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Hotels near Mayo Clinic Florida

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Check prices for these dates

Tonight
18 Oct - 19 Oct
Tomorrow
19 Oct - 20 Oct
Next weekend
23 Oct - 25 Oct
In two weeks
30 Oct - 1 Nov

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Our top choices for Mayo Clinic Florida hotels

A spacious living area with a high ceiling, a fireplace, and a bar area in the background.
A modern kitchen with a bar area, seating, and a view of the outdoors.
A multi-story hotel with a central entrance, surrounded by well-maintained lawns and palm trees.
An outdoor patio area with seating and a central fire feature, surrounded by buildings and palm trees.

1. Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Residence Inn By Marriott Jacksonville - Mayo Clinic Area
1.1 km from Mayo Clinic Florida
United States
Michaelanne
RM558
RM633 total
includes taxes & fees
23 Oct - 24 Oct
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
A modern restaurant with a bar area, wooden ceiling, and large windows.
A modern bar area with a central hanging light fixture, bar stools, and a well-stocked liquor display.
A covered outdoor seating area with chairs and sofas, a fountain, and a view of a lake and trees.
A modern lobby with a central seating area, wooden shelving with decorative items, and a large pillar.

2. Hilton Jacksonville at Mayo Clinic near Beaches

Hilton Jacksonville at Mayo Clinic near Beaches
0.8 km from Mayo Clinic Florida
United States
Patricia
RM687
RM780 total
includes taxes & fees
8 Nov - 9 Nov
Hilton Jacksonville at Mayo Clinic near Beaches
An outdoor seating area with a fire pit, wicker furniture, and a covered patio.
A modern kitchen with wooden cabinets, a built-in oven, and a coffee machine.
A multi-story hotel with a modern design, featuring a covered outdoor area with seating and a fire pit.
A hotel room with a bed, a sofa, a nightstand, and a wall-mounted lamp.

3. TownePlace Suites by Marriott Jacksonville East

TownePlace Suites by Marriott Jacksonville East
Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida
United States
gregory
RM502
RM570 total
includes taxes & fees
25 Oct - 26 Oct
TownePlace Suites by Marriott Jacksonville East
A lobby with a reception desk, seating area, and a staircase.
A modern hotel room with a large bed, a blue sofa, a small table, and a wall-mounted lamp.
Lobby sitting area
An indoor swimming pool with clear views of trees outside, a tiled floor, and a covered seating area.

4. Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
2.6 km from Mayo Clinic Florida
United States
frances
RM441
RM500 total
includes taxes & fees
15 Nov - 16 Nov
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
An outdoor seating area with stone fire pit, wicker furniture, and potted plants.
A bar area with a long counter, multiple stools, and shelves stocked with bottles.
A modern living room with two armchairs, a sofa, a coffee table, and a flat-screen TV mounted on the wall.
A hotel pool area with lounge chairs and umbrellas, surrounded by multi-story buildings with balconies.

5. Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
0.4 km from Mayo Clinic Florida
United States
Patricia
RM620
RM704 total
includes taxes & fees
24 Oct - 25 Oct
Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
A round marble table with a magazine, a pair of glasses, and a coffee cup.
A cafe with a front desk, a coffee machine, and two chairs outside.
A backyard with a swimming pool, wooden deck, and outdoor furniture.
A hotel room with two beds, a nightstand with a lamp, and a pair of slippers on the floor.

6. Hotel Palms

Hotel Palms
7.8 km from Mayo Clinic Florida
United States
Vinny
RM778
RM883 total
includes taxes & fees
19 Oct - 20 Oct
Hotel Palms
A multi-story hotel with a modern design, featuring a covered entrance and a parking area with handicapped accessibility.
A hotel room with two beds, a desk, a chair, and a large window with a view.
A beverage refrigerator stocked with various drinks, a small refrigerator, and a wall-mounted display with promotional items.
A kitchen counter with a flat-screen TV displaying a breakfast menu, a coffee machine, and a sign for fresh pancakes.

