Hotels in Otay Mesa West, San Diego

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
Next weekend

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Otay Mesa West hotels

Sycuan Casino Resort

Sycuan Casino Resort
4.0 star property
31.2 km from Otay Mesa West
9.2 out of 10, Wonderful, (1,761 reviews)
"Very clean resort. "
United States
Petrina
Sycuan Casino Resort

Courtyard by Marriott San Diego El Cajon

Courtyard by Marriott San Diego El Cajon
3.0 star property
25.8 km from Otay Mesa West
9.2 out of 10, Wonderful, (1,002 reviews)
"Clean, quiet, beautiful "
United States
Attia
The price is RM640
RM705 total
includes taxes & fees
8 Mar - 9 Mar
Courtyard by Marriott San Diego El Cajon

Best Western Plus La Mesa San Diego

Best Western Plus La Mesa San Diego
2.5 star property
23.2 km from Otay Mesa West
8.4 out of 10, Very good, (1,006 reviews)
"Room was clean, pleasant staff and great breakfast "
United States
Wendy
The price is RM450
RM495 total
includes taxes & fees
24 Feb - 25 Feb
Best Western Plus La Mesa San Diego

SpringHill Suites by Marriott Chula Vista Eastlake

SpringHill Suites by Marriott Chula Vista Eastlake
3.5 star property
12.4 km from Otay Mesa West
9.6 out of 10, Exceptional, (583 reviews)
"Clean room and friendly staff "
United States
Michael
The price is RM702
RM774 total
includes taxes & fees
15 Mar - 16 Mar
SpringHill Suites by Marriott Chula Vista Eastlake

Ayres Hotel San Diego South - Chula Vista

Ayres Hotel San Diego South - Chula Vista
3.0 star property
9.2 km from Otay Mesa West
9.8 out of 10, Exceptional, (1,119 reviews)
"Great location "
United States
Irma
The price is RM909
RM1,002 total
includes taxes & fees
8 Mar - 9 Mar
Ayres Hotel San Diego South - Chula Vista

Heritage Inn La Mesa

Heritage Inn La Mesa
2.0 star property
21.9 km from Otay Mesa West
7.0 out of 10, Good, (1,293 reviews)
"Very friendly at front desk I wish it was a little cheaper and I would stay the whole trip here"
United States
Haley
The price is RM250
RM276 total
includes taxes & fees
25 Feb - 26 Feb
Heritage Inn La Mesa

Lamplighter Inn & Suites at SDSU

Lamplighter Inn & Suites at SDSU
2.5 star property
21 km from Otay Mesa West
9.0 out of 10, Wonderful, (1,367 reviews)
"Good accommodations for the price point."
United States
Martin
Lamplighter Inn & Suites at SDSU

Best Western Chula Vista/Otay Valley Hotel

Best Western Chula Vista/Otay Valley Hotel
2.5 star property
2.4 km from Otay Mesa West
7.8 out of 10, Good, (1,624 reviews)
"Clean rooms and the breakfast was amazing "
United States
Vanessa
The price is RM403
RM443 total
includes taxes & fees
1 Mar - 2 Mar
Best Western Chula Vista/Otay Valley Hotel

La Quinta Inn by Wyndham San Diego Chula Vista

La Quinta Inn by Wyndham San Diego Chula Vista
3.0 star property
7.8 km from Otay Mesa West
8.6 out of 10, Excellent, (1,549 reviews)
"The room was very clean and the staff was very nice."
United States
Rod
The price is RM395
RM434 total
includes taxes & fees
4 Mar - 5 Mar
La Quinta Inn by Wyndham San Diego Chula Vista

Comfort Inn Chula Vista San Diego South

Comfort Inn Chula Vista San Diego South
2.5 star property
7.9 km from Otay Mesa West
8.2 out of 10, Very good, (1,354 reviews)
"It’s very comfortable and wonderful place. "
United States
Carmen
The price is RM406
RM447 total
includes taxes & fees
8 Mar - 9 Mar
Comfort Inn Chula Vista San Diego South

Hampton Inn San Diego-Kearny Mesa

Hampton Inn San Diego-Kearny Mesa
2.5 star property
29.7 km from Otay Mesa West
9.0 out of 10, Wonderful, (1,010 reviews)
"Absolutely wonderful hotel. Really great location with a lot of convenient dining and shopping options in the area. "
United States
Maxwell
The price is RM461
RM529 total
includes taxes & fees
8 Mar - 9 Mar
Hampton Inn San Diego-Kearny Mesa

Valli Hi Motel

Valli Hi Motel
2.5 star property
2.2 km from Otay Mesa West
8.4 out of 10, Very good, (1,005 reviews)
"Excelente "
Mexico
Julio
Valli Hi Motel

