Hotels in Otay Mesa West, San Diego

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Our top choices for Otay Mesa West hotels

Terrace/patio
Wyndham San Diego Bayside

Wyndham San Diego Bayside

Wyndham San Diego Bayside
4.0 star property
19.2 km from Otay Mesa West
8.4 out of 10, Very good, (6014)
"Always an amazing stay"
United States
Jana
The price is RM513
RM735 total
includes taxes & fees
4 Jan - 5 Jan 2026
Wyndham San Diego Bayside
Exterior
Hyatt Regency Mission Bay Spa and Marina

Hyatt Regency Mission Bay Spa and Marina

Hyatt Regency Mission Bay Spa and Marina
4.0 star property
Mission Bay, 27.2 km from Otay Mesa West
8.4 out of 10, Very good, (1589)
"Totally Recommend! Rooms are really clean and comfortable, the staff are great as well. "
United States
Fernando
The price is RM542
RM838 total
includes taxes & fees
10 Jan - 11 Jan 2026
Hyatt Regency Mission Bay Spa and Marina
Lobby
Wyndham Garden San Diego Near SeaWorld

Wyndham Garden San Diego Near SeaWorld

Wyndham Garden San Diego Near SeaWorld
3.0 star property
24.8 km from Otay Mesa West
7.4 out of 10, Good, (4128)
"Get location to the airport, safe, great staff, & overall wonderful stay"
United States
Tyler
The price is RM342
RM393 total
includes taxes & fees
7 Jan - 8 Jan 2026
Wyndham Garden San Diego Near SeaWorld
Daily buffet breakfast for a fee
DoubleTree by Hilton Hotel San Diego - Mission Valley

DoubleTree by Hilton Hotel San Diego - Mission Valley

DoubleTree by Hilton Hotel San Diego - Mission Valley
4.0 star property
23.5 km from Otay Mesa West
8.4 out of 10, Very good, (1444)
"The room was super quiet and clean. The staff was kind at check in and check out. We would definitely stay here again. "
United States
Janelle
The price is RM455
RM523 total
includes taxes & fees
3 Jan - 4 Jan 2026
DoubleTree by Hilton Hotel San Diego - Mission Valley
Hypo-allergenic bedding, in-room safe, desk, iron/ironing board
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego
4.0 star property
Marina District, 18.2 km from Otay Mesa West
9.0 out of 10, Wonderful, (2880)
"Lovely hotel with friendly staff."
United States
Lynnea
The price is RM713
RM1,047 total
includes taxes & fees
1 Jan - 2 Jan 2026
Manchester Grand Hyatt San Diego
View from room
Sheraton San Diego Resort

Sheraton San Diego Resort

Sheraton San Diego Resort
4.0 star property
21.4 km from Otay Mesa West
8.4 out of 10, Very good, (3179)
"The stay and staff were wonderful and very helpful.."
United States
Elsie
The price is RM506
RM727 total
includes taxes & fees
1 Jan - 2 Jan 2026
Sheraton San Diego Resort
Premium bedding, pillow-top beds, in-room safe, desk
The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection
3.0 star property
19.1 km from Otay Mesa West
8.8 out of 10, Excellent, (834)
"would stay again and recommend "
United States
Brendi
The price is RM447
RM519 total
includes taxes & fees
4 Jan - 5 Jan 2026
The DEXTRO Little Italy, BW Premier Collection
Outdoor pool, open 7:00 AM to 10:00 PM, pool cabanas (surcharge)
San Diego Mission Bay Resort

San Diego Mission Bay Resort

San Diego Mission Bay Resort
4.0 star property
Mission Bay, 26.7 km from Otay Mesa West
8.4 out of 10, Very good, (1317)
"Room was super clean and updated, location up against the bay was perfect. We really enjoyed our stay and want to come back soon!"
United States
Haley
The price is RM555
RM852 total
includes taxes & fees
13 Jan - 14 Jan 2026
San Diego Mission Bay Resort
Outdoor pool, pool loungers
Hilton San Diego Bayfront

Hilton San Diego Bayfront

Hilton San Diego Bayfront
4.0 star property
Marina District, 17.2 km from Otay Mesa West
8.6 out of 10, Excellent, (1892)
"Enjoyed my stay"
United States
Brandon
The price is RM490
RM766 total
includes taxes & fees
4 Jan - 5 Jan 2026
Hilton San Diego Bayfront
Outdoor pool, pool umbrellas, pool loungers
Hampton Inn San Diego-Downtown

Hampton Inn San Diego-Downtown

Hampton Inn San Diego-Downtown
2.5 star property
19.3 km from Otay Mesa West
8.2 out of 10, Very good, (2319)
"Nice and convenient place to stay!"
United States
Esperanza
The price is RM420
RM487 total
includes taxes & fees
18 Jan - 19 Jan 2026
Hampton Inn San Diego-Downtown
Exterior
Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter

Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter

Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter
3.0 star property
Gaslamp Quarter, 17.6 km from Otay Mesa West
9.0 out of 10, Wonderful, (1241)
"Clean, courteous staff, good location. "
United States
Carla
The price is RM555
RM643 total
includes taxes & fees
2 Jan - 3 Jan 2026
Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter
Exterior
Bay Club Hotel & Marina

Bay Club Hotel & Marina

Bay Club Hotel & Marina
3.5 star property
22.1 km from Otay Mesa West
9.2 out of 10, Wonderful, (3234)
"Great stay and location!"
United States
Jason
The price is RM434
RM498 total
includes taxes & fees
4 Jan - 5 Jan 2026
Bay Club Hotel & Marina
3 outdoor pools, pool cabanas (surcharge), pool umbrellas
Sycuan Casino Resort

