A storefront with a sign reading "The Beach Club" and various clothing items displayed in the window.

Hotels near Main Street Hyannis

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
30 Aug - 31 Aug
Tomorrow
31 Aug - 1 Sept
Next weekend
4 Sept - 6 Sept
In two weeks
11 Sept - 13 Sept

Filter by

Star rating

Guest rating

Our top choices for Main Street Hyannis hotels

A multi-story hotel with balconies, a flat roof, and a clear sky.
A reception area with a counter, a seated area with a lamp, and framed pictures on the wall.
An indoor swimming pool with clear water, surrounded by black chairs and tables.
A hotel room with two beds, a desk, a chair, a lamp, and a nightstand with a phone and a small table.

1. Hyannis Travel Inn

Hyannis Travel Inn
0.2 km from Main Street Hyannis
Canada
Anatolie
RM439
RM502 total
includes taxes & fees
31 Aug - 1 Sept
Hyannis Travel Inn
A stone fire pit with four white Adirondack chairs around it, overlooking a marina with boats.
A marina with multiple boats docked, surrounded by residential houses and greenery.
A hotel with a pool area, outdoor seating, and a flag.
A corridor with wooden flooring, wicker furniture, and large windows.

2. Anchor In Distinctive Waterfront Lodging

Anchor In Distinctive Waterfront Lodging
0.6 km from Main Street Hyannis
United States
Trish
RM872
RM1,113 total
includes taxes & fees
28 Sept - 29 Sept
Anchor In Distinctive Waterfront Lodging
A poolside area with a wooden pergola, green seating, and a sign reading "LE JARDIN BLEU".
A row of white bicycles with brown seats and wicker baskets, parked in front of a white building with black railings and large windows.
A bartender pouring a drink into a gold cocktail shaker.
A modern indoor dining area with a wooden table, chairs, and a decorative wall with string lights.

3. Uncommoner Hotel by Reverie Boutique Collection

Uncommoner Hotel by Reverie Boutique Collection
1.9 km from Main Street Hyannis
United States
vanessa
RM620
RM734 total
includes taxes & fees
7 Sept - 8 Sept
Uncommoner Hotel by Reverie Boutique Collection
A hotel room with a large bed, a chair, a table, and a window with curtains.
A brick pathway leading to a building with a sign reading "SeaCoast Inn" and the number 33.
A hotel corridor with patterned carpet, a decorative ceiling light, and a view of parked cars outside.
A coffee station with a Bunn branded juice dispenser, a coffee machine, and a variety of coffee pods.

4. SeaCoast Inn

SeaCoast Inn
0.1 km from Main Street Hyannis
United States
Alexandra
RM519
RM594 total
includes taxes & fees
31 Aug - 1 Sept
SeaCoast Inn
A covered walkway with wooden flooring, planter boxes with plants, and a white exterior wall.
A living room with a sofa, coffee table, and patterned chair. There are two wall-mounted ship wheels and a framed picture on the wall.
A spacious, modern restaurant with a long counter and multiple seating areas.
A hallway with a sign reading 'ASCEND COLLECTION,' a wooden planter with plants, and a reflective floor.

5. Heritage House Inn on Cape Cod, an Ascend Collection Hotel

Heritage House Inn on Cape Cod, an Ascend Collection Hotel
0.3 km from Main Street Hyannis
United States
JoAnne
RM493
RM564 total
includes taxes & fees
21 Sept - 22 Sept
Heritage House Inn on Cape Cod, an Ascend Collection Hotel
An indoor swimming pool with a wooden ceiling, potted plants, and lounge chairs.
A hotel room with a bed, a chair, a table with two glasses of wine, a lamp, and a window with a view of a lake.
A beach scene with a directional signpost and beach chairs.
A beachside table with two chairs, a blue umbrella, and a white tablecloth.

