Defiance hotels from RM280

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Top 10 trending Defiance hotels

Holiday Inn Express & Suites Wentzville St Louis West by IHG

2.5 star property
Wentzville
9.4 out of 10, Exceptional, (832)
"Excellent location, very clean and comfortable, great hot breakfast, and amazing staff!"
United States
Shannon
The price is RM452
RM543 total
includes taxes & fees
2 Jan - 3 Jan 2026
Holiday Inn Express & Suites Wentzville St Louis West by IHG

WoodSpring Suites St Peters-OFallon

2.5 star property
St. Peters
9.8 out of 10, Exceptional, (16)
"Very nice:) "
United States
Alicia
The price is RM304
RM350 total
includes taxes & fees
8 Dec - 9 Dec
WoodSpring Suites St Peters-OFallon

The Wildwood Hotel

3.5 star property
Wildwood
9.2 out of 10, Wonderful, (1599)
"The hotel was amazing from the staff to the rooms. Great location as well. Definitely recommend this place if traveling! "
United States
Brandi
The Wildwood Hotel

Hampton Inn St. Charles St. Peters

2.5 star property
St. Charles
8.0 out of 10, Very good, (1003)
"Great breakfast, clean room, hot tub!"
United States
Tony
The price is RM359
RM412 total
includes taxes & fees
14 Dec - 15 Dec
Hampton Inn St. Charles St. Peters

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

3.0 star property
Maryland Heights
7.4 out of 10, Good, (1003)
"Friendly staff "
United States
Keyona
The price is RM264
RM306 total
includes taxes & fees
5 Jan - 6 Jan 2026
Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

3.0 star property
Fenton
8.0 out of 10, Very good, (1029)
"Very friendly staff "
United States
Amber
The price is RM350
RM404 total
includes taxes & fees
14 Dec - 15 Dec
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Hollywood Casino & Hotel St. Louis

3.5 star property
Maryland Heights
8.4 out of 10, Very good, (2208)
"Decent room. Well priced and centrally located for out soccer tournament we were in town for"
United States
Travis
The price is RM400
RM526 total
includes taxes & fees
28 Dec - 29 Dec
Hollywood Casino & Hotel St. Louis

Courtyard by Marriott St. Louis Chesterfield

3.0 star property
Chesterfield
9.0 out of 10, Wonderful, (575)
"Very clean hotel with great staff "
United States
brad
The price is RM366
RM426 total
includes taxes & fees
26 Dec - 27 Dec
Courtyard by Marriott St. Louis Chesterfield

Comfort Inn & Suites St. Louis - O'Fallon

2.5 star property
O'Fallon
7.6 out of 10, Good, (1000)
"Great front desk experience, no issues booking same day!"
United States
Tracy
The price is RM297
RM350 total
includes taxes & fees
4 Jan - 5 Jan 2026
Comfort Inn & Suites St. Louis - O'Fallon

Hampton Inn St. Louis Wentzville

2.5 star property
Wentzville
9.0 out of 10, Wonderful, (638)
"The room was clean and quiet The staff was very nice the temperature was perfect"
United States
candice
The price is RM490
RM561 total
includes taxes & fees
2 Jan - 3 Jan 2026
Hampton Inn St. Louis Wentzville

Holiday Inn Express St. Louis West - O'Fallon by IHG

2.5 star property
O'Fallon
8.6 out of 10, Excellent, (829)
"The staff was so friendly and helpful! The hotel was exceptionally clean. Breakfast was very good with lots of variety!"
United States
Millie
The price is RM341
RM403 total
includes taxes & fees
11 Dec - 12 Dec
Holiday Inn Express St. Louis West - O'Fallon by IHG

Super 8 by Wyndham Eureka/Six Flags Nearby

2.0 star property
Eureka
7.0 out of 10, Good, (1000)
"A much needed comfortable bed and hot shower, staff was lovely. "
United States
Rachel
The price is RM250
RM291 total
includes taxes & fees
1 Jan - 2 Jan 2026
Super 8 by Wyndham Eureka/Six Flags Nearby

Baymont by Wyndham Warrenton

2.5 star property
Warrenton
7.4 out of 10, Good, (1000)
"Room very clean, most of staff helpful"
United States
Ranata
The price is RM344
RM395 total
includes taxes & fees
11 Dec - 12 Dec
Baymont by Wyndham Warrenton

