𝗧𝗢𝗣 𝗛𝗼𝘁𝗲𝗹𝘀 𝗶𝗻 Defiance from RM319 (2026) - Fully Refundable Options

A rustic covered bridge with a wooden structure and red accents, surrounded by lush greenery and trees.

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Our top choices for Defiance hotels

A hotel room with a bed, a sofa, a coffee table, and wall art.

A restaurant with wooden tables and chairs, a blue wall with white floral patterns, and a counter with a coffee machine.

A Sleep Inn & Suites hotel with a modern brick facade, a covered entrance, and a parking lot.

A hotel lobby with a reception desk, seating area, and a large potted plant.

1. Sleep Inn & Suites O'Fallon MO - Technology Drive

O'Fallon

Tim

RM323

RM381 total

includes taxes & fees

27 Sept - 28 Sept

A hotel room with two beds, a desk with a chair, a television, and a window with curtains.

A reception desk with a modern design, featuring a blue geometric wall and a wooden finish.

A modern hotel room with a desk, chair, and a large mirror.

A hotel lobby with a seating area, a reception desk, and a flat-screen TV mounted on the wall.

2. Holiday Inn Express St. Louis West - O'Fallon by IHG

O'Fallon

Greg

RM363

RM428 total

includes taxes & fees

30 Sept - 1 Oct

A hotel with a prominent tower, a fountain in the courtyard, and a well-maintained garden.

A spacious living area with a staircase, a large painting, and a chandelier.

A modern bathroom with a large mirror, white vanity, and a bathtub.

A hotel room with a large bed, a bedside lamp, a telephone, a mirror, and a bathroom with a sink and towel rack.

3. The Wildwood Hotel

Wildwood

Ramona

RM371

RM433 total

includes taxes & fees

21 Oct - 22 Oct

A modern dining area with a brick fireplace, yellow and blue chairs, and a blue sofa.

An indoor swimming pool with a blue interior, surrounded by white chairs and tables, and a blue ceiling.

4. Comfort Inn & Suites Chesterfield - St. Louis

Chesterfield

Donna

RM331

RM399 total

includes taxes & fees

4 Oct - 5 Oct

An outdoor patio area with a stone fire pit, wicker furniture, and a covered seating area with a view of the building's interior.

A multi-story hotel with a brick facade, a covered outdoor seating area with a fire feature, and a sign indicating it is a Marriott property.

A hotel room with a sofa, a side table, a lamp, a flat-screen TV, and a bed with a red blanket.

A hotel room with a large bed, bedside lamps, a TV, a desk, and a bathroom.

5. TownePlace Suites by Marriott St. Louis Chesterfield

Chesterfield

Bobbi jo

RM521

RM612 total

includes taxes & fees

6 Oct - 7 Oct

A multi-story hotel with a central entrance featuring a covered patio area.

A hotel room with a desk, chair, sofa, and a window with curtains.

A hotel lobby with a sectional sofa, a fireplace, a flat-screen TV, and framed artwork on the walls.

A hotel room with a sofa, armchair, bedside table, lamp, TV, and a bed with patterned bedding.

6. Staybridge Suites O'Fallon Chesterfield by IHG

O'Fallon

Norman

RM452

RM533 total

includes taxes & fees

4 Oct - 5 Oct

A spacious living room with a large painting, a fireplace, a staircase, and modern furniture.

A swimming pool with tiled edges and a hot tub area, surrounded by windows and chairs.

A hotel room with a dining area, a fireplace, and a view of the outdoors.

A hotel room with a large bed, two sofas, a desk, and a TV.

7. Best Western Plus Washington Hotel

Washington

Michael Macumber

RM526

RM598 total

includes taxes & fees

27 Sept - 28 Sept

An outdoor patio with a built-in grill, seating area, and stone walls.

An indoor swimming pool with clear glass walls, sunlit seating area, and lifeguard station.

A multi-story hotel with a parking lot in front.

A spacious lounge area with a stone fireplace, comfortable seating, and a large TV screen.

8. Residence Inn by Marriott St. Louis Chesterfield

Chesterfield

Brandon

RM770

RM901 total

includes taxes & fees

10 Oct - 11 Oct

A spacious lobby with a high ceiling, a central seating area with sofas and a coffee table, and a large window providing natural light.

A hotel with a covered entrance, multiple flags, and a well-maintained lawn.

A spacious lobby with a fireplace, comfortable seating, a large painting, and a view of the kitchen area.

A shop with a variety of snacks and beverages, including a refrigerated section with drinks and a display of packaged snacks.

9. Hilton Garden Inn St. Louis/O'Fallon MO

O'Fallon

Kassie

RM441

RM523 total

includes taxes & fees

4 Oct - 5 Oct

A modern kitchen with a bar area, wooden cabinets, and pendant lighting.

