O Brien hotels from RM242
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Go beyond your typical stay in O Brien
Pet friendly
Apartยญment
Family friendly
Waterpark
Condo
Check prices for these dates
Tonight
20 Aug - 21 AugTomorrow
21 Aug - 22 AugThis weekend
21 Aug - 23 AugNext weekend
28 Aug - 30 AugOur top choices for O Brien hotels
1. Hampton Inn & Suites Lake City
Hampton Inn & Suites Lake CityLake City
tracy
RM463
RM521 total
includes taxes & fees
25 Aug - 26 Aug
2. Comfort Suites Lake City
Comfort Suites Lake CityLake City
KHAJA
RM376
RM423 total
includes taxes & fees
31 Aug - 1 Sept
3. Super 8 by Wyndham Lake City
Super 8 by Wyndham Lake CityLake City
Mari
RM266
RM299 total
includes taxes & fees
13 Sept - 14 Sept
4. Best Western Plus Lake City
Best Western Plus Lake CityLake City
James
RM340
RM382 total
includes taxes & fees
6 Sept - 7 Sept
5. Tru by Hilton Lake City
Tru by Hilton Lake CityLake City
James
RM442
RM498 total
includes taxes & fees
13 Sept - 14 Sept
6. Home2 Suites by Hilton Lake City
Home2 Suites by Hilton Lake CityLake City
William
RM497
RM559 total
includes taxes & fees
13 Sept - 14 Sept
7. Fairfield Inn & Suites Lake City
Fairfield Inn & Suites Lake CityLake City
Adoniram
RM435
RM489 total
includes taxes & fees
27 Aug - 28 Aug
8. Days Inn by Wyndham Lake City I-10
Days Inn by Wyndham Lake City I-10Lake City
Serhii
RM240
RM270 total
includes taxes & fees
24 Aug - 25 Aug
9. Palms Garden Inn
Palms Garden InnLake City
Teresa
RM280
RM315 total
includes taxes & fees
26 Aug - 27 Aug
10. La Quinta Inn & Suite by Wyndham Lake City
La Quinta Inn & Suite by Wyndham Lake CityLake City
Priscilla J
RM380
RM427 total
includes taxes & fees
6 Sept - 7 Sept
11. Quality Inn Lake City
Quality Inn Lake CityLake City
Lucille
RM311
RM349 total
includes taxes & fees
30 Aug - 31 Aug
12. Holiday Inn & Suites Lake City by IHG
Holiday Inn & Suites Lake City by IHGLake City
Renee
RM394
RM443 total
includes taxes & fees
30 Aug - 31 Aug
13. Americas Best Value Inn Lake City
Americas Best Value Inn Lake CityLake City
Larissa
RM263
RM296 total
includes taxes & fees
25 Aug - 26 Aug
14. Regal Inn
Regal InnLake City
Samuel
RM252
RM283 total
includes taxes & fees
24 Aug - 25 Aug
15. The Blanche
The BlancheLake City
Brandi
RM603
RM678 total
includes taxes & fees
14 Sept - 15 Sept
16. TownePlace Suites by Marriott Lake City
TownePlace Suites by Marriott Lake CityLake City
Jennifer
RM483
RM543 total
includes taxes & fees
23 Aug - 24 Aug
17. Courtyard By Marriott Lake City
Courtyard By Marriott Lake CityLake City
Tonya
RM435
RM489 total
includes taxes & fees
13 Sept - 14 Sept
18. Days Inn by Wyndham Lake City I-75
Days Inn by Wyndham Lake City I-75Lake City
Brizheet
RM257
RM289 total
includes taxes & fees
23 Aug - 24 Aug
19. Motel 6 โ Lake City, Fl โ Medical Center
Motel 6 โ Lake City, Fl โ Medical CenterLake City
Pennee
RM264
RM297 total
includes taxes & fees
24 Aug - 25 Aug
20. Baymont by Wyndham Lake City I-75
Baymont by Wyndham Lake City I-75Lake City
Jasmine
RM235
RM264 total
includes taxes & fees
24 Aug - 25 Aug
Learn more about O Brien
Escape to this rural Florida gem where the Suwannee River offers peaceful kayaking trips and fishing adventures. Nearby Spirit of the Suwannee Music Park hosts live concerts, while O'Brien's local farms welcome visitors for fresh produce and family-friendly activities.
See all hotels in O Brien
Top O Brien Hotel Reviews
Baymont by Wyndham Lake City I-75
10/10 Excellent
"Nice place"
Super 8 by Wyndham Lake City
10/10 Excellent
"Everything was wonderful"
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
10/10 Excellent
"Good breakfast, great staff & clean room."
