Top 10 Hotels Near Santa Fe Depot Museum in Gainesville for 2026

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Our top choices for Santa Fe Depot Museum hotels

A modern hotel lobby with a wooden ceiling, a large TV, a sofa, a coffee table, and a patterned floor.

A hotel with a modern facade, a covered entrance, and a parking lot.

A spacious indoor area with a curved ceiling, a central bar area, multiple seating arrangements, and a large table in the foreground.

A swimming pool with clear lane markings, adjacent lounge chairs, and a tiled floor.

1. Fairfield Inn & Suites by Marriott Gainesville I-35

1.8 km from Santa Fe Depot Museum

BALTAZAR

RM392

RM451 total

includes taxes & fees

22 Oct - 23 Oct

A two-story house with a swimming pool, outdoor furniture, and a well-maintained garden.

A beach with a sunset, waves, and a few trees and structures in the distance.

A wooden deck with a hot tub, outdoor furniture, and a welcome sign on a building.

A two-story house with a tiled roof, multiple windows, and a front porch.

2. The Lancaster Manor B&B

0.8 km from Santa Fe Depot Museum

RM849

RM976 total

includes taxes & fees

14 Oct - 15 Oct

A modern hotel room with a large bed, a desk, a chair, and a sofa.

A motel with a covered parking area and multiple cars parked.

A reception area with a Days Inn sign, a counter with a tiled backsplash, a television, and a coffee machine.

A Days Inn reception area with a stone counter, a dining area with tables and chairs, and a large window on the right side.

3. Days Inn by Wyndham Gainesville

2.5 km from Santa Fe Depot Museum

Tina

RM294

RM338 total

includes taxes & fees

14 Oct - 15 Oct

A large indoor swimming pool with clear views through tall windows, a lounge chair, and a table with chairs.

A hotel kitchen with a central island, wooden cabinets, and a breakfast bar.

A hotel room with a large bed, wooden headboard, bedside tables, a desk with a chair, and a television.

A room with a blue sofa, a small ottoman, a lamp, and a window with curtains.

4. Comfort Suites Gainesville

2.5 km from Santa Fe Depot Museum

Tammera

RM290

RM334 total

includes taxes & fees

20 Oct - 21 Oct

A kitchen with a countertop, a refrigerator, a ceiling fan, and a window.

A bedroom with a bed, a desk, a chair, an air conditioning unit, a door, and a window.

A hotel room with a desk, a television on a stand, a mirror, and a small cabinet.

A small office with a desk, computer, chair, and a clock on the wall.

5. Budget Host Motel Gainesville

2.7 km from Santa Fe Depot Museum

Mark

RM225

RM258 total

includes taxes & fees

14 Oct - 15 Oct

A buffet with labeled containers of omelets and other dishes.

A Holiday Inn Express hotel with a covered entrance, multiple windows, and a brick facade.

A lobby with a coffee table, armchairs, a sofa, and lamps.

A coffee station with two coffee machines and a variety of coffee pods and cups.

6. Holiday Inn Express Hotel & Suites Gainesville by IHG

1.1 km from Santa Fe Depot Museum

Brent

RM323

RM371 total

includes taxes & fees

10 Nov - 11 Nov

A spacious living area with a sofa, a glass-top coffee table, a desk with a computer, and a magazine rack. There is a dining area with tables and chairs in the background.

A hotel room with two beds, a desk, a chair, a TV, and a large window with curtains.

A hotel hallway with carpeted floors, doors on both sides, and a ceiling with recessed lighting.

A reception desk with a mosaic tile design, a framed welcome sign, and a small table with a blue sign.

7. Super 8 by Wyndham Gainesville TX

2.7 km from Santa Fe Depot Museum

Sid

RM282

RM324 total

includes taxes & fees

14 Oct - 15 Oct

A hotel room with two beds, a desk with a chair, a television, and a minibar.

Two refrigerated beverage dispensers labeled 'CHILLED' and 'FROZEN' with various drinks inside.

A breakfast bar with coffee machines, a refrigerator, and a seating area with a wooden table and chairs.

