Cheap flights from Panama starting at RM646

View RM646 flight on Thu, 5 Feb 2026Opens in a new window

Popular airlines from Panama

  • Avianca

  • United

  • Copa

  • American Airlines

  • Delta

  • Aeromexico

  • Iberia

  • Be in the know

    Get alerts if flight prices drop or rise*

  • Book smarter

    Save up to 30% on select hotels after you book a flight*

  • Earn twice

    Earn your airline miles on top of our rewards
    Sign in

Cheapest flights from Panama

These prices were available within the past 7 days. Prices quoted are per person, return, for the period specified. Prices and availability are subject to change. Additional terms apply.

Copa
Thu, 5 Feb - Sun, 8 Feb
PTY
Panama City
MDE
Medellin
RM1,224 Return, found 19 hours ago
RM1,224
Return
found 19 hours ago
Select Copa flight, departing Thu, 5 Feb from Panama City to Medellin, returning Sun, 8 Feb, priced at RM1,224 found 19 hours ago
Copa
Thu, 5 Feb - Sun, 8 Feb
PTY
Panama City
MDE
Medellin
RM1,267 Return, found 19 hours ago
RM1,267
Return
found 19 hours ago
Select Copa flight, departing Thu, 5 Feb from Panama City to Medellin, returning Sun, 8 Feb, priced at RM1,267 found 19 hours ago
Copa
Thu, 5 Feb - Sun, 8 Feb
PTY
Panama City
MDE
Medellin
RM1,441 Return, found 19 hours ago
RM1,441
Return
found 19 hours ago
Select Copa flight, departing Thu, 5 Feb from Panama City to Medellin, returning Sun, 8 Feb, priced at RM1,441 found 19 hours ago
avianca
Thu, 5 Feb - Sun, 8 Feb
PTY
Panama City
MDE
Medellin
RM1,585 Return, found 19 hours ago
RM1,585
Return
found 19 hours ago
Select avianca flight, departing Thu, 5 Feb from Panama City to Medellin, returning Sun, 8 Feb, priced at RM1,585 found 19 hours ago
avianca
Thu, 5 Feb - Sun, 8 Feb
PTY
Panama City
MDE
Medellin
RM1,599 Return, found 19 hours ago
RM1,599
Return
found 19 hours ago
Select avianca flight, departing Thu, 5 Feb from Panama City to Medellin, returning Sun, 8 Feb, priced at RM1,599 found 19 hours ago
Copa
Thu, 5 Feb - Sun, 8 Feb
PTY
Panama City
MDE
Medellin
RM1,613 Return, found 19 hours ago
RM1,613
Return
found 19 hours ago
Select Copa flight, departing Thu, 5 Feb from Panama City to Medellin, returning Sun, 8 Feb, priced at RM1,613 found 19 hours ago
Copa
Thu, 5 Feb - Sun, 8 Feb
PTY
Panama City
MDE
Medellin
RM1,649 Return, found 19 hours ago
RM1,649
Return
found 19 hours ago
Select Copa flight, departing Thu, 5 Feb from Panama City to Medellin, returning Sun, 8 Feb, priced at RM1,649 found 19 hours ago
Copa
Thu, 5 Feb - Sun, 8 Feb
PTY
Panama City
MDE
Medellin
RM1,656 Return, found 19 hours ago
RM1,656
Return
found 19 hours ago
Select Copa flight, departing Thu, 5 Feb from Panama City to Medellin, returning Sun, 8 Feb, priced at RM1,656 found 19 hours ago
Copa
Thu, 5 Feb - Sun, 8 Feb
PTY
Panama City
MDE
Medellin
RM1,693 Return, found 19 hours ago
RM1,693
Return
found 19 hours ago
Select Copa flight, departing Thu, 5 Feb from Panama City to Medellin, returning Sun, 8 Feb, priced at RM1,693 found 19 hours ago
Copa
Thu, 5 Feb - Sun, 8 Feb
PTY
Panama City
MDE
Medellin
RM1,697 Return, found 19 hours ago
RM1,697
Return
found 19 hours ago
Select Copa flight, departing Thu, 5 Feb from Panama City to Medellin, returning Sun, 8 Feb, priced at RM1,697 found 19 hours ago

Explore a world of travel with Expedia

*Available to Expedia members.