A rustic covered bridge with a wooden structure and red accents, surrounded by lush greenery and trees.

Defiance hotels from RM308

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Next weekend
In two weeks

Filter by

Guest rating

Selecting then applying a filter from this group will update the results on a new page

Star rating

Our top choices for Defiance hotels

Quality Inn Foristell

Quality Inn Foristell
2.5 star property
Foristell
8.2 out of 10, Very good, (1,002 reviews)
"Staff was helpful, area was easy tp navigate. Place was great for the price"
United States
Ryan
The price is RM342
RM387 total
includes taxes & fees
16 Jul - 17 Jul
Quality Inn Foristell

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
3.0 star property
Fenton
7.8 out of 10, Good, (1,389 reviews)
"Will definitely stay again!"
United States
Trevor
The price is RM386
RM445 total
includes taxes & fees
2 Jul - 3 Jul
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Baymont by Wyndham Warrenton

Baymont by Wyndham Warrenton
2.5 star property
Warrenton
7.6 out of 10, Good, (1,003 reviews)
"Excellent place to stay!"
United States
Steven
The price is RM334
RM382 total
includes taxes & fees
12 Jul - 13 Jul
Baymont by Wyndham Warrenton

Holiday Inn Express & Suites St Peters by IHG

Holiday Inn Express & Suites St Peters by IHG
2.5 star property
St. Peters
9.4 out of 10, Exceptional, (418 reviews)
"Great stay. Easy and quick check in."
United States
John
The price is RM450
RM542 total
includes taxes & fees
5 Jul - 6 Jul
Holiday Inn Express & Suites St Peters by IHG

Super 8 by Wyndham Warrenton

Super 8 by Wyndham Warrenton
2.0 star property
Warrenton
7.4 out of 10, Good, (661 reviews)
"Terrific staff very helpful manager"
United States
Dale
The price is RM241
RM275 total
includes taxes & fees
5 Jul - 6 Jul
Super 8 by Wyndham Warrenton

Drury Inn & Suites Southwest St. Louis

Drury Inn & Suites Southwest St. Louis
3.0 star property
Valley Park
9.6 out of 10, Exceptional, (1,000 reviews)
The price is RM486
RM569 total
includes taxes & fees
1 Jul - 2 Jul
Drury Inn & Suites Southwest St. Louis

Best Western Plus Washington Hotel

Best Western Plus Washington Hotel
2.5 star property
Washington
9.0 out of 10, Wonderful, (700 reviews)
"Very clean and staff were friendly. Breakfast was good and will definitely stay here again. "
United States
Rod
The price is RM527
RM600 total
includes taxes & fees
2 Jul - 3 Jul
Best Western Plus Washington Hotel

Hampton Inn St. Charles St. Peters

Hampton Inn St. Charles St. Peters
2.5 star property
St. Charles
8.0 out of 10, Very good, (1,001 reviews)
"Good staff "
United States
Solomon
The price is RM466
RM536 total
includes taxes & fees
5 Jul - 6 Jul
Hampton Inn St. Charles St. Peters

Comfort Suites St Charles - St Louis

Comfort Suites St Charles - St Louis
2.5 star property
St. Charles
8.4 out of 10, Very good, (1,002 reviews)
"We had a great stay"
United States
Alexa
The price is RM404
RM464 total
includes taxes & fees
5 Jul - 6 Jul
Comfort Suites St Charles - St Louis

Hampton Inn St. Louis Wentzville

Hampton Inn St. Louis Wentzville
2.5 star property
Wentzville
9.0 out of 10, Wonderful, (721 reviews)
"Clean comfortable room and the staff are very friendly."
United States
Julie
The price is RM585
RM670 total
includes taxes & fees
26 Jul - 27 Jul
Hampton Inn St. Louis Wentzville

Fairfield Inn & Suites Wentzville

Fairfield Inn & Suites Wentzville
3.0 star property
Wentzville
9.0 out of 10, Wonderful, (685 reviews)
"Great room. Very comfortable, quiet and had a very restful nights sleep"
United States
Jeffrey
The price is RM565
RM646 total
includes taxes & fees
2 Jul - 3 Jul
Fairfield Inn & Suites Wentzville

Wingate by Wyndham St. Louis/Fenton Route 66

Wingate by Wyndham St. Louis/Fenton Route 66
3.0 star property
Fenton
7.8 out of 10, Good, (1,255 reviews)
"nice place"
United States
diana
The price is RM365
RM421 total
includes taxes & fees
5 Jul - 6 Jul
Wingate by Wyndham St. Louis/Fenton Route 66

Drury Plaza Hotel St. Louis St. Charles

Drury Plaza Hotel St. Louis St. Charles
3.0 star property
St. Charles
9.6 out of 10, Exceptional, (1,004 reviews)
"Clean rooms and friendly staff."
United States
Darla
The price is RM556
RM645 total
includes taxes & fees
2 Jul - 3 Jul
Drury Plaza Hotel St. Louis St. Charles

