Top 10 Hotels Near Sioux Empire Medical Museum in Sioux Falls for 2026

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Our top choices for Sioux Empire Medical Museum hotels

In-room safe, desk, laptop workspace, blackout curtains

1. Highpoint Hotel

University Heights, 0.2 km from Sioux Empire Medical Museum

Neema

RM692 total

includes taxes & fees

18 Aug - 19 Aug

2. Clubhouse Hotel Suites Sioux Falls

Mall District, 2.8 km from Sioux Empire Medical Museum

Caleb

RM705 total

includes taxes & fees

9 Aug - 10 Aug

3. Hotel On Phillips

Downtown Sioux Falls, 1.9 km from Sioux Empire Medical Museum

Randall

RM793 total

includes taxes & fees

23 Aug - 24 Aug

4. Home2 Suites By Hilton Sioux Falls/Sanford Medical Center

University Heights, 0.2 km from Sioux Empire Medical Museum

Michelle

RM666 total

includes taxes & fees

30 Aug - 31 Aug

5. Canopy By Hilton Sioux Falls Downtown

Downtown Sioux Falls, 2.5 km from Sioux Empire Medical Museum

Edith

RM866 total

includes taxes & fees

23 Aug - 24 Aug

6. Historic Victorian Inn

Cathedral, 1.5 km from Sioux Empire Medical Museum

"This house is an older and rustic, but the vibe is fantastic! Rooms were well kept and stocked with the necessities. Very quiet and peaceful even though it is a very short walking distance from downtown Sioux Falls (5 to 8 walk depending on what you wanted to do). Shops, Food, Bars, and Entertainment was super convenient to get to. Check in and out was very simple. I would recommend this place to anyone and will definitely stay there again."

Teachey Kent

RM515 total

includes taxes & fees

26 Aug - 27 Aug

7. Holiday Inn Express & Suites Sioux Falls At Empire Mall by IHG

Mall District, 3.1 km from Sioux Empire Medical Museum

Donald

RM555 total

includes taxes & fees

31 Aug - 1 Sept

8. Hilton Garden Inn Sioux Falls Downtown

Downtown Sioux Falls, 2.1 km from Sioux Empire Medical Museum

Janet Ann

RM566 total

includes taxes & fees

23 Aug - 24 Aug

9. Holiday Inn Sioux Falls-City Centre by IHG

Downtown Sioux Falls, 1.9 km from Sioux Empire Medical Museum

Lisa

RM564 total

includes taxes & fees

23 Aug - 24 Aug

10. Sheraton Sioux Falls Hotel & Convention Center

Northwest Sioux Falls, 2.9 km from Sioux Empire Medical Museum

Joan

RM520 total

includes taxes & fees

23 Aug - 24 Aug

11. Country Inn & Suites by Radisson, Sioux Falls

Downtown Sioux Falls, 2 km from Sioux Empire Medical Museum

Margie

RM474 total

includes taxes & fees

30 Aug - 31 Aug

12. The Center Inn

All Saints, 2.4 km from Sioux Empire Medical Museum

Dawn

RM435 total

includes taxes & fees

7 Aug - 8 Aug

3 indoor pools, open 9:00 AM to 10:00 PM, pool loungers

13. Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

Northwest Sioux Falls, 2.9 km from Sioux Empire Medical Museum

Wayne

RM368 total

includes taxes & fees

23 Aug - 24 Aug

14. Valley Inn

University Heights, 0.2 km from Sioux Empire Medical Museum

Reed

RM390 total

includes taxes & fees

14 Aug - 15 Aug

50-inch flat-screen TV with cable channels, fireplace, Netflix

15. Historic Twin Tudors Inn

1.4 km from Sioux Empire Medical Museum

Anonymous traveller

RM1,180 total

includes taxes & fees

10 Aug - 11 Aug

16. WoodSpring Suites Sioux Falls

2.8 km from Sioux Empire Medical Museum

Catherine

RM362 total

includes taxes & fees

12 Aug - 13 Aug

17. Ramada by Wyndham Sioux Falls

2.6 km from Sioux Empire Medical Museum

Aurelia Tara

RM237 total

includes taxes & fees

2 Sept - 3 Sept

18. Comfort Inn & Suites at Sanford Sports Complex

Northwest Sioux Falls, 6 km from Sioux Empire Medical Museum

Patricia

RM488 total

includes taxes & fees

23 Aug - 24 Aug

19. Hyatt Place Sioux Falls South

Mall District, 3.8 km from Sioux Empire Medical Museum

Kannan

RM579 total

includes taxes & fees

2 Sept - 3 Sept

20. Comfort Inn & Suites Avera Southwest

South Sioux Falls, 5.5 km from Sioux Empire Medical Museum

Adam

RM447 total

includes taxes & fees

16 Aug - 17 Aug

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Compare popular hotels close to Sioux Empire Medical Museum

