Upstate South Carolina hotels from RM278

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
Next weekend

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Upstate South Carolina hotels

Carolina Camp Cedar

Carolina Camp Cedar
3.5 star property
Pickens
10.0 out of 10, Exceptional, (3 reviews)
"The cottage was clean, staff was so friendly, our stay was quiet and peaceful… it was perfect! Definitely planning to stay there again!"
United States
Katlynn
The price is RM670
RM744 total
includes taxes & fees
28 Apr - 29 Apr
Carolina Camp Cedar

Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area
3.0 star property
Seneca
9.4 out of 10, Exceptional, (222 reviews)
"Excellent in every way … staff, room, amenities and very comfortable bed!"
United States
Sarah
The price is RM476
RM523 total
includes taxes & fees
3 May - 4 May
Fairfield Inn & Suites Seneca Clemson Univ Area

Holiday Inn Express Gaffney by IHG

Holiday Inn Express Gaffney by IHG
2.5 star property
Gaffney
8.8 out of 10, Excellent, (476 reviews)
"Very clean and staff the super kind and friendly 10/10 stay"
United States
Kevin
The price is RM365
RM398 total
includes taxes & fees
3 May - 4 May
Holiday Inn Express Gaffney by IHG

Clemson University's James F. Martin Inn

Clemson University's James F. Martin Inn
3.0 star property
Clemson
9.4 out of 10, Exceptional, (1,003 reviews)
"Lovely place to stay right on the lake. "
United States
Sara
The price is RM393
RM436 total
includes taxes & fees
11 May - 12 May
Clemson University's James F. Martin Inn

Quality Inn Seneca Clemson Area US-123

Quality Inn Seneca Clemson Area US-123
2.5 star property
Downtown
8.0 out of 10, Very good, (695 reviews)
"Very pleasant and helpful staff. Comfortable room though fairly small."
United States
William
The price is RM343
RM403 total
includes taxes & fees
18 May - 19 May
Quality Inn Seneca Clemson Area US-123

Inn on the Square, an Ascend Collection Hotel

Inn on the Square, an Ascend Collection Hotel
3.0 star property
Uptown Greenwood
9.2 out of 10, Wonderful, (736 reviews)
"Friendly staff, nice facility that is centrally located."
United States
Frederick
The price is RM496
RM551 total
includes taxes & fees
10 May - 11 May
Inn on the Square, an Ascend Collection Hotel

Lakeside Lodge Clemson

Lakeside Lodge Clemson
2.5 star property
Seneca
9.0 out of 10, Wonderful, (1,001 reviews)
"This place is tops! The area is great, rooms were wonderful, and amenities were amazing. Definitely plan on staying again asap!"
United States
Valarie Tina
The price is RM432
RM537 total
includes taxes & fees
9 May - 10 May
Lakeside Lodge Clemson

La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.

La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.
3.0 star property
Greenville
8.8 out of 10, Excellent, (199 reviews)
"Great place to stay"
United States
LOUIS
The price is RM300
RM340 total
includes taxes & fees
11 May - 12 May
La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.

Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
2.5 star property
Seneca
9.2 out of 10, Wonderful, (833 reviews)
"Great location and facilities"
United States
Brian
The price is RM462
RM508 total
includes taxes & fees
18 May - 19 May
Tru by Hilton Seneca Clemson

Best Western Seneca-Clemson

Best Western Seneca-Clemson
2.5 star property
Seneca
8.4 out of 10, Very good, (655 reviews)
"Room was clean and staff was very efficient. "
United States
Judith
The price is RM371
RM408 total
includes taxes & fees
13 May - 14 May
Best Western Seneca-Clemson

Hampton Inn Greer Greenville, SC

Hampton Inn Greer Greenville, SC
2.5 star property
Greer
9.6 out of 10, Exceptional, (452 reviews)
"great service all around."
United States
Alberto
The price is RM536
RM584 total
includes taxes & fees
4 May - 5 May
Hampton Inn Greer Greenville, SC

Microtel Inn & Suites by Wyndham Anderson/Clemson

Microtel Inn & Suites by Wyndham Anderson/Clemson
2.0 star property
Anderson
8.2 out of 10, Very good, (1,003 reviews)
"Front desk staff were very friendly. We had a welcoming and quiet 1 night stay."
United States
Nicole
The price is RM320
RM355 total
includes taxes & fees
3 May - 4 May
Microtel Inn & Suites by Wyndham Anderson/Clemson

Hampton Inn Gaffney

Hampton Inn Gaffney
2.5 star property
Gaffney
8.8 out of 10, Excellent, (706 reviews)
"Would stay again breakfast was amazing "
United States
Theresa
The price is RM363
RM396 total
includes taxes & fees
17 May - 18 May
Hampton Inn Gaffney

Best Western Plus Greenville I-385 Inn & Suites

Best Western Plus Greenville I-385 Inn & Suites
2.5 star property
Greenville
9.2 out of 10, Wonderful, (1,457 reviews)
"great stay"
United States
Gordon
The price is RM425
RM467 total
includes taxes & fees
17 May - 18 May
Best Western Plus Greenville I-385 Inn & Suites

Spartanburg Marriott

Spartanburg Marriott
3.5 star property
Spartanburg
8.6 out of 10, Excellent, (1,000 reviews)
"The staff was extremely helpful and friendly."
United States
Richard
The price is RM535
RM594 total
includes taxes & fees
11 May - 12 May
Spartanburg Marriott

Aloft Greenville Downtown

Aloft Greenville Downtown
3.0 star property
Greenville Downtown
9.2 out of 10, Wonderful, (1,003 reviews)
"Nice hotel very well located"
United States
Danilo
The price is RM583
RM641 total
includes taxes & fees
3 May - 4 May
Aloft Greenville Downtown

Deluxe Inn

Deluxe Inn
2.0 star property
Mauldin
The price is RM278
RM305 total
includes taxes & fees
28 Apr - 29 Apr
Deluxe Inn

SpringHill Suites by Marriott Greenville Downtown

SpringHill Suites by Marriott Greenville Downtown
2.5 star property
Greenville Downtown
9.6 out of 10, Exceptional, (1,005 reviews)
"Great breakfast buffet -- better than at most other hotels. Room was clean, staff was helpful and friendly. "
United States
Jennifer
The price is RM567
RM643 total
includes taxes & fees
24 May - 25 May
SpringHill Suites by Marriott Greenville Downtown

Baymont by Wyndham Easley/Greenville

Baymont by Wyndham Easley/Greenville
2.5 star property
Easley
7.4 out of 10, Good, (812 reviews)
"Fantastic place and staff most accommodating "
United States
Walter
The price is RM297
RM330 total
includes taxes & fees
28 Apr - 29 Apr
Baymont by Wyndham Easley/Greenville

The Abernathy of Clemson

The Abernathy of Clemson
4.0 star property
Clemson
9.6 out of 10, Exceptional, (593 reviews)
"Amazing hotel, amazing location. Highly recommended. "
United States
Michele
The price is RM603
RM669 total
includes taxes & fees
11 May - 12 May
The Abernathy of Clemson
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Holiday Rentals in Upstate South Carolina

Save an average of 15% on thousands of hotels when you're signed in

Stay near popular Southeastern United States attractions

Learn more about Upstate South Carolina

Check out the local area in Upstate South Carolina—home to attractions like Discovery Island Water Park and Heritage Park.

Photo by Ryan Watts
Open Photo by Ryan Watts

Top Upstate South Carolina Hotel Reviews

More cheap stays in Upstate South Carolina

Explore a world of travel with Expedia