Defiance hotels from RM315
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4 Sept - 6 SeptIn two weeks
11 Sept - 13 SeptOur top choices for Defiance hotels
1. Holiday Inn Express St. Louis West - O'Fallon by IHG
Holiday Inn Express St. Louis West - O'Fallon by IHGO'Fallon
David
RM407
RM480 total
includes taxes & fees
2 Sept - 3 Sept
2. Sleep Inn & Suites O'Fallon MO - Technology Drive
Sleep Inn & Suites O'Fallon MO - Technology DriveO'Fallon
Josh
RM330
RM389 total
includes taxes & fees
1 Sept - 2 Sept
3. The Wildwood Hotel
The Wildwood HotelWildwood
Hailey
RM355
RM414 total
includes taxes & fees
30 Sept - 1 Oct
4. TownePlace Suites by Marriott St. Louis Chesterfield
TownePlace Suites by Marriott St. Louis ChesterfieldChesterfield
Bobbi jo
RM515
RM605 total
includes taxes & fees
6 Sept - 7 Sept
5. Comfort Inn & Suites Chesterfield - St. Louis
Comfort Inn & Suites Chesterfield - St. LouisChesterfield
Joe
RM355
RM428 total
includes taxes & fees
13 Sept - 14 Sept
6. Hilton Garden Inn St. Louis/O'Fallon MO
Hilton Garden Inn St. Louis/O'Fallon MOO'Fallon
Kassie
RM492
RM583 total
includes taxes & fees
6 Sept - 7 Sept
7. Staybridge Suites O'Fallon Chesterfield by IHG
Staybridge Suites O'Fallon Chesterfield by IHGO'Fallon
Norman
RM463
RM546 total
includes taxes & fees
27 Sept - 28 Sept
8. Courtyard by Marriott St. Louis Chesterfield
Courtyard by Marriott St. Louis ChesterfieldChesterfield
Kelly
RM504
RM586 total
includes taxes & fees
6 Sept - 7 Sept
9. Residence Inn by Marriott O'Fallon
Residence Inn by Marriott O'FallonO'Fallon
Gerald
RM551
RM650 total
includes taxes & fees
20 Sept - 21 Sept
10. Hampton Inn & Suites St. Louis/Chesterfield
Hampton Inn & Suites St. Louis/ChesterfieldChesterfield
Jodi
RM442
RM515 total
includes taxes & fees
13 Sept - 14 Sept
11. Holiday Inn Express & Suites St. Louis - Chesterfield by IHG
Holiday Inn Express & Suites St. Louis - Chesterfield by IHGChesterfield
NEBAHAT
RM475
RM553 total
includes taxes & fees
13 Sept - 14 Sept
12. Hyatt Place St. Louis/Chesterfield
Hyatt Place St. Louis/ChesterfieldChesterfield
Taylor
RM471
RM546 total
includes taxes & fees
13 Sept - 14 Sept
13. Drury Plaza Hotel St. Louis Chesterfield
Drury Plaza Hotel St. Louis ChesterfieldChesterfield
Andrea T
RM523
RM607 total
includes taxes & fees
3 Sept - 4 Sept
14. Holiday Inn St. Louis West Six Flags by IHG
Holiday Inn St. Louis West Six Flags by IHGEureka
Rob
RM407
RM474 total
includes taxes & fees
21 Sept - 22 Sept
15. Comfort Inn Near Six Flags St. Louis
Comfort Inn Near Six Flags St. LouisPacific
David
RM376
RM431 total
includes taxes & fees
20 Sept - 21 Sept
16. Quality Inn Near Six Flags St. Louis
Quality Inn Near Six Flags St. LouisPacific
Diane
RM417
RM477 total
includes taxes & fees
1 Sept - 2 Sept
17. Drury Inn & Suites St. Louis St. Peters
Drury Inn & Suites St. Louis St. PetersSt. Peters
Melanie
RM443
RM509 total
includes taxes & fees
6 Sept - 7 Sept
18. Best Western Plus Washington Hotel
Best Western Plus Washington HotelWashington
Aaron
RM519
RM591 total
includes taxes & fees
6 Sept - 7 Sept
19. Residence Inn by Marriott St. Louis Chesterfield
Residence Inn by Marriott St. Louis ChesterfieldChesterfield
Tenisha
RM761
RM890 total
includes taxes & fees
5 Sept - 6 Sept
20. Hampton Inn St. Louis Wentzville
Hampton Inn St. Louis WentzvilleWentzville
Danielle
RM558
RM638 total
includes taxes & fees
20 Sept - 21 Sept
Stay near popular Defiance attractions
August A. Busch Memorial Conservation Area
8.6/10 (7 reviews)
This sprawling conservation area features over 30 lakes and historic WWII bunkers amid diverse habitats. Explore well-maintained trails while watching for migratory birds and wildlife in their natural environment.
