A colonial-style building with a bell tower, palm trees, and a paved walkway.

Best Luxury Hotels in Santa Cruz

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Check availability on Santa Cruz Luxury Hotels

Tonight
5 Oct - 6 Oct
Tomorrow
6 Oct - 7 Oct
This weekend
9 Oct - 11 Oct
Next weekend
16 Oct - 18 Oct

Our top choices for Santa Cruz luxury hotels

A spacious lobby with high ceilings, modern furniture, and large windows allowing natural light.
A hot tub with a wooden deck and stone walls, surrounded by a pool.
A restaurant with a long counter, dark chairs, and hanging lights.
A large, illuminated swimming pool surrounded by palm trees and pathways.

1. Camino Real Hotel

Camino Real Hotel
Santa Cruz
  • Waterside luxury retreat with full-service spa offers poolside cocktails, garden-view dining, and indoor-outdoor swimming pools.
RM658
RM658 total
11 Oct - 12 Oct
Camino Real Hotel
A modern hotel with a rooftop pool featuring illuminated blue and purple lights, lounge chairs, and a palm tree.
A restaurant with a high ceiling, large windows, and a view of the cityscape. Tables are set with plates, glasses, and cutlery.
A luxurious banquet hall with ornate chandeliers, floral arrangements, and elegant table settings.
A modern lobby with a curved staircase, seating area, and a large wooden bookshelf.

2. Marriott Santa Cruz de la Sierra Hotel

Marriott Santa Cruz de la Sierra Hotel
Santa Cruz
  • Luxury escape in Santa Cruz's business district offers full-service spa treatments, outdoor pool relaxation, and upscale dining.
RM432
RM432 total
1 Nov - 2 Nov
Marriott Santa Cruz de la Sierra Hotel
A modern restaurant with a city view, featuring glass tables, white chairs, and a large window with curtains.
A hotel room with a large bed, a desk, a chair, a telephone, and a view of the city through large windows.
A modern hotel lobby with a bar area, seating arrangements, and a television.
A small, enclosed garden area with various potted plants and a gravel path.

3. Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

Hampton by Hilton Santa Cruz/Equipetrol, Bolivia
Santa Cruz
  • Indulge in luxury and convenience at this 4.5-star Bolivia hotel offering fine dining, fitness amenities, and garden views.
RM301
RM301 total
10 Oct - 11 Oct
Hampton by Hilton Santa Cruz/Equipetrol, Bolivia
A hotel room with a bed, a desk with a chair, a television, and a window with a city view.
An aerial view of a residential area with a swimming pool, a playground, and a large building with a red roof.
A gym with various exercise equipment, including a treadmill, weight machines, and a bench.
A lobby with a marble floor, an elevator, and a view of the outdoor seating area.

4. Gran Hotel Santa Cruz

Gran Hotel Santa Cruz
Centro Histórico
RM265
RM265 total
6 Oct - 7 Oct
Gran Hotel Santa Cruz
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Top Santa Cruz Hotel Reviews

Frequently asked questions

Are you looking for a luxury hotel for your Santa Cruz holiday?
Travel to Santa Cruz (SRZ-El Trompillo) Airport or Santa Cruz (VVI-Viru Viru Intl.) Airport, and then treat yourself to a stay at one of 7 Santa Cruz luxury hotels. Santa Cruz has some interesting things to see and do including Plaza 24 de Septiembre and Blacutt Square, so you might want to take in the local sights during your visit.
What's the best high-end hotel in Santa Cruz?
Marriott Santa Cruz de la Sierra Hotel is a luxury hotel with a full-service spa and a rooftop terrace, and it's a popular choice for Expedia travellers looking for an elegant place to stay. Camino Real Hotel and Hampton by Hilton Santa Cruz/Equipetrol, Bolivia are two other upscale options for your trip.
How many luxury hotels are there in Santa Cruz?
Lie in the lap of luxury during your getaway to Santa Cruz in one of Expedia's 7 luxury hotels.
When can I expect good weather in Santa Cruz?
Planning for the weather is a good way to make your trip to Santa Cruz relaxing and enjoyable, especially when you're splurging. The hottest months are usually October and November, with an average temperature of 26°C, while the coldest months are June and July, with an average of 21°C. Average annual precipitation for Santa Cruz is 1208 mm.
What's there to see and do in Santa Cruz?
Enjoy all that Santa Cruz has to offer when you visit Plaza 24 de Septiembre, Blacutt Square and Ramon Tahuichi Aguilera Stadium. If you have a little extra time during your trip, you might want to make a stop at Santa Cruz Zoo and Ventura Mall.
How can I get around Santa Cruz?
It's easier to get around town comfortably when you know your options. To venture out into the surrounding area, hop aboard a train at Santa Cruz de la Sierra Station.