Sikeston

Travel Guide

A tree with sunlight filtering through its leaves, creating a warm glow.
A person walking through a cornfield.
A building with three tall chimneys, surrounded by blooming trees with pink and white flowers.
A sign for Lambert's, a place of worship.
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
Fully refundableReserve now, pay when you stay
The price is RM452 per night from 13 Jul to 14 Jul
RM452
RM520 total
13 Jul - 14 Jul
includes taxes & fees
Stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the breakfast and the helpful staff in ...
9.6/10 Exceptional! (1,007 reviews)
"We had a very good visit here. The staff was so friendly and helpful. Our room was spacious and clean. The A/C was so cool in the room."

Reviewed on 7 Jul 2026

Drury Inn & Suites Sikeston, MO
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2 out of 5
220 S Interstate Dr Sikeston MO
The price is RM280 per night from 14 Jul to 15 Jul
RM280
RM319 total
14 Jul - 15 Jul
includes taxes & fees
Stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff and the clean rooms ...
7.2/10 Good! (1,002 reviews)
"I had a stay at this hotel. The rooms were clean, comfortable, and well maintained. The staff was friendly, professional, and always willing to help. The location was in a convenient place for us to take a quick rest The breakfast was delicious with plenty of options, and the overall atmosphere was ..."

Reviewed on 4 Jul 2026

Days Inn and Suites by Wyndham Sikeston
Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55

2.5 out of 5
120 S Interstate Drive Sikeston MO
The price is RM345 per night from 26 Jul to 27 Jul
RM345
RM393 total
26 Jul - 27 Jul
includes taxes & fees
Stay at this hotel in Sikeston. Enjoy free breakfast, free parking and a fitness centre. Our guests praise the breakfast and the helpful staff in their reviews. ...
8.4/10 Very good! (1,001 reviews)
"Clean room & friendly staff!"

Reviewed on 3 Jul 2026

Best Western Plus Sikeston I-55
See all 319 properties in Sikeston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
The Atrium - A Boutique Hotel

The Atrium - A Boutique Hotel

2 out of 5
112 W Ste Maries St Perryville MO
Stay at this aparthotel in Perryville. Enjoy free Wi-Fi, free parking and bathrobes. Popular attractions Feltz Street Park and Perryville Country Club are located ...
9.6/10 Exceptional! (4 reviews)
"What an amazing little suite wrapped in a very thought-filled overall venue. Very unique room with a so many details. The overall building with fire pit, game rooms, and local vendor items…all was quite amazing. Every element is thought out very well. It is very convenient and overall comfortable. ..."

Reviewed on 13 Jun 2026

The Atrium - A Boutique Hotel
Urban Lofts

Urban Lofts

3 out of 5
102 N Jackson St Perryville MO
Stay at this aparthotel in Perryville. Enjoy free Wi-Fi, free parking and dry cleaning or laundry services. Popular attractions Feltz Street Park and Perryville ...
9.4/10 Exceptional! (22 reviews)
"Beautiful, clean property in the heart of city center. Many options for food and shopping within short walking distance."

Reviewed on 11 Jun 2026

Urban Lofts
See all properties in Sikeston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Sikeston attractions

Sikeston Depot Museum

7.6/10 (57 reviews)
You can spend time studying the exhibits at Sikeston Depot Museum during your travels in Sikeston. While in this family-friendly area, you can savour the top-notch restaurants.
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