Hotels near Duke Regional Hospital

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27 Dec - 28 Dec
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Our top choices for Duke Regional Hospital hotels

Lobby
Hampton Inn & Suites Durham/North I-85

Hampton Inn & Suites Durham/North I-85

Hampton Inn & Suites Durham/North I-85
2.5 star property
2.2 km from Duke Regional Hospital
9.0 out of 10, Wonderful, (1004)
"Clean rooms and courteous staff."
United States
Katina
The price is RM462
RM524 total
includes taxes & fees
3 Jan - 4 Jan 2026
Hampton Inn & Suites Durham/North I-85
Free buffet breakfast
Holiday Inn Express Durham by IHG

Holiday Inn Express Durham by IHG

Holiday Inn Express Durham by IHG
2.5 star property
2.4 km from Duke Regional Hospital
8.8 out of 10, Excellent, (957)
"We arrived at 12:25am. We were welcomed warmly and it was a very nice and pleasant check-in. The staff member that checked us in was so great. "
United States
Timothy
The price is RM393
RM446 total
includes taxes & fees
2 Jan - 3 Jan 2026
Holiday Inn Express Durham by IHG
Lobby
Red Roof Inn Durham - Duke Univ Medical Center

Red Roof Inn Durham - Duke Univ Medical Center

Red Roof Inn Durham - Duke Univ Medical Center
2.0 star property
2.3 km from Duke Regional Hospital
6.8 out of 10, (1002)
"Good motel...clean, easy acess "
United States
Howard
The price is RM235
RM273 total
includes taxes & fees
5 Jan - 6 Jan 2026
Red Roof Inn Durham - Duke Univ Medical Center
2 bedrooms
Renovated 2 Bed Walltown Home Walk to Duke A

Renovated 2 Bed Walltown Home Walk to Duke A

Renovated 2 Bed Walltown Home Walk to Duke A
2.0 star property
2.9 km from Duke Regional Hospital
The price is RM373
RM845 total
includes taxes & fees
11 Jan - 12 Jan 2026
Renovated 2 Bed Walltown Home Walk to Duke A
Premium bedding, desk, blackout curtains, iron/ironing board
Comfort Inn & Suites Durham near Duke University

Comfort Inn & Suites Durham near Duke University

Comfort Inn & Suites Durham near Duke University
2.5 star property
Croasdaile Farm Master, 3.3 km from Duke Regional Hospital
8.6 out of 10, Excellent, (1003)
"Friendly staff, clean room, nice breakfast"
United States
Jessica
The price is RM367
RM416 total
includes taxes & fees
2 Jan - 3 Jan 2026
Comfort Inn & Suites Durham near Duke University
BBQ/picnic Area
Courtyard Durham Near Duke University/Downtown

Courtyard Durham Near Duke University/Downtown

Courtyard Durham Near Duke University/Downtown
3.0 star property
Croasdaile Farm Master, 3.4 km from Duke Regional Hospital
8.2 out of 10, Very good, (1000)
"Great place "
United States
Silvia
The price is RM392
RM445 total
includes taxes & fees
2 Jan - 3 Jan 2026
Courtyard Durham Near Duke University/Downtown
Meeting facility
Hilton Garden Inn Durham/University Medical Center

Hilton Garden Inn Durham/University Medical Center

Hilton Garden Inn Durham/University Medical Center
3.0 star property
9th Street District, 4.1 km from Duke Regional Hospital
9.2 out of 10, Wonderful, (1000)
"Just right for an overnight business trip "
United States
Cody
The price is RM390
RM442 total
includes taxes & fees
4 Jan - 5 Jan 2026
Hilton Garden Inn Durham/University Medical Center
Courtyard
Residence Inn Durham McPherson/Duke University Medical Cntr

Residence Inn Durham McPherson/Duke University Medical Cntr

Residence Inn Durham McPherson/Duke University Medical Cntr
3.0 star property
Trinity Park, 4.1 km from Duke Regional Hospital
9.2 out of 10, Wonderful, (460)
"Hotel was great - very friendly staff."
United States
Lisa
The price is RM542
RM616 total
includes taxes & fees
26 Jan - 27 Jan 2026
Residence Inn Durham McPherson/Duke University Medical Cntr
Front of property – evening/night
University Inn Durham next to Duke University Medical Center

