Hotels in South Main, Houston

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Our top choices for South Main hotels

Wyndham Houston near NRG Park/Medical Center

Wyndham Houston near NRG Park/Medical Center
3.5 star property
South Main
7.0 out of 10, Good, (1,249 reviews)
"Property was nice. "
United States
Judson
The price is RM353
RM413 total
includes taxes & fees
24 Mar - 25 Mar
Wyndham Houston near NRG Park/Medical Center

Comfort Suites Houston near Medical Center- NRG Stadium

Comfort Suites Houston near Medical Center- NRG Stadium
2.5 star property
South Main
8.6 out of 10, Excellent, (1,003 reviews)
"Great location if you’re headed to NRG, room was very clean. Good for an overnight "
United States
Daisy
The price is RM368
RM431 total
includes taxes & fees
31 Mar - 1 Apr
Comfort Suites Houston near Medical Center- NRG Stadium

Candlewood Suites Houston Medical Center by IHG

Candlewood Suites Houston Medical Center by IHG
2.5 star property
South Main
7.4 out of 10, Good, (842 reviews)
"Room was clean. It had a musty smell though. "
United States
Ryan
The price is RM307
RM359 total
includes taxes & fees
5 Apr - 6 Apr
Candlewood Suites Houston Medical Center by IHG

Wingate Houston near NRG Park/Medical Center

Wingate Houston near NRG Park/Medical Center
3.0 star property
South Main
6.6 out of 10, (1,001 reviews)
"Great location"
United States
Jeremy
The price is RM309
RM362 total
includes taxes & fees
5 Apr - 6 Apr
Wingate Houston near NRG Park/Medical Center

Quality Inn & Suites NRG Park - Medical Center

Quality Inn & Suites NRG Park - Medical Center
2.5 star property
South Main
6.6 out of 10, (1,004 reviews)
"Courteous staff, clean room, quite property"
United States
Javier
The price is RM257
RM301 total
includes taxes & fees
5 Apr - 6 Apr
Quality Inn & Suites NRG Park - Medical Center

Hotel Royale

Hotel Royale
2.0 star property
20.9 km from South Main
9.2 out of 10, Wonderful, (17 reviews)
"Hotel is new and clean. Linens and trash were taken care of daily. Close to plenty of food options. Would stay again."
United States
Antonette
The price is RM317
RM371 total
includes taxes & fees
23 Mar - 24 Mar
Hotel Royale

Palace Inn Blue Edgebrook

Palace Inn Blue Edgebrook
3.0 star property
16.8 km from South Main
9.4 out of 10, Exceptional, (158 reviews)
"Nice place to stay"
United States
Bella
The price is RM428
RM516 total
includes taxes & fees
23 Mar - 24 Mar
Palace Inn Blue Edgebrook

Best Western Plus Pearland/Houston Medical Center Hotel

Best Western Plus Pearland/Houston Medical Center Hotel
2.5 star property
Southeast Houston, 10.2 km from South Main
9.2 out of 10, Wonderful, (179 reviews)
"Yes very great place"
United States
Lloyd
The price is RM349
RM408 total
includes taxes & fees
23 Mar - 24 Mar
Best Western Plus Pearland/Houston Medical Center Hotel

Crystal Inn - NorthWest - 290

Crystal Inn - NorthWest - 290
2.0 star property
24.8 km from South Main
9.8 out of 10, Exceptional, (39 reviews)
"The best hotel I’ve been in excellent rooms perfect customer service rooms are phenomenal"
United States
Michael
The price is RM420
RM483 total
includes taxes & fees
23 Mar - 24 Mar
Crystal Inn - NorthWest - 290

Holiday Inn Express Hotel & Suites - Houston Space Center by IHG

Holiday Inn Express Hotel & Suites - Houston Space Center by IHG
2.5 star property
30.8 km from South Main
9.0 out of 10, Wonderful, (1,002 reviews)
"Hotel is near the mall and super clean. "
United States
Isaiah
The price is RM349
RM408 total
includes taxes & fees
29 Mar - 30 Mar
Holiday Inn Express Hotel & Suites - Houston Space Center by IHG

Doubletree by Hilton Houston Hobby Airport

Doubletree by Hilton Houston Hobby Airport
4.0 star property
Southeast Houston, 14.5 km from South Main
8.8 out of 10, Excellent, (1,000 reviews)
"Great food at the bar. "
United States
Markus
The price is RM414
RM490 total
includes taxes & fees
5 Apr - 6 Apr
Doubletree by Hilton Houston Hobby Airport

Hilton Houston North

Hilton Houston North
3.5 star property
30.5 km from South Main
8.2 out of 10, Very good, (1,000 reviews)
"Very convenient location, clean, and staff was exceptional "
United States
Shatoria
The price is RM443
RM518 total
includes taxes & fees
4 Apr - 5 Apr
Hilton Houston North

Hampton Inn & Suites Houston-Bush Intercontinental Aprt

Hampton Inn & Suites Houston-Bush Intercontinental Aprt
3.0 star property
31.8 km from South Main
8.8 out of 10, Excellent, (1,804 reviews)
"Nice places to stay while waiting for our next flight"
Canada
Patricia
The price is RM374
RM440 total
includes taxes & fees
13 Apr - 14 Apr
Hampton Inn & Suites Houston-Bush Intercontinental Aprt

