A city skyline with high-rise buildings and a bridge over a body of water.

Hotels in Otay Mesa, San Diego

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
Next weekend

Filter by

Guest rating

Selecting then applying a filter from this group will update the results on a new page

Star rating

Our top choices for Otay Mesa hotels

Quality Suites San Diego Otay Mesa

Quality Suites San Diego Otay Mesa
2.5 star property
Otay Mesa
7.2 out of 10, Good, (1,011 reviews)
"Very clean, bed was comfortable!"
United States
Michael A
The price is RM468
RM532 total
includes taxes & fees
28 Jun - 29 Jun
Quality Suites San Diego Otay Mesa

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2.5 star property
Otay Mesa
8.2 out of 10, Very good, (1,750 reviews)
"Clean, friendly staff, great breakfast!!"
United States
Flor
The price is RM600
RM683 total
includes taxes & fees
5 Jul - 6 Jul
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Crowne Plaza San Diego - Mission Valley by IHG

Crowne Plaza San Diego - Mission Valley by IHG
3.5 star property
29.8 km from Otay Mesa
8.4 out of 10, Very good, (1,024 reviews)
"great stay"
United States
David
The price is RM505
RM582 total
includes taxes & fees
29 Jun - 30 Jun
Crowne Plaza San Diego - Mission Valley by IHG

Valli Hi Motel

Valli Hi Motel
2.5 star property
7.9 km from Otay Mesa
8.4 out of 10, Very good, (1,023 reviews)
"Great place to stay."
United States
Allan
The price is RM373
RM425 total
includes taxes & fees
29 Jun - 30 Jun
Valli Hi Motel

Sheraton San Diego Resort

Sheraton San Diego Resort
4.0 star property
28.1 km from Otay Mesa
8.4 out of 10, Very good, (3,532 reviews)
"Great location and shuttle service to and from the airport."
Canada
Malinda
The price is RM659
RM967 total
includes taxes & fees
1 Jul - 2 Jul
Sheraton San Diego Resort

Sycuan Casino Resort

Sycuan Casino Resort
4.0 star property
28.5 km from Otay Mesa
9.4 out of 10, Exceptional, (1,993 reviews)
"Always a great stay"
United States
Jeanette
The price is RM479
RM576 total
includes taxes & fees
12 Jul - 13 Jul
Sycuan Casino Resort

Lafayette Hotel & Club

Lafayette Hotel & Club
4.0 star property
26.8 km from Otay Mesa
9.4 out of 10, Exceptional, (1,745 reviews)
"Beautiful hotel"
United States
Cuauhtemoc
The price is RM1,031
RM1,185 total
includes taxes & fees
29 Jun - 30 Jun
Lafayette Hotel & Club

Best Western Chula Vista/Otay Valley Hotel

Best Western Chula Vista/Otay Valley Hotel
2.5 star property
7.1 km from Otay Mesa
8.0 out of 10, Very good, (1,815 reviews)
"The stay was great, and breakfast was delicious"
United States
Katie
The price is RM524
RM578 total
includes taxes & fees
30 Jun - 1 Jul
Best Western Chula Vista/Otay Valley Hotel

Wyndham Garden San Diego Near SeaWorld

Wyndham Garden San Diego Near SeaWorld
3.0 star property
31.3 km from Otay Mesa
7.4 out of 10, Good, (4,205 reviews)
"Clean room, staff was very helpful, parking was easy and accessible!"
United States
Hector
The price is RM508
RM584 total
includes taxes & fees
1 Jul - 2 Jul
Wyndham Garden San Diego Near SeaWorld

Studio 6 Suites San Ysidro, CA -San Diego South Bay

Studio 6 Suites San Ysidro, CA -San Diego South Bay
2.5 star property
6.9 km from Otay Mesa
8.0 out of 10, Very good, (1,690 reviews)
"It’s ok to stay one or two days"
United States
Valentina
The price is RM327
RM373 total
includes taxes & fees
25 Jun - 26 Jun
Studio 6 Suites San Ysidro, CA -San Diego South Bay

Best Western Plus Marina Gateway Hotel

Best Western Plus Marina Gateway Hotel
3.5 star property
16.9 km from Otay Mesa
9.2 out of 10, Wonderful, (3,880 reviews)
"Great stay"
United States
Cameron
The price is RM743
RM819 total
includes taxes & fees
2 Jul - 3 Jul
Best Western Plus Marina Gateway Hotel

Motel 6 El Cajon, CA - San Diego

Motel 6 El Cajon, CA - San Diego
2.0 star property
27 km from Otay Mesa
7.4 out of 10, Good, (1,695 reviews)
"A good place to stay if you need a place to crash in for the night"
United States
Ivy Ruth
The price is RM356
RM393 total
includes taxes & fees
29 Jun - 30 Jun
Motel 6 El Cajon, CA - San Diego

