Hotels in Otay Mesa, San Diego

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Top 10 Hotels in Otay Mesa, San Diego

Exterior
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

2.5 star property
Otay Mesa
8.0 out of 10, Very good, (1552)
"Good comfortable beds good breakfast "
United States
Andrey
The price is RM551
RM627 total
includes taxes & fees
7 Dec - 8 Dec
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Desk, laptop workspace, blackout curtains, iron/ironing board
Quality Suites San Diego Otay Mesa

Quality Suites San Diego Otay Mesa

2.5 star property
Otay Mesa
7.0 out of 10, Good, (1001)
"Beautiful place "
United States
Joe
The price is RM366
RM416 total
includes taxes & fees
7 Dec - 8 Dec
Quality Suites San Diego Otay Mesa
Serves dinner and happy hour
The Horton Grand, Downtown/Gaslamp Quarter

The Horton Grand, Downtown/Gaslamp Quarter

3.5 star property
Marina District, 24.3 km from Otay Mesa
9.0 out of 10, Wonderful, (2694)
"Clean facilities and friendly staff!"
United States
EMMA
The Horton Grand, Downtown/Gaslamp Quarter
Exterior
Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter

Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter

3.0 star property
Gaslamp Quarter, 24.1 km from Otay Mesa
9.0 out of 10, Wonderful, (1228)
"Very nice clean room and amenities and staff was pleasant and we love the location. "
United States
Arnold
The price is RM564
RM654 total
includes taxes & fees
20 Dec - 21 Dec
Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter
Outdoor pool
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4.0 star property
Gaslamp Quarter, 24 km from Otay Mesa
9.0 out of 10, Wonderful, (3138)
"Great stay"
United States
Laurence
The price is RM699
RM1,000 total
includes taxes & fees
21 Dec - 22 Dec
Hard Rock Hotel San Diego
Rooftop terrace
Palihotel San Diego Gaslamp Quarter

Palihotel San Diego Gaslamp Quarter

4.0 star property
Gaslamp Quarter, 24.5 km from Otay Mesa
8.6 out of 10, Excellent, (2081)
"Room was spotless and location great. "
United States
James
The price is RM572
RM663 total
includes taxes & fees
10 Dec - 11 Dec
Palihotel San Diego Gaslamp Quarter
Premium bedding, pillow-top beds, desk, laptop workspace
Staypineapple, Hotel Z, Gaslamp San Diego

Staypineapple, Hotel Z, Gaslamp San Diego

3.0 star property
Gaslamp Quarter, 24.2 km from Otay Mesa
9.4 out of 10, Exceptional, (1003)
"The room was immaculate, the staff were helpful and friendly and our stay was so wonderful. "
United States
Samantha Erin
The price is RM500
RM698 total
includes taxes & fees
26 Dec - 27 Dec
Staypineapple, Hotel Z, Gaslamp San Diego
Premium bedding, in-room safe, desk, laptop workspace
Best Western Plus Marina Gateway Hotel

Best Western Plus Marina Gateway Hotel

3.5 star property
16.9 km from Otay Mesa
9.2 out of 10, Wonderful, (3484)
"Clean room nice staff right off of the freeway. "
United States
Olivia
The price is RM477
RM526 total
includes taxes & fees
21 Dec - 22 Dec
Best Western Plus Marina Gateway Hotel
Terrace/patio
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4.0 star property
25.7 km from Otay Mesa
8.4 out of 10, Very good, (6066)
"Always an amazing stay"
United States
Jana
The price is RM556
RM764 total
includes taxes & fees
21 Dec - 22 Dec
Wyndham San Diego Bayside
Exterior
AC Hotel by Marriott San Diego Downtown Gaslamp Quarter

AC Hotel by Marriott San Diego Downtown Gaslamp Quarter

4.0 star property
Gaslamp Quarter, 24.4 km from Otay Mesa
8.8 out of 10, Excellent, (964)
"Great spot "
United States
George
The price is RM576
RM668 total
includes taxes & fees
4 Jan - 5 Jan 2026
AC Hotel by Marriott San Diego Downtown Gaslamp Quarter
Lobby
Gaslamp Plaza Suites

Gaslamp Plaza Suites

3.5 star property
Gaslamp Quarter, 24.6 km from Otay Mesa
9.0 out of 10, Wonderful, (1006)
"Great room, clean, spacious and quiet. "
United States
Maria
The price is RM456
RM519 total
includes taxes & fees
10 Dec - 11 Dec
Gaslamp Plaza Suites
Outdoor pool, pool loungers
Best Western Plus Suites Hotel Coronado Island

Best Western Plus Suites Hotel Coronado Island

2.5 star property
24.1 km from Otay Mesa
8.8 out of 10, Excellent, (1001)
"Good to spend a night or two-- nice staff-- friendly ad awesome breakfast"
United States
MICHELE
The price is RM645
RM710 total
includes taxes & fees
18 Dec - 19 Dec
Best Western Plus Suites Hotel Coronado Island
Property amenity
The Monsaraz San Diego, Tapestry Collection by Hilton