6. Bayside Resort Hotel

Bayside Resort Hotel
2.3 km from Main Street Hyannis
United States
Lester
RM650
RM790 total
includes taxes & fees
7 Sept - 8 Sept
Bayside Resort Hotel
A modern conference room with a long table, chairs, a flat-screen TV, and pendant lighting.
A Fairfield by Marriott hotel with a large sign, a covered entrance, and a building with a tower.
A hotel room with a bed, a TV, a sofa, a lamp, and a chair.
A modern reception area with a desk, chairs, a fireplace, and a decorative plant.

7. Fairfield Inn & Suites by Marriott Cape Cod Hyannis

Fairfield Inn & Suites by Marriott Cape Cod Hyannis
2.3 km from Main Street Hyannis
United States
Shruti
RM818
RM936 total
includes taxes & fees
7 Sept - 8 Sept
Fairfield Inn & Suites by Marriott Cape Cod Hyannis
An outdoor patio with wicker furniture, a fire pit, and umbrellas.
An indoor swimming pool with clear signage, lounge chairs, and a tiled floor.
A breakfast bar with waffle makers, a fruit bowl, and a coffee station.
A reception area with a sign reading "Welcome to the Patriot State" and a counter with a "Hilton" sign.

8. Hampton Inn & Suites Cape Cod-West Yarmouth

Hampton Inn & Suites Cape Cod-West Yarmouth
1.7 km from Main Street Hyannis
United States
Evan
RM726
RM831 total
includes taxes & fees
7 Sept - 8 Sept
Hampton Inn & Suites Cape Cod-West Yarmouth
A marina with boats docked, a wooden pier, and residential buildings in the background.
An outdoor dining area with white picket fencing, tables, and chairs.
A motel with a two-story structure, a covered parking area, and a small adjacent building.
A Cape Cod Inn with a 'VACANCY' sign, a white picket fence, and a duck-themed logo.

9. Cape Cod Inn

Cape Cod Inn
0.2 km from Main Street Hyannis
United States
Julianne
RM439
RM502 total
includes taxes & fees
31 Aug - 1 Sept
Cape Cod Inn
An indoor swimming pool with a high ceiling and large windows.
A modern bar area with a curved wooden counter, multiple stools, and a display case with beverages.
A café interior with a wooden counter, a menu board, and a refrigerated display.

10. Courtyard By Marriott Cape Cod Hyannis

Courtyard By Marriott Cape Cod Hyannis
1.7 km from Main Street Hyannis
United States
Erin
RM863
RM987 total
includes taxes & fees
7 Sept - 8 Sept
Courtyard By Marriott Cape Cod Hyannis
An indoor swimming pool with a brick wall, a white table with chairs, and a large window.
A Courtyard Resort sign, a building with a brick facade, and a parking lot.
A compact hotel room with a kitchenette, a bed, a dining area, and a view through a large window.
A reception area with a reception desk, a clock, a fire alarm, and a sign for the courtyard resort.

11. Courtyard Resort

Courtyard Resort
0.3 km from Main Street Hyannis
United States
Kimberly
RM519
RM594 total
includes taxes & fees
20 Sept - 21 Sept
Courtyard Resort
An outdoor seating area with wooden furniture and a fire pit, surrounded by trees and a gravel path.
A decorative shark sculpture with the text "Cape Sands Inn" at a beachside location.
A lobby with a wooden floor, a reception desk, a large window, and a ceiling fan.
A neatly made bed with white linens, a painting of a sailboat on the wall, and a door leading to a balcony.

12. Cape Sands Inn

Cape Sands Inn
1.9 km from Main Street Hyannis
United States
Christina
RM340
RM390 total
includes taxes & fees
20 Sept - 21 Sept
Cape Sands Inn
A long dining table with chairs, a kitchen area, and a large window.
A reception area with a check-in counter, blue chairs, a waiting area, and a glass door leading to a dining area.
A Comfort Inn hotel with a modern facade, large glass windows, and a clear sky.
An indoor swimming pool with clear blue water, tiled walls, and a ceiling painted in blue.

