Top 10 San Francisco Hotels of 2026

The Bridge of the Americas in summer, Panama City

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Property	Property class	Guest rating
Plaza Paitilla Inn Hotel	3.5 star property	9.4 Exceptional 2,149 reviews	View
Sheraton Grand Panama	4.0 star property	8.6 Excellent 1,005 reviews	View
Aloft by Marriott Panama	3.5 star property	8.8 Excellent 1,000 reviews	View
Las Americas Golden Tower Panama	4.0 star property	9.0 Wonderful 1,023 reviews	View
Courtyard by Marriott Panama Multiplaza Mall	4.0 star property	9.0 Wonderful 1,002 reviews	View

Where to stay in San Francisco

Find the best San Francisco areas for the activities you enjoy most.

Casco Viejo

Unique features of Casco Viejo include the historical sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.

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Bella Vista

Travellers love Bella Vista for its popular shops, and you can see more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina. You might spend time checking out top sights like Via Espana and Iglesia del Carmen.

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Panama City Old Town streets and buildings

El Cangrejo

The ample dining options and casino gaming are top of the list for many visitors to El Cangrejo. A stop by Via Espana or Crown Casino might round out your trip.

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Panoramic view of Panama City Skyline - Panama City, Panama

Calidonia

Calidonia is a destination travellers like for its shopping, and you might hop aboard the metro at Estación Lotería or Santo Tomas Station to explore sights like Via Espana.

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Balcony of a colonial house, Casco Viejo, Panama City, Panama, Central America

San Felipe

While visiting San Felipe, you might make a stop by sights like Independence Square and Interoceanic Canal Museum.

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Top San Francisco Hotel Reviews

Sheraton Grand Panama

8/10 Good

"Very well maintained and beautiful place."

Plaza Paitilla Inn Hotel

6/10 Okay

"Receptionist was very friendly and room clean I would recommend any one. "

Hotel Riu Plaza Panama

6/10 Okay

"There is no weekend entertainment at this hotel,you only see the staff at the front desk. No one even call your room to ask how your experiences. Limited English language especially house keeping, room service. The staff at the front of the building are very helpful with transportation and understand English.One pool not even big enough for all the guest.Breakfast was quiet okay with enough varieties."

Las Americas Golden Tower Panama

10/10 Excellent

"We arrived about 2 hours before check in time but they were so accommodating and immediately gave us a room. Starting with the bellhop who directed us to the lobby which was in the 5th floor (unusual) who ss soon ss he found out that we were going to leave st 5 AM to another adventure, he ordered a breakfast box for us to take in to our trip. Dinner was exquisite, we had the pork ribs and mashed potatoes suggested by the waiter who obviously know his menu, they were to die for. Dessert was also delicious. The pool is indoors and the gym is absolutely amazing. I am definitely coming back after visiting San Blas and stay here a little bit longer. I highly recommend Americas Golden Tower hotel 🏨 "

Frequently asked questions

What is San Francisco like?

San Francisco is a welcoming neighbourhood that travellers like for its restaurants. Make sure that you visit Multiplaza Pacific Mall and Calle 50 as part of your San Francisco travel plans.

Where is the best hotel for a stay in San Francisco?

Based on our traveller data, Courtyard by Marriott Panama Multiplaza Mall is one of the top choices for your stay in San Francisco. This hotel is steps from Multiplaza Pacific Mall, and offers a restaurant and an outdoor pool. Other good choices for your stay in the area include Plaza Paitilla Inn Hotel and Las Americas Golden Tower Panama.

How many hotels can I expect to find in San Francisco?

If you're searching for places to stay in Panama City, Expedia has something to meet your needs with 319 San Francisco hotels and other accommodation options to choose from.

If I need to cancel my hotel reservation in San Francisco, will I receive a refund?

Yes! Most hotel reservations are fully refundable provided that you cancel before the hotel's cancellation deadline, which often is within 24-48 hours of check in. If you booked a non-refundable reservation, you may still be able to cancel and be given a refund within 24 hours of booking. Add dates, click "Search", then use the filter option "fully refundable" to view the best deals in San Francisco.

What is there to do in this Panama City neighbourhood?

While you're in San Francisco, a shopping trip to Multiplaza Pacific Mall, Avenida Balboa or Via Espana might be the perfect way to find that souvenir you've been looking for. Calle 50 and Panama Canal Murals are some other stops worth a visit in the neighbourhood. A few places to visit in the area around San Francisco include Colonial Religious Art Museum, Bingo 90 and Pacific Center. When you're sightseeing in Panama City, Soho City Center and National Shrine of the Heart of Mary are also worth a stop.

Hotels in San Francisco, Panama City

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Our top choices for San Francisco hotels

Megapolis Hotel Panamá

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Plaza Paitilla Inn Hotel

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Las Americas Golden Tower Panama

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Compare popular hotels in San Francisco

Where to stay in San Francisco

Casco Viejo

Bella Vista

El Cangrejo

Calidonia

San Felipe

Top San Francisco Hotel Reviews

Sheraton Grand Panama

Frequently asked questions