South Main
Houston
Visit South Main
Popular places to visit
NRG Stadium
Catch an event at NRG Stadium during your trip to Houston. Attend a sporting event or simply enjoy the top-notch restaurants while you're in the area.
George R. Brown Convention Center
During your trip, find out what's happening in George R. Brown Convention Center, a top convention centre in Houston. Experience the entertainment choices and acclaimed art galleries in this vibrant area.
Daikin Park
Catch an event at Daikin Park during your trip to Houston. Experience the entertainment choices and lively festivals in this vibrant area.
Toyota Center
Catch an event at Toyota Center during your trip to Houston. Experience the acclaimed theatre scene and entertainment choices in this vibrant area.
Space Center Houston
Visit the heart of the American space industry in the control centre that put man on the moon.
NASA Johnson Space Center
After visiting NASA Johnson Space Center, make a plan to see the other sights and activities in Houston. Amble around the area's lakeside or attend a sporting event.
Things to do
Space Center Houston Admission Ticket
Houston's Official City & Mural Tour!
NASA's Space Center Admission Plus Houston City Tour
Houston Museum of Natural Sciences: Planetarium Ticket
Houston Museum of Natural Science and Cockrell Butterfly Center
Top hotels in South Main
Wyndham Houston near NRG Park/Medical Center
This is the hotel you book for location only. We would stay there again to be close to NRG stadium. The bed was comfortable. They do have a bar with outdoor patio and a restaurant there which was very convenient. The hotel needs updating and maintenance.
Reviewed on 19 Mar 2026
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
Clean room great staff
Reviewed on 20 Mar 2026
Hotel Zaza Houston Museum District
Very Beautiful and welcoming!
Reviewed on 19 Mar 2026
The Royal Sonesta Houston Galleria
Clean hotel. Rooms could use some updating.
Reviewed on 20 Mar 2026
Club Quarters Hotel Downtown, Houston
Nice and cooperative staff. They allowed me an early check in which made my trip very comfortable. The rooms are small and basic but clean. There was no refrigerator in my room which I was expecting. Overall, it was nice experience.
Reviewed on 19 Mar 2026
Blossom Hotel Houston, Curio Collection by Hilton
They didn’t have extra blankets. The bed had stains on it and some one else hair. Gross me out. They need to take their time cleaning those rooms. I had forgot my disinfectant spray. But I put a T-shirt over my pillow because of the hair and stains. My first my experience was really nice this one ...
Reviewed on 20 Mar 2026
Other neighbourhoods around South Main
Astrodome
While you're in Astrodome, take in top sights like NRG Stadium or NRG Astrodome, and hop on the metro to see more of the city at Stadium Park/Astrodome Station or Smith Lands Station.
Texas Medical Center
Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.
Museum District
Known for its abundant dining options and interesting museums, there's plenty to explore in Museum District. Top attractions like Children's Museum of Houston and Houston Natural Science Museum are major draws, and you can catch the metro at Museum District Station or Hermann Park/Rice U Station to see more of the city.
South Central Houston
If you're spending time in South Central Houston, check out sights like Children's Museum of Houston or Houston Natural Science Museum and hop on the metro to see more of the city at Elgin/Third Ward Station or TSU/UH Athletics District Station.
Montrose
Unique features of Montrose include the theatres and museums. Make a stop by Menil Collection or Rothko Chapel while you're exploring the area.
River Oaks
Gardens and monuments are just a few things travellers like about River Oaks. A stop by River Oaks Country Club is also recommended if you've got time to explore the area.
