𝗧𝗢𝗣 𝗛𝗼𝘁𝗲𝗹𝘀 𝗶𝗻 St. Charles from RM230 (2026) - Fully Refundable Options

An aerial view of a town with industrial buildings, roads, and green areas.

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Our top choices for St. Charles hotels

A spacious living area with a high ceiling, wooden beams, a blue armchair, a sofa, and a glass coffee table.

An outdoor seating area with wicker chairs and tables, surrounded by vibrant flowers and a red umbrella.

A rustic bar area with wooden beams, a wooden counter, and sacks of grain.

A cozy living room with a fireplace, a staircase, and a dining area.

1. Stone Mill Hotel & Suites

Lanesboro

Bernie

RM429

RM460 total

includes taxes & fees

26 Oct - 27 Oct

A modern hotel lobby with a reception desk, seating area, and a kitchenette.

A modern hotel lobby with a reception desk, seating area, and a large window providing natural light.

A hotel with a covered entrance, multiple floors, and a parking lot.

A hotel room with a large bed, a desk, a chair, and a kitchenette.

2. Spark by Hilton Rochester South

Rochester

Stanton

RM333

RM384 total

includes taxes & fees

1 Nov - 2 Nov

A bar with wooden stools and a neon sign.

A modern kitchen with wooden cabinets, a microwave, an oven, and a dishwasher.

An indoor swimming pool with a slide, seating area, and a large frog statue.

3. AmericInn by Wyndham Rochester Near Mayo Clinic

Rochester

blake

RM298

RM343 total

includes taxes & fees

25 Oct - 26 Oct

A hotel room with two beds, a desk, a chair, and a lamp.

A swimming pool with a capacity sign, a lifeguard warning sign, and a spa rules sign.

A lobby with a checkered floor, two blue armchairs, a table with a lamp, and a 'WELCOME' sign.

A living room with a brick fireplace, two armchairs with decorative pillows, and a framed map on the wall.

4. Country Trails Inn & Suites

Preston

Jeannie

RM516

RM570 total

includes taxes & fees

22 Oct - 23 Oct

A reception area with a wooden reception desk, a "Welcome to the Bread & Butter State" sign, and a "Please Center" sign.

A modern lounge area with seating arrangements, a reception desk, and a patterned wall.

A coffee station with four coffee dispensers, a stack of disposable cups, and a tray with various coffee-related items.

A pool area with a table and chairs, a lifeguard chair, and a pool lift.

5. Hampton Inn Rochester-South

Rochester

dennis

RM414

RM476 total

includes taxes & fees

4 Nov - 5 Nov

An outdoor patio area with yellow umbrellas, wicker furniture, and a sign for Centerstone Plaza Hotel.

A restaurant interior with wooden tables, chairs, and a stone wall.

A garden with a water feature, rocks, and yellow umbrellas.

A modern reception area with a wooden reception desk, glass pendant lights, and a long hallway with seating.

6. Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

Historic Southwest

Deanna

RM466

RM537 total

includes taxes & fees

23 Oct - 24 Oct

A modern hotel lobby with a reception desk, seating area, and a dining space.

A hotel room with a bed, desk, chair, and a bathroom.

A Holiday Inn Express building with a stone facade and illuminated signage.

A modern hotel room with a wooden desk, orange chair, dark sofa, and a small table.

7. Holiday Inn Express Rochester South - Mayo Area by IHG

Rochester

Rick

RM359

RM414 total

includes taxes & fees

19 Nov - 20 Nov

A multi-story building with a balcony, surrounded by various potted plants and flowers.

A porch with a variety of potted plants and flowers, a sign reading "OFFICE Welcome to Green Gables," and a door with a green doorbell.

An outdoor patio with tables and chairs, green umbrellas, and a wooden deck.

A bedroom with a four-poster bed, a sitting area with a sofa, a small table with a vase, and a bathtub.

