What is Medical Center District like?

Travellers are sure to enjoy a stay in San Antonio's Medical Center District neighbourhood. Consider a visit to Cinemark San Antonio 16 as part of your Medical Center District travel plans.

What's a favourite hotel to stay in Medical Center District?

Based on our traveller data, La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW is one of the top choices for your stay in Medical Center District. This hotel offers free breakfast and an outdoor pool. Other good options for your stay in the area include Drury Inn & Suites San Antonio Northwest Medical Center and Courtyard by Marriott Medical Center San Antonio .

How many hotels will I be able to find in Medical Center District?

Expedia has 124 hotels and other accommodation options in Medical Center District to choose from, making this an ideal home base for exploring the greater San Antonio area.

If I need to cancel my hotel reservation in Medical Center District, will I receive a refund?

Yes, you'll find most hotel reservations are fully refundable if you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you booked a non-refundable reservation, you may still be able to cancel and receive a refund within a 24-hour period of your booking. Add your dates and click on "Search", then use the "fully refundable" filter to review the top deals on offer in Medical Center District.

What can I see and do in this San Antonio neighbourhood?

Cinemark San Antonio 16 is an attraction you might want to check out while you're in Medical Center District. Wonderland of the Americas Mall and Regal Huebner Oaks are also worth a visit when you're out sightseeing in San Antonio.

Top 10 Medical Center District Hotels of 2026

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Our top choices for Medical Center District hotels

A modern living room with a fireplace, a flat-screen TV, and a stone accent wall.

1. Fairfield Inn & Suites by Marriott San Antonio Medical Center

Medical Center District

Freddie

RM456 total

includes taxes & fees

29 Sept - 30 Sept

A modern bar area with wooden bar counters, black bar stools, and pendant lighting.

2. Courtyard by Marriott Medical Center San Antonio

Medical Center District

Erik

RM430 total

includes taxes & fees

2 Oct - 3 Oct

A self-service snack and drink vending area with multiple shelves stocked with various products.

3. La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

Medical Center District

Maria

RM428 total

includes taxes & fees

4 Oct - 5 Oct

A spacious lobby with multiple seating areas, a central coffee table, and a view of the upper floors.

4. Drury Inn & Suites San Antonio Northwest Medical Center

Medical Center District

Clifton T

RM435 total

includes taxes & fees

1 Oct - 2 Oct

A spacious lobby with a central staircase, seating area, and large windows.

5. San Antonio Marriott Northwest Medical Center

Medical Center District

Mario

RM488 total

includes taxes & fees

26 Oct - 27 Oct

A modern kitchen with a large window, wooden counter, and two bar stools.

6. Park Inn by Radisson, Medical Center

Medical Center District

Joanne

RM320 total

includes taxes & fees

19 Oct - 20 Oct

A building entrance with a glass door, a Pepsi vending machine, and a yellow bollard.

7. OYO Inn & Suites Medical Center San Antonio

Medical Center District

Melanie

RM262 total

includes taxes & fees

8 Oct - 9 Oct

A gas station with a sign for 'Atria Inn & Suites' and a 'Clearance - 12' sign.

8. Atria Inn & Suites

Medical Center District

José

RM275 total

includes taxes & fees

27 Sept - 28 Sept

A modern bedroom with a large bed, bedside tables, a desk, and a chair.

9. Motel 6 San Antonio, TX - Northwest Medical Center

Medical Center District

Rachel

RM233 total

includes taxes & fees

24 Oct - 25 Oct

A hotel room with two beds, a desk, a chair, a mirror, and a bathroom.

10. Studio 6 San Antonio, Tx - Northwest Medical Center

Medical Center District

Ruben

RM223 total

includes taxes & fees

4 Oct - 5 Oct

A hotel room with a large bed, a desk with a chair, a television on a stand, and a mirror on the wall.

11. Flex Studios

Medical Center District

Jasper

RM212 total

includes taxes & fees

27 Sept - 28 Sept

A hotel room with two beds, a TV, a desk, and a kitchenette in the background.

12. Studio 6 Extended Stay - San Antonio, TX - Medical Center

Medical Center District

Jerron

A modern bar area with a central island, bar stools, and a kitchen counter with appliances.

13. Hyatt Place San Antonio-Northwest/Medical Center

3.7 km from Medical Center District

Erica

RM454 total

includes taxes & fees

5 Oct - 6 Oct

A spacious dining area with multiple tables and chairs, a bar area, and a television mounted on the wall.

14. Hampton Inn & Suites San Antonio Northwest/Medical Center

Northwest Side, 4.7 km from Medical Center District

Efrain

RM400 total

includes taxes & fees

11 Oct - 12 Oct

An indoor swimming pool with a hot tub, tiled flooring, and a seating area with tables and chairs.

15. Drury Inn & Suites Near La Cantera Parkway

La Cantera District, 9.5 km from Medical Center District

Eduardo

RM454 total

includes taxes & fees

1 Oct - 2 Oct

A hotel pool area with lounge chairs and a building with large windows in the background.

16. The Westin San Antonio North

3.4 km from Medical Center District

Jack

RM490 total

includes taxes & fees

2 Oct - 3 Oct

A hotel with a modern design, featuring a covered parking area and multiple parking spaces.

