Top 10 Hotels Near Sioux Empire Medical Museum in Sioux Falls for 2026

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Our top choices for Sioux Empire Medical Museum hotels

A spacious bar area with a large TV screen, a fireplace, and a wine rack.

A spacious lobby with modern seating, large windows, and a city view.

A modern bar area with a black marble column, bar stools, and a view of the city through large windows.

A hotel room with a large bed, wooden wardrobe, a TV, and a kitchenette area.

1. Highpoint Hotel

University Heights, 0.2 km from Sioux Empire Medical Museum

Randell J

RM496

RM552 total

includes taxes & fees

10 Nov - 11 Nov

A large, two-story building with a stone facade and multiple windows, illuminated by warm lighting.

A spacious lobby with multiple seating areas, a fireplace, and large windows.

An indoor swimming pool with a water slide, a large umbrella structure, and a frog-shaped water feature.

A spacious lobby with a central seating area, a staircase, and a fireplace.

2. Clubhouse Hotel Suites Sioux Falls

Mall District, 2.8 km from Sioux Empire Medical Museum

Tammie

RM621

RM744 total

includes taxes & fees

13 Nov - 14 Nov

A Hampton Inn hotel with a modern design, featuring a prominent red sign, a covered entrance, and stone pillars.

A swimming pool with clear water, surrounded by a tiled deck and seating areas.

A hotel room with a desk, two beds, a TV, and a window with a striped blind.

A snack and beverage display area with various snacks and drinks.

3. Hampton Inn Sioux Falls

Mall District, 3.1 km from Sioux Empire Medical Museum

Mary

RM398

RM445 total

includes taxes & fees

22 Nov - 23 Nov

A lobby with a large safe, a checkered floor, and a sofa with cushions.

A lobby with a grand chandelier, blue curtains, and a round glass table with a vase of flowers.

A modern hotel room with a large bed, a decorative wall, a nightstand, a chair, and a large window with a city view.

A modern hotel room with a desk, chair, and bed. It features a large window with a city view, a flat-screen TV, and a wooden wardrobe.

4. Hotel On Phillips

Downtown Sioux Falls, 1.9 km from Sioux Empire Medical Museum

Mark

RM768

RM850 total

includes taxes & fees

11 Nov - 12 Nov

A patio with wicker chairs and a round table with a fire pit.

A breakfast area with a long table, orange chairs, and various breakfast items displayed on shelves.

An indoor swimming pool with two lanes, safety railings, and lounge chairs.

A modern hotel room with a bed, a sofa, a small table, a TV, and a bathroom visible through an open door.

5. Home2 Suites By Hilton Sioux Falls/Sanford Medical Center

University Heights, 0.2 km from Sioux Empire Medical Museum

Ross

RM499

RM555 total

includes taxes & fees

1 Nov - 2 Nov

A modern lobby with a glass fireplace, seating areas, and indoor plants.

A bar area with a long counter, multiple stools, and shelves stocked with bottles.

A modern dining area with a large marble table, comfortable chairs, a built-in fireplace, and a large TV mounted on a dark wall.

A modern building with a sign reading "THE STEEL DISTRICT" and a covered walkway.

6. Canopy By Hilton Sioux Falls Downtown

Downtown Sioux Falls, 2.5 km from Sioux Empire Medical Museum

Marnie

RM586

RM676 total

includes taxes & fees

22 Nov - 23 Nov

A modern lobby with a large wooden column, seating areas, and a mural on the wall.

A retail space with shelves stocked with various products, a refrigerated display, and a clothing rack.

A conference room with a long table, chairs, and a projector screen.

A multi-story hotel with a modern design, featuring balconies and large windows.

7. Hilton Garden Inn Sioux Falls Downtown

Downtown Sioux Falls, 2.1 km from Sioux Empire Medical Museum

Samuel

RM503

RM584 total

includes taxes & fees

1 Nov - 2 Nov

A buffet with labeled containers of omelets and other dishes.

A snack and beverage display with various brands and products.

A hotel room with a large bed, a small desk, a chair, a kitchenette, and a nightstand with a lamp.

A Holiday Inn Express & Suites building with a brick facade, illuminated signage, and a covered entrance area.

8. Holiday Inn Express & Suites Sioux Falls At Empire Mall by IHG

Mall District, 3.1 km from Sioux Empire Medical Museum

Hagel

RM388

RM433 total

includes taxes & fees

22 Nov - 23 Nov

A multi-level hotel lobby with a central seating area, multiple floors, and a variety of amenities including a bar and dining space.