Hotel Palmeras Chula Vista

Hotel Palmeras Chula Vista
2.0 star property
7.8 km from Otay Mesa West
7.2 out of 10, Good, (2,163 reviews)
"Good stay, quiet,place was easy to find."
United States
Annie
The price is RM259
RM285 total
includes taxes & fees
24 Feb - 25 Feb
Hotel Palmeras Chula Vista

Hotel Milagro

Hotel Milagro
2.0 star property
8.5 km from Otay Mesa West
7.8 out of 10, Good, (1,008 reviews)
"Great frienly and welcoming staff. Clean and comfy."
United States
Raquel
The price is RM259
RM285 total
includes taxes & fees
1 Mar - 2 Mar
Hotel Milagro

Holiday Inn Express San Diego South - Chula Vista by IHG

Holiday Inn Express San Diego South - Chula Vista by IHG
2.5 star property
8 km from Otay Mesa West
9.4 out of 10, Exceptional, (1,035 reviews)
"Clean, Spacious Room, Polite Staff, Nice Breakfast"
United States
ALFREDO
The price is RM438
RM482 total
includes taxes & fees
15 Mar - 16 Mar
Holiday Inn Express San Diego South - Chula Vista by IHG

Hercor Hotel - Urban Boutique

Hercor Hotel - Urban Boutique
3.0 star property
6.8 km from Otay Mesa West
8.6 out of 10, Excellent, (1,385 reviews)
"Excellent service and spotless place. "
United States
Ruslan
The price is RM388
RM427 total
includes taxes & fees
26 Feb - 27 Feb
Hercor Hotel - Urban Boutique

Berkshire Motor Hotel

Berkshire Motor Hotel
2.5 star property
North Park, 21.2 km from Otay Mesa West
8.4 out of 10, Very good, (1,003 reviews)
"Clean, very chill easy check in"
United States
Susana
The price is RM351
RM396 total
includes taxes & fees
24 Feb - 25 Feb
Berkshire Motor Hotel

Best Western Americana Inn

Best Western Americana Inn
2.5 star property
2.1 km from Otay Mesa West
9.0 out of 10, Wonderful, (1,224 reviews)
"Great stay"
United States
Elisa
The price is RM450
RM511 total
includes taxes & fees
24 Feb - 25 Feb
Best Western Americana Inn

The Rambler Hotel

The Rambler Hotel
3.0 star property
8 km from Otay Mesa West
9.2 out of 10, Wonderful, (2,059 reviews)
"Absolutely amazing stay will def be coming back!"
United States
Victor
The price is RM410
RM474 total
includes taxes & fees
1 Mar - 2 Mar
The Rambler Hotel

Sun Outdoors San Diego Bay

Sun Outdoors San Diego Bay
2.0 star property
8.2 km from Otay Mesa West
10.0 out of 10, Exceptional, (84 reviews)
"Friendly staff, cute cottages, a lot of things to do. "
United States
Akiko
The price is RM734
RM936 total
includes taxes & fees
25 Feb - 26 Feb
Sun Outdoors San Diego Bay
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Otay Mesa West

Find the best Otay Mesa West areas for the activities you enjoy most.

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Mission Beach

If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.

Pacific Beach

Relax in beachside cafés in the morning, surf clean breaks in the afternoon and dance with a youthful club crowd at night at this coastal San Diego strip.

Gaslamp Quarter

The historic heart of San Diego has a fascinating history, and today is a thriving hub for food, retail and entertainment.

Ocean Beach

With a secluded sunbathing beach, swimming-only beach, special surf beach, volleyball beach and dog beach, San Diego’s “OB” sure takes beaches seriously.

Top Otay Mesa West Hotel Reviews

Frequently asked questions

What is Otay Mesa West like?
Otay Mesa West is a neighbourhood that travellers like for its cathedral.
If I need to cancel my hotel reservation in Otay Mesa West, will I receive a refund?
Yes! The majority of room reservations are refundable if you cancel before the hotel's cancellation deadline, which is often 24 or 48 hours before the scheduled arrival. If you have a non-refundable reservation, you may still be able to cancel and receive a refund within 24 hours of your booking. Put your dates in and click on "Search", then you can use the "fully refundable" filter to review top deals in Otay Mesa West.
What is there to do around this San Diego neighbourhood?
A few places to visit in the area around Otay Mesa West include San Ysidro Border Crossing, Las Americas Premium Outlets and Sesame Place San Diego. While you're out sightseeing in San Diego, make sure that you visit other sights such as Tijuana Customs - Garita El Chaparral or North Island Credit Union Amphitheatre.
How can I get around Otay Mesa West and the greater San Diego area?
Ready to get out and explore the city? Iris Avenue Trolley Station is the closest metro station.

Explore a world of travel with Expedia