Hotels in Otay Mesa, San Diego

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Our top choices for Otay Mesa hotels

Quality Suites San Diego Otay Mesa

Quality Suites San Diego Otay Mesa
2.5 star property
Otay Mesa
7.0 out of 10, Good, (1,003 reviews)
"Good for short stay"
Japan
Yuki
The price is RM440
RM500 total
includes taxes & fees
5 May - 6 May
Quality Suites San Diego Otay Mesa

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2.5 star property
Otay Mesa
8.2 out of 10, Very good, (1,712 reviews)
"Amazing stay"
United States
Samantha
The price is RM506
RM575 total
includes taxes & fees
17 May - 18 May
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Ocean Villa Inn

Ocean Villa Inn
2.5 star property
Ocean Beach, 33.7 km from Otay Mesa
8.0 out of 10, Very good, (1,253 reviews)
"Amazing def will stay again "
United States
Tanya
The price is RM414
RM467 total
includes taxes & fees
29 Apr - 30 Apr
Ocean Villa Inn

Studio 6 Suites San Ysidro, CA -San Diego South Bay

Studio 6 Suites San Ysidro, CA -San Diego South Bay
2.5 star property
6.9 km from Otay Mesa
8.0 out of 10, Very good, (1,619 reviews)
"Clean room, friendly and nice staff, easy parking and safe "
United States
Erik
The price is RM305
RM348 total
includes taxes & fees
29 Apr - 30 Apr
Studio 6 Suites San Ysidro, CA -San Diego South Bay

Best Western San Diego Pacific Beach/Mission Bay

Best Western San Diego Pacific Beach/Mission Bay
2.5 star property
Bay Park, 33.6 km from Otay Mesa
8.2 out of 10, Very good, (372 reviews)
"Clean upgraded rooms, good breakfast, easy parking, friendly staff, very convenient location that is safe. "
United States
Aimee
The price is RM344
RM396 total
includes taxes & fees
10 May - 11 May
Best Western San Diego Pacific Beach/Mission Bay

Sycuan Casino Resort

Sycuan Casino Resort
4.0 star property
28.5 km from Otay Mesa
9.4 out of 10, Exceptional, (1,874 reviews)
"Great accommodations!"
United States
Tamaryn
The price is RM390
RM476 total
includes taxes & fees
4 May - 5 May
Sycuan Casino Resort

Lafayette Hotel & Club

Lafayette Hotel & Club
4.0 star property
26.8 km from Otay Mesa
9.2 out of 10, Wonderful, (1,617 reviews)
"Amazing ambiance and vibes. It was our second time staying here and we will for sure be staying again soon."
United States
betty
The price is RM984
RM1,131 total
includes taxes & fees
4 May - 5 May
Lafayette Hotel & Club

Best Western Chula Vista/Otay Valley Hotel

Best Western Chula Vista/Otay Valley Hotel
2.5 star property
7.1 km from Otay Mesa
7.8 out of 10, Good, (1,726 reviews)
"Nice place , good breakfast , staff very polite "
United States
DIEM
The price is RM433
RM477 total
includes taxes & fees
10 May - 11 May
Best Western Chula Vista/Otay Valley Hotel

Sheraton San Diego Resort

Sheraton San Diego Resort
4.0 star property
28.1 km from Otay Mesa
8.4 out of 10, Very good, (3,494 reviews)
"Great place to stay "
United States
Tonya
The price is RM613
RM904 total
includes taxes & fees
12 May - 13 May
Sheraton San Diego Resort

Wyndham Garden San Diego Near SeaWorld

Wyndham Garden San Diego Near SeaWorld
3.0 star property
31.3 km from Otay Mesa
7.4 out of 10, Good, (4,209 reviews)
"Great overall stay. Would stay again. "
United States
German
The price is RM447
RM514 total
includes taxes & fees
12 May - 13 May
Wyndham Garden San Diego Near SeaWorld

La Quinta Inn by Wyndham San Diego Chula Vista

La Quinta Inn by Wyndham San Diego Chula Vista
3.0 star property
12.9 km from Otay Mesa
8.6 out of 10, Excellent, (1,602 reviews)
"Great stay"
United States
Helda
The price is RM400
RM440 total
includes taxes & fees
10 May - 11 May
La Quinta Inn by Wyndham San Diego Chula Vista

SpringHill Suites by Marriott Chula Vista Eastlake

SpringHill Suites by Marriott Chula Vista Eastlake
3.5 star property
10.5 km from Otay Mesa
9.6 out of 10, Exceptional, (636 reviews)
"Best hotel ever!"
United States
Nicholas
The price is RM711
RM784 total
includes taxes & fees
10 May - 11 May
SpringHill Suites by Marriott Chula Vista Eastlake

