Hotels in Otay Mesa, San Diego

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Check prices for these dates

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14 Nov - 15 Nov
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15 Nov - 16 Nov
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20 Nov - 22 Nov
In two weeks
27 Nov - 29 Nov

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Our top choices for Otay Mesa hotels

A modern interior with a long table and blue chairs, large windows with a view of palm trees and parked vehicles outside.

1. Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2.5 star property
Otay Mesa
8.4 out of 10, Very good, (1,959 reviews)
"Will stay again, I loved it"
United States
Shelly Ann
The price is RM531
RM604 total
includes taxes & fees
13 Dec - 14 Dec
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
A breakfast station with bread, bagels, waffles, and a coffee machine.

2. Quality Suites San Diego Otay Mesa

Quality Suites San Diego Otay Mesa
2.5 star property
Otay Mesa
7.2 out of 10, Good, (1,003 reviews)
"clean room nice place to stay"
Mexico
Anonymous traveller
The price is RM444
RM505 total
includes taxes & fees
6 Dec - 7 Dec
Quality Suites San Diego Otay Mesa
A spacious lobby with a modern design, featuring a large seating area, a reception desk, and large windows offering views of the city.

3. Ayres Hotel San Diego South - Chula Vista

Ayres Hotel San Diego South - Chula Vista
3.0 star property
6.5 km from Otay Mesa
9.8 out of 10, Exceptional, (1,027 reviews)
"I was very impressed with this hotel. The rooms were comfortable and modern and the staff was warm and welcoming."
United States
Rosemary
The price is RM657
RM724 total
includes taxes & fees
29 Nov - 30 Nov
Ayres Hotel San Diego South - Chula Vista
A modern kitchen area with a self-serve station, including a waffle maker, coffee machine, and various food items.

4. Best Western Chula Vista/Otay Valley Hotel

Best Western Chula Vista/Otay Valley Hotel
2.5 star property
7.1 km from Otay Mesa
8.0 out of 10, Very good, (2,040 reviews)
"Me and my husband loved it we tried different ones and this one is one of the best from now on is going to be our favorite to stay,very clean and breakfast was so good so many options for breakfast"
United States
Edna
The price is RM447
RM493 total
includes taxes & fees
22 Nov - 23 Nov
Best Western Chula Vista/Otay Valley Hotel
A buffet with various food items, including omelets and other dishes, served in metal trays.

5. Holiday Inn Express San Diego South - Chula Vista by IHG

Holiday Inn Express San Diego South - Chula Vista by IHG
2.5 star property
14.5 km from Otay Mesa
9.4 out of 10, Exceptional, (1,659 reviews)
"Great stay"
United States
Daniel
The price is RM622
RM684 total
includes taxes & fees
15 Nov - 16 Nov
Holiday Inn Express San Diego South - Chula Vista by IHG
View from property

6. SpringHill Suites by Marriott Chula Vista Eastlake

SpringHill Suites by Marriott Chula Vista Eastlake
3.5 star property
10.5 km from Otay Mesa
9.6 out of 10, Exceptional, (825 reviews)
"Great hotel"
United States
leslie
The price is RM664
RM732 total
includes taxes & fees
6 Dec - 7 Dec
SpringHill Suites by Marriott Chula Vista Eastlake
A breakfast bar with La Quinta branding, a coffee machine, and a waffle display.

7. La Quinta Inn by Wyndham San Diego Chula Vista

La Quinta Inn by Wyndham San Diego Chula Vista
3.0 star property
12.9 km from Otay Mesa
8.6 out of 10, Excellent, (1,801 reviews)
"Clean room , friendly staff , always helpful, breakfast good , always great to return"
United States
Luis
The price is RM420
RM462 total
includes taxes & fees
29 Nov - 30 Nov
La Quinta Inn by Wyndham San Diego Chula Vista
A modern living room with a large window, a fireplace, and a kitchen area.

8. Rodeway Inn San Diego South San Ysidro Border

Rodeway Inn San Diego South San Ysidro Border
2.0 star property
5.8 km from Otay Mesa
8.0 out of 10, Very good, (325 reviews)
"Great service beautiful hotel"
United States
Guadalupe
The price is RM308
RM351 total
includes taxes & fees
23 Nov - 24 Nov
Rodeway Inn San Diego South San Ysidro Border
A hotel lobby with a patterned carpet, a reception desk, a sofa with cushions, and potted plants.

9. Comfort Inn Chula Vista San Diego South

Comfort Inn Chula Vista San Diego South
2.5 star property
13 km from Otay Mesa
8.4 out of 10, Very good, (1,731 reviews)
"It was a nice hotel. I’d stay here again."
United States
Lori
The price is RM442
RM487 total
includes taxes & fees
22 Nov - 23 Nov
Comfort Inn Chula Vista San Diego South
A room with two teal armchairs, a small round table with a lamp, and a large cityscape painting on the wall.