University Inn Durham next to Duke University Medical Center

University Inn Durham next to Duke University Medical Center
2.0 star property
4.5 km from Duke Regional Hospital
8.8 out of 10, Excellent, (1001)
"Great place"
United States
Chase
The price is RM462
RM524 total
includes taxes & fees
28 Dec - 29 Dec
University Inn Durham next to Duke University Medical Center
Premium bedding, desk, blackout curtains, iron/ironing board
The Durham Hotel

The Durham Hotel

The Durham Hotel
4.0 star property
Downtown Durham, 4.5 km from Duke Regional Hospital
9.0 out of 10, Wonderful, (645)
"Great stay. Very nice boutique hotel. "
United States
nadav
The price is RM753
RM855 total
includes taxes & fees
1 Jan - 2 Jan 2026
The Durham Hotel
Daily cooked-to-order breakfast (USD 19.95 per person)
Durham Marriott City Center

Durham Marriott City Center

Durham Marriott City Center
3.5 star property
Downtown Durham, 4.5 km from Duke Regional Hospital
8.8 out of 10, Excellent, (824)
"The room was clean. The staff was very helpful and the food was good. "
United States
Tia
The price is RM514
RM584 total
includes taxes & fees
11 Jan - 12 Jan 2026
Durham Marriott City Center
Outdoor pool
Royal Inn

Royal Inn

Royal Inn
2.0 star property
4.7 km from Duke Regional Hospital
5.8 out of 10, (1027)
"It was ok"
United States
Precious
The price is RM324
RM367 total
includes taxes & fees
27 Jan - 28 Jan 2026
Royal Inn
Reception
Hampton Inn & Suites Durham University Medical Center

Hampton Inn & Suites Durham University Medical Center

Hampton Inn & Suites Durham University Medical Center
2.5 star property
5 km from Duke Regional Hospital
9.6 out of 10, Exceptional, (403)
"Great breakfast, clean rooms and beds "
United States
Fabiola B
The price is RM462
RM524 total
includes taxes & fees
3 Jan - 4 Jan 2026
Hampton Inn & Suites Durham University Medical Center
Exterior
SureStay Plus Hotel by Best Western Durham Medical Center

SureStay Plus Hotel by Best Western Durham Medical Center

SureStay Plus Hotel by Best Western Durham Medical Center
2.5 star property
5.3 km from Duke Regional Hospital
5.8 out of 10, (1002)
"Courteous Staff. Rooms stark cold, minimum furnishings, clean bedding and linen. Outside appearance not the best!!"
United States
Paul
The price is RM269
RM306 total
includes taxes & fees
5 Jan - 6 Jan 2026
SureStay Plus Hotel by Best Western Durham Medical Center
Front of property
The Lodge at Duke Medical Center

The Lodge at Duke Medical Center

The Lodge at Duke Medical Center
3.0 star property
4.6 km from Duke Regional Hospital
8.4 out of 10, Very good, (1002)
"Room was clean and great customer service. "
United States
Anne
The price is RM522
RM593 total
includes taxes & fees
28 Dec - 29 Dec
The Lodge at Duke Medical Center
Exterior
Unscripted Durham, Part of JDV by Hyatt

Unscripted Durham, Part of JDV by Hyatt

Unscripted Durham, Part of JDV by Hyatt
3.5 star property
Downtown Durham, 4.5 km from Duke Regional Hospital
8.2 out of 10, Very good, (1002)
"We stay here at least annually and always will. "
United States
Paul
The price is RM514
RM653 total
includes taxes & fees
11 Jan - 12 Jan 2026
Unscripted Durham, Part of JDV by Hyatt
Interior entrance
21c Museum Hotel Durham

21c Museum Hotel Durham

21c Museum Hotel Durham
4.0 star property
Downtown Durham, 4.6 km from Duke Regional Hospital
8.4 out of 10, Very good, (1000)
"Amazing staff, comfortable rooms, best shower, convenient location. "
United States
Lauren
The price is RM651
RM759 total
includes taxes & fees
18 Jan - 19 Jan 2026
21c Museum Hotel Durham
Property amenity
Aloft Durham Downtown

