𝗧𝗢𝗣 𝗛𝗼𝘁𝗲𝗹𝘀 𝗶𝗻 St. Charles from RM270 (2026) - Fully Refundable Options

An aerial view of a town with industrial buildings, roads, and green areas.

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Our top choices for St. Charles hotels

A hotel room with a large bed, a separate bathroom with a bathtub, a desk with a chair, and a large mirror.

A multi-story hotel with a prominent "American" sign, a parking lot with several cars, and a landscaped entrance area.

A hotel room with a sofa, a small table, a TV, a microwave, and a door.

An indoor swimming pool with clear water, a lifeguard on duty sign, and a seating area with chairs and tables.

1. AmericInn by Wyndham Winona

Winona

SANDRA

RM492

RM549 total

includes taxes & fees

20 Sept - 21 Sept

A modern hotel lobby with a reception desk, seating area, and a kitchenette.

A modern hotel lobby with a reception desk, seating area, and a large window providing natural light.

A hotel with a covered entrance, multiple floors, and a parking lot.

A hotel room with a large bed, a desk, a chair, and a kitchenette.

2. Spark by Hilton Rochester South

Rochester

Helena

RM362

RM416 total

includes taxes & fees

13 Sept - 14 Sept

A hotel room with two beds, a large landscape painting above the headboard, a bedside table with a phone, and a blue patterned rug.

A modern room with two sofas, a coffee table, and large windows with curtains.

A breakfast area with a coffee station, a refrigerator, and a dining table with chairs.

A reception area with a counter, a clock, a desk with a computer, and a framed picture on the wall.

3. Days Inn by Wyndham Winona

Winona

LeAndre

RM275

RM307 total

includes taxes & fees

13 Sept - 14 Sept

A hotel room with a large bed, a desk with a chair, a window with a view of the outdoors, and two bedside lamps.

A gym with treadmills, elliptical machines, and a stationary bike.

A conference room with round tables and chairs, white walls, and a carpeted floor.

An indoor swimming pool with a checkered tile wall, a door labeled 'Mechanical Room,' and a window with a view outside.

4. Comfort Inn & Suites Rochester South Mayo Clinic

Rochester

Richard

RM328

RM378 total

includes taxes & fees

4 Oct - 5 Oct

A two-story house with a porch and a covered entryway.

A room with two patterned sofas, a small table with a lamp, and a window with curtains.

A porch with a white door labeled "WENNESON" and a welcome wreath.

A bedroom with a wooden wardrobe, a bedside table with a lamp, and a bed with white bedding and a red pillow.

5. The Wen Inn formerly Andor Wenneson

Peterson

Ruth

RM455

RM497 total

includes taxes & fees

7 Sept - 8 Sept

A modern hotel lobby with a reception desk, seating area, and a dining space.

A Holiday Inn Express building with a stone facade and illuminated signage.

A modern breakfast area with a counter displaying various food items, a water dispenser, and a sign indicating a bakery section.

A modern hotel room with a wooden desk, orange chair, dark sofa, and a small table.

6. Holiday Inn Express Rochester South - Mayo Area by IHG

Rochester

Dezel

RM396

RM456 total

includes taxes & fees

4 Oct - 5 Oct

An outdoor patio area with a concrete floor, wooden fence, and string lights.

A modern living room with a stone fireplace, a blue armchair, a round coffee table, and a large window offering a view of the outdoors.

A breakfast bar with a wooden counter, a coffee machine, and a refrigerator.

7. Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

Kutzky Park

Jon

RM451

RM520 total

includes taxes & fees

18 Sept - 19 Sept

An outdoor seating area with wicker chairs and tables, surrounded by vibrant flowers and a red umbrella.

A rustic bar area with wooden beams, a wooden counter, and sacks of grain.

A bedroom with a large bed, a bathtub, a wooden rocking chair, and a desk with a lamp.

A cozy living room with a fireplace, a staircase, and a dining area.

