Top 10 Main Street Hotels of 2026

Q: What is Main Street like?

Main Street is a neighbourhood that travellers like for its art, university setting and entertainment choices.

Q: If I need to cancel my hotel reservation in Main Street, will I receive a refund?

Yes, most hotel bookings are fully refundable if you cancel prior to the hotel's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you may still be able to cancel and receive a refund within a 24-hour period of booking. Plug in your dates, click on "Search", then you can use the "fully refundable" filter to view top deals in Main Street.

Q: What is there to do around this Ann Arbor neighbourhood?

Ann Arbor Hands On Museum, Ann Arbor Art Center and Kempf House Museum are just a few of the places to visit in and around Main Street. When you're sightseeing in Ann Arbor, Kelsey Museum of Archaeology at the University of Michigan and Hill Auditorium are also worth a stop.

A cityscape at sunset with a mix of modern and older buildings, a clear sky, and a distant view of a flat landscape.

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Our top choices for Main Street hotels

A hotel with a prominent circular sign on top, multiple floors, and a well-lit entrance.

1. Residence Inn Ann Arbor Downtown

Downtown, < 0.1 km from Main Street

Laura

RM766 total

includes taxes & fees

5 Nov - 6 Nov

A modern kitchen with a marble countertop, glass display cases, and neatly arranged plates and bowls.

2. AC Hotel Ann Arbor Downtown

Downtown, 0.3 km from Main Street

Peter

RM793 total

includes taxes & fees

15 Nov - 16 Nov

A bar area with a long wooden table, bar stools, a chandelier, and a chalkboard with mathematical equations.

3. Graduate by Hilton Ann Arbor

Kerrytown, 0.6 km from Main Street

Christopher

RM786 total

includes taxes & fees

15 Nov - 16 Nov

A modern lobby with a staircase, seating area, and large windows overlooking a street.

4. The Vanguard Ann Arbor, Autograph Collection

Old Fourth Ward, 1.1 km from Main Street

Brandyn

RM924 total

includes taxes & fees

8 Nov - 9 Nov

A hotel room with a bed, two chairs, a desk with a lamp, a telephone, and a framed picture on the wall.

5. Bell Tower Hotel

Central Campus Medical, 0.8 km from Main Street

Jennifer

RM775 total

includes taxes & fees

1 Nov - 2 Nov

A garden with a variety of flowers and plants, a balcony with potted plants, and a green fence.

6. Ann Arbor B&B Inn

Old Fourth Ward, 0.9 km from Main Street

David

RM746 total

includes taxes & fees

10 Nov - 11 Nov

A modern hotel lobby with a long dining table, multiple bar stools, a TV mounted on the wall, and a patterned carpet.

7. Hampton Inn & Suites Ann Arbor West

3.3 km from Main Street

AMY

RM442 total

includes taxes & fees

1 Nov - 2 Nov

A modern hotel with a prominent entrance, multiple floors, and a well-lit facade.

8. Homewood Suites by Hilton Ann Arbor

Bryant Pattengill East, 3.5 km from Main Street

Marie-Eve

RM554 total

includes taxes & fees

27 Oct - 28 Oct

A spacious hotel lobby with a modern design, featuring a large seating area, a bar, and a view of the cityscape through large windows.

9. Ann Arbor City Club Apartments

Downtown, 0.2 km from Main Street

Jeanne

RM1,346 total

includes taxes & fees

15 Nov - 16 Nov

A spacious indoor pool area with a spiral staircase, lounge chairs, and a dining area with tables and chairs.

10. Weber's Hotel & Restaurant

3.6 km from Main Street

Melissa

RM689 total

includes taxes & fees

25 Oct - 26 Oct

A spacious lobby with a modern design, featuring a mix of seating areas and a bar.

11. Hyatt Place Ann Arbor

Bryant Pattengill East, 4.6 km from Main Street

David

RM612 total

includes taxes & fees

26 Oct - 27 Oct

A large, multi-story stone house with a prominent red door, multiple windows, and a balcony.

12. Stone Chalet B&B Inn and Event Center

Baden-Ann Arbor Hills, 2.6 km from Main Street

Felice

RM947 total

includes taxes & fees

20 Oct - 21 Oct

An outdoor seating area with tables and benches, a covered section with string lights, and a clear view of the street.

13. Home2 Suites By Hilton Ann Arbor South

4.3 km from Main Street

Timothy

RM458 total

includes taxes & fees

15 Nov - 16 Nov

An indoor swimming pool with multiple lanes, surrounded by lounge chairs and a sunshade.

14. Wyndham Garden Ann Arbor

3.2 km from Main Street

William

RM341 total

includes taxes & fees

25 Oct - 26 Oct

A modern living room with a stone fireplace, comfortable seating, and large windows offering a view of the outdoors.

15. Courtyard By Marriott Ann Arbor

Bryant Pattengill East, 4.7 km from Main Street

Misty

RM535 total

includes taxes & fees

25 Oct - 26 Oct

A modern hotel lobby with a marble floor, leather seating, a chandelier, and large windows with curtains.

16. Sheraton Ann Arbor Hotel

Bryant Pattengill East, 4.7 km from Main Street

heather

RM612 total

includes taxes & fees

25 Oct - 26 Oct

A compact kitchen with a dining table, a microwave, a coffee maker, and a refrigerator.

