10 Best Business Hotels in Eastern South Dakota for 2026

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Check availability on Eastern South Dakota Business Hotels

Tonight

Tomorrow

This weekend

Next weekend

Our top choices for Eastern South Dakota business-friendly hotels

A hotel room with a large bed, a separate bathroom with a bathtub, and a seating area.

A reception desk with a wooden finish and a sign that reads "American Inn." There is a refrigerator stocked with beverages and snacks, and a small shelf with various items.

A multi-story American Inn with a prominent sign, a covered entrance, and a landscaped driveway.

A hotel hallway with carpeted floors and doors on both sides.

1. AmericInn by Wyndham Hartford SD

Hartford

Laurel

RM333

RM362 total

includes taxes & fees

18 Oct - 19 Oct

A swimming pool with clear blue water, surrounded by a tiled deck and a seating area with chairs and tables.

A hotel room with a bed, a sofa, a desk, and a chair.

A modern hotel room with a kitchenette, a sofa, a dining table, a small round table, a bed, and a view of the outdoors.

An outdoor patio area with tables and chairs, string lights, and a view of the city skyline.

2. Comfort Inn & Suites at Sanford Sports Complex

Northwest Sioux Falls

jason

RM419

RM468 total

includes taxes & fees

18 Oct - 19 Oct

A spacious living area with a wooden staircase, two patterned armchairs, a small table, and a dining set.

A spacious interior with a curved wooden staircase, a reception area, and a dining area with multiple chairs and tables.

A reception area with a wooden counter, a stone accent wall, a ceiling fan, and a phone.

A restaurant with wooden flooring, tables, and chairs. There is a counter with food items and a coffee machine.

3. Econo Lodge Watertown

Watertown

William

RM260

RM291 total

includes taxes & fees

4 Oct - 5 Oct

A hotel room with a large bed, a blue sofa, a nightstand with a lamp, and a mural of a waterfall on the wall.

A multi-story hotel with a covered entrance, brick facade, and a large tree in front.

A hotel lobby with a fireplace, seating area, and a bar.

A spacious indoor area with tables and chairs, large windows, and a kitchenette area.

4. Clarion Pointe Sioux Falls Airport

Northwest Sioux Falls

Rachel

RM367

RM411 total

includes taxes & fees

11 Oct - 12 Oct

A hotel room with two beds, a nightstand with a lamp, and a large painting of a lighthouse and pier on the wall.

A gym with cardio machines, a mirror, and a sign with rules.

A spacious lobby with a patterned carpet, wooden beams, a reception desk, and a large framed picture on the wall.

A modern kitchen with a central island, built-in appliances, and a patterned backsplash.

5. Days Inn by Wyndham Watertown

Watertown

Rebecca

RM294

RM328 total

includes taxes & fees

11 Oct - 12 Oct

A lobby with a curved ceiling, blue sofas, a central ottoman, and a wall mural of a river scene.

A buffet area with a glass enclosure, serving trays, and a mural in the background.

A modern bar area with seating and a bar counter.

A modern lounge area with a sofa, chairs, and a small table, featuring a flat-screen TV and a fireplace.

6. Royal River Casino and Hotel

Flandreau

Karla

RM312

RM396 total

includes taxes & fees

1 Oct - 2 Oct

An outdoor patio area with seating and a fire feature, surrounded by modern architecture and plants.

A modern hotel lobby with a reception desk, seating area, and a large window providing natural light.

A group of people at a social event in a spacious indoor venue with tables and chairs arranged for dining or socializing.

A modern lobby with a white sofa, pendant lighting, and a gold sculpture.

7. Holiday Inn Express & Suites Sioux City North-Event Center by IHG

Dakota Dunes

Dustin and Karen

RM388

RM416 total

includes taxes & fees

29 Oct - 30 Oct

A spacious bar area with a large TV screen, a fireplace, and a wine rack.

A spacious living room with a fireplace, large windows, and modern furniture.

A modern bar area with a black marble column, bar stools, and a view of the city through large windows.

A spacious lobby with modern seating, large windows, and a city view.

8. Highpoint Hotel

University Heights

Randell J

RM496

RM552 total

includes taxes & fees

11 Oct - 12 Oct

View all properties

Top Eastern South Dakota Hotel Reviews

Days Inn by Wyndham Sioux Falls Empire

10/10 Excellent

"This was a special get away for us and the room and property was awesome. The breakfast was great way to start the morning. Very wide selection."

La Quinta Inn & Suites by Wyndham Sioux Falls

10/10 Excellent

"Great stay! Clean. Comfortable beds."

Clubhouse Hotel Suites Sioux Falls

10/10 Excellent

"It was a very nice place"

Thunderbird Lodge

8/10 Good

"Very clean, nice staff, good location, but our rooms were dated and a little threadbare. Stains on the carpet, water spots on the ceiling. I think we were in an older part of the hotel because they were pretty full, so the main building might be more updated."

Baymont by Wyndham Sioux Falls

8/10 Good

"Hotel was fine. Clean. Room heater wouldn’t turn on but we didn’t need it. Best thing is right next door to ihop with 24 hour service."

Country Inn & Suites by Radisson, Sioux Falls

8/10 Good

"Stayed here before and it’s a good place for a reasonable rate. Clean, updated furniture. Comfortable bed. Really good Continental breakfast. The pool and hot tub are nice, although very disappointed the hot tub was out of order as we were looking forward to that after being in the road a lot. It would’ve been nice if the reception would’ve informed us of that upon check in so we didn’t get our suits on and go all the way down there in anticipation - only to find out it was out of order once we were a foot from getting in. We dined at the restaurant in the hotel this time, Ode, and it was very good, great service."