Old Town Western Inn & Suites

Old Town Western Inn & Suites
2.5 star property
Old Town San Diego, 29.6 km from Otay Mesa
7.8 out of 10, Good, (1,006 reviews)
"Staff was super friendly and located just short walk to downtown with good restaurants and coffee shop."
United States
Juan
The price is RM384
RM433 total
includes taxes & fees
29 Apr - 30 Apr
Old Town Western Inn & Suites

Bay Club Hotel & Marina

Bay Club Hotel & Marina
3.5 star property
29.2 km from Otay Mesa
9.2 out of 10, Wonderful, (3,562 reviews)
"Great stay!"
United States
ANAT
The price is RM532
RM612 total
includes taxes & fees
5 May - 6 May
Bay Club Hotel & Marina

Comfort Inn Chula Vista San Diego South

Comfort Inn Chula Vista San Diego South
2.5 star property
13 km from Otay Mesa
8.2 out of 10, Very good, (1,456 reviews)
"Great breakfast lots of amenities. Good location, willstay again."
United States
Dannell
The price is RM432
RM476 total
includes taxes & fees
10 May - 11 May
Comfort Inn Chula Vista San Diego South

Holiday Inn Express San Diego Airport - Old Town by IHG

Holiday Inn Express San Diego Airport - Old Town by IHG
2.5 star property
28.8 km from Otay Mesa
9.0 out of 10, Wonderful, (1,066 reviews)
"Good hotel. "
United States
Joseph Raymond
The price is RM557
RM641 total
includes taxes & fees
3 May - 4 May
Holiday Inn Express San Diego Airport - Old Town by IHG

Old Town Inn

Old Town Inn
2.5 star property
30.1 km from Otay Mesa
9.2 out of 10, Wonderful, (1,865 reviews)
"Nice staff, so clean, very pleasant stay."
United States
Rachel
The price is RM620
RM711 total
includes taxes & fees
20 May - 21 May
Old Town Inn

Best Western Americana Inn

Best Western Americana Inn
2.5 star property
8 km from Otay Mesa
9.0 out of 10, Wonderful, (1,263 reviews)
"Clean room, nice staff, a simple breakfast, and free parking on site."
United States
Nicole
The price is RM483
RM550 total
includes taxes & fees
6 May - 7 May
Best Western Americana Inn

Best Western Plus Marina Gateway Hotel

Best Western Plus Marina Gateway Hotel
3.5 star property
16.9 km from Otay Mesa
9.2 out of 10, Wonderful, (3,807 reviews)
"Great resort "
United States
Ines
The price is RM601
RM663 total
includes taxes & fees
10 May - 11 May
Best Western Plus Marina Gateway Hotel

Ocean Beach Hotel

Ocean Beach Hotel
3.0 star property
Ocean Beach, 33.5 km from Otay Mesa
8.8 out of 10, Excellent, (1,324 reviews)
"Great location!"
United States
Paul
The price is RM711
RM802 total
includes taxes & fees
10 May - 11 May
Ocean Beach Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Otay Mesa

Find the best Otay Mesa areas for the activities you enjoy most.

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Pacific Beach

Relax in beachside cafés in the morning, surf clean breaks in the afternoon and dance with a youthful club crowd at night at this coastal San Diego strip.

Mission Beach

If you're spending some time in Mission Beach, Mission Beach and Mission Bay are top sights worth seeing.

Gaslamp Quarter

The historic heart of San Diego has a fascinating history, and today is a thriving hub for food, retail and entertainment.

Ocean Beach

With a secluded sunbathing beach, swimming-only beach, special surf beach, volleyball beach and dog beach, San Diego’s “OB” sure takes beaches seriously.

Top Otay Mesa Hotel Reviews

Frequently asked questions

What's it like in Otay Mesa?
Otay Mesa is a neighbourhood that travellers like for its beaches, restaurants and shopping.
Where is the best hotel for a stay in Otay Mesa?
Based on Expedia customer reviews, Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG is the highest ranked property in Otay Mesa. This hotel offers free breakfast and an outdoor pool. Another top choice in the area is Quality Suites San Diego Otay Mesa.
If I need to cancel my hotel reservation in Otay Mesa, will I receive a refund?
Yes! Most room reservations are refundable provided that you cancel before the hotel's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you booked a non-refundable reservation, it might still be possible to cancel it and be given a refund within a 24-hour period of booking. Add dates, click "Search", then filter by "fully refundable" to view top deals in Otay Mesa.
What is there to do in this San Diego neighbourhood?
A few places to visit in the area around Otay Mesa include High Performance Center in Tijuana, Parque Industrial FINSA Tijuana and Otay Sports Fields. While you're out sightseeing, Caliente Casino and Alameda Otay are a couple of additional sights to visit in San Diego.

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