Panama City Vacation Rentals

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Check prices for these dates

In two weeks
16 Jan - 18 Jan
In two months
27 Feb - 1 Mar
In three months
27 Mar - 29 Mar
In four months
24 Apr - 26 Apr

Our top choices for Panama City holiday rentals

Terrace/patio
La Isabela Suites

La Isabela Suites

La Isabela Suites
3.5 star property
Casco Viejo
10.0 out of 10, Exceptional, (171)
"Wonderful charming property in the heart of the historic district. "
United States
Angela
La Isabela Suites
Premium bedding, in-room safe, individually decorated
Las Clementinas

Las Clementinas

Las Clementinas
3.5 star property
Casco Viejo
9.4 out of 10, Exceptional, (172)
"Fabulous room and wonderful people that work there. "
Canada
Leah
The price is RM567
RM623 total
includes taxes & fees
11 Jan - 12 Jan 2026
Las Clementinas
50-inch LED TV with satellite channels
Arcadia Condo Suites

Arcadia Condo Suites

Arcadia Condo Suites
2.5 star property
Costa del Este
9.4 out of 10, Exceptional, (177)
"Was a great buy. Beautiful views and spacious rooms. Great amenities. "
United States
Lesley
The price is RM336
RM557 total
includes taxes & fees
19 Jan - 20 Jan 2026
Arcadia Condo Suites
Microwave, coffee/tea maker, cookware/dishes/utensils
La Palma Aparta Suite

La Palma Aparta Suite

La Palma Aparta Suite
3.0 star property
Amador
The price is RM192
RM333 total
includes taxes & fees
12 Jan - 13 Jan 2026
La Palma Aparta Suite
Balcony
Casa Contemporanea by Wynwood House

Casa Contemporanea by Wynwood House

Casa Contemporanea by Wynwood House
4.0 star property
Casco Viejo
8.2 out of 10, Very good, (20)
"Great place!"
United States
Jad
The price is RM475
RM624 total
includes taxes & fees
19 Jan - 20 Jan 2026
Casa Contemporanea by Wynwood House
Living area
Torres de Alba Hotel & Suites

Torres de Alba Hotel & Suites

Torres de Alba Hotel & Suites
3.5 star property
Bella Vista
8.8 out of 10, Excellent, (486)
"Room was clean, neat great staff"
United States
Alfredo
Torres de Alba Hotel & Suites
Exterior
Centriqo by Wynwood house

Centriqo by Wynwood house

Centriqo by Wynwood house
3.0 star property
Veracruz
The price is RM519
RM704 total
includes taxes & fees
19 Jan - 20 Jan 2026
Centriqo by Wynwood house
Private kitchen
Mini Design By Wynwood House

Mini Design By Wynwood House

Mini Design By Wynwood House
2.0 star property
Bella Vista
The price is RM463
RM621 total
includes taxes & fees
14 Jan - 15 Jan 2026
Mini Design By Wynwood House
Outdoor pool
Studio Apartment with Ocean View

Studio Apartment with Ocean View

Studio Apartment with Ocean View
3.0 star property
Calidonia
8.0 out of 10, Very good, (2)
"It was similar to a hotel room, but a little smaller.. the bed is big enough for just one person and check in was the most difficult thing he had to wait outside in the rain and download apps"
United States
Gwendolyn
The price is RM263
RM290 total
includes taxes & fees
15 Jan - 16 Jan 2026
Studio Apartment with Ocean View
Outdoor pool, free pool cabanas, pool loungers
Yoo Panama & Arts Tower

Yoo Panama & Arts Tower

Yoo Panama & Arts Tower
3.0 star property
Bella Vista
9.6 out of 10, Exceptional, (57)
"Ron was amazing and so was the property!"
United States
John
Yoo Panama & Arts Tower
Outdoor pool
Wanders Panama by Boutique Apartments

Wanders Panama by Boutique Apartments

Wanders Panama by Boutique Apartments
4.0 star property
San Francisco
10.0 out of 10, Exceptional, (2)
"I will go again thank you so much"
United States
GISY ITZEL
The price is RM668
RM1,355 total
includes taxes & fees
5 Jan - 6 Jan 2026
Wanders Panama by Boutique Apartments
Property grounds
Swette Love 10 Minutes From the Airport Tocumen

Swette Love 10 Minutes From the Airport Tocumen

Swette Love 10 Minutes From the Airport Tocumen
2.0 star property
Las Mañanitas
The price is RM311
RM389 total
includes taxes & fees
5 Jan - 6 Jan 2026
Swette Love 10 Minutes From the Airport Tocumen
Iron/ironing board, free WiFi, bed sheets
Donovan By Wynwood House

Donovan By Wynwood House

Donovan By Wynwood House
3.0 star property
Casco Viejo
8.4 out of 10, Very good, (45)
"I always love to stay at Wynwood properties in Panama "
United States
Alberto B
The price is RM303
RM455 total
includes taxes & fees
18 Jan - 19 Jan 2026
Donovan By Wynwood House
Outdoor pool
Yoo by Wynwood House

Yoo by Wynwood House

Yoo by Wynwood House
4.0 star property
Calidonia
9.2 out of 10, Wonderful, (5)
"I will be back!"
United States
Jeffrey
The price is RM712
RM926 total
includes taxes & fees
27 Jan - 28 Jan 2026
Yoo by Wynwood House
Outdoor pool
Boutique Apartments Panama

Boutique Apartments Panama

Boutique Apartments Panama
3.5 star property
Bella Vista
7.6 out of 10, Good, (223)
"The view was amazing and the place was great could stay here again "
United States
Yonnette
Boutique Apartments Panama
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Panama City Hotel Reviews

Hyatt Regency Panama City

Hyatt Regency Panama City

10/10 Excellent
"Grear"
queen victoria 1-night trip
Posted 7 hours ago
Hyatt Regency Panama City

Find out more about Panama City

Search for holiday rentals in Panama City on Expedia.co.uk! You can easily find your home rentals, villas, holiday apartments in Panama City using one of the methods below:

  • View our selection of featured holiday rentals in Panama City
  • Use the map to find apartments and other holiday homes in the Panama City neighbourhood you prefer
  • Enter your travel dates to view the best deals on holiday rentals in Panama City while they last

Look no further and take a look at our great range of rental properties in Panama City!

Frequently asked questions

Can I find holiday rentals in Panama City?

Yes, there are holiday rentals in Panama City close to Panama Canal Railway, or you can select a more secluded option if you're looking for a relaxing stay. Tourists like the array of shops and top-notch restaurants in Panama City. While you're in the area, grab a bite or have a drink at the lively bars and cafes.

How many holiday rentals are there in Panama City?

With 54 Expedia holiday rentals, you're guaranteed to find just the right place for your Panama City stay.

What can I see and do in Panama City?

Cultural attractions include National Theater and Interoceanic Canal Museum, whereas Cinta Costera and Miraflores Locks are a couple of picturesque spots to enjoy the outdoors. Albrook Shopping Mall and Via Espana are other places to visit while you're in town.

What are holiday rentals like in Panama City?

Holiday rentals are privately owned properties you can book for a few days, or a quick weekend, in Panama City. Holiday rentals offer extras like WiFi and washers and dryers so you'll feel right at home. If you're concerned about a clean environment, holiday rentals can provide a sense of privacy away from public hotel lifts and lobbies bustling with people while still allowing you a great travel experience. You'll also get more space in a holiday rental than in a standard hotel, which is another reason why a holiday rental is a great choice for family gatherings.