8. Green Gables Inn

Lanesboro

Gary

RM420

RM451 total

includes taxes & fees

26 Oct - 27 Oct

A hotel room with a large bed, bedside tables, a mirror, and a patterned carpet.

A modern living room with a sofa, coffee table, and a TV mounted on a stone wall.

A hotel breakfast area with a self-serve station, including a waffle maker, toaster, and various food items.

9. Quality Inn & Suites Mayo Clinic Area

Rochester

Jessica

RM276

RM323 total

includes taxes & fees

13 Nov - 14 Nov

An outdoor seating area with a fire feature, blue cushioned chairs, and a modern building with large windows in the background.

A modern bar area with seating and a counter.

A modern Hyatt House hotel with a prominent 'Hyatt House' sign, multiple floors, and a parking garage.

A modern dining area with round tables and chairs, a large painting on the wall, and a flat-screen TV mounted above a geometric-patterned wall.

10. Hyatt House Rochester/Mayo Clinic Area

Downtown Rochester

Elsie

RM518

RM597 total

includes taxes & fees

29 Oct - 30 Oct

A hotel room with a large bed, a separate bathroom with a bathtub, a desk with a chair, and a large mirror.

A hotel lobby with seating, a fireplace, a clock, and a reception area.

A multi-story hotel with a prominent "American" sign, a parking lot with several cars, and a landscaped entrance area.

An indoor swimming pool with clear water, a lifeguard on duty sign, and a seating area with chairs and tables.

11. AmericInn by Wyndham Winona

Winona

Jonathan

RM524

RM585 total

includes taxes & fees

15 Nov - 16 Nov

A swimming pool with clear blue water, surrounded by lounge chairs and a view of residential buildings through large windows.

A modern hotel with a flat roof, multiple windows, and a covered outdoor seating area.

An outdoor patio area with wicker furniture, a central fire feature, and a stone building in the background.

A modern reception area with a brick-patterned wall, two reception desks, a flat-screen TV, and seating arrangements including a sofa and chairs.

12. Residence Inn by Marriott Rochester Mayo Clinic Area South

Rochester

Chee

RM559

RM644 total

includes taxes & fees

13 Nov - 14 Nov

A modern hotel room with a large bed, a sofa, a small table, a desk, and a wardrobe.

An outdoor dining area with wooden beams, tables, and chairs.

A modern interior with a wooden ceiling, a large black shelving unit, and a refrigerator stocked with beverages.

A spacious outdoor dining area with modern furniture and large windows offering views of the city.

13. Hotel Indigo Rochester – Mayo Clinic Area by IHG

Downtown Rochester

Naomi

RM437

RM503 total

includes taxes & fees

7 Nov - 8 Nov

A two-story house with a porch and a covered entryway.

A porch with a white door labeled "WENNESON" and a welcome wreath.

A room with two patterned sofas, a small table with a lamp, and a window with curtains.

A hallway with a wooden floor, a chandelier, a bust sculpture, and a door leading to another room.

14. The Wen Inn formerly Andor Wenneson

Peterson

Jessica

RM613

RM666 total

includes taxes & fees

19 Nov - 20 Nov

A room with a fireplace, two leather armchairs, a sofa, and a large window providing a view of the outdoors.

A hotel room with a bed, a sink, a microwave, and a window with curtains.

A long, narrow hotel corridor with a carpeted floor, light fixtures along the walls, and a ceiling with recessed lighting.

A paved garden area with two benches, a potted plant with yellow flowers, and a variety of greenery.

15. Brentwood Inn & Suites

Downtown Rochester

Elaine

RM490

RM564 total

includes taxes & fees

23 Oct - 24 Oct

A modern indoor patio with a fire feature, seating, and large windows.

A modern living room with a fireplace, large windows, and a flat-screen TV mounted on the wall.

A modern interior with a seating area, a bookshelf, and a window with a view of trees.

A modern hotel lobby with a large glass wall, a green wall mural, and a seating area with sofas and chairs.