17. Best Western Medical Center North Inn & Suites Near Six Flags

Northwest Side, 5.2 km from Medical Center District

Gerald

RM317 total

includes taxes & fees

29 Sept - 30 Sept

A Holiday Inn Express reception desk with a modern design, featuring a large illuminated sign, a reception area, and a potted plant.

18. Holiday Inn Express San Antonio-Airport by IHG

8.9 km from Medical Center District

Liz

RM506 total

includes taxes & fees

11 Oct - 12 Oct

A hotel lobby with a reception desk, seating area, and a television.

19. La Quinta Inn & Suites by Wyndham San Antonio Northwest

Far West Side, 10.4 km from Medical Center District

Ashley

RM401 total

includes taxes & fees

27 Sept - 28 Sept

A modern breakfast bar with a menu board, a coffee machine, and a variety of breakfast items displayed.

20. Courtyard by Marriott San Antonio Lackland

6.5 km from Medical Center District

Michael

RM381 total

includes taxes & fees

4 Oct - 5 Oct

View all properties

Compare popular hotels in Medical Center District

Property	Property class	Guest rating
Drury Inn & Suites San Antonio Northwest Medical Center	3.0 star property	9.2 Wonderful 1,464 reviews	View
Fairfield Inn & Suites by Marriott San Antonio Medical Center	3.0 star property	9.0 Wonderful 1,084 reviews	View
Courtyard by Marriott Medical Center San Antonio	3.0 star property	8.8 Excellent 1,001 reviews	View
San Antonio Marriott Northwest Medical Center	3.5 star property	8.6 Excellent 1,165 reviews	View
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW	3.0 star property	8.4 Very good 3,685 reviews	View

Where to stay in Medical Center District

Find the best Medical Center District areas for the activities you enjoy most.

A boat tour on a canal with a bridge in the background.

Downtown San Antonio

Explore the network of pedestrian paths that follows the beautiful San Antonio River to discover restaurants and bars, gift shops, galleries and museums.

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A riverside walkway with colorful umbrellas, a stone bridge, and historic buildings.

Far West Side

While visiting Far West Side, you might make a stop by sights like Aquatica San Antonio Waterpark and Hill Country Golf Club.

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A riverside walkway adorned with colorful umbrellas and festive lights.

Uptown Central

If you're spending some time in Uptown Central, Marion Koogler McNay Art Museum and Alamo Quarry Market are top sights worth seeing.

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A historic stone building with a central arched doorway, a flagpole with a flag, and a paved courtyard.

Northwest Side

If you're spending some time in Northwest Side, Huebner Oaks and Crystal Ice Palace are top sights worth seeing.

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A historic stone building with a large wooden door, arched windows, and ornate columns.

Stone Oak

Stone Oak is known for its abundant dining options, and you can plan a trip to Shops at Hardy Oak and Alta Vista at Stone Oak while you're in town.

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Top Medical Center District Hotel Reviews

Courtyard by Marriott Medical Center San Antonio

10/10 Excellent

"The staff at this place are outstanding. From check in to grounds to the restaurant. Essie is fabulous!!! We absolutely love talking to her when we are staying. Such a professional and warm person. There is also a grounds person, and I don't know his name, He opens the door for me when I am bringing in my luggage every time we visit. My husband has been under going care for a Hip that got infected with Dr. Buttacavoli at UT Health Orthopedics for months now. There is another organization I want to give a shout out too. This hotel is within 10 minutes of the Dr.'s office and hospital. So you couldn't ask for a better place to stay. Prices are great, and you will not be disappointed in your choice booking here at all."

Hotels in Medical Center District, San Antonio

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Our top choices for Medical Center District hotels

1. Fairfield Inn & Suites by Marriott San Antonio Medical Center

2. Courtyard by Marriott Medical Center San Antonio

3. La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

4. Drury Inn & Suites San Antonio Northwest Medical Center

5. San Antonio Marriott Northwest Medical Center

6. Park Inn by Radisson, Medical Center

7. OYO Inn & Suites Medical Center San Antonio

8. Atria Inn & Suites

9. Motel 6 San Antonio, TX - Northwest Medical Center

10. Studio 6 San Antonio, Tx - Northwest Medical Center

11. Flex Studios

12. Studio 6 Extended Stay - San Antonio, TX - Medical Center

13. Hyatt Place San Antonio-Northwest/Medical Center

14. Hampton Inn & Suites San Antonio Northwest/Medical Center

15. Drury Inn & Suites Near La Cantera Parkway

16. The Westin San Antonio North

17. Best Western Medical Center North Inn & Suites Near Six Flags

18. Holiday Inn Express San Antonio-Airport by IHG

19. La Quinta Inn & Suites by Wyndham San Antonio Northwest

20. Courtyard by Marriott San Antonio Lackland

Compare popular hotels in Medical Center District

Where to stay in Medical Center District

Downtown San Antonio

Far West Side

Uptown Central

Northwest Side

Stone Oak

Top Medical Center District Hotel Reviews

Courtyard by Marriott Medical Center San Antonio

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