A flooded area with trees standing in water.

Hotels near Santee National Wildlife Refuge

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
3 Jul - 5 Jul
Next weekend
10 Jul - 12 Jul

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Santee National Wildlife Refuge hotels

Property amenity

Fairfield Inn & Suites by Marriott Santee

Fairfield Inn & Suites by Marriott Santee
3.0 star property
7 km from Santee National Wildlife Refuge
9.8 out of 10, Exceptional, (1,002 reviews)
"Nice hotel stay, excellent staff and accommodations."
United States
Carl
The price is RM547
RM607 total
includes taxes & fees
29 Jul - 30 Jul
Fairfield Inn & Suites by Marriott Santee
Free breakfast

Hampton Inn Santee-I-95

Hampton Inn Santee-I-95
2.5 star property
7 km from Santee National Wildlife Refuge
9.6 out of 10, Exceptional, (1,000 reviews)
"Nice breakfast, rooms spacious, convenient location"
United States
Gloria
The price is RM516
RM573 total
includes taxes & fees
2 Aug - 3 Aug
Hampton Inn Santee-I-95
Exterior

Best Western Plus Santee Inn

Best Western Plus Santee Inn
2.5 star property
7 km from Santee National Wildlife Refuge
8.8 out of 10, Excellent, (1,002 reviews)
"We loved our one night stay, it’s was quiet and warming."
United States
Lisett
The price is RM457
RM507 total
includes taxes & fees
7 Jul - 8 Jul
Best Western Plus Santee Inn
Free daily buffet breakfast

Tru By Hilton Santee

Tru By Hilton Santee
2.5 star property
7.2 km from Santee National Wildlife Refuge
9.2 out of 10, Wonderful, (871 reviews)
"The room was very clean and the staff were extremely friendly"
United States
Jeffrey
The price is RM433
RM480 total
includes taxes & fees
27 Jul - 28 Jul
Tru By Hilton Santee
Desk, blackout curtains, iron/ironing board, free WiFi

Baymont by Wyndham Santee

Baymont by Wyndham Santee
2.5 star property
7.2 km from Santee National Wildlife Refuge
8.0 out of 10, Very good, (1,470 reviews)
"Great overnight stop"
United States
Gary
The price is RM326
RM362 total
includes taxes & fees
5 Jul - 6 Jul
Baymont by Wyndham Santee
Children’s activities

Holiday Inn Santee by IHG

Holiday Inn Santee by IHG
3.0 star property
7.2 km from Santee National Wildlife Refuge
8.2 out of 10, Very good, (1,000 reviews)
"Room was super clean and nice. Convenient location off of 95 and near Santee state park. Only minor complaint is the pool wasn't heated as stated. "
United States
Stefanie
The price is RM408
RM453 total
includes taxes & fees
2 Aug - 3 Aug
Holiday Inn Santee by IHG
Frette Italian sheets, premium bedding, pillow-top beds

Comfort Inn & Suites Santee

Comfort Inn & Suites Santee
2.5 star property
7.2 km from Santee National Wildlife Refuge
8.0 out of 10, Very good, (1,000 reviews)
"Clean rooms that were connecting which we requested. Friendly staff. Good breakfast. Met all our needs while traveling with six children."
United States
Leah
The price is RM428
RM476 total
includes taxes & fees
27 Jul - 28 Jul
Comfort Inn & Suites Santee
Lobby

Super 8 by Wyndham Santee/I-95

Super 8 by Wyndham Santee/I-95
2.0 star property
7 km from Santee National Wildlife Refuge
6.8 out of 10, (468 reviews)
"Ok hotel when money is tight. Only stayed one night but the room was clean and the beds were pretty comfy."
United States
Christalyn
The price is RM260
RM289 total
includes taxes & fees
9 Jul - 10 Jul
Super 8 by Wyndham Santee/I-95
Exterior

Red Roof Inn Santee

Red Roof Inn Santee
2.0 star property
7 km from Santee National Wildlife Refuge
6.6 out of 10, (656 reviews)
"Yes, great room."
United States
Gerald
The price is RM257
RM285 total
includes taxes & fees
8 Jul - 9 Jul
Red Roof Inn Santee
In-room safe, iron/ironing board, free WiFi, bed sheets

Travelodge by Wyndham Santee

Travelodge by Wyndham Santee
2.0 star property
7.1 km from Santee National Wildlife Refuge
7.2 out of 10, Good, (746 reviews)
"Staff was very friendly. "
United States
Sriram
The price is RM261
RM290 total
includes taxes & fees
5 Jul - 6 Jul
Travelodge by Wyndham Santee
Free daily full breakfast