8. Stone Mill Hotel & Suites

Lanesboro

Jenifer

RM425

RM456 total

includes taxes & fees

16 Sept - 17 Sept

A reception area with a wooden reception desk, a "Welcome to the Bread & Butter State" sign, and a "Please Center" sign.

A modern lounge area with seating arrangements, a reception desk, and a patterned wall.

A coffee station with four coffee dispensers, a stack of disposable cups, and a tray with various coffee-related items.

A hotel room with a bed, a desk, a chair, a TV, and a bathroom visible through an open door.

9. Hampton Inn Rochester-South

Rochester

Lynne

RM381

RM439 total

includes taxes & fees

1 Oct - 2 Oct

A La Quinta Inn & Suites hotel with a well-lit entrance, a parking area, and a clear view of the building's facade.

A hotel reception area with wooden reception desks, a cityscape mural on the wall, and a check-in counter with a bookshelf.

An indoor swimming pool with a slide, seating areas, and a lifeguard station.

A modern lobby with a teal sofa, yellow chairs, a small round table, and a fireplace with a TV.

10. La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

Rochester

Jason

RM306

RM352 total

includes taxes & fees

20 Sept - 21 Sept

An outdoor seating area with wooden pillars, colorful striped cushions, and potted plants.

A modern lounge area with a sofa, chairs, and tables.

A modern restaurant with a counter, seating area, and a TV screen.

An indoor swimming pool with wooden ceiling beams, yellow chairs, and tables along the sides.

11. Home2 Suites by Hilton Rochester Mayo Clinic Area

Rochester

Vickie

RM494

RM569 total

includes taxes & fees

12 Sept - 13 Sept

An indoor swimming pool with slides, seating areas, and a covered section with umbrellas.

A hotel room with a kitchen area, a bed, a TV, and a seating area.

A modern kitchen with granite countertops, a built-in microwave, and a sink. There are two wooden chairs and a small table.

A hotel room with two beds, a desk with a chair, a TV, and a window with curtains.

12. Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Rochester

Margita

RM380

RM438 total

includes taxes & fees

18 Sept - 19 Sept

A hotel room with two beds, a desk, a chair, and a lamp.

A swimming pool with a capacity sign, a lifeguard warning sign, and a spa rules sign.

A hotel lobby with a dining area, a fireplace, and a television displaying a map.

A living room with a brick fireplace, two armchairs with decorative pillows, and a framed map on the wall.

13. Country Trails Inn & Suites

Preston

Rebecca

RM512

RM565 total

includes taxes & fees

7 Sept - 8 Sept

An outdoor seating area with a fire feature, blue cushioned chairs, and a modern building with large windows in the background.

A modern indoor pool area with lounge chairs and a pool.

A modern dining area with round tables and chairs, a large painting on the wall, and a flat-screen TV mounted above a geometric-patterned wall.

A modern Hyatt House hotel with a prominent 'Hyatt House' sign, multiple floors, and a parking garage.

14. Hyatt House Rochester/Mayo Clinic Area

Downtown Rochester

Mary Jo

RM477

RM549 total

includes taxes & fees

2 Oct - 3 Oct

An outdoor patio area with yellow umbrellas, wicker furniture, and a sign for Centerstone Plaza Hotel.

A restaurant interior with wooden tables, chairs, and a stone wall.

A modern reception area with a wooden reception desk, glass pendant lights, and a long hallway with seating.

A modern living room with a dark wall, a decorative light fixture, and a patterned wall art piece.

15. Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

Historic Southwest

Bill

RM436

RM502 total

includes taxes & fees

7 Sept - 8 Sept

A Holiday Inn Express building with a covered entrance, outdoor seating area, and a well-lit facade.

A hotel room with two beds, a desk, a chair, a television, and a kitchenette.

A hotel dining area with multiple tables and chairs, a coffee station, and a seating area with sofas.