Sleep Inn & Suites O'Fallon MO - Technology Drive

2.5 star property
O'Fallon
8.8 out of 10, Excellent, (1002)
"Nice breakfast, friendly staff"
United States
Damon
The price is RM359
RM423 total
includes taxes & fees
8 Dec - 9 Dec
Sleep Inn & Suites O'Fallon MO - Technology Drive

Hilton Garden Inn St. Louis/O'Fallon MO

3.0 star property
O'Fallon
8.8 out of 10, Excellent, (714)
"Clean room, quiet"
United States
Laura
The price is RM358
RM424 total
includes taxes & fees
22 Dec - 23 Dec
Hilton Garden Inn St. Louis/O'Fallon MO

Country Inn & Suites by Radisson, St. Charles Historic District

2.5 star property
St. Charles Historic District
9.4 out of 10, Exceptional, (1003)
"Love this hotel. "
United States
Lisa
The price is RM475
RM546 total
includes taxes & fees
1 Jan - 2 Jan 2026
Country Inn & Suites by Radisson, St. Charles Historic District

Quality Inn

2.5 star property
Foristell
8.2 out of 10, Very good, (903)
"Easy check in and out, the staff is very nice and professional. I would stay there any time Im in the area and need a room. Highly recommended."
United States
Ivaylo
The price is RM344
RM389 total
includes taxes & fees
21 Dec - 22 Dec
Quality Inn

Comfort Suites St Charles - St Louis

2.5 star property
St. Charles
8.4 out of 10, Very good, (1002)
"Nice staff at reception. "
United States
Denise
The price is RM362
RM416 total
includes taxes & fees
21 Dec - 22 Dec
Comfort Suites St Charles - St Louis

Best Western Plus Fenton

2.5 star property
Fenton
9.2 out of 10, Wonderful, (168)
"Clean room, nice staff, great food, and great service "
United States
Thuy
The price is RM436
RM504 total
includes taxes & fees
9 Dec - 10 Dec
Best Western Plus Fenton

Holiday Inn St. Louis West Six Flags by IHG

3.0 star property
Eureka
9.0 out of 10, Wonderful, (1002)
"Great place to stay"
United States
John
The price is RM444
RM517 total
includes taxes & fees
15 Dec - 16 Dec
Holiday Inn St. Louis West Six Flags by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Defiance attractions

Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighbouring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

A covered bridge at the Historic Daniel Boone Home Park in Defiance, Missouri

Top Defiance Hotel Reviews

More cheap stays in Defiance

Frequently asked questions

What's the best place to stay in Defiance?
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham, located 17.9 mi (28.8 km) from the heart of Defiance, is a top choice for your stay, based on our traveller data. Two other options for your visit to the area are Hollywood Casino & Hotel St. Louis and The Wildwood Hotel. See all available top hotels, or vacation rentals in Defiance.
If I need to cancel my hotel reservation in Defiance, will I receive a refund?
Yes! The majority of room reservations are fully refundable if you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you have a reservation that's non-refundable, you might be able to cancel it and receive a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Defiance.
What are some accommodation options with pools in Defiance?
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham: Features an indoor pool, an outdoor pool and buffet. The Wildwood Hotel and Ameristar Casino Resort and Spa are two additional hotels with an on-site pool. View all hotels with pools in Defiance.
How is it staying in Defiance?
Visitors can enjoy all that Defiance has to offer, including the wineries and parks. Top sights in the area include St. Louis Union Station and Gateway Arch. In Defiance, there are 20 hotels and other accommodation options to choose from. Find out more about Defiance.
What should I do while I'm visiting Defiance?
Natural beauty is on display at Matson Hill Park Trailhead, August A. Busch Memorial Conservation Area and Missouri River. A couple of additional sights to add to your itinerary are Yellow Farmhouse Winery and Chandler Hill Vineyards. Take a look at what more there is to see and do in Expedia's Defiance guide.
What's the weather like in Defiance?
The hottest months are usually July and August, with an average temperature of 24°C, while the coldest months are January and February, with an average of 3°C. Average annual precipitation for Defiance is 1228 mm.