13. Comfort Inn Hyannis - Cape Cod

Comfort Inn Hyannis - Cape Cod
0.3 km from Main Street Hyannis
United States
catherine
RM540
RM618 total
includes taxes & fees
20 Sept - 21 Sept
Comfort Inn Hyannis - Cape Cod
A Holiday Inn hotel entrance with a covered walkway, a parking lot, and a landscaped area with a water feature.
A swimming pool with lounge chairs and umbrellas, surrounded by a fence and a building with multiple windows.
A spacious living area with a large sofa, a flat-screen TV, and a view of the outdoors through large windows.
A hotel room with a bed, bedside table, lamp, desk with computer, chair, and a fireplace.

14. Holiday Inn Hyannis by IHG

Holiday Inn Hyannis by IHG
2.9 km from Main Street Hyannis
United States
Julie
RM656
RM751 total
includes taxes & fees
27 Sept - 28 Sept
Holiday Inn Hyannis by IHG
An outdoor patio with round tables and chairs, a fire pit, and a covered seating area with string lights.
A large indoor swimming pool with multiple lanes, surrounded by rows of chairs and a high ceiling with large windows.
A DoubleTree hotel with a brick facade and a large sign.
A modern lounge area with a stone wall, a flat-screen TV, and comfortable seating.

15. Doubletree by Hilton Cape Cod - Hyannis

Doubletree by Hilton Cape Cod - Hyannis
0.9 km from Main Street Hyannis
United States
John
RM795
RM910 total
includes taxes & fees
7 Sept - 8 Sept
Doubletree by Hilton Cape Cod - Hyannis
A modern living room with a sofa, coffee table, and kitchen area with appliances.
A hotel room with a desk, a television, a microwave, and a window with curtains.
A bedroom with a bed, a dresser, a TV, a window with blinds, and an air conditioner.
A sign for Hyannis Host Inn with a building in the background.

16. Hyannis Host Inn

Hyannis Host Inn
1.6 km from Main Street Hyannis
United States
Caroline
RM395
RM452 total
includes taxes & fees
2 Sept - 3 Sept
Hyannis Host Inn
An indoor swimming pool with a covered area, poolside chairs, and a table.
A spacious living area with a kitchen, a coffee machine, a television, and a magazine rack.
A spacious living area with a large TV, comfortable seating, and a view of the outside.
A white building with large windows and a blue sign indicating it is a bank.

17. Americas Best Value Inn & Suites Hyannis Cape Cod

Americas Best Value Inn & Suites Hyannis Cape Cod
0.5 km from Main Street Hyannis
United States
Katie
RM358
RM410 total
includes taxes & fees
20 Sept - 21 Sept
Americas Best Value Inn & Suites Hyannis Cape Cod
A beach with clear skies and gentle waves.
A sand sculpture of a sun with sunglasses and the text "Fun in the Sun" on a beach.
A swimming pool with clear blue water, surrounded by a tiled deck and a building with a green roof in the background.
A reception area with a wooden counter, a blue accent wall, and striped armchairs.

18. Sunbird ANNEX Resort

Sunbird ANNEX Resort
2.3 km from Main Street Hyannis
United States
Eric
RM308
RM352 total
includes taxes & fees
13 Sept - 14 Sept
Sunbird ANNEX Resort
A two-story hotel with a curved facade, a balcony, and a sign indicating the lobby.
A modern living room with two sofas, a coffee table, and a stone wall with a fireplace.
An outdoor seating area with wicker furniture, umbrellas, and a stone wall.
A waterfront hotel with a view of the marina and boats.

19. Hyannis Harbor Hotel

Hyannis Harbor Hotel
0.6 km from Main Street Hyannis
United States
Melanie
RM799
RM1,006 total
includes taxes & fees
31 Aug - 1 Sept
Hyannis Harbor Hotel
A beach with clear skies and gentle waves.
A grassy area with blue Adirondack chairs arranged around a central fire pit. In the background, there are two buildings with a playground structure.
A swimming pool with clear blue water, surrounded by a tiled deck and a building with a green roof in the background.
A fire pit with chairs arranged around it, set on sandy ground with a wooden fence and foliage in the background.