16. Holiday Inn Express & Suites Rochester – Mayo Clinic Area by IHG

Kutzky Park

Janet

RM445

RM512 total

includes taxes & fees

12 Sept - 13 Sept

A modern hotel lobby with a dining area, seating arrangements, and a stone fireplace.

An indoor swimming pool with clear glass walls, a tiled floor, and a few chairs around the pool area.

A hotel with a modern design, featuring a stone facade and a covered entrance.

An outdoor patio area with stone walls, a stone fireplace, and multiple tables and chairs.

17. Fairfield Inn & Suites by Marriott Winona

Winona

Mary

RM542

RM605 total

includes taxes & fees

20 Sept - 21 Sept

A spacious hotel lobby with multiple seating areas, including sofas and round tables, and a large dining area with yellow chairs.

A grocery store with refrigerated and frozen sections, shelves stocked with snacks, and a variety of beverages.

A hotel room with a blue sofa, a wooden bench, a small table with a lamp, a painting of a flower, and a kitchenette in the background.

A reception area with two counters, a patterned wall, and a wooden floor.

18. Hilton Garden Inn Rochester Downtown, MN

Downtown Rochester

BRIAN

RM461

RM531 total

includes taxes & fees

12 Sept - 13 Sept

A swimming pool with clear blue water, surrounded by lounge chairs and a view of residential buildings through large windows.

A modern reception area with a brick-patterned wall, two reception desks, a flat-screen TV, and seating arrangements including a sofa and chairs.

A modern lounge area with seating, a fireplace, and a bar area.

A modern hotel with a flat roof, multiple windows, and a covered outdoor seating area.

19. Residence Inn by Marriott Rochester Mayo Clinic Area South

Rochester

Heather

RM534

RM615 total

includes taxes & fees

26 Sept - 27 Sept

A coffee shop interior with a wooden counter, menu boards, and seating area.

A hotel exterior with a 'Townplace Suites' sign, outdoor seating area, and 'OPEN' signage.

A hotel room with a bed, bedside table, and a window with curtains.

20. TownePlace Suites by Marriott Rochester Mayo Clinic Area

Kutzky Park

Amanda

RM554

RM638 total

includes taxes & fees

18 Sept - 19 Sept

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Learn more about St. Charles

St. Charles awaits: its natural setting and more!

See all hotels in St. Charles

Top St. Charles Hotel Reviews

EVEN Hotel Rochester - Mayo Clinic Area by IHG

8/10 Good

"My husband left a pill case in the room. I have called twice and they still have not gotten back to me. It’s minus on an otherwise lovely stay."

Aspen Select

10/10 Excellent

"The room had everything we needed.Restaurant right next Door.We would return."

Hampton Inn Rochester-South

10/10 Excellent

"clean room. breakfast was good...close proximity to lots of places"

Med City Inn & Suites - Mayo Clinic Area

8/10 Good

"Everything"

Hyatt House Rochester/Mayo Clinic Area

8/10 Good

"Great location, 5 minute walk to Mayo. Great pillows, cold AC! Both very important to us. 4th floor patio is awesome. Staff is very friendly and helpful! Breakfast was also very good. Forgot to mention, with all of the construction around Mayo, this place was super easy to get in and out of."

Hotel Indigo Rochester – Mayo Clinic Area by IHG

10/10 Excellent

"Best happy hour ever! Great prices, nice selection of food, and generous portions. Chef is very good, Darian does a fabulous job at the bar. Breakfast is also a good value and tasty food."

