Hotels in Sant' Ambrogio, Florence

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27 Dec - 28 Dec
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28 Dec - 29 Dec
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2 Jan - 4 Jan
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9 Jan - 11 Jan

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Our top choices for Sant' Ambrogio hotels

Lobby lounge
The James Suite Hotel Firenze 1564 - Small Luxury Hotels of the World

The James Suite Hotel Firenze 1564 - Small Luxury Hotels of the World

The James Suite Hotel Firenze 1564 - Small Luxury Hotels of the World
5.0 star property
Sant' Ambrogio
10.0 out of 10, Exceptional, (13)
"This hotel was quite the find! The staff was amazing, attentive, respectful. The amenities, attention to detail, experience was amazing! We will definitely be back."
United States
Nicole
The price is RM1,755
RM2,007 total
includes taxes & fees
8 Jan - 9 Jan 2026
The James Suite Hotel Firenze 1564 - Small Luxury Hotels of the World
Rooftop terrace
Appartamento Puccini

Appartamento Puccini

Appartamento Puccini
Sant' Ambrogio
7.8 out of 10, Good, (76)
"The apartment is located perfectly"
Germany
Thomas
Appartamento Puccini
Living area
Ciompi Prestige by Mmega

Ciompi Prestige by Mmega

Ciompi Prestige by Mmega
Sant' Ambrogio
9.0 out of 10, Wonderful, (2)
Ciompi Prestige by Mmega
Private kitchenette
Santa Croce Place by Mmega

Santa Croce Place by Mmega

Santa Croce Place by Mmega
Sant' Ambrogio
6.8 out of 10, (5)
"The apartment was not kept well. Consumables like sugar, detergent etc. kept under lock and key. Mosquitoes were a hassle. The bathroom was very tiny. The bedroom is next to the road, so was very noisy. Although it is located at an excellent location."
India
Sachit
The price is RM364
RM839 total
includes taxes & fees
10 Jan - 11 Jan 2026
Santa Croce Place by Mmega
City view
Iris Apartments by Mmega

Iris Apartments by Mmega

Iris Apartments by Mmega
Sant' Ambrogio
7.8 out of 10, Good, (12)
"Excellent location bit a bit noisy at night."
United States
Stephen
The price is RM409
RM889 total
includes taxes & fees
10 Jan - 11 Jan 2026
Iris Apartments by Mmega
Terrace/patio
Pilastri Garden by Mmega

Pilastri Garden by Mmega

Pilastri Garden by Mmega
Sant' Ambrogio
6.0 out of 10, (2)
"Overall the property was good for the night we had! Great location. Accommodated the people we had. It was quiet "
United States
Sara
Pilastri Garden by Mmega
Minibar, individually decorated, individually furnished, desk
Villa Tortorelli

Villa Tortorelli

Villa Tortorelli
Sant' Ambrogio
9.6 out of 10, Exceptional, (66)
"Beautiful property! Loved our stay here! "
United States
Olga
Villa Tortorelli
Private kitchen
Borgo Pinti Cozy Flat 

Borgo Pinti Cozy Flat 

Borgo Pinti Cozy Flat 
Sant' Ambrogio
7.4 out of 10, Good, (3)
"Excellent property beyond our expectations. After a stressful day of traveling internationally, the key and entry taxed us. The key continued to be an issue for us (skeleton key with 4 locks). But otherwise, it's location and the property itself, awesome!"
United States
Stephanie
Borgo Pinti Cozy Flat 
1 bedroom, premium bedding, down duvets, desk
Palazzo dei Ciompi Suites

Palazzo dei Ciompi Suites

Palazzo dei Ciompi Suites
Sant' Ambrogio
7.6 out of 10, Good, (392)
"worst customer service and guest support I have had ever experienced "
United States
Eduard
Palazzo dei Ciompi Suites
Reception
Residenza d'Epoca White Room

Residenza d'Epoca White Room

Residenza d'Epoca White Room
Sant' Ambrogio
7.4 out of 10, Good, (63)
"LOVED this place! It’s huge, cute, clean, centrally located, and has a super nice bathroom. Also has your own A/C unit which was awesome! Highly recommend especially for the price."
United States
Amelia
Residenza d'Epoca White Room
Front of property
Palazzo Pazzi Vitali Luxury Apartments