8. Quality Inn Gainesville

0.9 km from Santa Fe Depot Museum

Roxann

RM225

RM261 total

includes taxes & fees

14 Oct - 15 Oct

A spacious living area with a stone accent wall, a brown sofa, and a kitchen in the background.

A gazebo with a roof and open sides, surrounded by grass and trees.

A laundry area with two washing machines and a dryer, a water fountain, and a sign indicating guest laundry hours.

A long corridor with a dining area featuring tables and chairs, a kitchen area, and a reception desk.

9. Loyalty Inn Gainesville

3 km from Santa Fe Depot Museum

Jimmy

RM191

RM220 total

includes taxes & fees

22 Oct - 23 Oct

A hotel room with a bed, a desk with a computer, a TV, a microwave, and a refrigerator.

A spacious dining area with multiple wooden tables and chairs, a counter with food service equipment, and large windows with blinds.

A modern lobby with a green sofa, blue armchairs, a glass coffee table, and potted plants.

10. Suburban Studios Gainesville

0.9 km from Santa Fe Depot Museum

Lynzee

RM202

RM232 total

includes taxes & fees

20 Oct - 21 Oct

A spacious lobby with a reception desk, a staircase, and seating area.

A spacious lobby with a fireplace, patterned wallpaper, and modern seating arrangements.

A swimming pool with a metal railing, surrounded by lounge chairs and a door in the background.

A hotel room with a large bed, two bedside lamps, a bathroom with a bathtub, and a large mirror.

11. La Quinta Inn & Suites by Wyndham Gainesville

5.7 km from Santa Fe Depot Museum

Teresa

RM344

RM403 total

includes taxes & fees

18 Oct - 19 Oct

A spacious kitchen with checkered flooring, wooden cabinets, and various appliances.

A laundry area with a wall-mounted soap, bleach, and softener dispenser, a washing machine, and stacked dryers.

A gym with treadmills, elliptical machines, and a weight bench.

A kitchen with wooden cabinets, a refrigerator, and a tiled floor.

12. Hampton Inn & Suites Gainesville

6.4 km from Santa Fe Depot Museum

Charlie

RM325

RM375 total

includes taxes & fees

10 Nov - 11 Nov

A hotel room with two beds, each with a green headboard, white bedding, and red accents. There are abstract paintings on the wall above the beds.

A building with a sign reading "Lindsay Inn" and a covered entrance area with columns.

A compact kitchen area with a microwave and a black dishwasher.

A small, modern room with a gray sofa, a green armchair, a bed with a red blanket, a white pillow, and a painting on the wall.

13. Lindsay Inn

7.9 km from Santa Fe Depot Museum

Tammera

RM286

RM320 total

includes taxes & fees

21 Oct - 22 Oct

A hotel room with a bed, bedside table, lamp, and a television on a dresser.

A building with a covered entrance, a clock, and a sign with a flag.

A spacious lobby with a ceiling fan, a reception desk, a refrigerator, and a door leading to the outside.

A kitchen with wooden cabinets, a black countertop, and a black rug.

14. OYO Hotel Valley View TX, I-35

16.5 km from Santa Fe Depot Museum

Brian

RM249

RM294 total

includes taxes & fees

5 Nov - 6 Nov

A spacious living room with patterned sofas, a coffee table, and a flat-screen TV mounted on the wall.

A reception area with a curved reception desk, a flat-screen TV mounted on the wall, and framed artwork above the desk.

A modern kitchen with a large island, bar stools, and a flat-screen TV.

A hotel room with two beds, a desk, a TV, and a window.

15. Best Western Red River Inn & Suites

13.9 km from Santa Fe Depot Museum

Douglas

RM392

RM439 total

includes taxes & fees

28 Oct - 29 Oct

A modern living room with a fireplace, two bean bag chairs, a television, and large windows with blinds.

A modern hotel lobby with dark wood flooring, comfortable seating, a flat-screen TV, and a reception desk.

A modern restaurant with a bar area, dark wooden flooring, and contemporary furniture.

A hotel room with a bed, a chair, a small table, and a bathroom with a sink and mirror.

