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Hotels near Mississippi River

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Top 10 Hotels Near Mississippi River

Balcony
River's Edge Motel

River's Edge Motel

2.0 star property
13.6 km from Mississippi River
9.0 out of 10, Wonderful, (354)
"Staff was really nice and helpful."
United States
rhonda
The price is RM331
RM375 total
includes taxes & fees
11 Dec - 12 Dec
River's Edge Motel
Interior
The Eagles Nest Inn

The Eagles Nest Inn

3.0 star property
14.2 km from Mississippi River
9.4 out of 10, Exceptional, (19)
"The room was great. Large and attractive!! Nice bathroom. Had all the convenience you need from TV to mini frig. "
United States
Judith
The price is RM395
RM449 total
includes taxes & fees
4 Dec - 5 Dec
The Eagles Nest Inn
Desk, laptop workspace, iron/ironing board, free WiFi
Baymont by Wyndham Hannibal

Baymont by Wyndham Hannibal

2.5 star property
26.3 km from Mississippi River
6.4 out of 10, (734)
" There actually was a pool & there actually was a hot breakfast. It didn't just say there was & not have what was listed. One of the best we've been to as of late. Would stay again if in the area. "
United States
Thomas
The price is RM246
RM284 total
includes taxes & fees
2 Jan - 3 Jan 2026
Baymont by Wyndham Hannibal
55-inch TV with cable channels, Netflix, Hulu
Riverside Inn Hannibal

Riverside Inn Hannibal

2.5 star property
25.1 km from Mississippi River
9.4 out of 10, Exceptional, (164)
"Great place to stay!"
United States
Sandy
The price is RM609
RM842 total
includes taxes & fees
6 Dec - 7 Dec
Riverside Inn Hannibal
Indoor pool, seasonal outdoor pool, pool umbrellas, pool loungers
Best Western On The River

Best Western On The River

2.5 star property
25.3 km from Mississippi River
8.6 out of 10, Excellent, (1001)
"The staff were friendly and very helpful and the room was clean and comfortable."
United States
Todd
The price is RM422
RM484 total
includes taxes & fees
2 Jan - 3 Jan 2026
Best Western On The River
Desk, iron/ironing board, free WiFi, bed sheets
Super 8 by Wyndham O'Fallon MO/St. Louis Area

Super 8 by Wyndham O'Fallon MO/St. Louis Area

2.0 star property
90.7 km from Mississippi River
6.8 out of 10, (991)
"Clean room and amazing staff"
United States
Michael
The price is RM288
RM340 total
includes taxes & fees
31 Dec - 1 Jan 2026
Super 8 by Wyndham O'Fallon MO/St. Louis Area
Lobby
Economy Inn Wentzville

Economy Inn Wentzville

2.0 star property
86.8 km from Mississippi River
6.4 out of 10, (499)
"The Building has a nice exterior"
United States
Christopher
The price is RM248
RM281 total
includes taxes & fees
4 Dec - 5 Dec
Economy Inn Wentzville
Exterior
Sleep Inn & Suites Hannibal West

Sleep Inn & Suites Hannibal West

2.5 star property
30.3 km from Mississippi River
9.6 out of 10, Exceptional, (1000)
"great stay!"
United States
Guy
The price is RM418
RM484 total
includes taxes & fees
28 Dec - 29 Dec
Sleep Inn & Suites Hannibal West
Lobby
Relax Inn Saint Charles

Relax Inn Saint Charles

2.0 star property
98 km from Mississippi River
6.6 out of 10, (1000)
"Great place to stay "
United States
Askar
The price is RM260
RM299 total
includes taxes & fees
17 Dec - 18 Dec
Relax Inn Saint Charles
Lobby
Days Inn by Wyndham St Peters/St Charles

Days Inn by Wyndham St Peters/St Charles

2.0 star property
93.8 km from Mississippi River
6.4 out of 10, (1000)
"Staff was very friendly. Room was kept clean."
United States
Sandra
The price is RM256
RM295 total
includes taxes & fees
21 Dec - 22 Dec
Days Inn by Wyndham St Peters/St Charles
Front of property
Garden House Bed and Breakfast

Garden House Bed and Breakfast

2.0 star property
25.2 km from Mississippi River
8.6 out of 10, Excellent, (35)
"Overall stay was great and the host chris is great aswell nothing bad to say about any aspect of our stay!"
United States
Josh
The price is RM315
RM362 total
includes taxes & fees
4 Dec - 5 Dec
Garden House Bed and Breakfast
Down duvets, blackout curtains, iron/ironing board, free WiFi
Lighthouse Inn & Suites

Lighthouse Inn & Suites

4.0 star property
25.8 km from Mississippi River
8.8 out of 10, Excellent, (23)
"Very nice room, close enough to walk to riverfront attractions. "
United States
Robert
The price is RM698
RM802 total
includes taxes & fees
4 Dec - 5 Dec
Lighthouse Inn & Suites
Lobby
Baymont by Wyndham Keokuk