SpringHill Suites by Marriott Chula Vista Eastlake

SpringHill Suites by Marriott Chula Vista Eastlake
3.5 star property
10.5 km from Otay Mesa
9.6 out of 10, Exceptional, (676 reviews)
"It was great, one of the best stays we have had while traveling this year!"
United States
Ken
The price is RM993
RM1,095 total
includes taxes & fees
20 Jul - 21 Jul
SpringHill Suites by Marriott Chula Vista Eastlake

Ocean Villa Inn

Ocean Villa Inn
2.5 star property
Ocean Beach, 33.7 km from Otay Mesa
8.0 out of 10, Very good, (1,294 reviews)
"This is very pet friendly and staff is great"
United States
Arturo
The price is RM930
RM1,048 total
includes taxes & fees
28 Jun - 29 Jun
Ocean Villa Inn

Best Western San Diego Pacific Beach/Mission Bay

Best Western San Diego Pacific Beach/Mission Bay
2.5 star property
Bay Park, 33.6 km from Otay Mesa
8.2 out of 10, Very good, (441 reviews)
"Location was great!"
United States
Richard
The price is RM580
RM667 total
includes taxes & fees
6 Jul - 7 Jul
Best Western San Diego Pacific Beach/Mission Bay

Holiday Inn Express San Diego Airport - Old Town by IHG

Holiday Inn Express San Diego Airport - Old Town by IHG
2.5 star property
28.8 km from Otay Mesa
9.2 out of 10, Wonderful, (1,087 reviews)
"Staff was so great nice rooms really great stay"
United States
Amelia
The price is RM596
RM685 total
includes taxes & fees
30 Jun - 1 Jul
Holiday Inn Express San Diego Airport - Old Town by IHG

Hampton Inn & Suites San Diego Airport Liberty Station

Hampton Inn & Suites San Diego Airport Liberty Station
2.5 star property
29.2 km from Otay Mesa
9.2 out of 10, Wonderful, (1,704 reviews)
"Good location, clean room and nice staff. A great place to stay."
United States
Patricia
The price is RM711
RM817 total
includes taxes & fees
30 Jun - 1 Jul
Hampton Inn & Suites San Diego Airport Liberty Station

Best Western Americana Inn

Best Western Americana Inn
2.5 star property
8 km from Otay Mesa
8.8 out of 10, Excellent, (1,312 reviews)
"The breakfast was great, the staff was helpful, and the room was clean and spacious!"
United States
Christopher
The price is RM506
RM576 total
includes taxes & fees
12 Jul - 13 Jul
Best Western Americana Inn

Hilton Garden Inn San Diego Old Town/SeaWorld Area

Hilton Garden Inn San Diego Old Town/SeaWorld Area
3.0 star property
Old Town San Diego, 30.5 km from Otay Mesa
8.8 out of 10, Excellent, (1,472 reviews)
"Hotel is lovely mission style in keeping with the area. The location is very convenient to local attractions."
United States
Toni
The price is RM659
RM758 total
includes taxes & fees
1 Jul - 2 Jul
Hilton Garden Inn San Diego Old Town/SeaWorld Area

Comfort Inn Sea World Area

Comfort Inn Sea World Area
3.5 star property
30.8 km from Otay Mesa
8.6 out of 10, Excellent, (3,805 reviews)
"Nice staff and good breakfast"
United States
Fernando
The price is RM560
RM644 total
includes taxes & fees
30 Jun - 1 Jul
Comfort Inn Sea World Area
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Otay Mesa

Find the best Otay Mesa areas for the activities you enjoy most.

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Pacific Beach

Relax in beachside cafés in the morning, surf clean breaks in the afternoon and dance with a youthful club crowd at night at this coastal San Diego strip.

Mission Beach

If you're spending some time in Mission Beach, Mission Beach and Mission Bay are top sights worth seeing.

Gaslamp Quarter

The historic heart of San Diego has a fascinating history, and today is a thriving hub for food, retail and entertainment.

Mission Bay

If you're spending some time in Mission Bay, Mission Bay and Mission and Pacific Beaches are top sights worth seeing.

Top Otay Mesa Hotel Reviews

Frequently asked questions

What's it like in Otay Mesa?
Otay Mesa is a neighbourhood that travellers like for its beaches, restaurants and shopping.
Where is the best hotel for a stay in Otay Mesa?
Based on our traveller data, Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG is one of the top choices for your stay in Otay Mesa. This hotel offers free breakfast and an outdoor pool.
If I need to cancel my hotel reservation in Otay Mesa, will I receive a refund?
Yes! Most room reservations are refundable provided that you cancel before the hotel's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you booked a non-refundable reservation, it might still be possible to cancel it and be given a refund within a 24-hour period of booking. Add dates, click "Search", then filter by "fully refundable" to view top deals in Otay Mesa.
What is there to do in this San Diego neighbourhood?
A few places to visit in the area around Otay Mesa include High Performance Center in Tijuana, Parque Industrial FINSA Tijuana and Otay Sports Fields. While you're out sightseeing, Caliente Casino and Alameda Otay are a couple of additional sights to visit in San Diego.

Explore a world of travel with Expedia