A hotel room with a bed, a sofa, a TV, and a desk.

A multi-level hotel lobby with a central courtyard, featuring a patterned floor, multiple levels of balconies, and a rock formation.

A multi-level hotel lobby with a central atrium, multiple floors, and a variety of seating areas.

9. Sheraton Sioux Falls Hotel & Convention Center

Northwest Sioux Falls, 2.9 km from Sioux Empire Medical Museum

Gloria

RM430

RM480 total

includes taxes & fees

8 Nov - 9 Nov

A spacious lobby with multiple seating areas, a bar, and a staircase leading to an upper level.

A modern hotel room with a large window, a round coffee table, a sofa, a chair, and a small table with a lamp.

A modern hotel lobby with a bar area, seating arrangements, and a view of the lobby.

A large conference room with a central stage, round tables with white chairs, and a patterned carpet.

10. Holiday Inn Sioux Falls-City Centre by IHG

Downtown Sioux Falls, 1.9 km from Sioux Empire Medical Museum

Guy

RM469

RM584 total

includes taxes & fees

22 Nov - 23 Nov

A swimming pool with lounge chairs and umbrellas, a view of the outside, and a sign indicating the hotel name.

A hotel room with a wooden table, a laptop, a telephone, a glass of orange juice, a lamp, and a chair.

A hotel room with a large bed, a desk, a chair, and a view of a building through the window.

A multi-story hotel with a flat roof, a parking lot, and several cars parked in front.

11. Country Inn & Suites by Radisson, Sioux Falls

Downtown Sioux Falls, 2 km from Sioux Empire Medical Museum

Hayley

RM356

RM399 total

includes taxes & fees

22 Nov - 23 Nov

A hotel room with two beds, a desk with a computer, a television, and a couch.

A sign for Center Inn with a parking lot and buildings in the background.

A hotel reception area with a Christmas tree, a clock, and a sign indicating a non-smoking policy.

A black leather chair, a floor lamp, and a window with a view of parked cars.

12. The Center Inn

All Saints, 2.4 km from Sioux Empire Medical Museum

thomas

RM428

RM478 total

includes taxes & fees

22 Nov - 23 Nov

A hotel room with a bed, two bedside lamps, a nightstand, a mirror, and a small desk with a telephone.

A small cafe with a 'Good Morning' sign, a coffee machine, a microwave, and a refrigerator.

A small, cozy room with a sofa, two armchairs, a coffee table, and a desk with a lamp. There are two framed pictures on the wall.

13. Valley Inn

University Heights, 0.2 km from Sioux Empire Medical Museum

Ibrahim Ozer

RM400

RM447 total

includes taxes & fees

14 Nov - 15 Nov

An indoor pool area with a slide, seating, and tropical decor.

A lobby with a stone fire feature, seating area, and a reception desk.

A restaurant with booths and tables, a TV screen, and a view of the outdoors.

A living room with a fireplace, a television, and a dining area with a table and chairs.

14. Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

Northwest Sioux Falls, 2.9 km from Sioux Empire Medical Museum

Sami

RM253

RM286 total

includes taxes & fees

22 Nov - 23 Nov

A living room with a fireplace, a television, a chandelier, a sofa, and a coffee table.

A cozy living room with a sectional sofa, a wooden coffee table, and a chandelier.

A wooden door with a glass panel, leading to a brick-paved entrance.

A two-story house with a steeply pitched roof, a front porch, and a brick entrance.

15. Historic Twin Tudors Inn

1.4 km from Sioux Empire Medical Museum

Anonymous traveller

RM1,099

RM1,246 total

includes taxes & fees

23 Oct - 24 Oct

16. Sioux Falls Inn

Northwest Sioux Falls, 3.1 km from Sioux Empire Medical Museum

Maria

RM291

RM327 total

includes taxes & fees

22 Nov - 23 Nov

A reception area with a counter, a food mart sign, and a security camera.

A Ramada hotel with a covered entrance, parking lot, and handicap-accessible parking spaces.

A breakfast bar with seating, a microwave, toaster, and a coffee maker.

A swimming pool with a tiled floor, a poolside table, and chairs.