Baymont by Wyndham Keokuk

2.5 star property
96.1 km from Mississippi River
6.2 out of 10, (488)
"Great location for geode hunting. Irish Pub behind the hotel is the best."
United States
Marty
The price is RM249
RM279 total
includes taxes & fees
7 Dec - 8 Dec
Baymont by Wyndham Keokuk
Lobby sitting area
Motel 6 Hannibal, MO

Motel 6 Hannibal, MO

2.0 star property
26.1 km from Mississippi River
7.4 out of 10, Good, (1009)
"Very clean rooms and staff is very friendly "
United States
Sherrie
The price is RM240
RM276 total
includes taxes & fees
10 Dec - 11 Dec
Motel 6 Hannibal, MO
Indoor pool, pool loungers
Comfort Inn & Suites - Hannibal

Comfort Inn & Suites - Hannibal

2.5 star property
26.2 km from Mississippi River
7.6 out of 10, Good, (658)
"The beds were super comfy"
United States
Jayme
The price is RM353
RM418 total
includes taxes & fees
2 Jan - 3 Jan 2026
Comfort Inn & Suites - Hannibal
Exterior
Super 8 by Wyndham Hannibal

Super 8 by Wyndham Hannibal

2.0 star property
26.3 km from Mississippi River
7.2 out of 10, Good, (1006)
"My stay was excellent staff very friendly and breakfast was always great "
United States
Sherrie
The price is RM269
RM309 total
includes taxes & fees
4 Dec - 5 Dec
Super 8 by Wyndham Hannibal
Exterior
LAKEVIEWINN

LAKEVIEWINN

2.5 star property
89.4 km from Mississippi River
5.6 out of 10, (30)
"I enjoyed it! And the owners were so sweet and understanding. I would absolutely stay there again!"
United States
Evelyn
The price is RM335
RM378 total
includes taxes & fees
4 Dec - 5 Dec
LAKEVIEWINN
Property amenity
Extended Stay America Select Suites St Louis Earth City

Extended Stay America Select Suites St Louis Earth City

2.5 star property
107.1 km from Mississippi River
6.6 out of 10, (875)
"Everything at this property was great! The management and staff were excellent, shout out to Jennifer and Randy!! "
United States
Charles
The price is RM331
RM397 total
includes taxes & fees
26 Dec - 27 Dec
Extended Stay America Select Suites St Louis Earth City
Premium bedding, desk, laptop workspace, iron/ironing board
La Quinta Inn by Wyndham St. Louis Hazelwood - Airport North

La Quinta Inn by Wyndham St. Louis Hazelwood - Airport North

3.0 star property
109.6 km from Mississippi River
6.4 out of 10, (1011)
"Room was clean to perfection with nice comfortable beds."
United States
Roquita
The price is RM271
RM331 total
includes taxes & fees
7 Dec - 8 Dec
La Quinta Inn by Wyndham St. Louis Hazelwood - Airport North
Desk, laptop workspace, free WiFi, bed sheets
Days Inn by Wyndham Hannibal

Days Inn by Wyndham Hannibal

2.0 star property
26.4 km from Mississippi River
7.4 out of 10, Good, (214)
"Left before breakfast great cup of coffee"
United States
David
The price is RM268
RM308 total
includes taxes & fees
17 Dec - 18 Dec
Days Inn by Wyndham Hannibal
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Mississippi River Hotel Reviews

Pear Tree Inn St. Louis Airport

Pear Tree Inn St. Louis Airport

10/10 Excellent
"Very clean "
Mary 1-night trip
Posted 3 days ago
Pear Tree Inn St. Louis Airport

Hotels near other Mississippi River attractions

Mark Twain Cave

4.4/5 (128 reviews)
Explore the great outdoors at Mark Twain Cave, a lovely green space in Hannibal. While in this trendy area, you can savour the top-notch restaurants.
See properties

Mark Twain Cave and Cameron Cave

4.5/5 (51 reviews)
You can find out about the history of Hannibal with a visit to Mark Twain Cave and Cameron Cave. While in this family-friendly area, you can savour the top-notch restaurants.
See properties

Frequently asked questions

What's the area like around Mississippi River?
Mississippi River is located in an area that travellers like for its baseball games. When you want to settle in and find a place to stay, take a look at some of the hotels and other accommodation options that Expedia offers in the area.
What's the best hotel to stay close to Mississippi River?
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel is one of the top choices for your stay based on our traveller data, and this hotel offers a restaurant and a 24-hour fitness centre. You'll find it 81.8 mi (131.6 km) from Mississippi River. Other good options around the area include Forest Park Hotel by MDR and Clayton Plaza Hotel & Extended Stay.
If I need to cancel the hotel reservation for my stay near Mississippi River, will I receive a refund?
Yes! Most room reservations are fully refundable as long as you cancel before the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your scheduled arrival. If you have a reservation that's non-refundable, it may still be possible to cancel it and get a refund within a 24-hour period of booking. Add dates, click "Search", then use the "fully refundable" filter to review the best deals near Mississippi River.