I stayed at Casa Sant'Andrea a day after it reopened after C-19 restrictions. I arrived early to leave my bag but the receptionist was really welcoming and kindly allowed me to check in early. The accommodation is in a really convenient location as it is near the main bus and train station although I did need to use 'Google Maps' to find it the first time! Casa Sant'Andrea's location means that 'getting home' after a day exploring the twisting alleys of Venice is really easy. There is a boat stop just outside Casa Sant'Andrea but for a greater choice of boats it is just a few minutes walk to the Grand Canal where you can get a boat to anywhere you want (perhaps with one change). It is definitely worth getting a travel card which can be purchased from the information office adjacent to the bus station.
The room I stayed in was simple (as is described by Casa Sant'Andrea's website) with a large ensuite. My room overlooked the canal which was lovely. 24hr access is possible.
The breakfast buffet is plentiful with a choice of cereal, yogurt, croissants, meat/cheese, bread roll, hot drink & juice drink. Due to C-19 restrictions the buffet was served rather than 'help yourself' which was fine.
I stayed for three nights and would recommend Casa Sant'Andrea to anyone not looking for a 'posh' hotel.