20. Sunbird Cape Cod Resort

Sunbird Cape Cod Resort
2.3 km from Main Street Hyannis
United States
Geralda
RM502
RM575 total
includes taxes & fees
1 Sept - 2 Sept
Sunbird Cape Cod Resort
View all properties

Compare popular hotels close to Main Street Hyannis

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
A multi-story hotel with balconies, a flat roof, and a clear sky.
Hyannis Travel Inn
9.6
Exceptional
1,012 reviews
View
A stone fire pit with four white Adirondack chairs around it, overlooking a marina with boats.
Anchor In Distinctive Waterfront Lodging
9.4
Exceptional
1,002 reviews
View
A poolside area with a wooden pergola, green seating, and a sign reading "LE JARDIN BLEU".
Uncommoner Hotel by Reverie Boutique Collection
9.2
Wonderful
296 reviews
View
A hotel room with a large bed, a chair, a table, and a window with curtains.
SeaCoast Inn
9.0
Wonderful
857 reviews
View
A covered walkway with wooden flooring, planter boxes with plants, and a white exterior wall.
Heritage House Inn on Cape Cod, an Ascend Collection Hotel
9.0
Wonderful
131 reviews
View

Top Main Street Hyannis Hotel Reviews

Hyannis Harbor Hotel

Hyannis Harbor Hotel

10/10 Excellent
"It was a last minute booking because issues at my initial hotel I booked for my trip. The staff was kind and vey accommodating, Maria was wonderful! Facilities were clean and hotel is located very convenient if you are traveling to the islands. Bed was super comfortable and room has everything you need. Definitely will be back again!"
Indira 3-night trip
Posted 1 hour ago
Hyannis Harbor Hotel
Comfort Inn Hyannis - Cape Cod

Comfort Inn Hyannis - Cape Cod

8/10 Good
"Decent stay"
Radhika 3-night trip
Posted 9 hours ago
Comfort Inn Hyannis - Cape Cod
Cape Sands Inn

Cape Sands Inn

10/10 Excellent
"The cape sands inn was the best choice for our stay! Centrally located, they have everything you could need. The pools were amazing! Staff was friendly enough despite their limited staffing. The fire pit was a true highlight! We even extended our stay an extra night because the only thing we missed during our trip was just a relaxing day at the motel!"
Tammy 3-night trip
Posted 10 hours ago
Cape Sands Inn
Bayside Resort Hotel

Bayside Resort Hotel

8/10 Good
"Pros-The pool inside and outside were great and the gaming room had a good selection. The free breakfast had a good variety and fire pit on site bar where we could toast samores. It was very picturesque and not too far from the bars and restaurants on Main Street. Cons- the room was damp and housing keeping pretty non existent. We got new towels but the room was not cleaned most days ."
Mr. Anthony 4-night trip
Posted 15 hours ago
Bayside Resort Hotel
Americas Best Value Inn & Suites Hyannis Cape Cod

Americas Best Value Inn & Suites Hyannis Cape Cod

10/10 Excellent
"Very good"
Nana 1-night trip
Posted 16 hours ago
Americas Best Value Inn & Suites Hyannis Cape Cod
Uncommoner Hotel by Reverie Boutique Collection

Uncommoner Hotel by Reverie Boutique Collection

10/10 Excellent
"Great location! Clean rooms, 2 great pools!"
Michelle Nicole 6-night trip
Posted 17 hours ago
Uncommoner Hotel by Reverie Boutique Collection
Cape Cod Inn

Cape Cod Inn

10/10 Excellent
"While the rooms are typical of an older motel, the Cape Cod Inn is very well maintained and the rooms are spotless. The managers were lovely and helpful. The rooms have updated furniture with a comfortable bed. Everything worked well. The location of the hotel, right on Main St in the heart of Hyannis, was great. I would definitely return."
Janice 3-night trip
Posted 23 hours ago
Cape Cod Inn
Anchor In Distinctive Waterfront Lodging

Anchor In Distinctive Waterfront Lodging

10/10 Excellent
"Great stay! The room had a slight smell to it, but you got accustomed to it quickly after entering. The staff was very friendly and helpful. Pool and firepit were very nice."
Danita 2-night trip
Posted 2 days ago
Anchor In Distinctive Waterfront Lodging
Doubletree by Hilton Cape Cod - Hyannis

Doubletree by Hilton Cape Cod - Hyannis

8/10 Good
"I like that it was close to the center. Huge parking lot and clean rooms."
Jacqueline 2-night trip
Posted 3 days ago
Doubletree by Hilton Cape Cod - Hyannis

Other attractions near Main Street Hyannis

A bronze statue of a man in a polo shirt standing in front of a building with a brick facade, white columns, and an American flag.

