A coastal town with a pier, boats, and a hillside with buildings.

Best Luxury Hotels in Pythagorio

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Check availability on Pythagorio Luxury Hotels

Tonight
20 Aug - 21 Aug
Tomorrow
21 Aug - 22 Aug
This weekend
21 Aug - 23 Aug
Next weekend
28 Aug - 30 Aug

Our top choices for Pythagorio luxury hotels

A modern resort with a central pool, lounge areas, and mountain views.
A beachside lounge area with outdoor seating, a large umbrella, and a view of the sea.
A beachside resort with outdoor seating areas, umbrellas, and a view of the sea.
A spa area with two massage tables, a stone floor, and a bamboo partition.

1. Casa Cook Samos

Casa Cook Samos
Samos
  • Beachfront luxury meets spa indulgence at Casa Cook Samos, where Mediterranean elegance awaits.
RM1,713
RM1,947 total
includes taxes & fees
2 Sept - 3 Sept
Casa Cook Samos
A beach with rows of beige lounge chairs and umbrellas, a clear sky, and a calm sea with a distant mountain.
A beachside lounge with white umbrellas and beige lounge chairs, a wooden deck, and a view of the sea and a pier in the background.
A coastal hotel with a swimming pool, surrounded by greenery and overlooking the sea.
A modern kitchen with a central island, pendant lighting, and a tiled backsplash.

2. Doryssa Seaside Resort

Doryssa Seaside Resort
Samos
  • Relish beachfront luxury at this Samos seaside resort where warm staff, 2 outdoor pools, and a private beach create an indulgent escape.
RM986
RM1,151 total
includes taxes & fees
18 Sept - 19 Sept
Doryssa Seaside Resort
A row of wooden beach umbrellas with white cushions on a sandy beach, overlooking the sea.
A covered outdoor seating area with wooden flooring, white cushioned chairs, and tables.
A modern bedroom with a bed, bedside tables, a small stool, a desk, and a view of the ocean.
A serene outdoor setting with a pool, a person in a white dress, and a view of the sea.

3. Proteas Blu Resort - Adults Only

Proteas Blu Resort - Adults Only
Samos
  • Private beachfront luxury meets seaside serenity at this adults-only Samos resort offering spa indulgences and ocean-view dining.
RM683
RM819 total
includes taxes & fees
12 Sept - 13 Sept
Proteas Blu Resort - Adults Only
A person in a colorful swimsuit standing on a balcony overlooking the ocean.
An indoor swimming pool with lounge chairs, a table, and a ceiling with wooden beams.
A beach with clear blue water, a sandy shore, and a few boats. There are buildings with colorful roofs in the background.
A buffet area with a variety of food options, including a section labeled "Pastry" and another labeled "Bacon."

4. Hydrele Beach Hotel

Hydrele Beach Hotel
Samos
RM657
RM766 total
includes taxes & fees
1 Sept - 2 Sept
Hydrele Beach Hotel
An outdoor cafe with tables, chairs, potted plants, and a tree with ripe oranges.
A modern interior with a central seating area, a kitchen in the background, and large windows.
A modern kitchen with dark cabinetry, a central island, and two chairs.
A spa area with a hot tub, two bean bag chairs, and several potted plants.

5. Doryssa Theorem Hotel

Doryssa Theorem Hotel
Samos
RM805
RM930 total
includes taxes & fees
25 Aug - 26 Aug
Doryssa Theorem Hotel
A pool area with lounge chairs and umbrellas, surrounded by stone walls and greenery.
A boutique hotel entrance with a stone pathway, wooden gates, and potted plants.
A bedroom with a wooden wall, a hanging textured light fixture, and a bed with pillows.
A wooden deck with lounge chairs and a pool.

6. Doryssa Boutique Hotel

Doryssa Boutique Hotel
Samos
RM745
RM864 total
includes taxes & fees
8 Sept - 9 Sept
Doryssa Boutique Hotel
A modern outdoor seating area with a view of a coastal town and mountains.
A modern interior with a dark wood reception desk, a sofa, a large abstract painting, and a potted plant.
A modern multi-story building with a landscaped courtyard, featuring a mix of flat and sloped roofs, and a variety of plants and trees.

