Hotels in Serra Mesa, San Diego

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Our top choices for Serra Mesa hotels

Sycuan Casino Resort

Sycuan Casino Resort
4.0 star property
28.8 km from Serra Mesa
9.4 out of 10, Exceptional, (1,937 reviews)
"Excellent and comfortable stay"
United States
Sean
The price is RM391
RM478 total
includes taxes & fees
26 May - 27 May
Sycuan Casino Resort

The Alcala Hotel Mission Valley/Seaworld

The Alcala Hotel Mission Valley/Seaworld
2.5 star property
6.6 km from Serra Mesa
8.2 out of 10, Very good, (89 reviews)
"Everything was clean and nice, great breakfast 😋"
United States
Balwin
The price is RM329
RM378 total
includes taxes & fees
26 May - 27 May
The Alcala Hotel Mission Valley/Seaworld

Sheraton San Diego Resort

Sheraton San Diego Resort
4.0 star property
10.1 km from Serra Mesa
8.4 out of 10, Very good, (3,537 reviews)
"Excellent food, friendly staff, easy check-in, and beautiful setting. "
United States
Emily
The price is RM669
RM970 total
includes taxes & fees
25 May - 26 May
Sheraton San Diego Resort

Ramada by Wyndham San Diego Poway Miramar

Ramada by Wyndham San Diego Poway Miramar
2.0 star property
18.2 km from Serra Mesa
7.2 out of 10, Good, (1,003 reviews)
"Well maintained property, staff were professional and very nice"
United States
Cherie
The price is RM336
RM369 total
includes taxes & fees
25 May - 26 May
Ramada by Wyndham San Diego Poway Miramar

Best Western Americana Inn

Best Western Americana Inn
2.5 star property
28.1 km from Serra Mesa
9.0 out of 10, Wonderful, (1,276 reviews)
"Everything was very pleasant,the place was super clean, and the breakfast was delicious👍"
United States
Nancy
The price is RM450
RM512 total
includes taxes & fees
28 May - 29 May
Best Western Americana Inn

San Diego Mission Bay Resort

San Diego Mission Bay Resort
4.0 star property
Mission Bay, 7.2 km from Serra Mesa
8.6 out of 10, Excellent, (1,443 reviews)
"Perfect place for a family trip "
United States
Krystal
The price is RM664
RM973 total
includes taxes & fees
25 May - 26 May
San Diego Mission Bay Resort

GreenTree Inn San Diego Mission Bay

GreenTree Inn San Diego Mission Bay
2.5 star property
Pacific Beach, 7.3 km from Serra Mesa
8.0 out of 10, Very good, (2,118 reviews)
"Great experience, will stay here again"
United States
Victoria
The price is RM383
RM440 total
includes taxes & fees
27 May - 28 May
GreenTree Inn San Diego Mission Bay

Wyndham Garden San Diego Near SeaWorld

Wyndham Garden San Diego Near SeaWorld
3.0 star property
9 km from Serra Mesa
7.4 out of 10, Good, (4,226 reviews)
"Nice stay, clean room"
United States
Luis
The price is RM392
RM451 total
includes taxes & fees
27 May - 28 May
Wyndham Garden San Diego Near SeaWorld

Pleasant Inn

Pleasant Inn
2.5 star property
4.8 km from Serra Mesa
8.4 out of 10, Very good, (1,414 reviews)
"Staff was very friendly and helpful. Good location for sights we wanted to see."
United States
Steve
The price is RM315
RM361 total
includes taxes & fees
1 Jun - 2 Jun
Pleasant Inn

Lafayette Hotel & Club

Lafayette Hotel & Club
4.0 star property
5.3 km from Serra Mesa
9.4 out of 10, Exceptional, (1,659 reviews)
"This is a must stay place in San Diego"
United States
Kristi
The price is RM986
RM1,134 total
includes taxes & fees
25 May - 26 May
Lafayette Hotel & Club

Heritage Inn San Diego

Heritage Inn San Diego
2.0 star property
9.1 km from Serra Mesa
7.4 out of 10, Good, (1,460 reviews)
"I really like the hotel Was close to sea world and lots of eating places with in walking distance."
United States
Latrice
The price is RM280
RM322 total
includes taxes & fees
26 May - 27 May
Heritage Inn San Diego

Ash&9th

Ash&9th
2.0 star property
9.4 km from Serra Mesa
8.2 out of 10, Very good, (623 reviews)
"Great location and basic amenities for the price. The desk staff are amazing and helpful."
United States
Kimberly
The price is RM347
RM394 total
includes taxes & fees
26 May - 27 May
Ash&9th