7. Holiday Inn Express & Suites Jacksonville - Town Center by IHG

Holiday Inn Express & Suites Jacksonville - Town Center by IHG
Southside, 7.7 km from Mayo Clinic Florida
United States
Aneudi
RM416
RM473 total
includes taxes & fees
29 Oct - 30 Oct
Holiday Inn Express & Suites Jacksonville - Town Center by IHG
A modern outdoor seating area with white wicker chairs, a glass fire pit with burning wood, and a view of palm trees and a building in the background.
A pathway leading to a sunset over a beach with sand and grass.
A modern hotel lobby with a long reception desk, seating area, and large windows.
A modern conference room with a long table, several chairs, and pendant lighting.

8. Element by Marriott Jacksonville Beach

Element by Marriott Jacksonville Beach
5.4 km from Mayo Clinic Florida
United States
Lisa
RM588
RM667 total
includes taxes & fees
1 Nov - 2 Nov
Element by Marriott Jacksonville Beach
An outdoor patio area with seating, a fire pit, and a barbecue grill.
A modern hotel with a sign reading "Towneplace Suites by Marriott" and a parking lot in front.
A reception area with a modern design, featuring a reception desk, a refrigerator with snacks, and a wooden slatted wall.
A modern living room with sofas, a coffee table, and a dining area.

9. TownePlace Suites by Marriott® Jacksonville Mayport

TownePlace Suites by Marriott® Jacksonville Mayport
10.8 km from Mayo Clinic Florida
United States
irina
RM486
RM551 total
includes taxes & fees
15 Nov - 16 Nov
TownePlace Suites by Marriott® Jacksonville Mayport
A laptop on a wooden desk with a white mug, a spoon, and a smartphone.
A conference room with multiple tables and chairs, large windows with curtains, and a flat-screen TV mounted on the wall.
Lobby
Room

10. Hyatt Studios Jacksonville/St Johns Town Center

Hyatt Studios Jacksonville/St Johns Town Center
Deerwood, 7.8 km from Mayo Clinic Florida
United States
Mandy
RM449
RM510 total
includes taxes & fees
28 Oct - 29 Oct
Hyatt Studios Jacksonville/St Johns Town Center
A modern bar area with a central island, multiple seating options, and a variety of bottles displayed on shelves.
An outdoor seating area with white furniture and a well-maintained lawn, surrounded by large windows and a modern building facade.
A modern hotel building with a flat facade, large windows, and a sign reading "ACHTEL JACKSONVILLE".
A modern bar area with seating, a bar counter, and a view of the city through large windows.

11. AC Hotel Jacksonville St Johns Town Center

AC Hotel Jacksonville St Johns Town Center
Southside, 8.1 km from Mayo Clinic Florida
United States
Emily
RM731
RM829 total
includes taxes & fees
22 Oct - 23 Oct
AC Hotel Jacksonville St Johns Town Center
An outdoor seating area with a fire feature, chairs, and a table.
A modern bar area with a counter, bar stools, and a television screen.
A modern hotel room with two beds, a flat-screen TV, a desk, and a large window with a view of a building.
A gym with treadmills, dumbbells, and exercise balls, overlooking a swimming pool.

12. Hotel Indigo Jacksonville-Deerwood Park by IHG

Hotel Indigo Jacksonville-Deerwood Park by IHG
Southside, 10.8 km from Mayo Clinic Florida
United States
Carol
RM482
RM547 total
includes taxes & fees
12 Nov - 13 Nov
Hotel Indigo Jacksonville-Deerwood Park by IHG
An outdoor patio with seating, a fire pit, and string lights.
A modern living room with a dining area, a flat-screen TV, and a bookshelf.
A swimming pool with lounge chairs and umbrellas, surrounded by palm trees and a fence.
A modern bar area with a counter, bar stools, and a television screen. There are round tables with chairs in the dining area.