Quality Inn & Suites Santee I-95

Quality Inn & Suites Santee I-95
2.5 star property
6.9 km from Santee National Wildlife Refuge
6.0 out of 10, (550 reviews)
"Rooms are clean and staff was super nice and accommodating "
United States
Will
The price is RM226
RM273 total
includes taxes & fees
26 Jul - 27 Jul
Quality Inn & Suites Santee I-95
Lobby

Ramada by Wyndham Santee I-95

Ramada by Wyndham Santee I-95
2.0 star property
7.1 km from Santee National Wildlife Refuge
6.4 out of 10, (567 reviews)
"The room was very clean, the staff very friendly, and the restaurant/bar had good food and drinks and the pool tables added a unique touch!"
United States
Phyllis
The price is RM292
RM324 total
includes taxes & fees
21 Jul - 22 Jul
Ramada by Wyndham Santee I-95
Desk, iron/ironing board, free WiFi, bed sheets

Econo Lodge Santee

Econo Lodge Santee
2.0 star property
7.1 km from Santee National Wildlife Refuge
6.4 out of 10, (314 reviews)
"Very clean room, fast staff, a lot of food spots nearby! "
United States
Santiana
The price is RM246
RM274 total
includes taxes & fees
22 Jul - 23 Jul
Econo Lodge Santee
Restaurant

Sunset Inn Manning I 95

Sunset Inn Manning I 95
2.0 star property
18.9 km from Santee National Wildlife Refuge
5.0 out of 10, (56 reviews)
"Ok good value"
United States
William
The price is RM207
RM230 total
includes taxes & fees
7 Jul - 8 Jul
Sunset Inn Manning I 95
Lake view

Bells Marina & Resort

Bells Marina & Resort
2.5 star property
19.5 km from Santee National Wildlife Refuge
8.6 out of 10, Excellent, (93 reviews)
"Super quaint, quiet, nice little get away."
United States
Karen
The price is RM309
RM356 total
includes taxes & fees
7 Jul - 8 Jul
Bells Marina & Resort
1 bedroom

Starlight Stays

Starlight Stays
2.5 star property
19.8 km from Santee National Wildlife Refuge
7.2 out of 10, Good, (22 reviews)
"staff is Dependable and reliable and very kind "
United States
Andreana
The price is RM275
RM306 total
includes taxes & fees
5 Jul - 6 Jul
Starlight Stays
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels close to Santee National Wildlife Refuge

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
Property amenity
Fairfield Inn & Suites by Marriott Santee
3.0 star property
9.8
Exceptional
1,002 reviews
View
Free breakfast
Hampton Inn Santee-I-95
2.5 star property
9.6
Exceptional
1,000 reviews
View
Exterior
Best Western Plus Santee Inn
2.5 star property
8.8
Excellent
1,002 reviews
View
Free daily buffet breakfast
Tru By Hilton Santee
2.5 star property
9.2
Wonderful
871 reviews
View
Desk, blackout curtains, iron/ironing board, free WiFi
Baymont by Wyndham Santee
2.5 star property
8.0
Very good
1,470 reviews
View

Top Santee National Wildlife Refuge Hotel Reviews

Hampton Inn Manning

Hampton Inn Manning

10/10 Excellent
"First time staying here as the new Hampton by Hilton. Stayed 2 times years ago and it was okay but now it’s like new to me. Room was nice and spacious, clean and smelled wonderful. Staff and property was on point. Will stay again for sure."
Felecia 1-night trip
Posted 3 hours ago
Hampton Inn Manning

Hotels near other Santee National Wildlife Refuge attractions

Pine Island

Commune with nature and explore the great outdoors at Pine Island during your travels in Summerton. While you're in the area, wander around the parks.
See properties

Frequently asked questions

What's the area like around Santee National Wildlife Refuge?
Santee National Wildlife Refuge is located in a welcoming area of Summerton known for its array of dining options and golfing. You'll find 124 hotels and other accommodations within a few miles for a convenient home base.
What's the best hotel to stay near Santee National Wildlife Refuge?
Baymont by Wyndham Santee is one of the top choices for your stay based on our traveller data, and this hotel offers free breakfast and free parking. It's located 4.5 mi (7.2 km) from Santee National Wildlife Refuge. Other good choices within a few miles include Fairfield Inn & Suites by Marriott Santee and Tru By Hilton Santee.
How many hotels should I expect to find near Santee National Wildlife Refuge?
Expedia has 124 hotels and other accommodation options a few miles from Santee National Wildlife Refuge.
If I need to cancel the hotel reservation for my stay near Santee National Wildlife Refuge, will I receive a refund?
Yes! The majority of hotel room reservations are fully refundable as long as you cancel before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If you have a reservation that's non-refundable, you might be able to cancel it and get a refund within a 24-hour period of your booking. Put your dates in and click on "Search", then you can filter by "fully refundable" to get the best options available near Santee National Wildlife Refuge.