Top 10 Serra Mesa Hotels of 2026

A residential area with houses, roads, and a hilly landscape.

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Our top choices for Serra Mesa hotels

1. Hampton Inn San Diego-Kearny Mesa

3.5 km from Serra Mesa

Heather

RM590 total

includes taxes & fees

23 Aug - 24 Aug

2. DoubleTree by Hilton Hotel San Diego - Mission Valley

4.2 km from Serra Mesa

Benedict

RM651 total

includes taxes & fees

13 Aug - 14 Aug

3. Holiday Inn Express San Diego Airport - Old Town by IHG

7.9 km from Serra Mesa

Tirthankar

RM710 total

includes taxes & fees

2 Aug - 3 Aug

4. Pleasant Inn

4.8 km from Serra Mesa

Sydney Reegan

RM438 total

includes taxes & fees

10 Aug - 11 Aug

5. Best Western Seven Seas

5.3 km from Serra Mesa

John

RM440 total

includes taxes & fees

9 Aug - 10 Aug

6. Hampton Inn & Suites San Diego Airport Liberty Station

10.6 km from Serra Mesa

Aimee

RM759 total

includes taxes & fees

23 Aug - 24 Aug

7. Hilton Garden Inn San Diego Old Town/SeaWorld Area

Old Town San Diego, 7.4 km from Serra Mesa

Laura

RM531 total

includes taxes & fees

23 Aug - 24 Aug

8. Homewood Suites by Hilton San Diego Hotel Circle/SeaWorld Area

6.4 km from Serra Mesa

Andrea

RM707 total

includes taxes & fees

23 Aug - 24 Aug

9. Town and Country San Diego

5.3 km from Serra Mesa

Cynthia

RM975 total

includes taxes & fees

16 Aug - 17 Aug

10. Legacy Resort Hotel & Spa

5.8 km from Serra Mesa

Shakundala

RM823 total

includes taxes & fees

2 Aug - 3 Aug

11. Hampton Inn San Diego/Mission Valley

6.4 km from Serra Mesa

Julie

RM615 total

includes taxes & fees

24 Aug - 25 Aug

12. California Suites Hotel

4.8 km from Serra Mesa

Amalia

RM418 total

includes taxes & fees

2 Aug - 3 Aug

13. GreenTree Inn San Diego Mission Bay

Pacific Beach, 7.3 km from Serra Mesa

Dennis

RM476 total

includes taxes & fees

23 Aug - 24 Aug

14. Kings Inn San Diego

6 km from Serra Mesa

Manuel

RM605 total

includes taxes & fees

24 Aug - 25 Aug

15. Embassy Suites by Hilton San Diego La Jolla

University City, 10.3 km from Serra Mesa

Kristine

RM999 total

includes taxes & fees

27 Aug - 28 Aug

16. Best Western Plus Hacienda Hotel Old Town

Old Town San Diego, 7.6 km from Serra Mesa

Allan

RM672 total

includes taxes & fees

23 Aug - 24 Aug

17. Crowne Plaza San Diego - Mission Valley by IHG

6.4 km from Serra Mesa

Tom

RM589 total

includes taxes & fees

17 Aug - 18 Aug

18. Best Western Inn & Suites San Diego – Zoo/SeaWorld Area

6.6 km from Serra Mesa

Merlyn A.

RM771 total

includes taxes & fees

23 Aug - 24 Aug

Outdoor pool, pool umbrellas, pool loungers

19. Handlery Hotel

5.7 km from Serra Mesa

Gregory

RM630 total

includes taxes & fees

19 Aug - 20 Aug

20. Fairfield Inn & Suites San Diego Old Town

Old Town San Diego, 7.8 km from Serra Mesa

Alex Fernando

RM658 total

includes taxes & fees

23 Aug - 24 Aug

View all properties

Where to stay in Serra Mesa

Find the best Serra Mesa areas for the activities you enjoy most. Learn more about Serra Mesa

A plaza with a traditional building, benches, and a large tree.

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

See properties

A beach with surfers and swimmers during sunset.

Pacific Beach

Relax in beachside cafés in the morning, surf clean breaks in the afternoon and dance with a youthful club crowd at night at this coastal San Diego strip.

See properties

A roller coaster under construction with scaffolding and a ticket booth in the foreground.

Mission Beach

If you're spending some time in Mission Beach, Mission Beach and Mission Bay are top sights worth seeing.