13. Hyatt Place Jacksonville / St. Johns Town Center

Hyatt Place Jacksonville / St. Johns Town Center
Southside, 8.6 km from Mayo Clinic Florida
United States
Becky
RM519
RM589 total
includes taxes & fees
22 Oct - 23 Oct
Hyatt Place Jacksonville / St. Johns Town Center
A modern bar area with wooden accents, a variety of beverages, and seating arrangements.
A patio area with a stone fire pit, outdoor furniture, and a brick floor.
A multi-story hotel with a prominent entrance, a parking lot, and well-maintained landscaping.
A modern bar area with a wooden counter, multiple seating options including bar stools and round tables, and a menu board.

14. Courtyard by Marriott Jacksonville I-295/East Beltway

Courtyard by Marriott Jacksonville I-295/East Beltway
Arlington, 13.2 km from Mayo Clinic Florida
United States
Chloie Marie
RM395
RM448 total
includes taxes & fees
1 Nov - 2 Nov
Courtyard by Marriott Jacksonville I-295/East Beltway
An outdoor patio area with a stone fire pit, wicker furniture, and a grill.
A swimming pool with lounge chairs and a building with multiple floors and balconies.
A modern kitchen with dark wooden cabinets, a stainless steel refrigerator, a microwave, and a dishwasher.
A modern living room with a fireplace, leather armchairs, a sofa, and ottomans.

15. Residence Inn by Marriott Jacksonville South/Bartram Park

Residence Inn by Marriott Jacksonville South/Bartram Park
17.1 km from Mayo Clinic Florida
United States
Nicholas
RM511
RM580 total
includes taxes & fees
25 Oct - 26 Oct
Residence Inn by Marriott Jacksonville South/Bartram Park
A spacious lobby with a reception desk, seating area, and large windows.
An indoor dining area with tables and chairs, a ceiling fan, and a view of the outdoors.
A multi-story hotel with a central entrance, large windows, and a well-lit facade.
A bar area with wooden chairs, a round table, and a brick wall.

16. Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass

Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass
8.5 km from Mayo Clinic Florida
United States
Madison
RM481
RM536 total
includes taxes & fees
29 Oct - 30 Oct
Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass
An outdoor patio with blue and red chairs, tables, and potted plants.
A hotel room with a bed, a desk with a microwave, a coffee maker, and a mini-fridge.
A rectangular swimming pool with a tiled deck, surrounded by a black metal fence. There are lounge chairs with blue cushions and white frames along the pool's edge.
A coffee station with two coffee machines and a variety of coffee pods and cups.

17. Holiday Inn Express Jacksonville South Bartram Prk by IHG

Holiday Inn Express Jacksonville South Bartram Prk by IHG
17.1 km from Mayo Clinic Florida
United States
Max
RM412
RM468 total
includes taxes & fees
25 Oct - 26 Oct
Holiday Inn Express Jacksonville South Bartram Prk by IHG
A covered entrance with a dark tiled floor, white columns, and a green bench.
A gym with treadmills, elliptical machines, and dumbbells.
A modern hotel lobby with a bar area, seating arrangements, and a reception desk.
A large, multi-story hotel with a prominent entrance, a covered area with lights, and a star-shaped design on the facade.

18. Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area
4.2 km from Mayo Clinic Florida
United States
William Garita
RM489
RM555 total
includes taxes & fees
25 Oct - 26 Oct
Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area
A beach with a sandy shore, waves, and buildings in the background.
A Best Western hotel with a modern design, located near a beach with a pier.
A modern cafe with a central counter, seating area, and a wooden accent wall with 'BW' letters.
A modern lobby with a grey sofa, two round tables, a reception desk, and a wooden wall with shelves displaying trophies and awards.

