Top B&B in Lewis County in 2026

Three red brick buildings with chimneys, surrounded by green grass and trees under a clear blue sky.

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Our top choices for Lewis County bed & breakfast

A wooden staircase with a handrail, a small table with a lamp, and a chair in a room with a door and windows.

1. Garden House Bed and Breakfast

Hannibal

Edward

RM495 total

includes taxes & fees

12 Sept - 13 Sept

2. Main Street Bed & Breakfast

Hannibal

Paul

A large, two-story brick house with a prominent dome on the right side, a front porch with steps, and a well-maintained front yard with purple flowers and green shrubs.

3. Johnstone Mansion

Keokuk

Darlene

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Top Lewis County Hotel Reviews

Comfort Inn & Suites - Hannibal

10/10 Excellent

"The staff was very polite and respectful. The stay was very pleasant and I plan to stay again. I did not eat the breakfast so I can not say anything about it. I was very please, good job staff."

Microtel Inn & Suites by Wyndham Quincy Downtown/River Area

8/10 Good

"I try not to be a very picky person, and I wish I had gotten pictures, but if I'm paying $160 for a room I would like for it not to smell musty and old. Also, the furniture was worse for wear. The tops of the dressers were in horrible condition. The curtains were very old and did not slide across the window easily at all. The breakfast was waffles, biscuits and gravy, apples and yogurt. Now, with that said, the jacuzzi tub was exactly what I needed after being in a car for 12 hours prior. Both it and the bathroom were clean. The room was spacious and even thought the AC was constantly turning on and off literally every 2-3 mintues it kept the room cool. Had to use the iron and it was clean and usable...did its job. The view of the bridges over the river at night was relaxing. I checked in at 9pm and out at 11am."