San Francisco hotels from

Hotel Mykonos Panama, located 10.4 mi (16.8 km) from the heart of San Francisco, is a top choice for your stay, based on our traveller data. Other good options for your stay in the area are Hotel Gran David and Hotel Galería. See all available top hotels, or vacation rentals in San Francisco.

Yes! You'll find that most room reservations are refundable if you cancel before the hotel’s cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you booked a non-refundable reservation, you might be able to still cancel and receive a refund within 24 hours of booking. Filter your search by fully refundable to find flexible hotel deals in San Francisco.

Visitors to San Francisco will definitely find plenty to explore and enjoy. There are 16 hotels and other accommodation options in the surrounding area. Find out more about San Francisco.

Places to visit in the wider area include Parque Acuatico Italia Guadalupe Panama, Laguna de La Yeguada and Parque Nacional Cerro Hoya. You'll also find Catedral of Santiago Apostol and Los Pozos Termales in the area. Take a look at what more there is to see and do in Expedia's San Francisco guide.

The hottest months are usually March and April, with an average temperature of 27°C, while the coldest months are January and December, with an average of 25°C. The rainiest months in San Francisco are October, August, June and November, with each month seeing an average of 447 mm of rainfall.