19. Best Western Oceanfront

Best Western Oceanfront
5.7 km from Mayo Clinic Florida
United States
Stephanie
RM533
RM604 total
includes taxes & fees
19 Oct - 20 Oct
Best Western Oceanfront
Pool
A coastal hotel with a long promenade, beach access, and a pier in the distance.
A hotel with a beach view, multiple parking levels, and a prominent 'Four Points' sign.
A hotel room with a large bed, a desk, a chair, a TV, and a view of the ocean.

20. Four Points by Sheraton Jacksonville Beachfront

Four Points by Sheraton Jacksonville Beachfront
5.6 km from Mayo Clinic Florida
United States
Rachel
RM690
RM784 total
includes taxes & fees
8 Nov - 9 Nov
Four Points by Sheraton Jacksonville Beachfront
View all properties

Compare popular hotels close to Mayo Clinic Florida

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
A spacious living area with a high ceiling, a fireplace, and a bar area in the background.
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
9.4
Exceptional
609 reviews
View
A modern restaurant with a bar area, wooden ceiling, and large windows.
Hilton Jacksonville at Mayo Clinic near Beaches
9.4
Exceptional
378 reviews
View
An outdoor seating area with a fire pit, wicker furniture, and a covered patio.
TownePlace Suites by Marriott Jacksonville East
9.2
Wonderful
664 reviews
View
A lobby with a reception desk, seating area, and a staircase.
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
9.0
Wonderful
1,006 reviews
View
An outdoor seating area with stone fire pit, wicker furniture, and potted plants.
Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
8.4
Very good
799 reviews
View

Hotels recommended for families near Mayo Clinic Florida

A modern restaurant with a bar area, wooden ceiling, and large windows.
A modern bar area with a central hanging light fixture, bar stools, and a well-stocked liquor display.
A covered outdoor seating area with chairs and sofas, a fountain, and a view of a lake and trees.
A modern lobby with a central seating area, wooden shelving with decorative items, and a large pillar.

Hilton Jacksonville at Mayo Clinic near Beaches

Hilton Jacksonville at Mayo Clinic near Beaches
Jacksonville
RM687
RM780 total
includes taxes & fees
8 Nov - 9 Nov
Hilton Jacksonville at Mayo Clinic near Beaches
A spacious living area with a high ceiling, a fireplace, and a bar area in the background.
A modern kitchen with a bar area, seating, and a view of the outdoors.
A multi-story hotel with a central entrance, surrounded by well-maintained lawns and palm trees.
An outdoor patio area with seating and a central fire feature, surrounded by buildings and palm trees.

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Residence Inn By Marriott Jacksonville - Mayo Clinic Area
Isle of Palms
RM558
RM633 total
includes taxes & fees
23 Oct - 24 Oct
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
An outdoor seating area with stone fire pit, wicker furniture, and potted plants.
A bar area with a long counter, multiple stools, and shelves stocked with bottles.
A modern living room with two armchairs, a sofa, a coffee table, and a flat-screen TV mounted on the wall.
A hotel pool area with lounge chairs and umbrellas, surrounded by multi-story buildings with balconies.

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
Jacksonville
RM620
RM704 total
includes taxes & fees
24 Oct - 25 Oct
Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
A lobby with a reception desk, seating area, and a staircase.
A modern hotel room with a large bed, a blue sofa, a small table, and a wall-mounted lamp.
Lobby sitting area
An indoor swimming pool with clear views of trees outside, a tiled floor, and a covered seating area.

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
Jacksonville
RM441
RM500 total
includes taxes & fees
15 Nov - 16 Nov
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
A covered entrance with a dark tiled floor, white columns, and a green bench.
A gym with treadmills, elliptical machines, and dumbbells.
A modern hotel lobby with a bar area, seating arrangements, and a reception desk.
A large, multi-story hotel with a prominent entrance, a covered area with lights, and a star-shaped design on the facade.

