Best Luxury Hotels in Southern Indiana

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check availability on Southern Indiana Luxury Hotels

Our top choices for Southern Indiana luxury hotels

The Grady

The Grady
4.0 star property
Downtown Louisville
9.4 out of 10, Exceptional, (1,003 reviews)
"Such an amazing hotel...restaurant is delicious! "
United States
Craig
The price is RM588
RM692 total
includes taxes & fees
1 Feb - 2 Feb
The Grady

The Brown Hotel

The Brown Hotel
4.5 star property
Downtown Louisville
9.4 out of 10, Exceptional, (1,171 reviews)
"Very beautiful facility and great location "
United States
Anthony
The Brown Hotel

Hotel Distil, Autograph Collection

Hotel Distil, Autograph Collection
4.0 star property
Downtown Louisville
9.6 out of 10, Exceptional, (439 reviews)
"Exceptionally handsome hotel design, extraordinary restaurant and service, fantastic location. "
United States
Carol
The price is RM746
RM878 total
includes taxes & fees
8 Feb - 9 Feb
Hotel Distil, Autograph Collection

21c Museum Hotel Louisville

21c Museum Hotel Louisville
4.5 star property
Downtown Louisville
9.4 out of 10, Exceptional, (1,001 reviews)
"Location and the staff was fabulous."
United States
Madeline
The price is RM568
RM689 total
includes taxes & fees
25 Jan - 26 Jan
21c Museum Hotel Louisville

Omni Louisville Hotel

Omni Louisville Hotel
4.0 star property
Downtown Louisville
9.2 out of 10, Wonderful, (1,764 reviews)
"Beautiful, spacious hotel. Spotless room, kind and helpful staff."
United States
Gizella
The price is RM678
RM797 total
includes taxes & fees
25 Jan - 26 Jan
Omni Louisville Hotel

Louisville Marriott Downtown

Louisville Marriott Downtown
4.0 star property
Downtown Louisville
9.0 out of 10, Wonderful, (1,000 reviews)
"Very nice hotel. Great stay!"
United States
Brad
The price is RM728
RM857 total
includes taxes & fees
8 Feb - 9 Feb
Louisville Marriott Downtown

Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham
4.0 star property
Downtown Louisville
9.0 out of 10, Wonderful, (4,005 reviews)
"Great hotel"
United States
Lazaro
The price is RM548
RM645 total
includes taxes & fees
27 Jan - 28 Jan
Galt House Hotel Trademark Collection by Wyndham

Hotel Bourré Bonne Louisville, Curio Collection by Hilton

Hotel Bourré Bonne Louisville, Curio Collection by Hilton
4.0 star property
Downtown Louisville
9.2 out of 10, Wonderful, (67 reviews)
"Amazing property! Best hotel in Louisville! Will be staying there again!"
United States
Norman
The price is RM683
RM804 total
includes taxes & fees
26 Jan - 27 Jan
Hotel Bourré Bonne Louisville, Curio Collection by Hilton

Hyatt Regency Louisville

Hyatt Regency Louisville
4.0 star property
Downtown Louisville
8.8 out of 10, Excellent, (1,003 reviews)
"Great hotel close to 4th street. Overall nice stay. "
United States
Collin
The price is RM548
RM645 total
includes taxes & fees
31 Jan - 1 Feb
Hyatt Regency Louisville

Seelbach Hilton Louisville Downtown

Seelbach Hilton Louisville Downtown
4.0 star property
Downtown Louisville
8.6 out of 10, Excellent, (1,002 reviews)
"The area was congested but the motel was good. "
United States
Byrd
The price is RM595
RM700 total
includes taxes & fees
3 Feb - 4 Feb
Seelbach Hilton Louisville Downtown
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Southern Indiana Hotel Reviews

Explore a world of travel with Expedia