Aloft Durham Downtown

Aloft Durham Downtown
3.0 star property
American Tobacco District, 4.9 km from Duke Regional Hospital
9.0 out of 10, Wonderful, (731)
"Very friendly staff, very clean and convenient location"
United States
Robert
The price is RM753
RM855 total
includes taxes & fees
25 Jan - 26 Jan 2026
Aloft Durham Downtown
BBQ/picnic Area
AC Hotel Durham

AC Hotel Durham

AC Hotel Durham
3.0 star property
5.4 km from Duke Regional Hospital
9.2 out of 10, Wonderful, (619)
"Room was very clean, staff very helpful and nice. "
United States
Tia
The price is RM479
RM543 total
includes taxes & fees
4 Jan - 5 Jan 2026
AC Hotel Durham
Terrace/patio
SpringHill Suites by Marriott Durham City View

SpringHill Suites by Marriott Durham City View

SpringHill Suites by Marriott Durham City View
3.5 star property
5.4 km from Duke Regional Hospital
9.2 out of 10, Wonderful, (456)
"Extremely clean room, nice fragrance throughout the hotel, and friendly staff."
United States
Mary
The price is RM381
RM432 total
includes taxes & fees
4 Jan - 5 Jan 2026
SpringHill Suites by Marriott Durham City View
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Duke Regional Hospital Hotel Reviews

The Durham Hotel

The Durham Hotel

10/10 Excellent
"Staff was the Best. Housekeeper was so kind and thoughtful."
Edwin 2-night trip
Posted 2 days ago
The Durham Hotel
The Lodge at Duke Medical Center

The Lodge at Duke Medical Center

10/10 Excellent
"Excellent"
Christian 2-night trip
Posted 9 days ago
The Lodge at Duke Medical Center

Hotels near other Duke Regional Hospital attractions

Sennett's hole is a swimming hole accessed from the west point outpost on the eno river. There are lots of rocks to lounge on on one side, and a rope swing on the other. It's great spot to hang out!
Photo by Nikki Benson
Open Photo by Nikki Benson

West Point on the Eno

Explore the great outdoors at West Point on the Eno, a lovely green space in Durham. Attend a sporting event or visit the stunning cathedral in this family-friendly area.
See properties
Brightleaf is part of downtown Durham, NC's renaissance. Old tobacco warehouses have found new life as shops and restaurants.
Photo by Jeff Bechtel
Open Photo by Jeff Bechtel

Brightleaf Square

You can do some window-shopping at Brightleaf Square during your visit to Durham. Discover the lively festivals and stunning cathedral in this family-friendly area.
See properties

Frequently asked questions

What's the area like around Duke Regional Hospital?
Duke Regional Hospital is located in an area of Durham known for its stunning cathedral. If you're looking for a convenient place to stay, take a look at the 11 hotels and other accommodation options you'll find within a mile.
What's the best hotel to stay close to Duke Regional Hospital?
Hampton Inn & Suites Durham/North I-85 is one of the top choices for your stay based on our traveller data, and this hotel offers free breakfast and an indoor pool. It's located 1.3 mi (2.2 km) from Duke Regional Hospital. Other good choices within a few miles include Comfort Inn & Suites Durham near Duke University and Holiday Inn Express Durham by IHG.
How many hotels can I expect to find near Duke Regional Hospital?
Expedia has 11 hotels and other accommodation options within a mile from Duke Regional Hospital.
If I need to cancel the hotel reservation for my stay near Duke Regional Hospital, will I receive a refund?
Yes, you'll find most hotel reservations are fully refundable as long as you cancel prior to the accommodation's cancellation deadline, which is usually within 24-48 hours of your arrival date. If your reservation is non-refundable, you may still be able to cancel and get a refund within a 24-hour period of booking. Add your dates and click on "Search", then use the filter option "fully refundable" to view the best deals near Duke Regional Hospital.
What can I see and do near Duke Regional Hospital?
You might want to spend some time browsing the exhibits at Museum of Life and Science, Nasher Museum of Art at Duke University or Bennett Place. While you're exploring, swing by American Tobacco Campus, Cameron Indoor Stadium and Wallace Wade Stadium to learn a bit about the area. You can watch performances at Carolina Theatre, Durham Performing Arts Center and Manbites Dog Theater if you're interested in local theatre.