Hotels in Santa Ana, Antigua Guatemala

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Top 10 Hotels in Santa Ana, Antigua Guatemala

Interior
Casa Buho B&B

Casa Buho B&B

3.0 star property
Santa Ana
9.2 out of 10, Wonderful, (48)
"Great place !!"
United States
Abner Israel Polanco
The price is RM270
RM330 total
includes taxes & fees
6 Dec - 7 Dec
Casa Buho B&B
Garden view
Hostal Casa Buho

Hostal Casa Buho

3.0 star property
Santa Ana
8.6 out of 10, Excellent, (21)
"Nice clean affordable accomodations and very accomodating and amicable hosts."
United States
Feng
The price is RM204
RM249 total
includes taxes & fees
6 Dec - 7 Dec
Hostal Casa Buho
Front of property
Villas Santa Ana-Ricardo

Villas Santa Ana-Ricardo

3.5 star property
Santa Ana
8.6 out of 10, Excellent, (12)
"Space was clean and had a cozy vibe."
United States
Evelin
Villas Santa Ana-Ricardo
3 outdoor pools, pool umbrellas
Hotel Soleil La Antigua

Hotel Soleil La Antigua

4.0 star property
1.8 km from Santa Ana
8.6 out of 10, Excellent, (1002)
"Great room"
United States
Elvin
Hotel Soleil La Antigua
Reception hall
Barceló Guatemala City

Barceló Guatemala City

4.5 star property
22.7 km from Santa Ana
9.2 out of 10, Wonderful, (3092)
"Barcelo is a nice, clean and comfortable place to stay"
United States
Ana
The price is RM273
RM333 total
includes taxes & fees
4 Jan - 5 Jan 2026
Barceló Guatemala City
Fitness studio
Hotel Museo Spa Casa Santo Domingo

Hotel Museo Spa Casa Santo Domingo

4.5 star property
Barrio de La Concepción, 1.1 km from Santa Ana
9.2 out of 10, Wonderful, (1005)
"Great overall stay"
United States
Jose
The price is RM979
RM1,245 total
includes taxes & fees
4 Jan - 5 Jan 2026
Hotel Museo Spa Casa Santo Domingo
2 treatment rooms
Hotel Las Americas

Hotel Las Americas

4.0 star property
22.3 km from Santa Ana
8.4 out of 10, Very good, (1005)
"Excellent breakfast, nice room and nice view to the aurora airport "
Mexico
Ronald Fernando Rivera
Hotel Las Americas
Breakfast, lunch, dinner served; international cuisine, garden views
Clarion Suites Guatemala City

Clarion Suites Guatemala City

4.0 star property
23.3 km from Santa Ana
9.0 out of 10, Wonderful, (1003)
"My stay at this place was excellent "
United States
Diego
The price is RM415
RM506 total
includes taxes & fees
26 Dec - 27 Dec
Clarion Suites Guatemala City
Egyptian cotton sheets, premium bedding, in-room safe, desk
El Convento Boutique Hotel

El Convento Boutique Hotel

4.0 star property
Historic Center, 1.5 km from Santa Ana
9.4 out of 10, Exceptional, (796)
"Great hotel to explore Antigua "
United States
vered
The price is RM815
RM1,056 total
includes taxes & fees
21 Dec - 22 Dec
El Convento Boutique Hotel
Terrace/patio
Los Pasos Boutique Hotel & Spa

Los Pasos Boutique Hotel & Spa

4.5 star property
0.7 km from Santa Ana
9.4 out of 10, Exceptional, (1000)
"Great place to stay. "
United States
tania
The price is RM624
RM761 total
includes taxes & fees
8 Dec - 9 Dec
Los Pasos Boutique Hotel & Spa
Exterior
Hotel Posada de Don Rodrigo Antigua

Hotel Posada de Don Rodrigo Antigua

3.5 star property
Historic Center, 1.5 km from Santa Ana
9.4 out of 10, Exceptional, (639)
"Great hotel right in the center of the action. The facilities and hotel vibes are awesome! The restaurant has great food and all the staff is kind all around. The beds I found to be uncomfortable, but not a deal breaker as the hotel pros outweigh the cons. "
United States
Juan
The price is RM663
RM909 total
includes taxes & fees
26 Dec - 27 Dec
Hotel Posada de Don Rodrigo Antigua
4 restaurants, breakfast, lunch, dinner served; international cuisine
InterContinental Real Guatemala by IHG

InterContinental Real Guatemala by IHG

5.0 star property
23.2 km from Santa Ana
9.2 out of 10, Wonderful, (1000)
"Very friendly staff and clean room"
United States
Julia
The price is RM556
RM728 total
includes taxes & fees
22 Dec - 23 Dec
InterContinental Real Guatemala by IHG
Property amenity
Porta Hotel Antigua