10. SureStay Hotel by Best Western Chula Vista San Diego Bay

SureStay Hotel by Best Western Chula Vista San Diego Bay
3.0 star property
14.7 km from Otay Mesa
8.0 out of 10, Very good, (2,034 reviews)
"A good hotel, with a good location at a very good price, has a reasonable breakfast."
Brazil
Sergio
The price is RM310
RM342 total
includes taxes & fees
16 Nov - 17 Nov
SureStay Hotel by Best Western Chula Vista San Diego Bay
A spacious restaurant with high ceilings, exposed beams, and hanging plants. There are multiple seating areas with tables and chairs.

11. Best Western Plus Marina Gateway Hotel

Best Western Plus Marina Gateway Hotel
3.5 star property
16.9 km from Otay Mesa
9.2 out of 10, Wonderful, (4,235 reviews)
"Clean room and really nice area for our stay"
United States
Brandon
The price is RM511
RM563 total
includes taxes & fees
22 Nov - 23 Nov
Best Western Plus Marina Gateway Hotel
A hotel room with two beds, a desk, and a chair.

12. Howard Johnson by Wyndham National City/San Diego South

Howard Johnson by Wyndham National City/San Diego South
2.0 star property
18.3 km from Otay Mesa
7.6 out of 10, Good, (1,189 reviews)
"Great stay for a stay !"
United States
Monserrat
The price is RM295
RM325 total
includes taxes & fees
16 Nov - 17 Nov
Howard Johnson by Wyndham National City/San Diego South
A motel with a sign indicating amenities like Wi-Fi, TV, and pool.

13. Valli Hi Motel

Valli Hi Motel
2.0 star property
7.9 km from Otay Mesa
8.2 out of 10, Very good, (1,174 reviews)
"Clean rooms and nice staff"
United States
Wendy
The price is RM331
RM377 total
includes taxes & fees
15 Nov - 16 Nov
Valli Hi Motel
A spacious lobby with a fireplace, wooden furniture, and a chandelier.

14. Best Western Americana Inn

Best Western Americana Inn
2.5 star property
8 km from Otay Mesa
8.8 out of 10, Excellent, (1,420 reviews)
"Great service from the staff!"
United States
Erika
The price is RM427
RM486 total
includes taxes & fees
22 Nov - 23 Nov
Best Western Americana Inn
A modern hotel with a prominent 'Hercor Hotel' sign, multiple balconies, and a 'Urban Boutique' label.

15. Hercor Hotel - Urban Boutique

Hercor Hotel - Urban Boutique
3.0 star property
13.6 km from Otay Mesa
8.8 out of 10, Excellent, (1,584 reviews)
"Really nice place"
United States
justin
The price is RM454
RM501 total
includes taxes & fees
18 Nov - 19 Nov
Hercor Hotel - Urban Boutique
An outdoor seating area with a sofa, two tables, and a fire feature.

16. Holiday Inn Express & Suites San Diego - Mission Valley by IHG

Holiday Inn Express & Suites San Diego - Mission Valley by IHG
2.5 star property
28.8 km from Otay Mesa
8.8 out of 10, Excellent, (1,000 reviews)
"Breakfast included. Staff are very helpful."
United States
Rosita
The price is RM510
RM599 total
includes taxes & fees
15 Nov - 16 Nov
Holiday Inn Express & Suites San Diego - Mission Valley by IHG
A hotel with a central courtyard, palm trees, and a fountain.

17. Hilton Garden Inn San Diego Old Town/SeaWorld Area

Hilton Garden Inn San Diego Old Town/SeaWorld Area
3.0 star property
Old Town San Diego, 30.5 km from Otay Mesa
8.8 out of 10, Excellent, (1,561 reviews)
"Great stay."
United States
Christopher
The price is RM444
RM510 total
includes taxes & fees
6 Dec - 7 Dec
Hilton Garden Inn San Diego Old Town/SeaWorld Area
A hotel room with a large window offering a city view, a bed, a chair, and a small table.

18. The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection
3.0 star property
25.4 km from Otay Mesa
8.8 out of 10, Excellent, (2,375 reviews)
"Really enjoyed my stay!"
United States
Kelly
The price is RM517
RM599 total
includes taxes & fees
22 Nov - 23 Nov
The DEXTRO Little Italy, BW Premier Collection
A hotel room with a large bed, two bedside lamps, a nightstand, and a window with curtains.

19. Comfort Inn San Diego Old Town

Comfort Inn San Diego Old Town
2.5 star property
Old Town San Diego, 29.6 km from Otay Mesa
8.2 out of 10, Very good, (2,086 reviews)
"A great stay and very close to the airport for those frequent trips"
United States
Ernesto
The price is RM406
RM467 total
includes taxes & fees
13 Dec - 14 Dec
Comfort Inn San Diego Old Town
An outdoor dining area with tables set for two, string lights overhead, and a view of a building in the background.