7. Nirema Hotel & Spa Samos - MGallery Collection (opening Q3 2026)

Nirema Hotel & Spa Samos - MGallery Collection (opening Q3 2026)
Samos
RM1,436
RM1,644 total
includes taxes & fees
19 Sept - 20 Sept
Nirema Hotel & Spa Samos - MGallery Collection (opening Q3 2026)
A coastal town with terraced houses, a dock with boats, and potted plants on a balcony.
An aerial view of a coastal residential area with a swimming pool, multiple houses, and a road leading to the sea.
A buffet with various food items and a glass partition.
A swimming pool with lounge chairs and umbrellas, surrounded by greenery and a view of a coastal town.

8. Arion Hotel

Arion Hotel
Samos
RM863
RM863 total
includes taxes & fees
18 Sept - 19 Sept
Arion Hotel
A wooden deck with lounge chairs and a thatched umbrella.
A hotel room with a bed, a large mirror, a TV, a bathroom with a large sink, and a view of a pool and building outside.
An outdoor seating area with modern furniture and a stone wall.
A pool area with a wooden pergola structure, a clear night sky, and a mountain backdrop.

9. Samian Mare Hotel Suites & Spa

Samian Mare Hotel Suites & Spa
Samos
RM687
RM800 total
includes taxes & fees
25 Aug - 26 Aug
Samian Mare Hotel Suites & Spa
A wooden deck with lounge chairs and a thatched umbrella.
A terrace with a table and chairs overlooking a coastal view.
A modern bathroom with two round sinks, a large mirror, and a view of the sea.
A restaurant with a view of the ocean, wooden tables and chairs, and a bar area with shelves of bottles and glasses.

10. Erato by Samian Mare

Erato by Samian Mare
Samos
RM812
RM937 total
includes taxes & fees
25 Aug - 26 Aug
Erato by Samian Mare
View all properties

Top Pythagorio Hotel Reviews

Doryssa Seaside Resort

Doryssa Seaside Resort

10/10 Excellent
"Loved this place so much. The pool was excellent, breakfast delicious, restaurants real good and plenty of them for choices. The property is very beautiful. We had the deluxe garden view which I recommend. We only stood 3 nights but I would stay longer next time and one day we took a ferry to Turkey for a day trip to Ephesus which was fantastic. You would need to rent a car if you want to sightsee the island as well."
Christine 3-night trip
Posted 5 days ago
Doryssa Seaside Resort
Proteas Blu Resort - Adults Only

Proteas Blu Resort - Adults Only

8/10 Good
"Inner architecture is not good, rooms are good and clean, staff are really nice and helpful. I bought sea view room but it was not that much sea view it was more like concrete view, Beach and pool side are quite nice Breakfast was very good"
ercan 1-night trip
Posted 7 days ago
Proteas Blu Resort - Adults Only

Frequently asked questions

Are you searching for the perfect hotel for your luxury trip to Pythagorio?
During your visit, you might want to enjoy the port which Pythagorio is known for.
What's the best luxury hotel in Pythagorio?
Casa Cook Samos is a luxury hotel with a beachfront restaurant and 2 bars, and it's a popular choice for Expedia travellers looking for an elegant place to stay. Proteas Blu Resort - Adults Only and Doryssa Seaside Resort are other upscale choices for your trip.
When can I expect good weather in Pythagorio?
Planning for the weather is an important factor for making your trip to Pythagorio a success, especially when you're splurging. The hottest months are usually August and July, with an average temperature of 25°C, while the coldest months are January and February, with an average of 13°C. Average annual precipitation for Pythagorio is 837 mm.
What's there to see and do in Pythagorio?
Experience Pythagorio with a stop at Samos Pythagorion Archaeological Museum, Pythagoreion and Castle of Lycurgus. If you have spare time during your trip, you might want to make a stop at Tunnel of Eupalinos and Glicorisa Beach.