Palazzo Pazzi Vitali Luxury Apartments

Palazzo Pazzi Vitali Luxury Apartments
Sant' Ambrogio
10.0 out of 10, Exceptional, (1)
"This property is under-rated and we are thankful we stumbled upon this. We had a nearly 3000 sf apartment to ourselves and the photos don't do it justice. We stay at luxury lodging everywhere we go and this was no different. There was so much room to relax and spread out. Great for multi family, or large family. Our unit on the second floor was ideal because the bedrooms were in the ack and very quiet. While the main living areas overlook this beautiful street with opera singers and live...
United States
Richard
The price is RM2,602
RM3,873 total
includes taxes & fees
2 Jan - 3 Jan 2026
Palazzo Pazzi Vitali Luxury Apartments
Daily buffet breakfast (EUR 8 per person)
Alfieri9

Alfieri9

Alfieri9
3.0 star property
Sant' Ambrogio
9.6 out of 10, Exceptional, (158)
"Hotel was in a nice quiet neighborhood, but still only a short walk to main attractions. The breakfast was excellent. Staff interactions were good."
United States
Colin
Alfieri9
Living area
Don Giovanni by Mmega

Don Giovanni by Mmega

Don Giovanni by Mmega
Sant' Ambrogio
9.0 out of 10, Wonderful, (7)
"Perfect location Very clean Nicely appointed"
United States
Luanne
The price is RM601
RM1,099 total
includes taxes & fees
9 Jan - 10 Jan 2026
Don Giovanni by Mmega
Terrace/patio
Dimora del Cardinale - Residenza d'epoca

Dimora del Cardinale - Residenza d'epoca

Dimora del Cardinale - Residenza d'epoca
Sant' Ambrogio
9.8 out of 10, Exceptional, (56)
"We had an easy check-in. Friendly staff welcomed us and we settled in quickly so we could enjoy the sites. We walked to all tours and restaurants. The restaurant next door was so good, we ate their twice! The property is well located to everything - food, shopping and more!"
United States
Stacey
The price is RM468
RM572 total
includes taxes & fees
27 Jan - 28 Jan 2026
Dimora del Cardinale - Residenza d'epoca
Daily buffet breakfast (EUR 7.00 per person)
Locanda Orchidea - B&B

Locanda Orchidea - B&B

Locanda Orchidea - B&B
Sant' Ambrogio
9.2 out of 10, Wonderful, (233)
"Perfect location, superb room, + wonderful staff - a brilliant stay all round! "
United Kingdom
TARA
Locanda Orchidea - B&B
Interior entrance
Hotel Villa Liana

Hotel Villa Liana

Hotel Villa Liana
3.0 star property
Sant' Ambrogio
8.6 out of 10, Excellent, (343)
"the breakfast was delicious!"
United States
Catherine
Hotel Villa Liana
Garden
Hotel Regency

Hotel Regency

Hotel Regency
5.0 star property
Sant' Ambrogio
9.4 out of 10, Exceptional, (443)
"Amazing stay as always. Beautiful hotel but the staff make it great. Feels like a home away from home. Perfect location that is easily walkable everywhere in the historic center."
United States
Aaron
The price is RM1,153
RM1,345 total
includes taxes & fees
16 Jan - 17 Jan 2026
Hotel Regency
Exterior
Hotel D'Azeglio

Hotel D'Azeglio

Hotel D'Azeglio
2.0 star property
Sant' Ambrogio
7.8 out of 10, Good, (340)
"The place was walking distance very clean and quiet stuff very friendly a plus including breakfast "
United States
Beatriz
The price is RM347
RM425 total
includes taxes & fees
6 Jan - 7 Jan 2026
Hotel D'Azeglio
Private kitchen
Wine Apartments Florence Colorino

Wine Apartments Florence Colorino

Wine Apartments Florence Colorino
Sant' Ambrogio
7.0 out of 10, Good, (2)
"It was clean and spacious."
United States
Joseph
Wine Apartments Florence Colorino
Restaurant
Hotel Bodoni

Hotel Bodoni

Hotel Bodoni
2.0 star property
Sant' Ambrogio
8.2 out of 10, Very good, (792)
"Nice people and convenient location!!!!"
United States
julio
The price is RM304
RM378 total
includes taxes & fees
8 Jan - 9 Jan 2026
Hotel Bodoni
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Sant' Ambrogio

Find the best Sant' Ambrogio areas for the activities you enjoy most.

