Defiance hotels from RM298

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Our top choices for Defiance hotels

Drury Inn & Suites Southwest St. Louis

Drury Inn & Suites Southwest St. Louis
3.0 star property
Valley Park
9.6 out of 10, Exceptional, (1,005 reviews)
"Very clean place with great food and friendly staff. "
Canada
Kara
The price is RM479
RM561 total
includes taxes & fees
3 May - 4 May
Drury Inn & Suites Southwest St. Louis

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
3.0 star property
Fenton
8.0 out of 10, Very good, (1,179 reviews)
"Everything was great for overnight stay. "
United States
Regina
The price is RM359
RM415 total
includes taxes & fees
6 Apr - 7 Apr
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Baymont by Wyndham Warrenton

Baymont by Wyndham Warrenton
2.5 star property
Warrenton
7.6 out of 10, Good, (1,000 reviews)
"The room was clean. The parking was easy."
United States
Chris
The price is RM322
RM368 total
includes taxes & fees
7 Apr - 8 Apr
Baymont by Wyndham Warrenton

Holiday Inn Express St. Louis West - O'Fallon by IHG

Holiday Inn Express St. Louis West - O'Fallon by IHG
2.5 star property
O'Fallon
8.6 out of 10, Excellent, (894 reviews)
"It was a wonderful stay for my girls and her birthday. She had a blast and the room was Lovely 😍🌹"
United States
Amanda
The price is RM383
RM451 total
includes taxes & fees
19 Apr - 20 Apr
Holiday Inn Express St. Louis West - O'Fallon by IHG

WoodSpring Suites St Peters-OFallon

WoodSpring Suites St Peters-OFallon
2.5 star property
St. Peters
8.8 out of 10, Excellent, (70 reviews)
"Nice hotel with good staff."
United States
Michael
The price is RM360
RM427 total
includes taxes & fees
3 Apr - 4 Apr
WoodSpring Suites St Peters-OFallon

Hampton Inn St. Louis Wentzville

Hampton Inn St. Louis Wentzville
2.5 star property
Wentzville
9.0 out of 10, Wonderful, (680 reviews)
"Very pet friendly. "
United States
Sara
The price is RM515
RM590 total
includes taxes & fees
14 Apr - 15 Apr
Hampton Inn St. Louis Wentzville

Sleep Inn & Suites O'Fallon MO - Technology Drive

Sleep Inn & Suites O'Fallon MO - Technology Drive
2.5 star property
O'Fallon
9.0 out of 10, Wonderful, (1,000 reviews)
"This was one of our best stays ever nice hot breakfast. Clean room nice staff will stay again "
United States
Lavania
The price is RM353
RM417 total
includes taxes & fees
19 Apr - 20 Apr
Sleep Inn & Suites O'Fallon MO - Technology Drive

Drury Plaza Hotel St. Louis Chesterfield

Drury Plaza Hotel St. Louis Chesterfield
3.0 star property
Chesterfield
9.8 out of 10, Exceptional, (1,118 reviews)
"It’s a great place very happy!"
United States
Chris
The price is RM548
RM635 total
includes taxes & fees
16 Apr - 17 Apr
Drury Plaza Hotel St. Louis Chesterfield

Hampton Inn St. Charles St. Peters

Hampton Inn St. Charles St. Peters
2.5 star property
St. Charles
8.0 out of 10, Very good, (1,000 reviews)
"Everything was great as always at this location as i have stayed here many times"
United States
Gregory
The price is RM459
RM527 total
includes taxes & fees
3 May - 4 May
Hampton Inn St. Charles St. Peters

Quality Inn Foristell

Quality Inn Foristell
2.5 star property
Foristell
8.2 out of 10, Very good, (959 reviews)
"Comfy beds, but the trim, doors, and other finishings look pretty rough and in need of replacement. Simple enough breakfast and was just there for a night to sleep so it did the job."
United States
Laura
The price is RM355
RM400 total
includes taxes & fees
19 Apr - 20 Apr
Quality Inn Foristell

Drury Inn & Suites St. Louis St. Peters

Drury Inn & Suites St. Louis St. Peters
3.0 star property
St. Peters
9.4 out of 10, Exceptional, (1,009 reviews)
"Great stay! Very clean and staff was very nice. Definitely will be staying there on my return visit to the area!"
United States
Roxanne
The price is RM482
RM554 total
includes taxes & fees
6 Apr - 7 Apr
Drury Inn & Suites St. Louis St. Peters

Super 8 by Wyndham Union

Super 8 by Wyndham Union
2.0 star property
Union
8.2 out of 10, Very good, (641 reviews)
"Pet friendly "
United States
Theresa
The price is RM330
RM364 total
includes taxes & fees
3 May - 4 May
Super 8 by Wyndham Union