16. Red River Inn And Suites

13.9 km from Santa Fe Depot Museum

Troy

RM404

RM453 total

includes taxes & fees

14 Oct - 15 Oct

A rustic interior with wooden floors, hanging plants, and a rustic ceiling.

A wooden cabin with a porch, surrounded by trees and a garden with yellow flowers.

A rustic dining area with a stone fireplace, wooden ceiling, and a table set for dining.

A backyard with a swimming pool, a wooden pergola, and a stone patio.

17. Oak Meadow Ranch

15 km from Santa Fe Depot Museum

Isaac

RM625

RM920 total

includes taxes & fees

9 Nov - 10 Nov

View all properties

Compare popular hotels close to Santa Fe Depot Museum

Property	Property class	Guest rating
The Lancaster Manor B&B	10.0 Exceptional 115 reviews	View
Fairfield Inn & Suites by Marriott Gainesville I-35	8.6 Excellent 1,003 reviews	View
Days Inn by Wyndham Gainesville	7.8 Good 1,005 reviews	View
Holiday Inn Express Hotel & Suites Gainesville by IHG	7.8 Good 1,000 reviews	View
Super 8 by Wyndham Gainesville TX	7.2 Good 1,001 reviews	View

Top Santa Fe Depot Museum Hotel Reviews

Fairfield Inn & Suites by Marriott Gainesville I-35

8/10 Good

"Courtney at the front desk was awesome. Very helpful, friendly and nice. The chair in our room was very wobbly, she found us a replacement right away. The carpet had some spots on it, but the room had a couch and a desk and chair. It was noisy. The bed was clean and comfortable and the shower was great."

OYO Hotel Valley View TX, I-35

10/10 Excellent

"This is not my first time staying. If I'm not able to stay at Winstar I always choose this hotel. Its clean, inexpensive and staff are always accommodating."

Red River Inn And Suites

10/10 Excellent

"The room was nice, everything worked, nice staff."

La Quinta Inn & Suites by Wyndham Gainesville

8/10 Good

"Really liked the place. It was blissfully quiet, the pool was comfortable and we had it to ourselves. The front desk staff was so kind! The bed was nice. Would recommend. My granddaughter asked if we could come back here every time we travel!"

Oak Meadow Ranch

10/10 Excellent

"Amazing adventure! Book the Tranquility Cabin and the Serenity Slot experience! We’re still on a high from this experience! It was an absolutely amazing adventure that exceeded every single one of our expectations. The entire process was seamless and incredibly well-organized. The guides/hosts were phenomenally knowledgeable, patient, and full of infectious energy that made the day even more special. It balanced pure excitement with wonderful hospitality, leaving both of us completely captivated. It was genuinely a life-disrupting, beautiful memory that we will treasure forever. Don't even hesitate—just book it! For us, we’re looking forward to arranging to bring more family with us next time for a possible giraffe adventure! Thank you again Oak Meadow Ranch for such a one-a-lifetime adventure!"

Holiday Inn Express Hotel & Suites Gainesville by IHG

10/10 Excellent

"Very clean property….also very convenient location."

Super 8 by Wyndham Gainesville TX

10/10 Excellent

"This is an older property but for the most part is nice, we felt safe. Really like the big fridge it kept our drinks very cold better than most motels. Only thing is all the road construction around the area. If you’re bougie this probably won’t be the place for you."

The Lancaster Manor B&B

10/10 Excellent

"You will not find a better couple to host you and you will not find a place with more character than this mansion. Everything was perfect from the check in to the food. We will be back!"

Budget Host Motel Gainesville

10/10 Excellent

"Every\nThing was excellent, clean room.Good parking , good air conditioner , nice staff"

Other attractions near Santa Fe Depot Museum

Cooke County Courthouse

7.6/10 (89 reviews)

After visiting Cooke County Courthouse, make a plan to see the other sights and activities in Gainesville. While you're in the area, find time to visit its casinos.

See properties

Depot Park

Depot Park is just one of the places to see in Gainesville, so why not enjoy the other things to explore during your travels? While in this family-friendly area, find time to visit its casinos.

See properties

Butterfield Stage Players

7.2/10 (64 reviews)

You can enjoy a show at Butterfield Stage Players during your stay in Gainesville. While you're in the area, find time to visit its casinos.