See properties

Gaslamp Quarter

The historic heart of San Diego has a fascinating history, and today is a thriving hub for food, retail and entertainment.

See properties

An aerial view of a coastal city with a marina, a large body of water, and a peninsula with buildings.

Mission Bay

If you're spending some time in Mission Bay, Mission Bay and Ski Beach are top sights worth seeing.

See properties

Top Serra Mesa Hotel Reviews

Days Inn by Wyndham San Diego Hotel Circle

8/10 Good

"Stayed on a weekday in summer and it was pretty packed. Room was quiet, comfortable and clean. There is a breakfast room with free coffee and creamer and vending machines if you’re hungry. Pool area was ok but lots of families with little kids using it (I know, what do you expect?!?) and the water was cloudy. Lots of chaise lounges and a few outdoor seating areas. Wi-Fi seems to have been maxed out in the evenings."

Omni San Diego Hotel at the Ballpark

8/10 Good

"My daughter and I were in town for Comic Con this year (2026) and needed a nice hotel to stay in which was close to the convention center: the Omni at the Ballpark certainly fit that bill. (I am a writer and had a booth at the convention.) We found the servers at the Fres.co (breakfast) and at Tortuga (lunch) to be very kind (the staff in general was eager to please). We availed ourselves of the pool and hot tub. The beds were comfortable. My only complaint is that Saturday night there was a private party at the pool. It ran well past midnight. It was very difficult to sleep with all of the noise."

Paradise Point Resort & Spa

10/10 Excellent

"We had an amazing stay. With two children, it was a very family friendly and beautiful location. We loved the main pool, including the music and overall environment. We also took advantage of the activities they offer such as shell painting, mini golf, and a four seat bike. Having all first floor bungalows is an added plus for ease, especially for families. Our bungalow had access to a grassy area which allowed for more space for the kids to play. We look forward to returning to this amazing resort!"

Frequently asked questions

What's it like in Serra Mesa?

Guests are sure to enjoy their time checking out all that San Diego's Serra Mesa neighbourhood has to offer. Consider a visit to Stadium Golf Center & Batting Cages as part of your Serra Mesa travel plans.

How many hotels can I expect to find in the Serra Mesa area?

Expedia has 37 hotels and other accommodation options in Serra Mesa to choose from, making this an ideal home base for exploring the greater San Diego area.

If I need to cancel my hotel reservation in Serra Mesa, will I receive a refund?

Yes, most hotel reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If you have a non-refundable reservation, it may still be possible to cancel it and get a refund within 24 hours of your booking. Plug in your dates, click on "Search", then filter by "fully refundable" to review top deals in Serra Mesa.

What can I see and do in this San Diego neighbourhood?

Stadium Golf Center & Batting Cages is an attraction you might want to check out while you're in Serra Mesa. When you're sightseeing in San Diego, Sharp Learning Resource Center and Convoy District are also worth a stop.

Hotels in Serra Mesa, San Diego

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Serra Mesa hotels

1. Hampton Inn San Diego-Kearny Mesa

2. DoubleTree by Hilton Hotel San Diego - Mission Valley

3. Holiday Inn Express San Diego Airport - Old Town by IHG

4. Pleasant Inn

5. Best Western Seven Seas

6. Hampton Inn & Suites San Diego Airport Liberty Station

7. Hilton Garden Inn San Diego Old Town/SeaWorld Area

8. Homewood Suites by Hilton San Diego Hotel Circle/SeaWorld Area

9. Town and Country San Diego

10. Legacy Resort Hotel & Spa

11. Hampton Inn San Diego/Mission Valley

12. California Suites Hotel

13. GreenTree Inn San Diego Mission Bay

14. Kings Inn San Diego

15. Embassy Suites by Hilton San Diego La Jolla

16. Best Western Plus Hacienda Hotel Old Town

17. Crowne Plaza San Diego - Mission Valley by IHG

18. Best Western Inn & Suites San Diego – Zoo/SeaWorld Area

19. Handlery Hotel

20. Fairfield Inn & Suites San Diego Old Town

Where to stay in Serra Mesa

Downtown San Diego

Pacific Beach

Mission Beach

Gaslamp Quarter

Mission Bay

Top Serra Mesa Hotel Reviews

Days Inn by Wyndham San Diego Hotel Circle

Frequently asked questions

Explore a world of travel with Expedia