TownePlace Suites by Marriott Wentzville

TownePlace Suites by Marriott Wentzville
3.0 star property
Wentzville
9.4 out of 10, Exceptional, (51 reviews)
"Clean room and the suite was nice. "
United States
Elizabeth
The price is RM612
RM721 total
includes taxes & fees
4 Apr - 5 Apr
TownePlace Suites by Marriott Wentzville

Holiday Inn Express & Suites St Peters by IHG

Holiday Inn Express & Suites St Peters by IHG
2.5 star property
St. Peters
9.4 out of 10, Exceptional, (398 reviews)
"Very clean room, great guest service, excellent bed "
United States
Margaret
The price is RM450
RM541 total
includes taxes & fees
5 Apr - 6 Apr
Holiday Inn Express & Suites St Peters by IHG

Wingate by Wyndham St. Louis/Fenton Route 66

Wingate by Wyndham St. Louis/Fenton Route 66
3.0 star property
Fenton
7.8 out of 10, Good, (1,180 reviews)
"Great location, comfy and clean rooms "
United States
Nestor
The price is RM342
RM395 total
includes taxes & fees
12 Apr - 13 Apr
Wingate by Wyndham St. Louis/Fenton Route 66

Best Western Plus Fenton

Best Western Plus Fenton
2.5 star property
Fenton
9.2 out of 10, Wonderful, (246 reviews)
"Easy parking, friendly staff, clean and comfy rooms. "
United States
Jan
The price is RM434
RM502 total
includes taxes & fees
15 Apr - 16 Apr
Best Western Plus Fenton

Comfort Suites St Charles - St Louis

Comfort Suites St Charles - St Louis
2.5 star property
St. Charles
8.4 out of 10, Very good, (1,007 reviews)
"The breakfast was good. They had two different waffle choices every day. "
United States
Josephine
The price is RM398
RM457 total
includes taxes & fees
3 May - 4 May
Comfort Suites St Charles - St Louis

Drury Plaza Hotel St. Louis St. Charles

Drury Plaza Hotel St. Louis St. Charles
3.0 star property
St. Charles
9.6 out of 10, Exceptional, (1,000 reviews)
"Clean rooms, friendly staff, great breakfast and kickback dinner."
United States
Amy
The price is RM532
RM616 total
includes taxes & fees
3 May - 4 May
Drury Plaza Hotel St. Louis St. Charles

The Wildwood Hotel

The Wildwood Hotel
3.5 star property
Wildwood
9.2 out of 10, Wonderful, (1,630 reviews)
"Staff was wonderful, location is great for our needs, and it was a quiet stay-which we loved. "
United States
Jessica
The price is RM357
RM416 total
includes taxes & fees
6 Apr - 7 Apr
The Wildwood Hotel

Quality Inn Near Six Flags St. Louis

Quality Inn Near Six Flags St. Louis
2.5 star property
Pacific
8.4 out of 10, Very good, (368 reviews)
"Breakfast menu is extremely limited. Breakfast does not have bread/ butter."
United States
Arinjay
The price is RM399
RM456 total
includes taxes & fees
6 Apr - 7 Apr
Quality Inn Near Six Flags St. Louis
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Defiance attractions

Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighbouring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

A covered bridge at the Historic Daniel Boone Home Park in Defiance, Missouri

Top Defiance Hotel Reviews

More cheap stays in Defiance

Frequently asked questions

What's the best place to stay in Defiance?
Hollywood Casino & Hotel St. Louis, located 18.1 mi (29.2 km) from the heart of Defiance, is a top choice for your stay, based on our traveller data. Two other options for your visit to the area are Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham and The Wildwood Hotel. See all available top hotels, or vacation rentals in Defiance.
If I need to cancel my hotel reservation in Defiance, will I receive a refund?
Yes! The majority of room reservations are fully refundable if you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you have a reservation that's non-refundable, you might be able to cancel it and receive a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Defiance.
What are some accommodation options with pools in Defiance?
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham: Offers an indoor pool, an outdoor pool and buffet. The Wildwood Hotel and Ameristar Casino Resort and Spa are two additional hotels with an on-site pool. View all hotels with pools in Defiance.
How is it staying in Defiance?
Visitors can enjoy all that Defiance has to offer, including the wineries and parks. Top sights in the area include St. Louis Union Station, Enterprise Center and Busch Stadium. In Defiance, there are 19 hotels and other accommodation options to choose from. Find out more about Defiance.
What should I do while I'm visiting Defiance?
Natural beauty is on display at Matson Hill Park Trailhead, August A. Busch Memorial Conservation Area and Missouri River. A couple of additional sights to add to your itinerary are Chandler Hill Vineyards and Historic Daniel Boone Home and Heritage Center. Take a look at what more there is to see and do in Expedia's Defiance guide.
What's the weather like in Defiance?
The hottest months are usually July and August, with an average temperature of 24°C, while the coldest months are January and February, with an average of 3°C. Average annual precipitation for Defiance is 1228 mm.

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