
Hotels in Middletown, San Diego
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Our top choices for Middletown hotels

1. City24 Hotel Little Italy Mission Hills
City24 Hotel Little Italy Mission Hills
2. Holiday Inn Express San Diego Airport - Old Town by IHG
Holiday Inn Express San Diego Airport - Old Town by IHG
3. Hampton Inn San Diego/Mission Valley
Hampton Inn San Diego/Mission Valley
4. Hilton Garden Inn San Diego Downtown/Bayside
Hilton Garden Inn San Diego Downtown/Bayside
5. Hampton Inn & Suites San Diego Airport Liberty Station
Hampton Inn & Suites San Diego Airport Liberty Station
6. TownePlace Suites by Marriott San Diego Downtown
TownePlace Suites by Marriott San Diego Downtown
7. Fairfield Inn & Suites San Diego Old Town
Fairfield Inn & Suites San Diego Old Town
8. Best Western Inn & Suites San Diego – Zoo/SeaWorld Area
Best Western Inn & Suites San Diego – Zoo/SeaWorld Area
9. The DEXTRO Little Italy, BW Premier Collection
The DEXTRO Little Italy, BW Premier Collection
10. Hampton Inn & Suites by Hilton San Diego SeaWorld Near Old Town
Hampton Inn & Suites by Hilton San Diego SeaWorld Near Old Town
11. Holiday Inn Express San Diego Downtown by IHG
Holiday Inn Express San Diego Downtown by IHG
12. Homewood Suites by Hilton San Diego Airport/Liberty Station
Homewood Suites by Hilton San Diego Airport/Liberty Station
13. DoubleTree by Hilton Hotel San Diego - Mission Valley
DoubleTree by Hilton Hotel San Diego - Mission Valley
14. Hampton Inn San Diego-Downtown
Hampton Inn San Diego-Downtown
15. Sheraton San Diego Resort
Sheraton San Diego Resort
16. Comfort Inn San Diego Old Town
Comfort Inn San Diego Old Town
17. Crowne Plaza San Diego - Mission Valley by IHG
Crowne Plaza San Diego - Mission Valley by IHG
18. Best Western Seven Seas
Best Western Seven Seas
19. Wyndham San Diego Bayside
Wyndham San Diego BaysideCompare popular hotels in Middletown
Property | Property class | Guest rating | Breakfast included | Pool | Spa | Pet-friendly | WiFi included | |
|---|---|---|---|---|---|---|---|---|
![]() City24 Hotel Little Italy Mission Hills | 9.6 Exceptional 242 reviews | View | ||||||
![]() Holiday Inn Express San Diego Airport - Old Town by IHG | 9.2 Wonderful 1,102 reviews | View | ||||||
![]() The DEXTRO Little Italy, BW Premier Collection | 8.8 Excellent 2,363 reviews | View | ||||||
![]() TownePlace Suites by Marriott San Diego Downtown | 8.8 Excellent 1,001 reviews | View | ||||||
![]() Kings Inn San Diego | 8.8 Excellent 3,848 reviews | View |
Where to stay in Middletown

Downtown San Diego
Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Pacific Beach
Relax in beachside cafés in the morning, surf clean breaks in the afternoon and dance with a youthful club crowd at night at this coastal San Diego strip.

Gaslamp Quarter
The historic heart of San Diego has a fascinating history, and today is a thriving hub for food, retail and entertainment.

Mission Beach
If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.

Mission Bay
If you're spending some time in Mission Bay, Mission Bay and Ski Beach are top sights worth seeing.






















































