20. Hilton San Diego Mission Valley

Hilton San Diego Mission Valley
4.0 star property
28.4 km from Otay Mesa
8.2 out of 10, Very good, (2,738 reviews)
"Breakfast was great and everything is really clean"
United States
Arantzasu
The price is RM499
RM573 total
includes taxes & fees
22 Nov - 23 Nov
Hilton San Diego Mission Valley
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare top hotels in Otay Mesa

A modern interior with a long table and blue chairs, large windows with a view of palm trees and parked vehicles outside.

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

2.5 star property
Otay Mesa
View
A breakfast station with bread, bagels, waffles, and a coffee machine.

Quality Suites San Diego Otay Mesa

2.5 star property
Otay Mesa
View
A spacious lobby with a modern design, featuring a large seating area, a reception desk, and large windows offering views of the city.

Ayres Hotel San Diego South - Chula Vista

3.0 star property
6.5 km from Otay Mesa
View
A modern kitchen area with a self-serve station, including a waffle maker, coffee machine, and various food items.

Best Western Chula Vista/Otay Valley Hotel

2.5 star property
7.1 km from Otay Mesa
View
A buffet with various food items, including omelets and other dishes, served in metal trays.

Holiday Inn Express San Diego South - Chula Vista by IHG

2.5 star property
14.5 km from Otay Mesa
View
8.4
Very good
1,959 reviews
7.2
Good
1,003 reviews
9.8
Exceptional
1,027 reviews
8.0
Very good
2,040 reviews
9.4
Exceptional
1,659 reviews
The price is RM531
RM604 total
includes taxes & fees
13 Dec - 14 Dec
The price is RM444
RM505 total
includes taxes & fees
6 Dec - 7 Dec
The price is RM657
RM724 total
includes taxes & fees
29 Nov - 30 Nov
The price is RM447
RM493 total
includes taxes & fees
22 Nov - 23 Nov
The price is RM622
RM684 total
includes taxes & fees
15 Nov - 16 Nov
  • Yes, Breakfast included
  • Yes, Pool
  • No Spa
  • No Pet-friendly
  • Yes, WiFi included
  • Yes, Parking
  • Yes, Breakfast included
  • No Pool
  • No Spa
  • No Pet-friendly
  • Yes, WiFi included
  • Yes, Parking
  • Yes, Breakfast included
  • Yes, Pool
  • No Spa
  • No Pet-friendly
  • Yes, WiFi included
  • Yes, Parking
  • Yes, Breakfast included
  • Yes, Pool
  • No Spa
  • No Pet-friendly
  • Yes, WiFi included
  • Yes, Parking
  • Yes, Breakfast included
  • Yes, Pool
  • No Spa
  • No Pet-friendly
  • Yes, WiFi included
  • Yes, Parking

Where to stay in Otay Mesa

Find the best Otay Mesa areas for the activities you enjoy most.
A large stadium with the sign "Cobo Park" and palm trees around it.

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

A pier extending into the ocean with buildings at the end, under a partly cloudy sky.

Pacific Beach

Relax in beachside cafés in the morning, surf clean breaks in the afternoon and dance with a youthful club crowd at night at this coastal San Diego strip.

A theater marquee with ornate designs and the name "Gaslamp Quarter".

Gaslamp Quarter

The historic heart of San Diego has a fascinating history, and today is a thriving hub for food, retail and entertainment.

A coastal cityscape with a long sandy beach, a pier, and dense urban buildings.

Mission Beach

If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.

An aerial view of a coastal city with a marina, a large body of water, and a peninsula with buildings.

Mission Bay

If you're spending some time in Mission Bay, Mission Bay and Ski Beach are top sights worth seeing.

Frequently Asked Questions

What's it like in Otay Mesa?

Otay Mesa is a neighbourhood that travellers like for its beaches, restaurants and shopping.

Where is the best hotel for a stay in Otay Mesa?

Based on our traveller data, Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG is one of the top choices for your stay in Otay Mesa. This hotel offers free breakfast and an outdoor pool.

If I need to cancel my hotel reservation in Otay Mesa, will I receive a refund?

Yes! Most room reservations are refundable provided that you cancel before the hotel’s cancellation deadline, which is usually within 24-48 hours of your arrival date. If you booked a non-refundable reservation, it might still be possible to cancel it and be given a refund within a 24-hour period of booking. Add dates, click "Search", then filter by "fully refundable" to view top deals in Otay Mesa.

What is there to do in this San Diego neighbourhood?

A few places to visit in the area around Otay Mesa include High Performance Center in Tijuana, Parque Industrial FINSA Tijuana and Otay Sports Fields. While you're out sightseeing, Caliente Casino and Alameda Otay are a couple of additional sights to visit in San Diego.