Photo by Visit Greenville, South Carolina
Upstate South Carolina Spa Hotels
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Check availability on Upstate South Carolina Hotels with Spa
Our top choices for Upstate South Carolina hotels with a spa
9.8 out of 10, Exceptional, (33 reviews)
- Retreat to this mountain hotel with therapeutic massage treatments, sauna, and seasonal outdoor pool for deep relaxation.
The price is RM1,616
RM1,778 total
includes taxes & fees
31 May - 1 Jun
9.8 out of 10, Exceptional, (713 reviews)
- Indulge in rejuvenating treatments at this upscale hotel with six couples spa rooms and scenic hiking trails for a peaceful escape.
The price is RM704
RM909 total
includes taxes & fees
3 May - 4 May
Grand Bohemian Lodge Greenville, Autograph Collection
Grand Bohemian Lodge Greenville, Autograph CollectionGreenville Downtown
9.6 out of 10, Exceptional, (483 reviews)
- Escape to a Tudor retreat with a full-service spa and rooftop garden overlooking the scenic river in Greenville.
The price is RM1,300
RM1,469 total
includes taxes & fees
10 May - 11 May
9.0 out of 10, Wonderful, (551 reviews)
- Experience mountain tranquility at this charming bed and breakfast, where spa services and garden views create a serene wellness retreat.
The price is RM541
RM610 total
includes taxes & fees
5 May - 6 May
9.2 out of 10, Wonderful, (293 reviews)
- Experience spa bliss at this charming B&B with relaxing massage treatment rooms and attentive staff who ensure a rejuvenating stay.
The price is RM459
RM517 total
includes taxes & fees
5 May - 6 May
8.2 out of 10, Very good, (376 reviews)
- Rejuvenate in a mountain spa retreat with 3 dedicated treatment rooms, hot tubs, and aromatherapy services along a scenic river.
The price is RM412
RM576 total
includes taxes & fees
3 May - 4 May
9.6 out of 10, Exceptional, (9 reviews)
- Relax in a mountain ranch sanctuary with 5 treatment rooms and outdoor spa areas for nature-inspired healing.
The price is RM1,423
RM1,604 total
includes taxes & fees
7 May - 8 May
8.6 out of 10, Excellent, (116 reviews)
- Rejuvenating retreat awaits at historic inn with spa services and an outdoor pool in scenic Lake Lure.
The price is RM560
RM633 total
includes taxes & fees
31 May - 1 Jun
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top Upstate South Carolina Hotel Reviews
Drury Inn & Suites Greenville
10/10 Excellent
Explore a world of travel with Expedia
- Condominium Resorts in Anderson County
- Anderson Hotels
- Central Hotels
- Red Roof Inn Hotels in Duncan
- Duncan Hotels
- Gay friendly Hotels in Easley
- Easley Hotels
- Fountain Inn Hotels
- Gramling Hotels
- Hotels near Greenville Downtown
- Greenville Downtown Hotels
- Greenville Hotels
- Hotels with smoking rooms in Greenville - Spartanburg
- Hotels with Spa in Greenwood
- Motel 6 Hotels in Inman
- Mauldin Hotels
- Hotels near Southern Wesleyan University
- Spartanburg Hotels
- Taylors Hotels
- Motel 6 Hotels in Upstate South Carolina
- Gay friendly Hotels in West End
- Hotels near WestGate Mall
- Woodruff Hotels
- Flights to Startex
- Flights from Honea Path
- Flights from Startex
- Flights from Gray Court
- Flights from Greenville - Spartanburg
- Flights from Anderson
- Flights from Boiling Springs
- Flights from Taylors
- Flights from Fountain Inn
- Flights from Lake Of The Ozarks (AIZ) to Greenville (GSP)
- Flights from Anderson (AND) to Pickens (LQK)
- Flights from Bar Harbor (BHB) to Greenville (GSP)
- Flights from León (BJX) to Greenville (GSP)
- Flights from Christchurch (CHC) to Greenville (GSP)
- Flights from Corumba (CMG) to Pickens (LQK)
- Flights from Changsha (CSX) to Greenville (GSP)
- Flights from Daytona Beach (DAB) to Spartanburg (SPA)
- Flights from Entebbe (EBB) to Greenville (GSP)
- Flights from Eagle River (EGV) to Greenville (GSP)
- Flights from Nancy (ENC) to Greenville (GSP)
- Flights from Yopal (EYP) to Greenville (GSP)
- Flights from Faro (FAO) to Greenville (GSP)
- Flights from Florence (FLO) to Greenville (GSP)
- Flights from Gaya (GAY) to Greenville (GSP)
- Flights from Iron Mountain (IMT) to Greenville (GSP)
- Flights from Kuala Lumpur (KUL) to Greenville (GSP)
- Flights from Los Angeles (LAX) to Greenville (GSP)
- Flights from Leesburg (LEE) to Greenville (GSP)
- Flights from Lexington (LEX) to Greenville (GSP)
- Flights from Mackinac Island (MCD) to Greenville (GSP)
- Flights from Medellín (MDE) to Greenville (GSP)
- Flights from Melbourne (MEL) to Greenville (GSP)
- Flights from Moses Lake (MWH) to Greenville (GSP)
- Flights from Myrtle Beach (MYR) to Greenville (GSP)
- Flights from Ocala (OCF) to Greenville (GSP)
- Flights from Paris (PAR) to Greenville (GDC)
- Flights from Phoenix (PHX) to Pickens (LQK)
- Flights from Pittsburgh (PIT) to Pickens (LQK)
- Flights from Providenciales (PLS) to Greenville (GSP)
- Flights from Rogers (ROG) to Greenville (GSP)
- Flights from Schenectady (SCH) to Greenville (GSP)
- Flights from Stuttgart (STR) to Greenville (GSP)
- Flights from Tirana (TIA) to Greenville (GSP)
- Flights from Washington (WAS) to Greenville (GDC)
- Flights from Arviat (YEK) to Pickens (LQK)
- Flights from Sydney (YQY) to Greenville (GSP)
- Visit Arial
- Barnet Park
- Cedar Lane Shopping Center
- Centre West Shopping Center
- Conestee Nature Preserve
- Frankie's Fun Park
- Golden Lanes and Golden Skate
- Visit Gramling
- Visit Greenville Downtown
- Greenville Holidays
- Hatcher Garden and Woodland Preserve
- Heritage Green
- Hollywild Animal Park
- Honea Path Holidays
- Visit Honea Path
- Inman Holidays
- Logos Theatre
- North Grove Medical Park
- Visit Startex
- Topgolf Greenville
- Wade Hampton Plaza Shopping Center
- Visit Wellford
- Younts Center for Performing Arts