17. Ramada by Wyndham Sioux Falls

2.6 km from Sioux Empire Medical Museum

Jonathan Robert

RM222

RM252 total

includes taxes & fees

2 Nov - 3 Nov

A swimming pool with clear blue water, surrounded by a tiled deck and a seating area with chairs and tables.

A hotel room with a bed, a sofa, a desk, and a chair.

An outdoor patio area with tables and chairs, string lights, and a view of the city skyline.

A modern hotel room with a kitchenette, a sofa, a dining table, a small round table, a bed, and a view of the outdoors.

18. Comfort Inn & Suites at Sanford Sports Complex

Northwest Sioux Falls, 6 km from Sioux Empire Medical Museum

Michelle Marie

RM415

RM463 total

includes taxes & fees

22 Nov - 23 Nov

A modern hotel lobby with seating areas, a bar, and a kitchen visible in the background.

A modern hotel dining area with a central island, high chairs, and a kitchen counter.

A hotel exterior with stone facade, outdoor seating area, and a neon sign.

A snack display area with various chips and snacks, a 'Treats' sign, and a beverage refrigerator.

19. Hampton Inn & Suites Southwest/Sioux Falls

South Sioux Falls, 5.5 km from Sioux Empire Medical Museum

Hettianne

RM448

RM499 total

includes taxes & fees

15 Nov - 16 Nov

A modern hotel room with a kitchenette, a bed, a desk, and a chair.

A modern living room with a flat-screen TV, a sofa, a coffee table, and a dining area with a table and chairs.

A compact hotel room with a kitchenette, a bed, a TV, and a seating area.

A modern hotel room with a kitchenette, a bed, a sofa, a dining area, and a view of the outdoors.

20. Staybridge Suites Sioux Falls Southwest by IHG

South Sioux Falls, 5.2 km from Sioux Empire Medical Museum

Bailey

RM494

RM550 total

includes taxes & fees

25 Oct - 26 Oct

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Compare top hotels near Sioux Empire Medical Museum

Highpoint Hotel University Heights, 0.2 km from Sioux Empire Medical Museum View	Clubhouse Hotel Suites Sioux Falls Mall District, 2.8 km from Sioux Empire Medical Museum View	Hampton Inn Sioux Falls Mall District, 3.1 km from Sioux Empire Medical Museum View	Hotel On Phillips Downtown Sioux Falls, 1.9 km from Sioux Empire Medical Museum View	Home2 Suites By Hilton Sioux Falls/Sanford Medical Center University Heights, 0.2 km from Sioux Empire Medical Museum View
9.8 Exceptional 382 reviews	9.6 Exceptional 1,243 reviews	9.4 Exceptional 1,007 reviews	9.6 Exceptional 1,629 reviews	9.4 Exceptional 678 reviews
RM496 RM552 total includes taxes & fees 10 Nov - 11 Nov	RM621 RM744 total includes taxes & fees 13 Nov - 14 Nov	RM398 RM445 total includes taxes & fees 22 Nov - 23 Nov	RM768 RM850 total includes taxes & fees 11 Nov - 12 Nov	RM499 RM555 total includes taxes & fees 1 Nov - 2 Nov

Top Sioux Empire Medical Museum Hotel Reviews

Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

8/10 Good

"Was the perfect place to stay for us going to the Denny Sanford concert in the evening. We could walk over there and back with no issues. Our room and the hotel was very clean and was a great night for me and my daughter."

Hotel On Phillips

10/10 Excellent

"Smaller size room than we are used to but very nice. Elevator very small too but do realize this building was previously a bank. Very elegant. Towels could have been softer."

Clubhouse Hotel Suites Sioux Falls

10/10 Excellent

"Very clean"

Valley Inn

10/10 Excellent

"It was close to the airport and lots of places to eat. The rooms were spacious and comfortable."

Home2 Suites By Hilton Sioux Falls/Sanford Medical Center

8/10 Good

"The stay was great! Although, we did not get the room we booked initially, which was a King Studio Suite. They for some reason changed us to a 2 double beds regular room. We were then told they had no King Studios available. But again, the hotel is great and the staff was great, and we would def stay again. This would be a 5 star review had we gotten the room we actually booked."

