Hotels in Penrose, St. Louis

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31 Dec - 1 Jan
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Our top choices for Penrose hotels

Exterior
Comfort Suites St Charles - St Louis

Comfort Suites St Charles - St Louis

Comfort Suites St Charles - St Louis
2.5 star property
24.2 km from Penrose
8.4 out of 10, Very good, (1001)
"Nice staff at reception. "
United States
Denise
The price is RM310
RM356 total
includes taxes & fees
11 Jan - 12 Jan 2026
Comfort Suites St Charles - St Louis
Lobby
Drury Plaza Hotel St. Louis St. Charles

Drury Plaza Hotel St. Louis St. Charles

Drury Plaza Hotel St. Louis St. Charles
3.0 star property
24 km from Penrose
9.6 out of 10, Exceptional, (1000)
"Staff and hotel were amazing"
United States
Allison
The price is RM466
RM540 total
includes taxes & fees
25 Jan - 26 Jan 2026
Drury Plaza Hotel St. Louis St. Charles
Lobby
Embassy Suites by Hilton St. Louis St. Charles

Embassy Suites by Hilton St. Louis St. Charles

Embassy Suites by Hilton St. Louis St. Charles
3.5 star property
25 km from Penrose
8.8 out of 10, Excellent, (1000)
"Breakfast was excellent along with clean comfortable beds. "
United States
Scott
The price is RM496
RM570 total
includes taxes & fees
11 Jan - 12 Jan 2026
Embassy Suites by Hilton St. Louis St. Charles
Premium bedding, pillow-top beds, in-room safe, desk
Best Western Plus The Charles Hotel

Best Western Plus The Charles Hotel

Best Western Plus The Charles Hotel
3.0 star property
24.4 km from Penrose
8.2 out of 10, Very good, (1009)
"Clean room, great stay"
United States
Becky
The price is RM371
RM431 total
includes taxes & fees
1 Jan - 2 Jan 2026
Best Western Plus The Charles Hotel
Free daily buffet breakfast
Country Inn & Suites by Radisson, St. Charles Historic District

Country Inn & Suites by Radisson, St. Charles Historic District

Country Inn & Suites by Radisson, St. Charles Historic District
2.5 star property
23.9 km from Penrose
9.4 out of 10, Exceptional, (1000)
"Everything was great!"
United States
Rita
The price is RM427
RM490 total
includes taxes & fees
25 Jan - 26 Jan 2026
Country Inn & Suites by Radisson, St. Charles Historic District
Premium bedding, desk, iron/ironing board, free cots/infant beds
Super 8 by Wyndham St Charles

Super 8 by Wyndham St Charles

Super 8 by Wyndham St Charles
2.0 star property
28.5 km from Penrose
8.0 out of 10, Very good, (1002)
"I'd stay at this place again. "
United States
Suzanne
The price is RM306
RM352 total
includes taxes & fees
11 Jan - 12 Jan 2026
Super 8 by Wyndham St Charles
Lobby
Tru by Hilton St. Charles St. Louis, MO

Tru by Hilton St. Charles St. Louis, MO

Tru by Hilton St. Charles St. Louis, MO
2.5 star property
24.2 km from Penrose
8.6 out of 10, Excellent, (776)
"Room was wonderful great location"
United States
Sandra
The price is RM428
RM496 total
includes taxes & fees
11 Jan - 12 Jan 2026
Tru by Hilton St. Charles St. Louis, MO
Exterior
Hampton Inn St. Charles St. Peters

Hampton Inn St. Charles St. Peters

Hampton Inn St. Charles St. Peters
2.5 star property
30.5 km from Penrose
8.0 out of 10, Very good, (1000)
"very friendly staff and good location "
United States
Heather
The price is RM363
RM417 total
includes taxes & fees
11 Jan - 12 Jan 2026
Hampton Inn St. Charles St. Peters
Desk, blackout curtains, iron/ironing board, free cots/infant beds
Drury Inn & Suites St. Louis Fairview Heights

Drury Inn & Suites St. Louis Fairview Heights

Drury Inn & Suites St. Louis Fairview Heights
3.0 star property
23.5 km from Penrose
9.2 out of 10, Wonderful, (1005)
"Great stay"
United States
Marlin
The price is RM381
RM430 total
includes taxes & fees
25 Jan - 26 Jan 2026
Drury Inn & Suites St. Louis Fairview Heights
Blackout curtains, free WiFi, bed sheets
Red Lion Inn & Suites Pontoon Beach

Red Lion Inn & Suites Pontoon Beach

Red Lion Inn & Suites Pontoon Beach
2.5 star property
17.4 km from Penrose
7.8 out of 10, Good, (583)
"Yes, very good, yes good breakfast, yes truck parking."
United States
mark
The price is RM237
RM268 total
includes taxes & fees
1 Jan - 2 Jan 2026
Red Lion Inn & Suites Pontoon Beach
Lobby
Best Western St. Louis-Kirkwood Route 66

Best Western St. Louis-Kirkwood Route 66

Best Western St. Louis-Kirkwood Route 66
3.5 star property
19.4 km from Penrose
8.4 out of 10, Very good, (1379)
"Great place and a great value"
United States
Dennis
The price is RM382
RM447 total
includes taxes & fees
4 Jan - 5 Jan 2026
Best Western St. Louis-Kirkwood Route 66
Desk, laptop workspace, blackout curtains, iron/ironing board
Sonesta Simply Suites St Louis Earth City