17. Sonesta Simply Suites Detroit Ann Arbor

4.3 km from Main Street

Sarah

RM412 total

includes taxes & fees

25 Oct - 26 Oct

A modern hotel room with a dining area, a kitchen with a dishwasher, and a seating area with a TV and lamp.

18. Residence Inn by Marriott Ann Arbor North

5.3 km from Main Street

ADNAN

RM675 total

includes taxes & fees

25 Oct - 26 Oct

A hotel with a modern design, featuring a prominent 'spark by Hilton' sign, a covered entrance, and a well-maintained garden with various plants.

19. Spark by Hilton Ann Arbor South

Bryant Pattengill East, 4.8 km from Main Street

Tracie

RM426 total

includes taxes & fees

25 Oct - 26 Oct

A Hilton Garden Inn with outdoor seating, fire pits, and string lights.

20. Hilton Garden Inn Ann Arbor

4.8 km from Main Street

James

RM516 total

includes taxes & fees

1 Nov - 2 Nov

View all properties

Where to stay in Main Street

Find the best Main Street areas for the activities you enjoy most.

A football stadium filled with spectators, a large scoreboard, and a football field with the word "MICHIGAN" on it.

South Central

If you're spending some time in South Central, Yost Ice Arena and Michigan Stadium are top sights worth seeing.

See properties

A cityscape with a mix of historic and modern buildings, a prominent church, and a large parking area.

Bryant Pattengill East

If you're spending some time in Bryant Pattengill East, Cobblestone Farm and Buhr Park are top sights worth seeing.

See properties

A theater marquee with "Taylor & Co" and "Making Sense" displayed.

Downtown

If you're spending some time in Downtown, Ann Arbor Hands On Museum and Ann Arbor Art Center are top sights worth seeing.

See properties

A river with rocks, autumn foliage, and a bridge.

Burns Park

When in Burns Park, you can plan a visit to Yost Ice Arena and University of Michigan Museum of Natural History, some noteworthy sights in the nearby area.

See properties

A cityscape with a prominent clock tower, various buildings, and a clear sky.

Old West Side

If you're looking for some top things to see and do in Old West Side and surrounding area, you can visit Ann Arbor Hands On Museum and University of Michigan Museum of Art.

See properties

Top Main Street Hotel Reviews

Saint John's Resort

8/10 Good

"It was a gorgeous building and grounds, but sorely understaffed. At check-in, we were given no information about amenities, internet, or any hotel features. I’ve never before been at a hotel at this price point that lacked a concierge, valet, and bellhop/ porter. We got lost looking for our room were offered no help lugging our bags up stairs. We couldn’t find any staff members to help us and, when we reached our room and had questions (we had been given the wrong room), our calls to the front desk went unanswered. The indoor and outdoor spaces were both stunning. Our apartment had many thoughtful, high-end touches, from a Dyson hairdryer to a mixology kit, to an umbrella. While we were there, it was beautifully decorated for fall and offered complimentary cider and donuts. It’s an amazing historical building that looks like it would be an unforgettable wedding venue, but it could use a lot more signage and staff to orient guests. A spa or salon on site would be nice, as well."

Frequently asked questions

What is Main Street like?

Main Street is a neighbourhood that travellers like for its art, university setting and entertainment choices.

If I need to cancel my hotel reservation in Main Street, will I receive a refund?

Yes, most hotel bookings are fully refundable if you cancel prior to the hotel's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you may still be able to cancel and receive a refund within a 24-hour period of booking. Plug in your dates, click on "Search", then you can use the "fully refundable" filter to view top deals in Main Street.

What is there to do around this Ann Arbor neighbourhood?

Ann Arbor Hands On Museum, Ann Arbor Art Center and Kempf House Museum are just a few of the places to visit in and around Main Street. When you're sightseeing in Ann Arbor, Kelsey Museum of Archaeology at the University of Michigan and Hill Auditorium are also worth a stop.

Hotels in Main Street, Ann Arbor

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Main Street hotels

1. Residence Inn Ann Arbor Downtown

2. AC Hotel Ann Arbor Downtown

3. Graduate by Hilton Ann Arbor

4. The Vanguard Ann Arbor, Autograph Collection

5. Bell Tower Hotel

6. Ann Arbor B&B Inn

7. Hampton Inn & Suites Ann Arbor West

8. Homewood Suites by Hilton Ann Arbor

9. Ann Arbor City Club Apartments

10. Weber's Hotel & Restaurant

11. Hyatt Place Ann Arbor

12. Stone Chalet B&B Inn and Event Center

13. Home2 Suites By Hilton Ann Arbor South

14. Wyndham Garden Ann Arbor

15. Courtyard By Marriott Ann Arbor

16. Sheraton Ann Arbor Hotel

17. Sonesta Simply Suites Detroit Ann Arbor

18. Residence Inn by Marriott Ann Arbor North

19. Spark by Hilton Ann Arbor South

20. Hilton Garden Inn Ann Arbor

Where to stay in Main Street

South Central

Bryant Pattengill East

Downtown

Burns Park

Old West Side

Top Main Street Hotel Reviews

Saint John's Resort

Frequently asked questions

Explore a world of travel with Expedia