Photo by Southernmost Illinois Tourism Bureau
Southern Illinois Spa Hotels
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Check availability on Southern Illinois Hotels with Spa
Our top choices for Southern Illinois hotels with a spa
9.4 out of 10, Exceptional, (490 reviews)
- Luxurious spa retreat with hot stone massages, sauna, and seasonal pools awaits at this casino resort with attentive staff and fine dining.
The price is RM588
RM653 total
includes taxes & fees
16 Aug - 17 Aug
2. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHGCape Girardeau
9.4 out of 10, Exceptional, (1,001 reviews)
- Luxurious spa sanctuary awaits with full-service treatments and indoor pool in this centrally located hotel.
The price is RM449
RM507 total
includes taxes & fees
6 Aug - 7 Aug
The price is RM490
RM544 total
includes taxes & fees
10 Aug - 11 Aug
8.6 out of 10, Excellent, (1,025 reviews)
- Riverside wellness oasis offers full-service spa with aromatherapy and hydrotherapy for a restorative retreat.
The price is RM604
RM773 total
includes taxes & fees
16 Aug - 17 Aug
9.0 out of 10, Wonderful, (2,017 reviews)
- Discover spa services, a steam room, and an Olympic-sized indoor pool at this modern hotel, all designed for rejuvenating getaways.
The price is RM587
RM707 total
includes taxes & fees
24 Aug - 25 Aug
9.4 out of 10, Exceptional, (1,002 reviews)
- Discover a tranquil haven with 12 treatment rooms, outdoor pool, and breathtaking views at this rejuvenating spa retreat.
The price is RM1,532
RM1,791 total
includes taxes & fees
2 Aug - 3 Aug
9.2 out of 10, Wonderful, (435 reviews)
- Unwind in a Victorian sanctuary with relaxing reflexology and soothing hydrotherapy treatments for total rejuvenation.
The price is RM794
RM1,074 total
includes taxes & fees
9 Aug - 10 Aug
9.2 out of 10, Wonderful, (577 reviews)
- Revel in a rejuvenating spa retreat with aromatherapy treatments and hot stone massages at this luxury St. Louis hotel.
The price is RM2,488
RM2,905 total
includes taxes & fees
7 Aug - 8 Aug
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top Southern Illinois Hotel Reviews
Drury Plaza Hotel Mt. Vernon
10/10 Excellent
Explore a world of travel with Expedia
- 5 Star Hotels in Marissa
- Aviston Hotels
- Breese Hotels
- Hotels with smoking rooms in Carbondale
- Centralia Hotels
- Budget Hotels in Williamson County
- Fairfield Hotels
- Cabin Rentals in Franklin County
- Greenville Hotels
- Highland Hotels
- Lebanon Hotels
- Makanda Hotels
- Marion Hotels
- Marissa Hotels
- Noble Hotels
- Sesser Hotels
- Sims Hotels
- Cabin Rentals in Southern Illinois
- Hotels with Views in Southern Illinois
- Hotels near Sparta Country Club
- Flights to Ava
- Flights to Scott Air Force Base
- Flights from Southern Illinois
- Flights from Makanda
- Flights from Bangkok (BKK) to Marion (MWA)
- Flights from Cody (COD) to Marion (MWA)
- Flights from Evansville (EVV) to Marion (MWA)
- Flights from Spokane (GEG) to Carbondale (MDH)
- Flights from Terre Haute (HUF) to Carbondale (MDH)
- Flights from Wilmington (ILM) to Belleville (BLV)
- Flights from Streaky Bay (KBY) to Marion (MWA)
- Flights from Midland (MAF) to Carbondale (MDH)
- Flights from Myrtle Beach (MYR) to Marion (MWA)
- Flights from Pensacola (PNS) to Marion (MWA)
- Flights from Reno (RNO) to Marion (MWA)
- Flights from Sheridan (SHR) to Marion (MWA)
- Flights from St. Louis (STL) to Carbondale (MDH)
- Flights from Knoxville (TYS) to Carbondale (MDH)
- Alvin Musgrove Park
- Ava Holidays
- Carmi Holidays
- Visit Carmi
- Ferne Clyffe State Park
- Grayville City Hall
- Heartland Regional Medical Center
- Herald Holidays
- Hogg Hollow Winery
- Ina Holidays
- Visit Ina
- Mascoutah Holidays
- Odin Holidays
- Rend Lake
- Salem Holidays
- Scott Air Force Base
- Shawnee National Forest
- Sih Medical Group
- Visit Vandalia
- Williamson County Fairgrounds