16. EVEN Hotel Rochester - Mayo Clinic Area by IHG

Kutzky Park

James

RM465

RM544 total

includes taxes & fees

23 Oct - 24 Oct

A hotel room with a large bed, a desk, a chair, a television, and a window with curtains.

A hotel lobby with leather sofas, a stone fireplace, and a patterned carpet.

A self-service breakfast station with a waffle maker, coffee machines, and a variety of condiments.

A reception area with a wooden reception desk, a red doormat, and framed awards on the wall.

17. Econo Lodge Mayo Clinic Area

Rochester

Ashley

RM270

RM311 total

includes taxes & fees

15 Nov - 16 Nov

A hotel room with a large bed, a desk with a chair, a window with a view of the outdoors, and two bedside lamps.

A hotel room with a desk, a chair, a flat-screen TV mounted on the wall, and a lamp on the desk.

A gym with treadmills, elliptical machines, and a stationary bike.

A kitchen with a waffle maker, a waffle iron, and a waffle maker instruction manual.

18. Comfort Inn & Suites Rochester South Mayo Clinic

Rochester

Terri

RM328

RM378 total

includes taxes & fees

19 Nov - 20 Nov

An outdoor seating area with wooden pillars, colorful striped cushions, and potted plants.

A modern lounge area with a sofa, chairs, and tables.

An indoor swimming pool with wooden ceiling beams, yellow chairs, and tables along the sides.

A modern restaurant with a counter, seating area, and a TV screen.

19. Home2 Suites by Hilton Rochester Mayo Clinic Area

Rochester

howard

RM451

RM519 total

includes taxes & fees

14 Nov - 15 Nov

An outdoor patio area with a concrete floor, wooden fence, and string lights.

A Fairfield Inn & Suites hotel with a modern design, featuring a prominent entrance and a parking area.

A breakfast bar with a wooden counter, a coffee machine, and a refrigerator.

20. Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

Kutzky Park

Brien

RM492

RM567 total

includes taxes & fees

6 Nov - 7 Nov

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Learn more about St. Charles

St. Charles awaits: its natural setting and more!

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Top St. Charles Hotel Reviews

Express Suites Riverport Inn & Suites

10/10 Excellent

"Nice hotel clean.."

AmericInn by Wyndham Rochester Near Mayo Clinic

10/10 Excellent

"Wonderful day! Highly recommended."

Hyatt House Rochester/Mayo Clinic Area

10/10 Excellent

"Very nice place, convient, clean"

The Plaza Hotel & Suites Winona

10/10 Excellent

"Room was large and comfortable. Great pool and hotter, it was super busy so we did not use it, but it looked fantastic."

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

8/10 Good

"."

Aspen Select

8/10 Good

"Small area to park in and not easy to get to"

Super 8 by Wyndham Winona MN

8/10 Good

"The property is conveniently located where it's just off of the round-about & close to the grocery store, gas station, Target shopping store, Farm & Fleet, etc. Staff was helpful in getting a room close to the door & a flight of stairs for senior citizen like us with arhritis & special needs. I specially liked the breakfast of coffee, waffle, yogurt, etc. Too bad there's no egg for my protein needs. The bathroom was very clean. I like the body wash, shampoo & conditioner dispensers. However, the table needs a lamp on the table, an ironing board, and some hangers. Other than that, everything's great. We had a comfortable and wonderful stay! Thank you very much. We will come back again!"