Holiday Inn Sioux Falls-City Centre by IHG

10/10 Excellent

"Clean rooms and great location"

Other attractions near Sioux Empire Medical Museum

University of Sioux Falls

8.0/10 (242 reviews)

Explore the campus of University of Sioux Falls during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

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Augustana College

8.2/10 (310 reviews)

Take a campus tour or just explore the area of Augustana College during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

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Center for Western Studies

You can spend time exploring the galleries in Center for Western Studies during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

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Delbridge Museum of Natural History

6.0/10 (1 review)

You can spend time browsing the exhibits at Delbridge Museum of Natural History during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

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Washington Pavilion

Washington Pavilion is just one of the places to see in Sioux Falls, so why not enjoy the other things to explore during your travels?

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Washington Pavilion of Arts and Science

9.0/10 (132 reviews)

You can make plans for a show at Washington Pavilion of Arts and Science during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

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Pettigrew Home and Museum

You can spend time studying the exhibits at Pettigrew Home and Museum during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

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Club David

After visiting Club David, make a plan to see the other sights and activities in Sioux Falls.

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Frequently asked questions

What's the area like around Sioux Empire Medical Museum?

Sioux Empire Medical Museum is located in a welcoming area of Sioux Falls known for its beautiful waterfalls and sporting events. If you're looking for a convenient place to stay, take a look at the 136 hotels and other accommodation options you'll find within a mile.

What's the best place to stay close to Sioux Empire Medical Museum?

Adjacent to Sioux Empire Medical Museum, Highpoint Hotel is one of the top choices for your stay based on our traveller data, and this hotel offers a restaurant and free parking. Other good choices close by include Valley Inn and Home2 Suites By Hilton Sioux Falls/Sanford Medical Center.

How many hotels are there close to Sioux Empire Medical Museum?

Expedia has 136 hotels and other accommodation options within a mile from Sioux Empire Medical Museum.

If I need to cancel the hotel reservation for my stay near Sioux Empire Medical Museum, will I receive a refund?

Yes, the majority of hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your check-in date. If you have a reservation that's non-refundable, you might still have the option to cancel and be given a refund within 24 hours of booking. Enter dates in and click on "Search", then use the "fully refundable" filter to view the best options available near Sioux Empire Medical Museum.

What can I see and do near Sioux Empire Medical Museum?

Washington Pavilion of Arts and Science, Old Courthouse Museum and Center for Western Studies feature a variety of fascinating exhibits to see while you're in town. Learn about local history at St. Joseph Cathedral and Pettigrew Home and Museum. You can enjoy live performances at Edith Mortenson Theatre Center and Orpheum Theatre Center.

Hotels near Sioux Empire Medical Museum

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Treat yourself

Be picky

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Our top choices for Sioux Empire Medical Museum hotels

1. Highpoint Hotel

2. Clubhouse Hotel Suites Sioux Falls

3. Hampton Inn Sioux Falls

4. Hotel On Phillips

5. Home2 Suites By Hilton Sioux Falls/Sanford Medical Center

6. Canopy By Hilton Sioux Falls Downtown

7. Hilton Garden Inn Sioux Falls Downtown

8. Holiday Inn Express & Suites Sioux Falls At Empire Mall by IHG

9. Sheraton Sioux Falls Hotel & Convention Center

10. Holiday Inn Sioux Falls-City Centre by IHG

11. Country Inn & Suites by Radisson, Sioux Falls

12. The Center Inn

13. Valley Inn

14. Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

15. Historic Twin Tudors Inn

16. Sioux Falls Inn

17. Ramada by Wyndham Sioux Falls

18. Comfort Inn & Suites at Sanford Sports Complex

19. Hampton Inn & Suites Southwest/Sioux Falls

20. Staybridge Suites Sioux Falls Southwest by IHG

Compare top hotels near Sioux Empire Medical Museum

Highpoint Hotel

Clubhouse Hotel Suites Sioux Falls

Hampton Inn Sioux Falls

Hotel On Phillips

Home2 Suites By Hilton Sioux Falls/Sanford Medical Center

Top Sioux Empire Medical Museum Hotel Reviews

Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

Hotel On Phillips

Clubhouse Hotel Suites Sioux Falls

Valley Inn

Home2 Suites By Hilton Sioux Falls/Sanford Medical Center

Holiday Inn Sioux Falls-City Centre by IHG

Other attractions near Sioux Empire Medical Museum

University of Sioux Falls

Augustana College

Center for Western Studies

Delbridge Museum of Natural History

Washington Pavilion

Washington Pavilion of Arts and Science

Pettigrew Home and Museum

Club David

Frequently asked questions