Sycuan Casino Resort

Sycuan Casino Resort
4.0 star property
31.4 km from Otay Mesa West
9.2 out of 10, Wonderful, (1651)
"Very nice getaway for the family "
United States
Richard
Sycuan Casino Resort
Premium bedding, pillow-top beds, desk, laptop workspace
Staypineapple, Hotel Z, Gaslamp San Diego

Staypineapple, Hotel Z, Gaslamp San Diego

Staypineapple, Hotel Z, Gaslamp San Diego
3.0 star property
Gaslamp Quarter, 17.8 km from Otay Mesa West
9.4 out of 10, Exceptional, (1001)
"Great location "
United States
Mohammad
The price is RM401
RM582 total
includes taxes & fees
6 Jan - 7 Jan 2026
Staypineapple, Hotel Z, Gaslamp San Diego
Property entrance
The Bristol Hotel San Diego

The Bristol Hotel San Diego

The Bristol Hotel San Diego
3.5 star property
18.5 km from Otay Mesa West
8.6 out of 10, Excellent, (1469)
"I loved my stay here"
United States
José
The Bristol Hotel San Diego
2 outdoor pools, open 6 AM to 10:00 PM, pool cabanas (surcharge)
Marriott Marquis San Diego Marina

Marriott Marquis San Diego Marina

Marriott Marquis San Diego Marina
4.0 star property
Marina District, 17.9 km from Otay Mesa West
9.2 out of 10, Wonderful, (1964)
"Great place to stay, everything close by"
United States
Manjinder
The price is RM741
RM1,072 total
includes taxes & fees
9 Jan - 10 Jan 2026
Marriott Marquis San Diego Marina
Exterior
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2.5 star property
11 km from Otay Mesa West
8.0 out of 10, Very good, (1569)
"Great place to stay. Really clean and helpful staff "
United States
Zulma
The price is RM542
RM617 total
includes taxes & fees
1 Jan - 2 Jan 2026
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Exterior
Comfort Inn San Diego Old Town

Comfort Inn San Diego Old Town

Comfort Inn San Diego Old Town
2.5 star property
Old Town San Diego, 23.2 km from Otay Mesa West
8.2 out of 10, Very good, (1920)
"Great stay "
United States
Vanessa
The price is RM339
RM390 total
includes taxes & fees
6 Jan - 7 Jan 2026
Comfort Inn San Diego Old Town
2 outdoor pools, a heated pool, pool loungers
The Dana on Mission Bay

The Dana on Mission Bay

The Dana on Mission Bay
3.5 star property
Mission Bay, 27.1 km from Otay Mesa West
9.0 out of 10, Wonderful, (3952)
"Great spot, great hotel, great food options!"
United States
Demes SP
The price is RM563
RM728 total
includes taxes & fees
4 Jan - 5 Jan 2026
The Dana on Mission Bay
Terrace/patio
Hampton Inn San Diego/Mission Valley

Hampton Inn San Diego/Mission Valley

Hampton Inn San Diego/Mission Valley
2.5 star property
23.5 km from Otay Mesa West
8.6 out of 10, Excellent, (1340)
"Clean room, Good breakfast and close to all attractions"
United States
SRIVANI
The price is RM372
RM428 total
includes taxes & fees
25 Jan - 26 Jan 2026
Hampton Inn San Diego/Mission Valley
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Otay Mesa West

Find the best Otay Mesa West areas for the activities you enjoy most.

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Gaslamp Quarter showing night scenes, a bar and street scenes

Gaslamp Quarter

The historic heart of San Diego has a fascinating history, and today is a thriving hub for food, retail and entertainment.

Pacific Beach Park showing a sandy beach

Pacific Beach

Relax in beachside cafés in the morning, surf clean breaks in the afternoon and dance with a youthful club crowd at night at this coastal San Diego strip.

Belmont Park showing rides and a park

Mission Beach

If you're spending some time in Mission Beach, Mission Beach and Mission Bay are top sights worth seeing.

Ocean Beach

With a secluded sunbathing beach, swimming-only beach, special surf beach, volleyball beach and dog beach, San Diego’s “OB” sure takes beaches seriously.

Top Otay Mesa West Hotel Reviews

Lafayette Hotel & Club

Lafayette Hotel & Club

10/10 Excellent
"Amazing Customer service!! When we walked in to our room, we noticed that there was a leak on the sealing of our room. We went to notify them at the front desk and they took very good care of us with another room. Very friendly staff and will recommend everyone to stay here."
Victor 1-night trip
Posted 21 hours ago
Lafayette Hotel & Club

Frequently asked questions

What is Otay Mesa West like?
Otay Mesa West is a neighbourhood that travellers like for its cathedral.
If I need to cancel my hotel reservation in Otay Mesa West, will I receive a refund?
Yes! The majority of room reservations are refundable if you cancel before the hotel's cancellation deadline, which is often 24 or 48 hours before the scheduled arrival. If you have a non-refundable reservation, you may still be able to cancel and receive a refund within 24 hours of your booking. Put your dates in and click on "Search", then you can use the "fully refundable" filter to review top deals in Otay Mesa West.
What is there to do around this San Diego neighbourhood?
A few places to visit in the area around Otay Mesa West include San Ysidro Border Crossing, Las Americas Premium Outlets and Sesame Place San Diego. While you're out sightseeing in San Diego, make sure that you visit other sights such as Tijuana Customs - Garita El Chaparral or North Island Credit Union Amphitheatre.
How can I get around Otay Mesa West and the greater San Diego area?
Ready to get out and explore the city? Iris Avenue Trolley Station is the closest metro station.

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