Photo by Pages of Travel
Chandler Hill Vineyards
7.8/10 (7 reviews)
This elegant Missouri winery showcases local and California wines from its hillside setting. Savour varietals on the expansive terrace while enjoying vineyard views and seasonal cuisine from their full-service kitchen.
Historic Daniel Boone Home and Heritage Center
9.6/10 (4 reviews)
Step into the limestone home where Daniel Boone's son Nathan crafted a frontier masterpiece with seven fireplaces. Explore the surrounding historic village for an authentic glimpse into 19th-century pioneer life.
Sugar Creek Winery
8.0/10 (1 review)
Sip award-winning Missouri wines at this hillside vineyard along the scenic Katy Trail. Relax on covered decks with your own picnic while enjoying live weekend music and panoramic countryside views.
Yellow Farmhouse Winery
This boutique winery in Defiance, Missouri was known for its distinctive unfiltered wines and relaxed atmosphere. Visitors could enjoy tastings with live music while picnicking on scenic grounds with vineyard views.
Matson Hill Park Trailhead
Wander through 475 acres of rugged forest terrain with challenging hiking paths and gravity-flow mountain bike trails. The historic 1830s Hays Home offers a glimpse into pioneer life amid the natural splendour.
Broemmelsiek Park
This 494-acre natural playground offers nine miles of trails through forests and around serene lakes. Attend a monthly stargazing event at the astronomy viewing area for a uniquely celestial park experience.
Hamburg Trail Trailhead
This moderate 6.9-mile loop winds through the scenic Weldon Spring Conservation Area, connecting to the Katy Trail State Park. Spot native wildlife while traversing diverse landscapes of shaded woodlands and open fields.
Learn more about Defiance
Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighbouring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.
See all hotels in Defiance
Top Defiance Hotel Reviews
Hilton St. Louis Frontenac
10/10 Excellent
"Clean"
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
10/10 Excellent
"We stay every time we come down in a convenient area"
Hollywood Casino & Hotel St. Louis
8/10 Good
"Room was great and the bath was amazing. But the bed was very uncomfortable."
Ameristar Casino Resort and Spa
8/10 Good
"All went well room clean, staff outstanding"
Drury Inn & Suites St. Louis St. Peters
10/10 Excellent
"Excellent service, room was clean beyond expectation. Will book here again"
Hampton Inn St. Charles St. Peters
10/10 Excellent
"Nice spot to sleep"
More cheap stays in Defiance
Days Inn and Suites by Wyndham St. Louis/Westport Plaza
1970 Craig Rd Maryland Heights MO
RM274
RM317 total
1 Sept - 2 Sept
includes taxes & fees
Sleep Inn & Suites O'Fallon MO - Technology Drive
1147 Technology Drive O'Fallon MO
RM330
RM389 total
1 Sept - 2 Sept
includes taxes & fees
Best Western Plus St. Louis West-Westport
12220 Dorsett Rd Maryland Heights MO
RM356
RM413 total
6 Sept - 7 Sept
includes taxes & fees
8/10 Very good! (1,099 reviews)
Best Western Plus Fenton
1680 Fenton Business Park Ct Fenton MO
RM399
RM461 total
1 Sept - 2 Sept
includes taxes & fees
Hampton Inn St. Charles St. Peters
3720 W Clay St St. Charles MO
RM426
RM489 total
7 Sept - 8 Sept
includes taxes & fees
8/10 Very good! (1,003 reviews)
Holiday Inn Express & Suites St. Louis - Chesterfield by IHG
11 Arnage Boulevard Chesterfield MO
RM475
RM553 total
13 Sept - 14 Sept
includes taxes & fees
9/10 Wonderful! (1,002 reviews)
