Mesopotamia

Travel Guide

Mesopotamia featuring forests and a river or creek
Mesopotamia showing forest scenes
Mesopotamia
Mesopotamia showing a river or creek and forest scenes
Mesopotamia featuring a waterfall and a river or creek

The awe-inspiring Iguazú Falls is the centerpiece attraction of this northeastern Argentine region, which also hosts the country’s biggest carnival celebration.

A heady mix of ancient history, natural beauty and flamboyant festivals features in Argentina’s hot and humid Mesopotamia region. Be inspired by thundering waterfalls, spot exotic wildlife, experience indigenous traditions and relax at sleepy riverside resorts. Mesopotamia sits sandwiched between two mighty rivers, the Río Paraná and Rió Uruguay, and is covered with subtropical rainforests and wetlands. It includes the provinces of Misiones, Corrientes and Entre Ríos.

Straddling the Río Iguazú in Misiones province, and shared between Argentina and Brazil, is the UNESCO-protected Iguazú National Park. Come here to admire the 275 individual waterfalls that make up the Iguazú Falls. Follow trails to panoramic lookouts, ride on a speedboat beneath a cascade and see wildlife such as toucans and monkeys. Access the Brazilian side of the park via a short drive from the town of Puerto Iguazú.

Tour the towns of Misiones to appreciate the province’s diversity. Find a gemstone mine in Wanda, flower-filled gardens in Montecarlo and colonial architecture in Oberá. Visit 17th-century Jesuit ruins at San Ignacio. Saltos del Moconá, in Parque Provincial Moconá, is another waterfall worth visiting.

Discover a breezy esplanade, graceful architecture and artisan markets, which showcase Guarani culture, in Corrientes city. Spend some time at easy-going river towns, including Itati and Ituzaingó. Be amazed by the craggy, granite ravine of Barrancas del Empedrado and hike amid thick forest in Mburucuya National Park. Go in search of some 350 bird species and the rare maned wolf at Esteros del Iberá wetlands reserve.

Hot springs, fishing trips, pristine reserves and boisterous carnival parties await in Entre Ríos province. Gualeguaychú explodes into color in February with arguably Argentina’s most famous carnival. The powdery, white sand at nearby Ñandubaysal evokes images of a tropical island paradise. Fish for huge dorado in Santa Elena and enjoy the charm of riverfront Colón. Don’t miss the enormous yatay palm trees in El Palmar National Park.

The southern area of Mesopotamia is just a short bus ride from Buenos Aires. You can also fly to Corrientes and Puerto Iguazú and then get around the region via public buses and organized tours.

Marriott Corrientes Hotel

Marriott Corrientes Hotel

4.5 out of 5
Av Costanera Juan Pablo II y Lavalle Corrientes
The price is RM519 per night from 5 Dec to 6 Dec
RM519
RM519 total
5 Dec - 6 Dec
Stay at this luxury hotel in Corrientes. Popular attractions Costanera de Corrientes and Cumba Cua Park are located nearby.
10/10 Exceptional! (3 reviews)
Very nice hotel

Reviewed on 9 Nov 2025

Marriott Corrientes Hotel
O2 Hotel Gualeguaychú

O2 Hotel Gualeguaychú

2.5 out of 5
115 3 de Febrero Gualeguaychú Entre Ríos
The price is RM145 per night from 25 Nov to 26 Nov
RM145
RM145 total
25 Nov - 26 Nov
Stay at this hotel in Gualeguaychú. Enjoy free Wi-Fi, a 24-hour front desk and a business centre. Popular attractions Gualeguaychú Cathedral and San Martin Square ...
7.6/10 Good! (63 reviews)
Hotel is very comfortable and clean. There is no breakfast or hotel parking, and the wifi does not work properly in most floors and rooms. Other than that, the staff is very friendly and nice.

Reviewed on 2 Jan 2025

O2 Hotel Gualeguaychú
La Casona de Susana

La Casona de Susana

3 out of 5
3 de Febrero 448 Colon Entre Rios
The price is RM199 per night from 3 Dec to 4 Dec
RM199
RM199 total
3 Dec - 4 Dec
Stay at this beach hotel in Colon. Enjoy free parking, an outdoor pool and a full-service spa. Popular attractions Termas De Colón and Colon Golf Club are located ...
La propietaria respeta el precio acordado. En verano si usás más de 8 horas por día el aire acondicionado te cobran un plus.

Reviewed on 13 Mar 2023

La Casona de Susana
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Donsuites Apart Hotel

Donsuites Apart Hotel

3 out of 5
La Rioja 442 Corrientes Corrientes
Stay at this aparthotel in Corrientes. Enjoy free breakfast, free Wi-Fi and a rooftop terrace. Popular attractions Museo de Artesanías Tradicionales Folclóricas ...
8.6/10 Excellent! (104 reviews)
Loved this place, super clean, and the staff were very nice and helpful😍

Reviewed on 30 Aug 2024

Donsuites Apart Hotel
Bungalows Mexico

Bungalows Mexico

2.5 out of 5
Carlos Granillo Posse N 197 Concepción del Uruguay Entre Rios
Stay at this cabin in Concepción del Uruguay. Enjoy free Wi-Fi, free parking and room service. Popular attractions Concepción del Uruguay City Racetrack and ...
Local estava limpo, a cama é ótima, mas o banheiro a água n esquentava. O atendimento foi bom, são atenciosos.

Reviewed on 29 Jul 2024

Bungalows Mexico
cabañas tesouro

cabañas tesouro

3 out of 5
mariano sanchez 158 Gualeguaychú Entre Ríos
Stay at this cabin in Gualeguaychú. Enjoy free Wi-Fi, a garden and furnished balconies or patios. Popular attractions Nuestra Senora Gaucha del Mate Monument ...
Nos tocaron vecinos bastante ruidosos, y se escuchaban sus conversaciones, porque la pared medianera es de 15. Pero la propiedad bien valio la pena, es comoda y funcional, volveriamos sin dudar.

Reviewed on 8 May 2023

cabañas tesouro
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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