La Quinta Inn by Wyndham San Diego Chula Vista

La Quinta Inn by Wyndham San Diego Chula Vista
3.0 star property
18.7 km from Serra Mesa
8.6 out of 10, Excellent, (1,618 reviews)
"Great stay"
United States
Helda
The price is RM425
RM468 total
includes taxes & fees
25 May - 26 May
La Quinta Inn by Wyndham San Diego Chula Vista

Comfort Inn Sea World Area

Comfort Inn Sea World Area
3.5 star property
8.2 km from Serra Mesa
8.6 out of 10, Excellent, (3,687 reviews)
"Room is clean, staff are especially helpful and courteous, breakfast was great…all in all made my stay comfortable and convenient because just minutes away from the airport…would stay here again"
United States
Parley Vinn Anastacius
The price is RM414
RM476 total
includes taxes & fees
25 May - 26 May
Comfort Inn Sea World Area

Best Western San Diego/Miramar Hotel

Best Western San Diego/Miramar Hotel
2.5 star property
10.1 km from Serra Mesa
8.0 out of 10, Very good, (1,331 reviews)
"Wonderful, kind staff and good breakfast"
United States
Kimberly
The price is RM426
RM490 total
includes taxes & fees
26 May - 27 May
Best Western San Diego/Miramar Hotel

Best Western Plus Hacienda Hotel Old Town

Best Western Plus Hacienda Hotel Old Town
3.0 star property
Old Town San Diego, 7.6 km from Serra Mesa
8.4 out of 10, Very good, (2,011 reviews)
"I highly recommend this hotel it is beautiful and the staff is great"
United States
Juanita
The price is RM496
RM570 total
includes taxes & fees
27 May - 28 May
Best Western Plus Hacienda Hotel Old Town

Holiday Inn Express San Diego South - Chula Vista by IHG

Holiday Inn Express San Diego South - Chula Vista by IHG
2.5 star property
18.5 km from Serra Mesa
9.4 out of 10, Exceptional, (1,169 reviews)
"Very nice place to stay"
United States
Lingzhi
The price is RM503
RM553 total
includes taxes & fees
25 May - 26 May
Holiday Inn Express San Diego South - Chula Vista by IHG

Old Town Western Inn & Suites

Old Town Western Inn & Suites
2.5 star property
Old Town San Diego, 7.9 km from Serra Mesa
7.8 out of 10, Good, (1,000 reviews)
"Very good area for visiting the area"
United States
Carla
The price is RM395
RM446 total
includes taxes & fees
25 May - 26 May
Old Town Western Inn & Suites

Wyndham San Diego Bayside

Wyndham San Diego Bayside
4.0 star property
9.9 km from Serra Mesa
8.4 out of 10, Very good, (6,155 reviews)
"Great place for a family vacation!"
United States
Ann
The price is RM569
RM798 total
includes taxes & fees
26 May - 27 May
Wyndham San Diego Bayside

California Suites Hotel

California Suites Hotel
2.0 star property
4.8 km from Serra Mesa
7.8 out of 10, Good, (2,558 reviews)
"Very comfortable, nice pool and hot tub, quiet, pretty location, and close to lots of stuff! Would stay here again! "
United States
Stephon
The price is RM332
RM381 total
includes taxes & fees
7 Jun - 8 Jun
California Suites Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Serra Mesa

Find the best Serra Mesa areas for the activities you enjoy most. Learn more about Serra Mesa
Learn more about Serra Mesa

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Pacific Beach

Relax in beachside cafés in the morning, surf clean breaks in the afternoon and dance with a youthful club crowd at night at this coastal San Diego strip.

Mission Beach

If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.

Gaslamp Quarter

The historic heart of San Diego has a fascinating history, and today is a thriving hub for food, retail and entertainment.

Mission Bay

If you're spending some time in Mission Bay, Mission Bay and Mission and Pacific Beaches are top sights worth seeing.

Top Serra Mesa Hotel Reviews

Frequently asked questions

What's it like in Serra Mesa?
Guests are sure to enjoy their time checking out all that San Diego's Serra Mesa neighbourhood has to offer. Consider a visit to Stadium Golf Center & Batting Cages as part of your Serra Mesa travel plans.
How many hotels can I expect to find in the Serra Mesa area?
Expedia has 38 hotels and other accommodation options in Serra Mesa to choose from, making this an ideal home base for exploring the greater San Diego area.
If I need to cancel my hotel reservation in Serra Mesa, will I receive a refund?
Yes, most hotel reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If you have a non-refundable reservation, it may still be possible to cancel it and get a refund within 24 hours of your booking. Plug in your dates, click on "Search", then filter by "fully refundable" to review top deals in Serra Mesa.
What can I see and do in this San Diego neighbourhood?
Stadium Golf Center & Batting Cages is an attraction you might want to check out while you're in Serra Mesa. When you're sightseeing in San Diego, Convoy District and Old Cactus Garden are also worth a stop.

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