The Monsaraz San Diego, Tapestry Collection by Hilton

3.5 star property
30.1 km from Otay Mesa
8.6 out of 10, Excellent, (613)
"Great hotel "
United States
Judy
The price is RM523
RM601 total
includes taxes & fees
14 Dec - 15 Dec
The Monsaraz San Diego, Tapestry Collection by Hilton
Property entrance
The Bristol Hotel San Diego

The Bristol Hotel San Diego

3.5 star property
24.9 km from Otay Mesa
8.6 out of 10, Excellent, (1441)
"Great stay, clean room. Staff was very friendly as well. Would stay again. "
United States
Alexis
The Bristol Hotel San Diego
Front of property
The Sofia Hotel

The Sofia Hotel

3.5 star property
24.9 km from Otay Mesa
8.4 out of 10, Very good, (1650)
"Great location and history to the hotel "
United States
Stephanie
The Sofia Hotel
2 outdoor pools, open 6 AM to 10:00 PM, pool cabanas (surcharge)
Marriott Marquis San Diego Marina

Marriott Marquis San Diego Marina

4.0 star property
Marina District, 24.5 km from Otay Mesa
9.2 out of 10, Wonderful, (1938)
"Great hotel"
United States
Farzana
The price is RM654
RM974 total
includes taxes & fees
20 Dec - 21 Dec
Marriott Marquis San Diego Marina
Exterior
Margaritaville Hotel San Diego Gaslamp Quarter

Margaritaville Hotel San Diego Gaslamp Quarter

4.0 star property
Gaslamp Quarter, 24.1 km from Otay Mesa
9.0 out of 10, Wonderful, (1156)
"Amenities and location were great. "
United States
Julie
The price is RM663
RM935 total
includes taxes & fees
17 Dec - 18 Dec
Margaritaville Hotel San Diego Gaslamp Quarter
Exterior
Bay Club Hotel & Marina

Bay Club Hotel & Marina

3.5 star property
29.2 km from Otay Mesa
9.2 out of 10, Wonderful, (3165)
"Great stay and location!"
United States
Jason
The price is RM478
RM549 total
includes taxes & fees
7 Dec - 8 Dec
Bay Club Hotel & Marina
Lobby
Best Western Plus La Mesa San Diego

Best Western Plus La Mesa San Diego

2.5 star property
24.5 km from Otay Mesa
8.2 out of 10, Very good, (1004)
"Great place "
United States
Fadi
The price is RM399
RM438 total
includes taxes & fees
4 Jan - 5 Jan 2026
Best Western Plus La Mesa San Diego
Living room
Alma San Diego Downtown, a Tribute Portfolio Hotel

Alma San Diego Downtown, a Tribute Portfolio Hotel

4.0 star property
24.7 km from Otay Mesa
9.0 out of 10, Wonderful, (867)
"Staff was amazing. Room was really nice and the view was PERFECT."
United States
Porscha
The price is RM555
RM811 total
includes taxes & fees
29 Dec - 30 Dec
Alma San Diego Downtown, a Tribute Portfolio Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Otay Mesa

Find the best Otay Mesa areas for the activities you enjoy most.

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Gaslamp Quarter showing night scenes, a bar and street scenes

Gaslamp Quarter

The historic heart of San Diego has a fascinating history, and today is a thriving hub for food, retail and entertainment.

Pacific Beach Park showing a sandy beach

Pacific Beach

Relax in beachside cafés in the morning, surf clean breaks in the afternoon and dance with a youthful club crowd at night at this coastal San Diego strip.

Belmont Park showing rides and a park

Mission Beach

If you're spending some time in Mission Beach, Mission Bay and Mission and Pacific Beaches are top sights worth seeing.

Ocean Beach

With a secluded sunbathing beach, swimming-only beach, special surf beach, volleyball beach and dog beach, San Diego’s “OB” sure takes beaches seriously.

Top Otay Mesa Hotel Reviews

Best Western Plus Marina Gateway Hotel

Best Western Plus Marina Gateway Hotel

10/10 Excellent
"Room clean and close to downtown "
Guillermo 2-night trip
Posted 3 days ago
Best Western Plus Marina Gateway Hotel

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Frequently asked questions

What's it like in Otay Mesa?
Otay Mesa is a neighbourhood that travellers like for its beaches, restaurants and shopping.
Where is the best hotel for a stay in Otay Mesa?
Based on Expedia customer reviews, Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG is the highest ranked property in Otay Mesa. This hotel offers free breakfast and an outdoor pool. Another top choice in the area is Quality Suites San Diego Otay Mesa.
If I need to cancel my hotel reservation in Otay Mesa, will I receive a refund?
Yes! Most room reservations are refundable provided that you cancel before the hotel's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you booked a non-refundable reservation, it might still be possible to cancel it and be given a refund within a 24-hour period of booking. Add dates, click "Search", then filter by "fully refundable" to view top deals in Otay Mesa.
What is there to do in this San Diego neighbourhood?
A few places to visit in the area around Otay Mesa include High Performance Center in Tijuana, Parque Industrial FINSA Tijuana and Otay Sports Fields. While you're out sightseeing, Caliente Casino and Alameda Otay are a couple of additional sights to visit in San Diego.