A calm lake with mountains in the background.

Seneca hotels from RM237

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
5 Sept - 6 Sept
Tomorrow
6 Sept - 7 Sept
Next weekend
11 Sept - 13 Sept
In two weeks
18 Sept - 20 Sept

Filter by

Star rating

Guest rating

Our top choices for Seneca hotels

1. Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
Seneca
United States
Susana
RM428
RM471 total
includes taxes & fees
13 Sept - 14 Sept
Tru by Hilton Seneca Clemson

2. Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area
Seneca
United States
Bryan
RM485
RM534 total
includes taxes & fees
27 Sept - 28 Sept
Fairfield Inn & Suites Seneca Clemson Univ Area

3. Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area
Seneca
United States
kendra
RM490
RM539 total
includes taxes & fees
4 Oct - 5 Oct
Hampton Inn & Suites Seneca-Clemson Area

4. Lakeside Lodge Clemson

Lakeside Lodge Clemson
Seneca
United States
Christopher
RM330
RM420 total
includes taxes & fees
9 Sept - 10 Sept
Lakeside Lodge Clemson

5. Best Western Seneca-Clemson

Best Western Seneca-Clemson
Seneca
United States
Michelle
RM392
RM431 total
includes taxes & fees
14 Sept - 15 Sept
Best Western Seneca-Clemson

6. Quality Inn Seneca US-123

Quality Inn Seneca US-123
Seneca
United States
Robert
RM306
RM361 total
includes taxes & fees
13 Sept - 14 Sept
Quality Inn Seneca US-123

7. Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area
Seneca
United States
Rosario
RM340
RM374 total
includes taxes & fees
6 Sept - 7 Sept
Days Inn by Wyndham Seneca / Clemson Area

8. Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Seneca
United States
Nirumol
RM376
RM592 total
includes taxes & fees
4 Oct - 5 Oct
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

9. Clemson University's James F. Martin Inn

Clemson University's James F. Martin Inn
Clemson
United States
Jennifer
RM452
RM501 total
includes taxes & fees
9 Sept - 10 Sept
Clemson University's James F. Martin Inn

10. The Abernathy of Clemson

The Abernathy of Clemson
Clemson
United States
Robert
RM615
RM682 total
includes taxes & fees
7 Sept - 8 Sept
The Abernathy of Clemson

11. Hampton Inn Clemson-University Area

Hampton Inn Clemson-University Area
Clemson
United States
DOUGLAS
RM428
RM475 total
includes taxes & fees
15 Sept - 16 Sept
Hampton Inn Clemson-University Area

12. Comfort Inn & Suites Clemson - University Area

Comfort Inn & Suites Clemson - University Area
Clemson
United States
Anita
RM409
RM454 total
includes taxes & fees
27 Sept - 28 Sept
Comfort Inn & Suites Clemson - University Area

13. Best Western Plus Clemson Hotel & Conference Center

Best Western Plus Clemson Hotel & Conference Center
Clemson
United States
Karen
RM409
RM454 total
includes taxes & fees
14 Sept - 15 Sept
Best Western Plus Clemson Hotel & Conference Center

14. The Inn at Patrick Square

The Inn at Patrick Square
Clemson
United States
Christy
RM602
RM669 total
includes taxes & fees
14 Sept - 15 Sept
The Inn at Patrick Square

15. The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson
Clemson
United States
Laurrie
RM966
RM1,072 total
includes taxes & fees
15 Sept - 16 Sept
The Shepherd Hotel Downtown Clemson

16. Holiday Inn Express & Suites Clemson by IHG

Holiday Inn Express & Suites Clemson by IHG
Clemson
United States
John
RM522
RM579 total
includes taxes & fees
6 Sept - 7 Sept
Holiday Inn Express & Suites Clemson by IHG

17. Courtyard Marriott Clemson

Courtyard Marriott Clemson
Clemson
United States
Gargi
RM506
RM562 total
includes taxes & fees
13 Sept - 14 Sept
Courtyard Marriott Clemson

18. Inn @ Clemson

Inn @ Clemson
Clemson
United States
Terry
RM324
RM360 total
includes taxes & fees
6 Sept - 7 Sept
Inn @ Clemson

19. Rodeway Inn & Suites Walhalla

Rodeway Inn & Suites Walhalla
Walhalla
United States
michael
RM309
RM345 total
includes taxes & fees
5 Oct - 6 Oct
Rodeway Inn & Suites Walhalla

20. Liberty Hall Bed and Breakfast

Liberty Hall Bed and Breakfast
Pendleton
United States
enrique
RM461
RM512 total
includes taxes & fees
7 Sept - 8 Sept
Liberty Hall Bed and Breakfast
View all properties
Save an average of 15% on thousands of hotels when you're signed in

Where to stay in Seneca

Find the best Seneca areas for the activities you enjoy most.