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area
Jacksonville Beach
RM489
RM555 total
includes taxes & fees
25 Oct - 26 Oct
Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area
An outdoor seating area with a fire pit, wicker furniture, and a covered patio.
A modern kitchen with wooden cabinets, a built-in oven, and a coffee machine.
A multi-story hotel with a modern design, featuring a covered outdoor area with seating and a fire pit.
A hotel room with a bed, a sofa, a nightstand, and a wall-mounted lamp.

TownePlace Suites by Marriott Jacksonville East

TownePlace Suites by Marriott Jacksonville East
Golden Glades - The Woods
RM502
RM570 total
includes taxes & fees
25 Oct - 26 Oct
TownePlace Suites by Marriott Jacksonville East
A spacious lobby with a glass floor, a reception desk, and a view of the ocean.
A modern building with multiple balconies overlooking a beach.
A multi-story hotel with a beach view, parking lot, and a nearby restaurant.
A cafe with a tropical mural, a coffee menu, and a variety of seating options.

Margaritaville Jacksonville Beach

Margaritaville Jacksonville Beach
Oceanfront
RM602
RM683 total
includes taxes & fees
1 Nov - 2 Nov
Margaritaville Jacksonville Beach
A beach with a sandy shore, waves, and buildings in the background.
A Best Western hotel with a modern design, located near a beach with a pier.
A modern cafe with a central counter, seating area, and a wooden accent wall with 'BW' letters.
A modern lobby with a grey sofa, two round tables, a reception desk, and a wooden wall with shelves displaying trophies and awards.

Best Western Oceanfront

Best Western Oceanfront
Oceanfront
RM533
RM604 total
includes taxes & fees
19 Oct - 20 Oct
Best Western Oceanfront

Top Mayo Clinic Florida Hotel Reviews

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

8/10 Good
"Great room! Only complaint was noisy ac motor next to bed."
Susan 1-night trip
Posted 2 days ago
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

10/10 Excellent
"They were awesome and couldn t ask for better serving."
Tonja 2-night trip
Posted 2 days ago
Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area
Holiday Inn Express Jacksonville Beach by IHG

Holiday Inn Express Jacksonville Beach by IHG

10/10 Excellent
"Nice weekend stay for the price close to the beach. Quiet area."
marcia 2-night trip
Posted 2 days ago
Holiday Inn Express Jacksonville Beach by IHG
TownePlace Suites by Marriott Jacksonville East

TownePlace Suites by Marriott Jacksonville East

8/10 Good
"."
Shaneen 1-night trip
Posted 2 days ago
TownePlace Suites by Marriott Jacksonville East

Frequently asked questions

What's the area like around Mayo Clinic Florida?
Mayo Clinic Florida is located in a welcoming area of Jacksonville known for its beautiful beaches and surfing. If you're looking for a convenient place to stay, take a look at the 44 hotels and other accommodation options you'll find within a mile.
Where is the best place to stay close to Mayo Clinic Florida?
Adjacent to Mayo Clinic Florida, Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches is one of the top choices for your stay based on our traveller data, and this hotel offers a restaurant and an outdoor pool. Other good choices close by include Hilton Jacksonville at Mayo Clinic near Beaches and Residence Inn By Marriott Jacksonville - Mayo Clinic Area.
How many hotels are there near Mayo Clinic Florida?
Expedia has 44 hotels and other accommodation options within a mile from Mayo Clinic Florida.
If I need to cancel the hotel reservation for my stay near Mayo Clinic Florida, will I receive a refund?
Yes! You'll find that most hotel bookings are fully refundable as long as you cancel before the accommodation's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you have a non-refundable reservation, you may still be able to cancel and get a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then use the "fully refundable" filter to view the top deals on offer near Mayo Clinic Florida.
What can I see and do near Mayo Clinic Florida?
You can catch a show at SeaWalk Pavillion, Players by the Sea and Blue Jay Listening Room. Spend some time exploring the the natural beauty of Huguenot Park, Oceanfront Park and Cradle Creek Preserve. Lounge by the water at Northeast Florida Beaches and Ponte Vedra Beach.