A sunset over a mountainous landscape with scattered clouds.

La Mesa Vacation Rentals

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

In two weeks
30 Oct - 1 Nov
In two months
11 Dec - 13 Dec
In three months
8 Jan - 10 Jan
In four months
5 Feb - 7 Feb

Our top choices for La Mesa holiday rentals

A high-rise hotel with multiple floors, a prominent sign at the top, and a well-lit facade.

1. Marriott Vacation Club®, San Diego

Marriott Vacation Club®, San Diego
3.5 star property
Downtown San Diego
9.4 out of 10, Exceptional, (1,250 reviews)
"Great for traveling families."
United States
Veronica Dangerfield
The price is RM588
RM681 total
includes taxes & fees
3 Nov - 4 Nov
Marriott Vacation Club®, San Diego
A beach with a hotel in the background.

2. Coronado Beach Resort

Coronado Beach Resort
3.0 star property
Historic Downtown Coronado
9.2 out of 10, Wonderful, (835 reviews)
"Amazing location, amenities, staff"
United States
Javier
The price is RM792
RM871 total
includes taxes & fees
25 Oct - 26 Oct
Coronado Beach Resort
A narrow, enclosed walkway with wooden railings and a metal grid barrier, leading to a building entrance.

3. City24 Hotel Little Italy Mission Hills

City24 Hotel Little Italy Mission Hills
4.5 star property
Middletown
9.6 out of 10, Exceptional, (224 reviews)
"Friendly staff!"
United States
Donavin
The price is RM469
RM668 total
includes taxes & fees
26 Oct - 27 Oct
City24 Hotel Little Italy Mission Hills
A modern lobby with a green sofa, a wooden accent wall, and a large plant.

4. Little Italy Inn - Limited Service Apart Hotel

Little Italy Inn - Limited Service Apart Hotel
2.5 star property
Downtown San Diego
8.4 out of 10, Very good, (360 reviews)
"Great area"
United States
Andrew
The price is RM399
RM462 total
includes taxes & fees
25 Oct - 26 Oct
Little Italy Inn - Limited Service Apart Hotel
A spacious lobby with a sofa, chairs, a bookshelf, and a large window with a view of greenery.

5. Uptown Inn by Vantaggio - Limited Service Apart-Hotel

Uptown Inn by Vantaggio - Limited Service Apart-Hotel
2.5 star property
Hillcrest
8.4 out of 10, Very good, (489 reviews)
"We had a great stay! The room had a charming Parisian feel—compact and studio-style, but completely modern and spotlessly clean."
United States
Josh
The price is RM382
RM430 total
includes taxes & fees
26 Oct - 27 Oct
Uptown Inn by Vantaggio - Limited Service Apart-Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top La Mesa Hotel Reviews

California Suites Hotel

California Suites Hotel

10/10 Excellent
"This is a pretty large property. They have security on the property after dark which is nice. The rooms were nice, but could use a remodel. The place is right for the price."
Ryan 5-night trip
Posted 4 hours ago
California Suites Hotel

Find out more about La Mesa

Search for holiday rentals in La Mesa on Expedia.co.uk! You can easily find your home rentals, villas, holiday apartments in La Mesa using one of the methods below:

  • View our selection of featured holiday rentals in La Mesa
  • Use the map to find apartments and other holiday homes in the La Mesa neighbourhood you prefer
  • Enter your travel dates to view the best deals on holiday rentals in La Mesa while they last

Look no further and take a look at our great range of rental properties in La Mesa!

Frequently asked questions

Are there holiday rentals in La Mesa?

Yes, there are holiday rentals in La Mesa close to La Mesa Memorial Fine Arts Center, or you can select a more secluded option if you're looking for a relaxing stay. Visitors like the top-notch restaurants and shops in La Mesa. Leave some time to check out the zoo and entertainment venues during your trip.

How many holiday rentals are there in La Mesa?

With 65 Expedia holiday rentals, you're guaranteed to find just the right place for your La Mesa stay.

What can I see and do in La Mesa?

While exploring the area, visit family-friendly sights like San Diego Zoo, or get outside and enjoy nature at Mission Bay. While in the area, you can also visit popular places such as Petco Park and Port of San Diego.

What are holiday rentals like in La Mesa?

Holiday rentals are privately owned properties you can book for a few days, or a quick weekend, in La Mesa. Holiday rentals feature amenities such as WiFi and washers and dryers so your stay will be comfortable. If you're concerned about a sanitised environment, holiday rentals can offer a sense of seclusion away from public hotel lifts and busy concierge desks while still allowing you the enjoyment of travel. You'll also have more space in a holiday rental than in a standard hotel, which is another reason why a holiday rental is a great choice for a small group gathering.