Downtown

City centre Seneca captures the essence of small-town Southern charm with its well-preserved railway heritage and historic brick buildings. Tree-lined streets lead to charming shops and local eateries housed in structures dating back to the 1800s. Ram Cat Alley's colourful murals tell stories of local history while the old courthouse square hosts community gatherings. This walkable district offers a peaceful retreat from big city life. Visitors can browse antique stores for railway memorabilia, sample authentic Southern comfort food, or explore the cultural exhibits at the Bertha Lee Strickland Museum. The nearby Lake Keowee provides outdoor recreation just minutes away.

Serenity Bay

Serenity Bay offers a peaceful retreat within Saxony Forest's coastal embrace. The quiet residential streets wind through mature trees, creating a tranquil atmosphere away from tourist crowds. Nature lovers can explore nearby Lake Keowee or enjoy the neighborhood's forest trails. The area perfectly balances woodland serenity with beach proximity. Visitors should plan for self-contained holiday rentals rather than hotels. While dining options are limited within the area, the natural surroundings provide ideal conditions for relaxation and outdoor recreation.

Pine Ridge Point

Lake Keowee's serene waters lap against the shores of Pine Ridge Point, a tranquil residential haven in Seneca. Private docks stretch into crystal-clear waters where boats gently bob. Towering pines create natural privacy between lakefront homes. Visitors enjoy peaceful mornings watching mist rise over the water. This area offers an authentic lakeside living experience without tourist crowds. Holiday rentals range from cosy cabins to luxury estates with private boat slips. Days revolve around swimming, fishing, and water sports on Lake Keowee. Nature trails wind through mature forests for hiking and birdwatching.

Indian Oaks

Indian Oaks offers a tranquil retreat in suburban Seneca where mature oak trees create natural canopies over peaceful residential streets. This family-oriented community provides an authentic glimpse into American suburban living without tourist crowds. Landscaped yards and community green spaces showcase South Carolina's native beauty. Visitors can enjoy quiet morning walks on spacious pavements while listening to birdsong. Lake Keowee lies just beyond the area boundaries for those seeking water activities. With minimal commercial presence, Indian Oaks delivers a genuinely restful experience away from urban bustle.

Stay near popular Seneca attractions

A waterfall surrounded by autumn foliage.

High Falls County Park

Nestled along Lake Keowee with the Blue Ridge Mountains as backdrop, High Falls County Park offers pristine swimming and camping spots. Reserve waterfront campsites early to enjoy the park's serene natural setting.
See properties
A grassy field with yellow flowers and trees in the foreground, with mountains in the background.

Blue Ridge Field

This historic park honours African-American education in Oconee County on the former Blue Ridge High School football grounds. Stroll the paved loop trail and explore community gardens in this peaceful green space.
See properties

Oconee County Library Seneca Branch

This welcoming community hub offers reading materials, digital resources, and programmes for all ages. Explore seasonal events like storytimes, trivia contests, and craft workshops in a tranquil learning environment.
See properties

South Cove Park

This lakeside retreat on Lake Keowee offers pristine beaches, boat ramps, and scenic picnic spots. Enjoy fishing, swimming, or simply relaxing amid the natural beauty of upstate South Carolina.
See properties

Friendship Recreation Area

After visiting Friendship Recreation Area, make a plan to see the other sights and activities in Seneca. Stroll along the lakeside or attend a sporting event in this family-friendly area.
See properties

Seneca City Hall

Seneca City Hall is just one of the places to see in Seneca, so why not enjoy the other things to explore during your travels?
See properties

The Gauntlet

You can make plans for a show at The Gauntlet during your trip to Seneca.
See properties

World of Energy

This free educational centre reveals the science of nuclear power through interactive exhibits and engaging displays. Explore the outdoor nature trail and butterfly garden for a complete energy learning experience.
See properties

Learn more about Seneca

Nestled along Lake Keowee's shoreline, this charming town offers spectacular waterfront activities from kayaking to fishing at South Cove County Park. Nearby Stumphouse Tunnel and Issaqueena Falls provide fascinating historical exploration and refreshing natural beauty, especially during summer's humid afternoons.

See all hotels in Seneca
A calm lake with mountains in the background.

Top Seneca Hotel Reviews

Best Western Seneca-Clemson

Best Western Seneca-Clemson

8/10 Good
"The rooms were clean and the staff were very friendly."
Christine 3-night trip
Posted 5 hours ago
Best Western Seneca-Clemson
Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson

10/10 Excellent
"This was a SUPER CLEAN property and everyone we came into contact with was very friendly."
Kimberly 3-night trip
Posted 17 hours ago
Tru by Hilton Seneca Clemson
Inn @ Clemson

Inn @ Clemson

10/10 Excellent
"Shower is amazing very clean"
Taquris 1-night trip
Posted 19 hours ago
Inn @ Clemson
Quality Inn Seneca US-123

Quality Inn Seneca US-123

8/10 Good
"Every thing was good"
Robert 4-night trip
Posted 2 days ago
Quality Inn Seneca US-123
Clemson University's James F. Martin Inn