Courtyard by Marriott Houston Intercontinental Airport

Courtyard by Marriott Houston Intercontinental Airport
3.0 star property
31.8 km from South Main
9.0 out of 10, Wonderful, (1,180 reviews)
"Enjoyed my stay!"
United States
Chelsea Renee
The price is RM465
RM544 total
includes taxes & fees
5 Apr - 6 Apr
Courtyard by Marriott Houston Intercontinental Airport

Tru by Hilton Houston Webster NASA

Tru by Hilton Houston Webster NASA
2.5 star property
30.7 km from South Main
9.0 out of 10, Wonderful, (1,000 reviews)
"Clean room, comfortable feeling, great staff "
United States
Jennifer
The price is RM315
RM369 total
includes taxes & fees
29 Mar - 30 Mar
Tru by Hilton Houston Webster NASA

Moxy Houston Downtown

Moxy Houston Downtown
3.0 star property
Downtown Houston, 11.2 km from South Main
8.8 out of 10, Excellent, (828 reviews)
"Great location wonderful staff"
United States
lakira
The price is RM388
RM463 total
includes taxes & fees
29 Mar - 30 Mar
Moxy Houston Downtown

Best Western Plus Manvel Inn & Suites

Best Western Plus Manvel Inn & Suites
2.5 star property
22.6 km from South Main
8.8 out of 10, Excellent, (768 reviews)
"This location has a gym, hot tub, and pool. The staff are all very courteous and helpful. The room was exceptionally clean and comfortable. I will definitely visit this location again."
United States
David
The price is RM313
RM354 total
includes taxes & fees
12 Apr - 13 Apr
Best Western Plus Manvel Inn & Suites

SpringHill Suites by Marriott Houston Intercontinental Arprt

SpringHill Suites by Marriott Houston Intercontinental Arprt
3.0 star property
31.8 km from South Main
9.0 out of 10, Wonderful, (1,688 reviews)
"wonderful stay "
United States
Stepfan
The price is RM430
RM503 total
includes taxes & fees
2 Apr - 3 Apr
SpringHill Suites by Marriott Houston Intercontinental Arprt

La Quinta Inn & Suites by Wyndham Houston Bush IAH South

La Quinta Inn & Suites by Wyndham Houston Bush IAH South
3.0 star property
31.2 km from South Main
8.2 out of 10, Very good, (1,672 reviews)
"The staff was very helpful and made our stay enjoyable."
United States
cynthia
The price is RM338
RM395 total
includes taxes & fees
15 Apr - 16 Apr
La Quinta Inn & Suites by Wyndham Houston Bush IAH South

Palace Inn Blue Houston East Beltway 8

Palace Inn Blue Houston East Beltway 8
2.5 star property
Northeast Houston, 29.5 km from South Main
9.0 out of 10, Wonderful, (375 reviews)
"Second time staying at this hotel, very friendly staff and clean rooms. Close to the highway, restaurants and movie theater. "
United States
KENDRA
The price is RM300
RM345 total
includes taxes & fees
2 Apr - 3 Apr
Palace Inn Blue Houston East Beltway 8
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Compare popular hotels in South Main

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
Individually decorated, individually furnished, desk, laptop workspace
Comfort Suites Houston near Medical Center- NRG Stadium
2.5 star property
8.6
Excellent
1,003 reviews
View
Premium bedding, pillow-top beds, in-room safe, individually decorated
Wyndham Houston near NRG Park/Medical Center
3.5 star property
7.0
Good
1,249 reviews
View
Lobby
Wingate Houston near NRG Park/Medical Center
3.0 star property
6.6
1,001 reviews
View
Hypo-allergenic bedding, in-room safe, individually decorated
Quality Inn & Suites NRG Park - Medical Center
2.5 star property
6.6
1,004 reviews
View
Room
Comfort Suites Near Texas Medical Center - NRG Stadium
2.0 star property
9.0
Wonderful
6 reviews
View

Where to stay in South Main

Find the best South Main areas for the activities you enjoy most.

Downtown Houston

Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.

The Galleria

Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.

Texas Medical Center

Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

Montrose

Unique features of Montrose include the theatres and museums. Make a stop by Menil Collection or Rothko Chapel while you're exploring the area.

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Downtown Transit Center Station.

Top South Main Hotel Reviews

Frequently asked questions

What is South Main like?
You'll be sure to have fun exploring Houston's South Main neighbourhood. Consider a visit to NRG Park as part of your South Main travel plans.
Where is the best hotel for a stay in South Main?
Based on Expedia customer reviews, Comfort Suites Houston near Medical Center- NRG Stadium is the highest ranked property in South Main. This hotel is a short 10-minute walk from NRG Stadium, and it offers free breakfast and a fitness centre. Other top choices in the neighbourhood include Candlewood Suites Houston Medical Center by IHG and Quality Inn & Suites NRG Park - Medical Center.
How many hotels should I expect to find in South Main?
If you're searching for places to stay in Houston, Expedia has something to meet your needs with 65 South Main hotels and other accommodation options to choose from.
If I need to cancel my hotel reservation in South Main, will I receive a refund?
Yes, you'll find most hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If you booked a non-refundable reservation, it may still be possible to cancel it and be given a refund within 24 hours of your booking. Add your dates and click on "Search", then filter by "fully refundable" to get the best options available in South Main.
What can I see and do in this Houston neighbourhood?
NRG Park is an attraction you might want to check out while you're in South Main. While you're out sightseeing in Houston, make sure that you visit other sights such as NRG Stadium or NRG Arena.
How can I get around South Main and the greater Houston area?
Ready to get out and explore the city? Fannin South Station is the closest metro station.

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