More cheap stays in St. Charles

Birch Hill Suite Rochester – Med City

3595 Commercial Drive SW Rochester MN

RM235

RM270 total

4 Oct - 5 Oct

includes taxes & fees

Super 8 by Wyndham Winona MN

1025 Sugar Loaf Rd Winona MN

RM251

RM285 total

13 Sept - 14 Sept

includes taxes & fees

Med City Inn & Suites - Mayo Clinic Area

435 16th Ave Nw Rochester MN

RM255

RM293 total

7 Sept - 8 Sept

includes taxes & fees

8/10 Very good! (1,016 reviews)

Brentwood Inn & Suites

123 Fourth Ave. NW Rochester MN

RM379

RM437 total

7 Sept - 8 Sept

includes taxes & fees

8.8/10 Excellent! (1,002 reviews)

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

1517 16th St Sw Rochester MN

RM380

RM438 total

18 Sept - 19 Sept

includes taxes & fees

8.2/10 Very good! (1,012 reviews)

Holiday Inn Express Rochester South - Mayo Area by IHG

4141 Maine Avenue SE Rochester MN

RM396

RM456 total

4 Oct - 5 Oct

includes taxes & fees

Frequently asked questions

Where is the best place to stay in St. Charles?

Kahler Grand Hotel, located 20.6 mi (33.1 km) from the heart of St. Charles, is a top choice for your stay, based on our traveller data. Two other options for your stay in the area are Kahler Inn and Suites - Mayo Clinic Area and Med City Inn & Suites - Mayo Clinic Area. See all available top hotels, or vacation rentals in St. Charles.

If I need to cancel my hotel reservation in St. Charles, will I receive a refund?

Yes! The majority of room reservations are fully refundable as long as you cancel prior to the hotel's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you have a non-refundable reservation, you might be able to cancel it and get a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in St. Charles.

What's it like to stay in St. Charles?

Visitors can enjoy all that St. Charles has to offer, including its parks. This city also attracts tourists with its welcoming locals. In St. Charles, there are 3 hotels and other accommodation options to choose from. Find out more about St. Charles.

What is there to see in St. Charles?

A couple of favourite places to visit are Whitewater State Park and Whitewater River. You'll also find Regional Sports Center and National Volleyball Center in the area. Take a look at what more there is to see and do in Expedia's St. Charles guide.

What's the weather like in St. Charles?

The hottest months are usually July and August, with an average temperature of 19°C, while the coldest months are January and February, with an average of -6°C. The snowiest months in St. Charles are January, March, February and April, with each month seeing an average of 20 cm of snowfall.

St. Charles hotels from RM270

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in St. Charles

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for St. Charles hotels

1. AmericInn by Wyndham Winona

2. Spark by Hilton Rochester South

3. Days Inn by Wyndham Winona

4. Comfort Inn & Suites Rochester South Mayo Clinic

5. The Wen Inn formerly Andor Wenneson

6. Holiday Inn Express Rochester South - Mayo Area by IHG

7. Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

8. Stone Mill Hotel & Suites

9. Hampton Inn Rochester-South

10. La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

11. Home2 Suites by Hilton Rochester Mayo Clinic Area

12. Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

13. Country Trails Inn & Suites

14. Hyatt House Rochester/Mayo Clinic Area

15. Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

16. Holiday Inn Express & Suites Rochester – Mayo Clinic Area by IHG

17. Fairfield Inn & Suites by Marriott Winona

18. Hilton Garden Inn Rochester Downtown, MN

19. Residence Inn by Marriott Rochester Mayo Clinic Area South

20. TownePlace Suites by Marriott Rochester Mayo Clinic Area

Learn more about St. Charles

Top St. Charles Hotel Reviews

EVEN Hotel Rochester - Mayo Clinic Area by IHG

Aspen Select

Hampton Inn Rochester-South

Med City Inn & Suites - Mayo Clinic Area

Hyatt House Rochester/Mayo Clinic Area

Hotel Indigo Rochester – Mayo Clinic Area by IHG

More cheap stays in St. Charles

Birch Hill Suite Rochester – Med City

Super 8 by Wyndham Winona MN

Med City Inn & Suites - Mayo Clinic Area

Brentwood Inn & Suites

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Holiday Inn Express Rochester South - Mayo Area by IHG

Frequently asked questions

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