Historic Centre of Florence

Lose yourself in the Renaissance charm of Florence’s old town, where masterpieces by Brunelleschi and Giotto line up alongside cafés, gelato shops and trattorias.

Duomo

Visitors to Duomo rave about its fascinating museums, stunning cathedral and popular shops. You might also want to make some time to see Piazza di Santa Maria Novella or Via de' Calzaiuoli while you're exploring the neighbourhood.

Santa Maria Novella

Enjoy the popular shops in Santa Maria Novella. Piazza di Santa Maria Novella is a worthwhile stop, and you can jump on the metro at Porta al Prato - Leopolda Tram Stop or Fratelli Rosselli Tram Stop to see more of Porta al Prato.

Uffizi Gallery showing street scenes as well as a large group of people

San Giovanni

If you're spending some time in San Giovanni, Piazza della Repubblica and Via de' Calzaiuoli are top sights worth seeing.

Santa Croce

Santa Croce is known for its interesting museums, and you can plan a trip to Basilica of Santa Croce and Piazza Santa Croce while you're in town.

Top Sant' Ambrogio Hotel Reviews

The James Suite Hotel Firenze 1564 - Small Luxury Hotels of the World

The James Suite Hotel Firenze 1564 - Small Luxury Hotels of the World

10/10 Excellent
"Everything was wonderful. If I had a criticism it would be that the breakfast room was too cold. But that would hardly prevent us from visiting again!"
Jade 3-night trip
Posted 3 weeks ago
The James Suite Hotel Firenze 1564 - Small Luxury Hotels of the World
Hotel Regency

Hotel Regency

10/10 Excellent
"Amazing stay as always. Beautiful hotel but the staff make it great. Feels like a home away from home. Perfect location that is easily walkable everywhere in the historic center."
Aaron 2-night trip
Posted 2 months ago
Hotel Regency

Frequently asked questions

What's it like in Sant' Ambrogio?
Guests are sure to enjoy their time checking out all that Florence's Sant' Ambrogio neighbourhood has to offer. Make sure that you visit Piazza Massimo D'Azeglio and Church of Santa Maria Maddalena dei Pazzi as part of your Sant' Ambrogio travel plans.
What's a favourite hotel to stay in Sant' Ambrogio?
Based on Expedia customer reviews, Alfieri9 is the highest ranked property in Sant' Ambrogio. This hotel is a short 15-minute walk from Piazza del Duomo, and it offers free WiFi and valet parking. Other favourite options in the area include B&B di Piazza del Duomo and Hotel Regency.
How many hotels can I expect to find in Sant' Ambrogio?
If you're searching for places to stay in Florence, Expedia has something to meet your needs with 527 Sant' Ambrogio hotels and other accommodation options to choose from.
If I need to cancel my hotel reservation in Sant' Ambrogio, will I receive a refund?
Yes, you'll find most hotel room reservations are fully refundable if you cancel before the hotel's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you have a non-refundable reservation, it might still be possible to cancel it and receive a refund within a 24-hour period of booking. Add your dates and click on "Search", then use the "fully refundable" filter to get the best options available in Sant' Ambrogio.
What is there to do around this Florence neighbourhood?
Landmarks in Sant' Ambrogio that you won't want to miss include Great Synagogue of Florence and Church of Santa Maria Maddalena dei Pazzi. Piazza Massimo D'Azeglio and Mercato di Sant'Ambrogio are also a couple of places to visit in the neighbourhood. A few places to visit in the area around Sant' Ambrogio include Piazza di Santa Maria Novella, Jewish Museum and FiesoleBike Day Tours. When you're sightseeing in Florence, Galleria d'Arte Civico69 and Teatro della Pergola are also worth a stop.

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