John F. Kennedy Hyannis Museum

8.8/10 (444 reviews)
Learn about the 35th president of the United States at this revealing museum, which is just a short distance from the Kennedy Compound.
See properties
A model boat with a rope tied around it, displayed in a museum setting.

Cape Cod Maritime Museum

9.0/10 (16 reviews)
You can spend an afternoon studying the exhibits at Cape Cod Maritime Museum during your trip to Hyannis. Stroll along the seaside in this family-friendly area or visit its seafood restaurants.
See properties
A white church with a steeple and a sign for Saint Francis Xavier Sunday masses.

St. Francis Xavier Church

8.6/10 (58 reviews)
After visiting St. Francis Xavier Church, make a plan to see the other sights and activities in Hyannis. Wander through the beautiful beaches and waterfront in this family-friendly area.
See properties
A memorial plaque with a bust of John F. Kennedy surrounded by a stone wall.

John F. Kennedy Memorial

9.0/10 (262 reviews)
Take a moment to reflect on John F. Kennedy’s defining role in American politics, as well as his untimely death, at this poignant memorial.
See properties

Hyannis Armory

Learn about the local history of Hyannis with a stop at Hyannis Armory. Wander the waterfront and beautiful beaches in the area.
See properties

Hyannis Youth & Community Center

8.2/10 (22 reviews)
You can take time to visit Hyannis Youth & Community Center during your travels to Hyannis. Stroll along the beautiful beaches or visit the shops in the area.
See properties

Zion Union Heritage Museum

6.0/10 (1 review)
You can spend an afternoon exploring the galleries in Zion Union Heritage Museum during your trip to Hyannis. Make time to visit the area's shops or simply enjoy its seafood restaurants.
See properties

Commotion Charters

6.0/10 (3 reviews)
Enjoy an outing to Commotion Charters during your stay in Hyannis. Attend a sporting event or simply enjoy the seafood restaurants while you're in the area.
See properties

Frequently asked questions

What's the area like around Main Street Hyannis?
Main Street Hyannis is located in a walkable area of Hyannis known for its top seafood restaurants and major shopping area. If you're looking for a convenient place to stay, take a look at the 198 hotels and other accommodation options you'll find within a mile.
Where is the best place to stay near Main Street Hyannis?
Adjacent to Main Street Hyannis, Americas Best Value Inn & Suites Hyannis Cape Cod is one of the top choices for your stay based on our traveller data, and this hotel offers an indoor pool and free parking. Other good options within a short distance include Hyannis Harbor Hotel and Heritage House Inn on Cape Cod, an Ascend Collection Hotel.
How many hotels can I expect to find near Main Street Hyannis?
Expedia has 198 hotels and other accommodation options within a mile from Main Street Hyannis.
If I need to cancel the hotel reservation for my stay near Main Street Hyannis, will I receive a refund?
Yes! Most hotel reservations are fully refundable if cancelled prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If your reservation is non-refundable, you might be able to still cancel and get a refund within 24 hours of your booking. Add dates, click "Search", then filter by "fully refundable" to review the top deals on offer near Main Street Hyannis.
What can I see and do near Main Street Hyannis?
John F. Kennedy Hyannis Museum, Whydah Pirate Museum and Edward Gorey House feature captivating exhibits. Hyannis Harbor, Sandy Neck Lighthouse and West Parish Meetinghouse are landmarks that you won't want to miss. Local parks like Lewis Bay, Veterans Memorial Park and Barnstable Dog Park are peaceful spots to stop and take in some fresh air.