10 Best Spa Hotels in Jeffersonville - Clarksville for 2026

A large building with a dome and columns, surrounded by trees and a grassy area.

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Our top choices for Jeffersonville - Clarksville hotels with a spa

A restaurant with round tables, chairs, chandeliers, and a bar area.

A large hotel with a prominent 'Caesars' sign, multiple floors, and a symmetrical facade.

A casino with multiple gaming tables and slot machines, a red carpet, and ornate chandeliers.

A spacious lobby with a geometric chandelier, a reception desk, and a red accent wall.

1. Caesars Southern Indiana Hotel & Casino - A Caesars Rewards Destination

Elizabeth

Refresh your spirit at this riverfront hotel with daily spa treatments and couples rooms, where aromatherapy and Ayurvedic therapies await.

RM247

RM356 total

includes taxes & fees

25 Oct - 26 Oct

A modern interior with large windows offering a city view, a circular light fixture, and leather seating.

A nighttime view of The GALT and The Galthouse buildings with illuminated signage, a busy street with light trails from moving vehicles, and a modern urban setting.

A balcony with a view of a river, a bridge, and a cityscape.

An outdoor patio with black tables and chairs, surrounded by large windows and a row of arches.

2. Galt House Hotel Trademark Collection by Wyndham

Downtown Louisville

Riverside sanctuary offers rejuvenating spa treatments, panoramic fitness views, and river-facing balconies for a relaxing urban retreat.

RM615

RM723 total

includes taxes & fees

25 Oct - 26 Oct

A cozy room with a geometric-patterned ceiling, a sofa, and a chair.

A modern bathroom with a shower, a sink, and a large mirror.

A cozy room with wooden walls, a table with a lamp, and shelves displaying books and decorative items.

3. 21c Museum Hotel Louisville

Downtown Louisville

Experience a rejuvenating spa escape at this luxury boutique hotel with massage rooms and 24-hour fitness centre in city centre Louisville.

RM656

RM793 total

includes taxes & fees

26 Oct - 27 Oct

A spacious lobby with a high ceiling, a central chandelier, and seating areas with tables and chairs.

A modern building entrance with a glass facade, wooden ceiling, and illuminated fixtures.

A rooftop bar with outdoor seating, including sofas and chairs, and a bar area with a television screen.

A modern interior with a fireplace, bookshelves, and seating areas.

4. Omni Louisville Hotel

Downtown Louisville

Immerse in spa bliss at this Louisville hotel where Mokara Spa offers therapeutic treatments and rooftop relaxation awaits.

RM1,141

RM1,342 total

includes taxes & fees

14 Oct - 15 Oct

A rustic bar area with a wooden bar counter, stools, and a variety of bottles and glasses.

A cozy room with a wooden wall, a sofa, and a dining table.

A modern bathroom with a shower, a vanity with a sink, and a toilet. There are wooden shelves and a vase with flowers on the vanity.

A living room with a sofa, coffee table, and a television mounted on the wall.

5. Pillow and Paddock B&B

La Grange

Relax in a cosy bed and breakfast retreat with a steamy hot tub, rejuvenating spa services, and a peaceful garden sanctuary.

RM1,375

RM1,516 total

includes taxes & fees

19 Oct - 20 Oct

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Choose what matters most at spa hotels in Jeffersonville - Clarksville

Pool

Breakfast included

Hot tub

4 stars

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Top Jeffersonville - Clarksville Hotel Reviews

Louisville Marriott Downtown

10/10 Excellent

"It was completely comfortable"

Room 1

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Our top choices for Jeffersonville - Clarksville hotels with a spa

1. Caesars Southern Indiana Hotel & Casino - A Caesars Rewards Destination