Clemson University's James F. Martin Inn

10/10 Excellent
"No complaints, very pretty atmosphere"
Kate 2-night trip
Posted 2 days ago
Clemson University's James F. Martin Inn
The Abernathy of Clemson

The Abernathy of Clemson

10/10 Excellent
"Easy, clean, and friendly!"
Laura Catherine 1-night trip
Posted 4 days ago
The Abernathy of Clemson
Quality Inn Clemson near University

Quality Inn Clemson near University

10/10 Excellent
"Everything was great"
Clarence 6-night trip
Posted 13 days ago
Quality Inn Clemson near University

More cheap stays in Seneca

Quality Inn Clemson near University

Quality Inn Clemson near University

3430 Clemson Blvd Anderson SC
RM214
RM237 total
30 Sept - 1 Oct
includes taxes & fees
Quality Inn Clemson near University
Days Inn by Wyndham Anderson

Days Inn by Wyndham Anderson

1007 George Smith Mill Rd Anderson SC
RM237
RM263 total
21 Sept - 22 Sept
includes taxes & fees
Days Inn by Wyndham Anderson
Inn @ Clemson

Inn @ Clemson

1303 Tiger Blvd Clemson SC
RM324
RM360 total
6 Sept - 7 Sept
includes taxes & fees
8/10 Very good! (1,009 reviews)
Inn @ Clemson
Lakeside Lodge Clemson

Lakeside Lodge Clemson

13500 Clemson Blvd Seneca SC
RM330
RM420 total
9 Sept - 10 Sept
includes taxes & fees
Lakeside Lodge Clemson
Best Western Plus Clemson Hotel & Conference Center

Best Western Plus Clemson Hotel & Conference Center

1310 Tiger Blvd Clemson SC
RM409
RM454 total
14 Sept - 15 Sept
includes taxes & fees
Best Western Plus Clemson Hotel & Conference Center
Comfort Inn & Suites Clemson - University Area

Comfort Inn & Suites Clemson - University Area

1305 Tiger Blvd Clemson SC
RM409
RM454 total
27 Sept - 28 Sept
includes taxes & fees
Comfort Inn & Suites Clemson - University Area

Frequently asked questions

Where is the best place for a stay in Seneca?
Lakeside Lodge Clemson is one of the top choices for your stay based on our traveller data. This hotel offers a restaurant and free parking. Other good options for your visit include Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy and Hampton Inn & Suites Seneca-Clemson Area. See all available top hotels, or vacation rentals in Seneca.
If I need to cancel my hotel reservation in Seneca, will I receive a refund?
Yes! You'll find that most room reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which is often 24 or 48 hours before the scheduled arrival. If you have a reservation that's non-refundable, you might still have the option to cancel and get a refund within 24 hours of your booking. Filter your search by fully refundable to find flexible hotel deals in Seneca.
What's the best family accommodation in Seneca?
Fairfield Inn & Suites Seneca Clemson Univ Area is a hotel with an outdoor pool and free parking, and it's a top choice on Expedia for families. Also, attractions in the area such as Ultimate Action Sports are fun for the whole family. Find more child-friendly accommodations in Seneca.
What is the top LGBTQ-friendly accommodation in Seneca?
Hampton Inn & Suites Seneca-Clemson Area is a top LGBTQ-friendly hotel that features free breakfast and free Wi-Fi. Tru by Hilton Seneca Clemson is another good choice for your trip. See all available hotels listed as LGBTQ-friendly in Seneca.
What's the best dog-friendly hotel in Seneca?
Lakeside Lodge Clemson is a top hotel for people travelling with their pets, and offers a restaurant and a seasonal outdoor pool for its human guests. Other good choices for you and your pet's trip include Tru by Hilton Seneca Clemson and Quality Inn Seneca US-123. See more pet-friendly hotel accommodations in Seneca.
What are some hotels with pools in Seneca?
Lakeside Lodge Clemson: Hotel located near Clemson University. Features free self parking, a seasonal outdoor pool and complimentary wireless Internet access. Hampton Inn & Suites Seneca-Clemson Area and Fairfield Inn & Suites Seneca Clemson Univ Area are two additional hotels that feature an on-site pool. View all hotels with pools in Seneca.
What is staying in Seneca like?
Visitors to Seneca will definitely enjoy the sporting events, lakeside setting and university setting. Welcoming and scenic, this city also attracts tourists with its cafes. In Seneca, there are 320 hotels and other accommodation options to choose from. Find out more about Seneca.
What should I see while I'm in Seneca?
Cultural venues include The Gauntlet and Oconee Community Theatre. Natural beauty is on display at Keowee Reservoir, Lake Keowee and Lake Hartwell. Exploring the waterfront is a great activity, and Keowee Key Golf Course is one place to visit. Take a look at what more there is to see and do in Expedia's Seneca guide.
What's the seasonal weather in Seneca?
The hottest months are usually July and August, with an average temperature of 25ยฐC, while the coldest months are January and February, with an average of 8ยฐC. Average annual precipitation for Seneca is 1565 mm.

Explore a world of travel with Expedia