Sikeston

Travel Guide

A tree with sunlight filtering through its leaves, creating a warm glow.
A person walking through a cornfield.
A building with three tall chimneys, surrounded by blooming trees with pink and white flowers.
A sign for Lambert's, a place of worship.
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
The price is RM380 per night from 30 Aug to 31 Aug
RM380
RM437 total
30 Aug - 31 Aug
includes taxes & fees
Stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the breakfast and the helpful staff in ...
Drury Inn & Suites Sikeston, MO
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2 out of 5
220 S Interstate Dr Sikeston MO
The price is RM265 per night from 24 Aug to 25 Aug
RM265
RM302 total
24 Aug - 25 Aug
includes taxes & fees
Stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff and the clean rooms ...
7.2/10 Good! (1,003 reviews)
"We stay here every time we are in Sikesons. Can't beat this hotel. Super clean 'comfortable!' beds, living room area, and bathrooms. Small hot breakfast. All for the best price out there. Don't skip on this hotel! Staff is always polite and helpful. We always love to walk out to the pond"

Reviewed on 20 Aug 2026

Days Inn and Suites by Wyndham Sikeston
Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55

2.5 out of 5
120 S Interstate Drive Sikeston MO
The price is RM328 per night from 23 Aug to 24 Aug
RM328
RM373 total
23 Aug - 24 Aug
includes taxes & fees
Stay at this hotel in Sikeston. Enjoy free breakfast, free parking and a fitness centre. Our guests praise the breakfast and the helpful staff in their reviews. ...
Best Western Plus Sikeston I-55
See all 311 properties in Sikeston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
The Atrium - A Boutique Hotel

The Atrium - A Boutique Hotel

2 out of 5
112 W Ste Maries St Perryville MO
Stay at this aparthotel in Perryville. Enjoy free Wi-Fi, free parking and bathrobes. Popular attractions Feltz Street Park and Perryville Country Club are located ...
9.6/10 Exceptional! (4 reviews)
"What an amazing little suite wrapped in a very thought-filled overall venue. Very unique room with a so many details. The overall building with fire pit, game rooms, and local vendor items…all was quite amazing. Every element is thought out very well. It is very convenient and overall comfortable. ..."

Reviewed on 13 Jun 2026

The Atrium - A Boutique Hotel
Urban Lofts

Urban Lofts

3 out of 5
102 N Jackson St Perryville MO
Stay at this aparthotel in Perryville. Enjoy free Wi-Fi, free parking and dry cleaning or laundry services. Popular attractions Feltz Street Park and Perryville ...
9.4/10 Exceptional! (22 reviews)
"Beautiful, clean property in the heart of city center. Many options for food and shopping within short walking distance."

Reviewed on 11 Jun 2026

Urban Lofts
See all properties in Sikeston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Sikeston attractions

Sikeston Depot Museum

7.6/10 (57 reviews)
You can spend time studying the exhibits at Sikeston Depot Museum during your travels in Sikeston. While in this relaxing area, you can savour the top-notch restaurants.
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