Porta Hotel Antigua

4.5 star property
1.1 km from Santa Ana
9.4 out of 10, Exceptional, (1001)
"Everything about this hotel was fantastic. The bed was so comfortable. "
United States
Raymond
The price is RM797
RM1,013 total
includes taxes & fees
9 Dec - 10 Dec
Porta Hotel Antigua
Outdoor pool
Hyatt Centric Guatemala City

Hyatt Centric Guatemala City

4.5 star property
23.3 km from Santa Ana
9.6 out of 10, Exceptional, (780)
"the hotel is perfectly located. The staff is happy, courteous, helpful. Food is good. Great Breakfast Buffett, good room service. We will return every time we go back to Guatemala City."
United States
Fernando
The price is RM552
RM673 total
includes taxes & fees
22 Dec - 23 Dec
Hyatt Centric Guatemala City
Exterior
All Suite El Marques de Antigua

All Suite El Marques de Antigua

3.5 star property
1 km from Santa Ana
9.4 out of 10, Exceptional, (294)
"Great location and very clean"
United States
Saul
All Suite El Marques de Antigua
Exterior
Naif Boutique Hotel

Naif Boutique Hotel

3.0 star property
Historic Center, 1.4 km from Santa Ana
9.0 out of 10, Wonderful, (368)
"Well located, friendly staff. Would stay again."
United States
Cristian Paolo
The price is RM626
RM764 total
includes taxes & fees
18 Dec - 19 Dec
Naif Boutique Hotel
Front of property
Mestizo Cortijo

Mestizo Cortijo

3.0 star property
4.3 km from Santa Ana
9.0 out of 10, Wonderful, (90)
"Nice place to stay and enjoy Antigua Guatemala "
United States
Allan
The price is RM487
RM595 total
includes taxes & fees
14 Dec - 15 Dec
Mestizo Cortijo
Exterior
La Capitania de San Pedro

La Capitania de San Pedro

2.5 star property
2.5 km from Santa Ana
10.0 out of 10, Exceptional, (4)
" La Capitanía de San Pedro was absolutely beautiful! The views, atmosphere, and hospitality made it unforgettable. I’d recommend it to anyone visiting Antigua Guatemala truly a perfect 10/10 experience!"
United States
Rudy
The price is RM284
RM346 total
includes taxes & fees
19 Dec - 20 Dec
La Capitania de San Pedro
Terrace/patio
Hotel La Galeria

Hotel La Galeria

3.0 star property
Historic Center, 1.4 km from Santa Ana
9.4 out of 10, Exceptional, (257)
"Room was beautiful and staff were all helpful"
Canada
Becky
Hotel La Galeria
Exterior
Wyndham Garden Guatemala City

Wyndham Garden Guatemala City

4.0 star property
23.2 km from Santa Ana
9.2 out of 10, Wonderful, (1606)
"Location and hotel is amazing and the staff is very helpful"
United States
Martha
The price is RM360
RM439 total
includes taxes & fees
1 Jan - 2 Jan 2026
Wyndham Garden Guatemala City
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Santa Ana

Find the best Santa Ana areas for the activities you enjoy most.

Historic Center

If you're spending some time in Historic Center, Central Park and Santa Catalina Arch are top sights worth seeing.

Barrio de La Concepción

While visiting Barrio de La Concepción, you might make a stop by sights like Casa Santo Domingo Museum and Jade Maya Factory and Museum.

Top Santa Ana Hotel Reviews

Hotel Soleil La Antigua

Hotel Soleil La Antigua

10/10 Excellent
"Love this hotel!! Need more food option or at least vending machines, because you’re not allowed to bring food from outside. But overall it is ⭐️⭐️⭐️⭐️⭐️ "
Raymond de 3-night trip
Posted 2 days ago
Hotel Soleil La Antigua

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Frequently asked questions

What's it like in Santa Ana?
Travellers to the Santa Ana neighbourhood in Antigua Guatemala will be sure to enjoy their stay.
What's a favourite place to stay in Santa Ana?
Based on Expedia customer reviews, Casa Buho B&B is the highest ranked property in Santa Ana. This hotel offers a restaurant and free parking.
How many hotels will I be able to find in Santa Ana?
If you're searching for places to stay in Antigua Guatemala, choose from one of Expedia's 18 hotels and other accommodation options in Santa Ana.
If I need to cancel my hotel reservation in Santa Ana, will I receive a refund?
Yes! You'll find that most hotel reservations are fully refundable provided that you cancel prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your scheduled arrival. If you booked a non-refundable reservation, it may still be possible to cancel it and be given a refund within 24 hours of your booking. Enter your dates, click on "Search", then use the "fully refundable" filter to view top deals in Santa Ana.
What are the top things to see and do in Santa Ana?
House of the Giants, Santa Clara Convent and Jade Maya Factory and Museum are just a few of the places to visit in and around Santa Ana. While you're out sightseeing in Antigua Guatemala, make sure that you visit other sights such as Tanque La Unión or Museo del Hermano Pedro.