Holiday Inn Express & Suites Wentzville St Louis West by IHG

Holiday Inn Express & Suites Wentzville St Louis West by IHG
2.5 star property
Wentzville
9.4 out of 10, Exceptional, (929 reviews)
"We have stay here before and requested to stay again. Great hotel."
United States
Steve
The price is RM552
RM658 total
includes taxes & fees
26 Jul - 27 Jul
Holiday Inn Express & Suites Wentzville St Louis West by IHG

Super 8 by Wyndham O'Fallon MO/St. Louis Area

Super 8 by Wyndham O'Fallon MO/St. Louis Area
2.0 star property
O'Fallon
7.0 out of 10, Good, (1,000 reviews)
"Clean room, friendly staff"
United States
Shelly
The price is RM285
RM336 total
includes taxes & fees
12 Jul - 13 Jul
Super 8 by Wyndham O'Fallon MO/St. Louis Area

Drury Inn & Suites St. Louis St. Peters

Drury Inn & Suites St. Louis St. Peters
3.0 star property
St. Peters
9.4 out of 10, Exceptional, (1,002 reviews)
"Great location and clean hotel!"
United States
Admir
The price is RM450
RM517 total
includes taxes & fees
5 Jul - 6 Jul
Drury Inn & Suites St. Louis St. Peters

Sleep Inn & Suites O'Fallon MO - Technology Drive

Sleep Inn & Suites O'Fallon MO - Technology Drive
2.5 star property
O'Fallon
9.0 out of 10, Wonderful, (1,023 reviews)
"We enjoyed our stay. The staff was very nice and the hotel was well kept and clean."
United States
Patrice
The price is RM343
RM404 total
includes taxes & fees
13 Jul - 14 Jul
Sleep Inn & Suites O'Fallon MO - Technology Drive

Hampton Inn & Suites St. Louis/Chesterfield

Hampton Inn & Suites St. Louis/Chesterfield
3.5 star property
Chesterfield
8.8 out of 10, Excellent, (891 reviews)
"Clean, great staff"
United States
mason
The price is RM419
RM488 total
includes taxes & fees
4 Jul - 5 Jul
Hampton Inn & Suites St. Louis/Chesterfield

TownePlace Suites by Marriott Wentzville

TownePlace Suites by Marriott Wentzville
3.0 star property
Wentzville
9.4 out of 10, Exceptional, (56 reviews)
"Room was excellent, staff very nice "
United States
Amy
The price is RM675
RM795 total
includes taxes & fees
2 Jul - 3 Jul
TownePlace Suites by Marriott Wentzville

WoodSpring Suites St Peters-OFallon

WoodSpring Suites St Peters-OFallon
2.5 star property
St. Peters
8.6 out of 10, Excellent, (176 reviews)
"The location was great"
United States
DeLante
The price is RM336
RM398 total
includes taxes & fees
23 Jul - 24 Jul
WoodSpring Suites St Peters-OFallon
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Stay near popular Defiance attractions

Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighbouring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

A rustic covered bridge with a wooden structure and red accents, surrounded by lush greenery and trees.

Top Defiance Hotel Reviews

More cheap stays in Defiance

Frequently asked questions

What's the best place to stay in Defiance?
Hollywood Casino & Hotel St. Louis, located 18.1 mi (29.2 km) from the heart of Defiance, is a top choice for your stay, based on our traveller data. Two other options for your visit to the area are Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham and The Wildwood Hotel. See all available top hotels, or vacation rentals in Defiance.
If I need to cancel my hotel reservation in Defiance, will I receive a refund?
Yes! The majority of room reservations are fully refundable if you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you have a reservation that's non-refundable, you might be able to cancel it and receive a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Defiance.
What are some accommodation options with pools in Defiance?
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham: Offers an indoor pool, an outdoor pool and buffet. The Wildwood Hotel and Ameristar Casino Resort and Spa are two additional hotels with an on-site pool. View all hotels with pools in Defiance.
How is it staying in Defiance?
Visitors can enjoy all that Defiance has to offer, including the wineries and parks. A top sight in the area is Six Flags St. Louis. In Defiance, there are 19 hotels and other accommodation options to choose from. Find out more about Defiance.
What should I do while I'm visiting Defiance?
Natural beauty is on display at August A. Busch Memorial Conservation Area, Missouri River and Matson Hill Park Trailhead. Additionally, you'll find Six Flags St. Louis in the area. Take a look at what more there is to see and do in Expedia's Defiance guide.
What's the weather like in Defiance?
The hottest months are usually July and August, with an average temperature of 24°C, while the coldest months are January and February, with an average of 3°C. Average annual precipitation for Defiance is 1228 mm.

Explore a world of travel with Expedia