See properties

State Theater

7.4/10 (54 reviews)

You can enjoy a show at State Theater during your stay in Gainesville. While you're in the area, find time to visit its casinos.

See properties

Morton Museum

7.2/10 (68 reviews)

You can spend time studying the exhibits at Morton Museum during your trip to Gainesville. While you're in the area, find time to visit its casinos.

See properties

Tom Thumb Park

After visiting Tom Thumb Park, make a plan to see the other sights and activities in Gainesville. While in this family-friendly area, find time to visit its casinos.

See properties

Jaycee Park

After visiting Jaycee Park, make a plan to see the other sights and activities in Gainesville. While in this family-friendly area, find time to visit its casinos.

See properties

Gainesville War Memorial

8.0/10 (109 reviews)

Find out about the history of Gainesville with a stop at Gainesville War Memorial. While you're in the area, find time to visit its casinos.

See properties

Frequently asked questions

What's the area like around Santa Fe Depot Museum?

Santa Fe Depot Museum is located in a welcoming area of Gainesville known for its first-class casinos. If you're looking for a convenient place to stay, take a look at the 17 hotels and other accommodation options you'll find within a mile.

What's the best place to stay near Santa Fe Depot Museum?

Quality Inn Gainesville is one of the top choices for your stay based on our traveller data, and this hotel offers free breakfast and free parking. It's located just a short 0.5 mi (0.9 km) from Santa Fe Depot Museum. Other good options within a short distance include Suburban Studios Gainesville and Holiday Inn Express Hotel & Suites Gainesville by IHG.

How many hotels are there near Santa Fe Depot Museum?

Expedia has 17 hotels and other accommodation options within a mile from Santa Fe Depot Museum.

If I need to cancel the hotel reservation for my stay near Santa Fe Depot Museum, will I receive a refund?

Yes! You'll find that most hotel reservations are fully refundable as long as you cancel before the hotel's cancellation deadline, which often is within 24-48 hours of check in. If you booked a non-refundable reservation, you might be able to cancel it and get a refund within a 24-hour period of booking. Enter your dates, click on "Search", then use the filter option "fully refundable" to review the best deals near Santa Fe Depot Museum.

What can I see and do near Santa Fe Depot Museum?

You can enjoy live performances at Butterfield Stage Players and State Theater. Get outside and spend some time strolling around Leonard Park, Tom Thumb Park and Jaycee Park. Gainesville War Memorial and Frank Buck Zoo are both worth a visit while you're out exploring.

Hotels near Santa Fe Depot Museum

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Santa Fe Depot Museum hotels

1. Fairfield Inn & Suites by Marriott Gainesville I-35

2. The Lancaster Manor B&B

3. Days Inn by Wyndham Gainesville

4. Comfort Suites Gainesville

5. Budget Host Motel Gainesville

6. Holiday Inn Express Hotel & Suites Gainesville by IHG

7. Super 8 by Wyndham Gainesville TX

8. Quality Inn Gainesville

9. Loyalty Inn Gainesville

10. Suburban Studios Gainesville

11. La Quinta Inn & Suites by Wyndham Gainesville

12. Hampton Inn & Suites Gainesville

13. Lindsay Inn

14. OYO Hotel Valley View TX, I-35

15. Best Western Red River Inn & Suites

16. Red River Inn And Suites

17. Oak Meadow Ranch

Compare popular hotels close to Santa Fe Depot Museum

Top Santa Fe Depot Museum Hotel Reviews

Fairfield Inn & Suites by Marriott Gainesville I-35

OYO Hotel Valley View TX, I-35

Red River Inn And Suites

La Quinta Inn & Suites by Wyndham Gainesville

Oak Meadow Ranch

Holiday Inn Express Hotel & Suites Gainesville by IHG

Super 8 by Wyndham Gainesville TX

The Lancaster Manor B&B

Budget Host Motel Gainesville

Other attractions near Santa Fe Depot Museum

Cooke County Courthouse

Depot Park

Butterfield Stage Players

State Theater

Morton Museum

Tom Thumb Park

Jaycee Park

Gainesville War Memorial

Frequently asked questions