Sonesta Simply Suites St Louis Earth City

Sonesta Simply Suites St Louis Earth City
2.0 star property
20.8 km from Penrose
8.6 out of 10, Excellent, (807)
"Friendly staff"
United States
Robert
The price is RM324
RM372 total
includes taxes & fees
25 Jan - 26 Jan 2026
Sonesta Simply Suites St Louis Earth City
Exterior
The Principal Hotel

The Principal Hotel

The Principal Hotel
3.5 star property
26.5 km from Penrose
9.8 out of 10, Exceptional, (195)
"Great place. Very nice rooms, new and clean."
United States
Jeff
The price is RM457
RM507 total
includes taxes & fees
4 Jan - 5 Jan 2026
The Principal Hotel
Lobby
Pear Tree Inn St. Louis Airport

Pear Tree Inn St. Louis Airport

Pear Tree Inn St. Louis Airport
2.5 star property
13.3 km from Penrose
9.4 out of 10, Exceptional, (2769)
"Very clean and will definitely stay there again next time!"
United States
Tonya
The price is RM364
RM429 total
includes taxes & fees
4 Jan - 5 Jan 2026
Pear Tree Inn St. Louis Airport
Meeting facility
Motel 6 Hazelwood, MO

Motel 6 Hazelwood, MO

Motel 6 Hazelwood, MO
2.0 star property
16.7 km from Penrose
8.4 out of 10, Very good, (1650)
"Great stay!"
United States
Ambrose
The price is RM242
RM296 total
includes taxes & fees
21 Jan - 22 Jan 2026
Motel 6 Hazelwood, MO
Casino
Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa
4.5 star property
23.6 km from Penrose
8.4 out of 10, Very good, (1001)
"Clean room, wonderful helpful pleasant staff, amenities, everything was great love staying here!"
United States
Robyn
The price is RM725
RM915 total
includes taxes & fees
11 Jan - 12 Jan 2026
Ameristar Casino Resort and Spa
Lobby
Drury Inn & Suites St. Louis Collinsville

Drury Inn & Suites St. Louis Collinsville

Drury Inn & Suites St. Louis Collinsville
3.0 star property
19.8 km from Penrose
9.6 out of 10, Exceptional, (1005)
"Nice to have food and drinks provided "
United States
MICHAEL
The price is RM398
RM457 total
includes taxes & fees
11 Jan - 12 Jan 2026
Drury Inn & Suites St. Louis Collinsville
Terrace/patio
Hampton Inn St. Louis - Columbia

Hampton Inn St. Louis - Columbia

Hampton Inn St. Louis - Columbia
2.5 star property
26.3 km from Penrose
8.6 out of 10, Excellent, (476)
"Breakfast was great and a very good atten"
United States
John
The price is RM398
RM442 total
includes taxes & fees
18 Jan - 19 Jan 2026
Hampton Inn St. Louis - Columbia
Lobby
Drury Inn & Suites Southwest St. Louis

Drury Inn & Suites Southwest St. Louis

Drury Inn & Suites Southwest St. Louis
3.0 star property
27.3 km from Penrose
9.4 out of 10, Exceptional, (1007)
"Great stay"
United States
Stuart
The price is RM466
RM545 total
includes taxes & fees
18 Jan - 19 Jan 2026
Drury Inn & Suites Southwest St. Louis
Lobby sitting area
Best Western Plus Pontoon Beach

Best Western Plus Pontoon Beach

Best Western Plus Pontoon Beach
3.0 star property
16.3 km from Penrose
8.6 out of 10, Excellent, (806)
"Staff and very nice, good breakfast, soft bed…. I would definitely stay again "
United States
LaSonya
The price is RM347
RM385 total
includes taxes & fees
4 Jan - 5 Jan 2026
Best Western Plus Pontoon Beach
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Penrose

Find the best Penrose areas for the activities you enjoy most.

Downtown St. Louis

Gourmet restaurants beloved sports teams and top sights from Busch Stadium to Gateway Arch National Park – discover Downtown St. Louis, a destination also famous for its historic sites.

Berkeley

Visitors highly recommend Berkeley for its abundant dining options, and you can make a stop by James S. McDonnell Prologue Room while you're in town.

Clayton

Take time in Clayton to visit attractions like Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center. You might also appreciate the abundant dining options, and you can hop on the metro at Clayton Station to see more of the city.

St. Charles Historic District

St. Charles Historic District is known for its ample dining options, and you can make a stop by Historic Main Street and Missouri River while in the area.

St. Louis featuring interior views

Downtown West

While visiting Downtown West, you might make a stop by sights like St. Louis Union Station and St. Louis Aquarium at Union Station.

Top Penrose Hotel Reviews

Pear Tree Inn St. Louis Airport

Pear Tree Inn St. Louis Airport

10/10 Excellent
"Everything was very clean! The staff was very helpful and friendly! Hot breakfast! A few minutes from the airport! "
Zen 1-night trip
Posted 13 hours ago
Pear Tree Inn St. Louis Airport

Frequently asked questions

What's it like in Penrose?
Travellers are sure to enjoy a stay in St. Louis's Penrose neighbourhood. Consider a visit to Julia Davis Branch Library as part of your Penrose travel plans.
If I need to cancel my hotel reservation in Penrose, will I receive a refund?
Yes! The majority of room reservations are refundable if you cancel before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of check in. If your reservation is non-refundable, you might still have the option to cancel and receive a refund within 24 hours of your booking. Put your dates in and click on "Search", then filter by "fully refundable" to get top deals in Penrose.
What is there to do around this St. Louis neighbourhood?
Julia Davis Branch Library is an attraction you might want to check out while you're in Penrose. Shelley House and Bellefontaine Cemetery are also worth a visit when you're out sightseeing in St. Louis.