Property	Property class	Guest rating
Highpoint Hotel	3.0 star property	9.8 Exceptional 236 reviews	View
Clubhouse Hotel Suites Sioux Falls	3.0 star property	9.6 Exceptional 1,161 reviews	View
Hotel On Phillips	2.5 star property	9.6 Exceptional 1,526 reviews	View
Home2 Suites By Hilton Sioux Falls/Sanford Medical Center	3.0 star property	9.4 Exceptional 664 reviews	View
Canopy By Hilton Sioux Falls Downtown	4.0 star property	9.4 Exceptional 243 reviews	View

Top Sioux Empire Medical Museum Hotel Reviews

Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

10/10 Excellent

"It was awesome. Grandkids loved the water park and having a room right by the pool. We liked being able to go eat and still watch the kids from where we were eating. Then we ordered for them when they got out of the pool. Our room had a table so they could sit and eat at. Lots of room in our room also. Huge bathroom, nice beds. Would recommend to anyone."

Clubhouse Hotel Suites Sioux Falls

10/10 Excellent

"We were passing through Sioux Falls and stopped at Clubhouse Suites — glad we did. The suite had plenty of room for the whole family to hang out, which was a nice break after a day of driving. My kids loved the pool, breakfast was great, and the staff even lit an outdoor fire for us in the evening, which was such a nice touch. Would definitely stay here again next time we're passing through."

Hilton Garden Inn Sioux Falls Downtown

8/10 Good

"The rooms were clean and comfortable. I know they are maybe in the process of renovating but the only places I saw any updates was the lobby bar and restaurant area and the 5th floor. It’s a nice hotel but some of the furniture in the rooms showed a lot of wear and tear. An option of a less expensive or free breakfast would be nice. The price we paid was outrageous for what we had available to us. Over all due to the area it is in and the cleanliness of the premises I would give 3 out of 5 stars."

Other attractions near Sioux Empire Medical Museum

University of Sioux Falls

8.0/10 (242 reviews)

Explore the campus of University of Sioux Falls during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

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Frequently asked questions

What's the area like around Sioux Empire Medical Museum?

Sioux Empire Medical Museum is located in a welcoming area of Sioux Falls known for its beautiful waterfalls and sporting events. If you're looking for a convenient place to stay, take a look at the 131 hotels and other accommodation options you'll find within a mile.

What's the best place to stay close to Sioux Empire Medical Museum?

Adjacent to Sioux Empire Medical Museum, Highpoint Hotel is one of the top choices for your stay based on our traveller data, and this hotel offers a restaurant and free parking. Another good choice is Valley Inn, located just 0.1 mi (0.2 km) away.

How many hotels are there close to Sioux Empire Medical Museum?

Expedia has 131 hotels and other accommodation options within a mile from Sioux Empire Medical Museum.

If I need to cancel the hotel reservation for my stay near Sioux Empire Medical Museum, will I receive a refund?

Yes, the majority of hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your check-in date. If you have a reservation that's non-refundable, you might still have the option to cancel and be given a refund within 24 hours of booking. Enter dates in and click on "Search", then use the "fully refundable" filter to view the best options available near Sioux Empire Medical Museum.

What can I see and do near Sioux Empire Medical Museum?

Washington Pavilion of Arts and Science, Old Courthouse Museum and The Outdoor Campus feature a variety of fascinating exhibits to see while you're in town. Learn about local history at St. Joseph Cathedral and Pettigrew Home and Museum. You can enjoy live performances at Edith Mortenson Theatre Center and Orpheum Theatre Center.

Hotels near Sioux Empire Medical Museum

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Our top choices for Sioux Empire Medical Museum hotels

1. Highpoint Hotel

2. Clubhouse Hotel Suites Sioux Falls

3. Hotel On Phillips

4. Home2 Suites By Hilton Sioux Falls/Sanford Medical Center

5. Canopy By Hilton Sioux Falls Downtown

6. Historic Victorian Inn

7. Holiday Inn Express & Suites Sioux Falls At Empire Mall by IHG

8. Hilton Garden Inn Sioux Falls Downtown

9. Holiday Inn Sioux Falls-City Centre by IHG

10. Sheraton Sioux Falls Hotel & Convention Center

11. Country Inn & Suites by Radisson, Sioux Falls

12. The Center Inn

13. Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

14. Valley Inn

15. Historic Twin Tudors Inn

16. WoodSpring Suites Sioux Falls

17. Ramada by Wyndham Sioux Falls

18. Comfort Inn & Suites at Sanford Sports Complex

19. Hyatt Place Sioux Falls South

20. Comfort Inn & Suites Avera Southwest

Compare popular hotels close to Sioux Empire Medical Museum

Top Sioux Empire Medical Museum Hotel Reviews

Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

Other attractions near Sioux Empire Medical Museum

University of Sioux Falls

Frequently asked questions