can also expect excellent customer service from these hotels, so get ready for a wonderful adventure. What kind of amenities will make your stay a wonderful one? 24-hour room service, so you can order that berry tart in the wee hours of the morning? A body scrub that will leave you feeling refreshed and alive? Butler services? Whatever it is your heart desires, you're bound to find it here. Don't want to take our word for it? Explore our listings and pick the perfect accommodation for your needs. 

But you aren't going to spend your entire holiday in your room, of course. You're in luck. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. No matter what's on your agenda, the 5-star hotels in Florida Keys are waiting for you to relax after an exciting day.

Make Your Escape

The results are in, and Florida Keys 5-star hotels are the place to be when you book your next holiday. If you've been dreaming about a holiday set here, then go ahead and book it. It's time to plan your next great escape -- this is a great time to find 5-star hotel deals in Florida Keys! Choose one of our Florida Keys 5-star hotels today and soothe yourself in luxe surroundings at your convenience.

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Frequently asked questions

How much does it cost to stay in a 5-star hotel in Florida Keys?
How much you pay for a 5-star hotel in Florida Keys depends on factors like when you plan to go and the length of your stay. A top tip for bagging an awesome deal? Use our pricing filters to check out the available accommodation for your chosen dates.
  • Search for the lowest price per night from RM1,077
What makes a hotel 5 stars in Florida Keys?
Impeccable guest service is integral to every 5-star hotel in Florida Keys. From the second you arrive, staff ensure your every need is met, whether recommending activities or providing a turn-down service. What's more, hotels must feature superior conveniences to meet the standard for a 5-star rating. These can include luxury bathrooms, on-site spa facilities, swimming pools, gastronomic restaurants and knowledgeable concierge.
Are there any 5-star all-inclusive resorts in Florida Keys?
Find a luxurious retreat that includes your room, meals, drinks and entertainment in Florida Keys with the help of our filters. Search for hotels with a 5-star rating and select the "All inclusive" filter. Have a look at what's included in the price. This way, you can take full advantage of all the perks on offer from the moment you arrive.

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