Comfort Suites Lake City
10/10 Excellent
"Clean, comfortable, roomy"
Tru by Hilton Lake City
10/10 Excellent
"Great"
Hampton Inn & Suites Lake City
10/10 Excellent
"Everything was perfect for our stay. The staff was friendly and helpful when we had questions. The rooms were clean and had everything we needed."
La Quinta Inn & Suite by Wyndham Lake City
10/10 Excellent
"From check in to check out, I had a great experience. I was traveling for a funeral and had not slept for 2 days! The staff helped me at the front to get to my room. The room was better than expected and the breakfast was just what I needed. Iโd recommend this stay to anyone"
Holiday Inn & Suites Lake City by IHG
8/10 Good
"The staff was outstanding and friendly. They had everything squared away at our arrival and accommodated our requests. The hotel was hosting several conferences yet the hotel was quiet that evening. The selection of restaurants and in house eating arrangements were numerous."
Best Western Plus Lake City
10/10 Excellent
"Todo bien"
More cheap stays in O Brien
Days Inn by Wyndham Lake City I-10
3430 N Us Highway 441 Lake City FL
RM240
RM270 total
24 Aug - 25 Aug
includes taxes & fees
Quality Inn Lake City
285 Sw Commerce Dr Lake City FL
RM311
RM349 total
30 Aug - 31 Aug
includes taxes & fees
8.2/10 Very good! (1,004 reviews)
Best Western Plus Lake City
350 SW Florida Gateway Dr Lake City FL
RM340
RM382 total
6 Sept - 7 Sept
includes taxes & fees
Comfort Suites Lake City
3690 W Us Highway 90 Lake City FL
RM376
RM423 total
31 Aug - 1 Sept
includes taxes & fees
9.4/10 Exceptional! (1,007 reviews)
Hampton Inn & Suites Alachua I-75
15930 Northwest 163rd Lane Alachua FL
RM429
RM483 total
26 Aug - 27 Aug
includes taxes & fees
Tru by Hilton Lake City
284 NW Centurion Court Lake City FL
RM442
RM498 total
13 Sept - 14 Sept
includes taxes & fees
9.2/10 Wonderful! (1,003 reviews)
Frequently asked questions
Explore a world of travel with Expedia
- Alachua Hotels
- Athena Hotels
- Bronson Hotels
- Hotels near Chiefland Farmers Flea Market
- Beach Resorts in Gainesville
- Guest Houses in Gilchrist County
- Glen St. Mary Hotels
- Horseshoe Beach Hotels
- Hotels with Swimming Pools in Lake City
- Pet friendly Hotels in Lake City
- Lake City Hotels
- Hilton Hotels in Lamont
- Lamont Hotels
- Live Oak Hotels
- Lulu Hotels
- Mayo Hotels
- Newberry Hotels
- Condominium Resorts in Northern Florida
- Drury Inn & Suites Hotels in Northern Florida
- Romantic Hotels in Northern Florida
- Old Town Hotels
- Flights to Bronson
- Flights to Chiefland
- Flights to Gainesville
- Flights to Lamont
- Flights to O Brien
- Flights to Wellborn
- Flights from Gainesville Regional
- Flights from Steinhatchee
- Flights from Bell
- Flights from Melrose
- Flights from O Brien
- Flights from Lake City
- Flights from Chiefland
- Flights from Mayo
- Flights from Bronson
- Flights from Pittsburgh (AGC) to Gainesville (GNV)
- Flights from Hartford (BDL) to Gainesville (GNV)
- Flights from Boston (BOS) to Gainesville (GNV)
- Flights from Cape Girardeau (CGI) to Gainesville (GNV)
- Flights from Cartagena (CTG) to Gainesville (GNV)
- Flights from Dodge City (DDC) to Gainesville (GNV)
- Flights from Dรผsseldorf (DUS) to Gainesville (GNV)
- Flights from Fort Lauderdale (FLL) to Gainesville (GNV)
- Flights from Gaithersburg (GAI) to Gainesville (GNV)
- Flights from Houma (HUM) to Gainesville (GNV)
- Flights from Niagara Falls (IAG) to Gainesville (GNV)
- Flights from Johnstown (JST) to Gainesville (GNV)
- Flights from Miami (MIA) to Gainesville (GNV)
- Flights from Mount Magnet (MMG) to Gainesville (GNV)
- Flights from Manassas (MNZ) to Gainesville (GNV)
- Flights from Ontario (ONT) to Gainesville (GNV)
- Flights from Pereira (PEI) to Gainesville (GNV)
- Flights from Pittsfield (PSF) to Gainesville (GNV)
- Flights from St. Louis (STL) to Gainesville (GNV)
- Flights from Touggourt (TGR) to Gainesville (GNV)