AeroStay Hotel

10/10 Excellent

"Peaceful"

My Place Hotel - Sioux Falls, SD

10/10 Excellent

"It was very clean. Useful little kitchenette. Ice maker worked!!! Great service from staff."

Clarion Pointe Sioux Falls Airport

10/10 Excellent

"Location was great for an overnight stay off of I-90. Room was very comfortable and clean. Breakfast was good."

Frequently asked questions

How much do business-friendly hotels in Eastern South Dakota cost?

Rates for business hotels in Eastern South Dakota range between RM291 and RM703 per night. No matter your budget, Expedia can help you find the ideal space to get your work done. These prices were available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.

What are the best business-friendly hotels in Eastern South Dakota?

There are multiple business-friendly hotels in Eastern South Dakota with a total average guest review rating of 8.9, so you're sure to find a place that suits your needs. Heading to Sioux Falls? Hotel On Phillips is a top choice for corporate travellers. This 2.5-stars option includes amenities such as pillow top mattresses and a Champagne service. Fairfield Inn & Suites Sioux Falls Airport also scores top marks from business guests. Make use of pillow top mattresses and a swimming pool at this 3-stars escape in Sioux Falls.

How many business-friendly hotels are there in Eastern South Dakota?

There are 114 business-friendly hotels in Eastern South Dakota. When work takes you out of town, Expedia makes it easy to find the ideal space with the amenities you want.

What are the best cheap business-friendly hotels in Eastern South Dakota?

That depends on which part of Eastern South Dakota work is taking you. If you're off to Sioux Falls, Hotel On Phillips meets the needs of business travellers at an affordable price. Pillow top mattresses and a cafe are among its many conveniences. On your way to Mitchell? Consider staying at Hampton Inn Mitchell. A swimming pool and designer toiletries help make this cheaper property a top pick for corporate visitors. Business-friendly hotels start at RM291 per night, so that important work trip doesn't have to stretch your finances. Eager to see the sights of Eastern South Dakota without blowing the budget? Take a break from your work events to visit popular free attractions like St. Joseph Cathedral in Sioux Falls. Mitchell also has loads of things to do that don't cost a dime, including Dakota Discovery Museum. This price was available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.

Are there any family-friendly hotels in Eastern South Dakota that are also business friendly?

If you're travelling for business in Eastern South Dakota and bringing the family along with you, Expedia will help you locate a cosy and convenient stay. Clubhouse Hotel Suites Sioux Falls in Sioux Falls is an excellent option for those juggling work and leisure. This 3-stars property comes with all the amenities you'll need, like complimentary breakfast and a children's pool. Holiday Inn & Suites Sioux Falls - Airport, an IHG Hotel is another fantastic choice in Sioux Falls. Enjoy the best of both worlds — combine corporate travel and quality time with your family at this 3-stars property. WiFi and laundry facilities are just two of the many conveniences you'll find here. When you've finished work, it's time to explore Sioux Falls with the kids. Popular family-friendly attractions include Great Plains Zoo and Wild Water West.

Why book your business-friendly hotel in Eastern South Dakota with Expedia?

With conveniences like meeting rooms, 24-hour room service and on-site restaurants, our business-friendly properties come with everything you'll need to settle that big contract — and then chill! Enter your preferred dates and travel destination and Expedia will help you with everything else.

How can I find cheap business-friendly hotels in Eastern South Dakota?

When work takes you to Eastern South Dakota, our "business friendly" filter will help you find the perfect hotel. From included breakfast and free WiFi to meeting rooms and workspaces, they come with the amenities you need to get the job done. Another tip? Narrow your search by your budget and preferred star rating to view the most affordable accommodation.

What is there to do in Eastern South Dakota near my business-friendly hotel?

There are so many things to keep you entertained in Eastern South Dakota. If you're off to Sioux Falls, you'll want to check out Great Plains Zoo, Washington Pavilion of Arts and Science and St. Joseph Cathedral. Planning to stay in Mitchell? Dakota Discovery Museum, Corn Palace and Mitchell Aquatic Centre are popular attractions here.

Room 1

Change your mind

Treat yourself

Be picky

Check availability on Eastern South Dakota Business Hotels

Our top choices for Eastern South Dakota business-friendly hotels

1. AmericInn by Wyndham Hartford SD

2. Comfort Inn & Suites at Sanford Sports Complex

3. Econo Lodge Watertown

4. Clarion Pointe Sioux Falls Airport

5. Days Inn by Wyndham Watertown

6. Royal River Casino and Hotel

7. Holiday Inn Express & Suites Sioux City North-Event Center by IHG

8. Highpoint Hotel

9. AmericInn by Wyndham Watertown

10. Grand Falls Casino & Golf Resort

Top Eastern South Dakota Hotel Reviews

Days Inn by Wyndham Sioux Falls Empire

La Quinta Inn & Suites by Wyndham Sioux Falls

Clubhouse Hotel Suites Sioux Falls

Thunderbird Lodge

Baymont by Wyndham Sioux Falls

Country Inn & Suites by Radisson, Sioux Falls

AeroStay Hotel

My Place Hotel - Sioux Falls, SD

Clarion Pointe Sioux Falls Airport

Frequently asked questions

Explore a world of travel with Expedia