More cheap stays in St. Charles

Super 8 by Wyndham Winona MN

1025 Sugar Loaf Rd Winona MN

RM202

RM230 total

15 Nov - 16 Nov

includes taxes & fees

7.6/10 Good! (1,006 reviews)

Birch Hill Suite Rochester – Med City

3595 Commercial Drive SW Rochester MN

RM237

RM273 total

22 Oct - 23 Oct

includes taxes & fees

Med City Inn & Suites - Mayo Clinic Area

435 16th Ave Nw Rochester MN

RM309

RM355 total

22 Oct - 23 Oct

includes taxes & fees

7.8/10 Good! (1,041 reviews)

Comfort Inn & Suites Rochester South Mayo Clinic

7320 Airport View Dr Sw Rochester MN

RM328

RM378 total

19 Nov - 20 Nov

includes taxes & fees

8.8/10 Excellent! (1,003 reviews)

Holiday Inn Express Rochester South - Mayo Area by IHG

4141 Maine Avenue SE Rochester MN

RM359

RM414 total

19 Nov - 20 Nov

includes taxes & fees

8.8/10 Excellent! (1,001 reviews)

Brentwood Inn & Suites

123 Fourth Ave. NW Rochester MN

RM490

RM564 total

23 Oct - 24 Oct

includes taxes & fees

Frequently asked questions

Where is the best place to stay in St. Charles?

AmericInn by Wyndham Rochester Near Mayo Clinic, located 20.5 mi (32.9 km) from the heart of St. Charles, is a top choice for your stay, based on our traveller data. Two other options for your stay in the area are Kahler Grand Hotel and Kahler Inn and Suites - Mayo Clinic Area. See all available top hotels, or vacation rentals in St. Charles.

If I need to cancel my hotel reservation in St. Charles, will I receive a refund?

Yes! The majority of room reservations are fully refundable as long as you cancel prior to the hotel's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you have a non-refundable reservation, you might be able to cancel it and get a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in St. Charles.

What's it like to stay in St. Charles?

Visitors can enjoy all that St. Charles has to offer, including its parks. This city also attracts tourists with its welcoming locals. In St. Charles, there are 3 hotels and other accommodation options to choose from. Find out more about St. Charles.

What is there to see in St. Charles?

A couple of favourite places to visit are Whitewater State Park and Whitewater River. You'll also find Regional Sports Center and National Volleyball Center in the area. Take a look at what more there is to see and do in Expedia's St. Charles guide.

What's the weather like in St. Charles?

The hottest months are usually July and August, with an average temperature of 19°C, while the coldest months are January and February, with an average of -6°C. The snowiest months in St. Charles are January, March, February and April, with each month seeing an average of 20 cm of snowfall.

St. Charles hotels from RM230

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in St. Charles

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for St. Charles hotels

1. Stone Mill Hotel & Suites

2. Spark by Hilton Rochester South

3. AmericInn by Wyndham Rochester Near Mayo Clinic

4. Country Trails Inn & Suites

5. Hampton Inn Rochester-South

6. Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

7. Holiday Inn Express Rochester South - Mayo Area by IHG

8. Green Gables Inn

9. Quality Inn & Suites Mayo Clinic Area

10. Hyatt House Rochester/Mayo Clinic Area

11. AmericInn by Wyndham Winona

12. Residence Inn by Marriott Rochester Mayo Clinic Area South

13. Hotel Indigo Rochester – Mayo Clinic Area by IHG

14. The Wen Inn formerly Andor Wenneson

15. Brentwood Inn & Suites

16. EVEN Hotel Rochester - Mayo Clinic Area by IHG

17. Econo Lodge Mayo Clinic Area

18. Comfort Inn & Suites Rochester South Mayo Clinic

19. Home2 Suites by Hilton Rochester Mayo Clinic Area

20. Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

Learn more about St. Charles

Top St. Charles Hotel Reviews

Express Suites Riverport Inn & Suites

AmericInn by Wyndham Rochester Near Mayo Clinic

Hyatt House Rochester/Mayo Clinic Area

The Plaza Hotel & Suites Winona

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Aspen Select

Super 8 by Wyndham Winona MN

More cheap stays in St. Charles

Super 8 by Wyndham Winona MN

Birch Hill Suite Rochester – Med City

Med City Inn & Suites - Mayo Clinic Area

Comfort Inn & Suites Rochester South Mayo Clinic

Holiday Inn Express Rochester South - Mayo Area by IHG

Brentwood Inn & Suites

Frequently asked questions

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