A hotel room with two beds, a sofa, a small table, a lamp, and a framed abstract painting on the wall.

A modern hotel entrance with a glass canopy, large windows, and a brick facade.

A hotel room with three computer workstations, each with a monitor, keyboard, and a lamp.

10. Hyatt Place St. Louis/Chesterfield

Chesterfield

Chelsea

RM528

RM612 total

includes taxes & fees

29 Sept - 30 Sept

Two people in a swimming pool with colorful inflatable rings.

A buffet counter with a variety of food items, including pastries and beverages, and a person serving.

A spacious lobby with a stone fireplace, a chandelier, and a staircase.

A lobby with a grand staircase, two patterned sofas, a glass coffee table, and a large mirror.

11. Holiday Inn St. Louis West Six Flags by IHG

Eureka

Rob

RM448

RM522 total

includes taxes & fees

30 Sept - 1 Oct

A modern kitchen area with a breakfast bar, a coffee machine, and a refrigerator displaying menu options.

A hotel room with two beds, a blue sofa, a small table, and a kitchenette.

A coffee station with two coffee machines and a display of coffee pods and cups.

A pool area with a blue pool lift chair, a pool user capacity sign, and a tiled wall.

12. Holiday Inn Express & Suites St. Louis - Chesterfield by IHG

Chesterfield

Steven

RM447

RM520 total

includes taxes & fees

27 Sept - 28 Sept

A courtyard with a central seating area, surrounded by trees and a building with a pitched roof.

A modern dining area with a long table, multiple chairs, and pendant lighting.

A store interior with a 'Treats' sign, snack shelves, and a chalkboard with a welcome message.

A reception desk with a "WELCOME TO THE SHOW ME STATE" sign, a wooden counter, and a Hilton Honors sign.

13. Hampton Inn & Suites St. Louis/Chesterfield

Chesterfield

Vijay

RM540

RM628 total

includes taxes & fees

4 Oct - 5 Oct

An indoor swimming pool with a hot tub, clear signage, and a view of the outside through large windows.

A hotel room with two beds, a desk with a TV, a chair, and a lamp.

A spacious living area with a blue wall, yellow armchairs, a blue sofa, and a wooden coffee table.

A modern hotel room with a grey sofa, a wooden coffee table, a flat-screen TV, a wooden dresser, and a large window with curtains.

14. Comfort Inn Near Six Flags St. Louis

Pacific

Amber

RM398

RM456 total

includes taxes & fees

26 Oct - 27 Oct

A spacious hotel lobby with a long reception desk, multiple seating areas, and large windows allowing natural light.

A Hampton Inn with a brick facade, outdoor seating area, and a clear sky.

A snack display area with various chips and snacks, a refrigerated section, and a wall with a 'Treats' sign.

An indoor swimming pool with a clear water area, a shallow end, and a tiled deck surrounding the pool. There are lounge chairs and tables on the deck, and a sign indicating a maximum capacity of 62.

15. Hampton Inn St. Louis Wentzville

Wentzville

Jill

RM598

RM684 total

includes taxes & fees

4 Oct - 5 Oct

A spacious lobby with a staircase, a blue sofa, and a wooden table.

A modern interior with a large window, a flat-screen TV mounted on a wall, and a seating area with colorful stools.

A hotel room with two beds, a desk, a chair, a TV, and a window with curtains.

A hotel reception desk with a blue water feature design, a sign reading "Quality by Choice Hotels," and a digital screen.

16. Quality Inn Foristell

Foristell

Adrian

RM348

RM393 total

includes taxes & fees

27 Sept - 28 Sept

An outdoor patio area with wicker furniture and a central fire feature.

A modern hotel lobby with a bar area, seating arrangements, and a reception desk.

A Courtyard Marriott hotel with a parking lot and a green shuttle service.

A modern hotel lobby with a reception desk, seating area, and a television screen displaying a map.

17. Courtyard by Marriott St. Louis Chesterfield

Chesterfield

Kelly

RM491

RM572 total

includes taxes & fees

4 Oct - 5 Oct

A spacious lobby with a stone fireplace, seating area, and a bar with high stools.

A modern living room with a fireplace, a flat-screen TV, a sofa, a coffee table, and a dining area.

A hotel pantry stocked with beverages and snacks, a refrigerated display case, and a sign reading "The Market".

A multi-story hotel with a central entrance, large windows, and a well-maintained lawn.

18. Residence Inn by Marriott O'Fallon

O'Fallon

Gerald

RM534

RM629 total

includes taxes & fees

11 Oct - 12 Oct

A spacious lobby with a central round table, two sofas, and a chandelier.

A Drury Plaza hotel with a modern design, featuring a curved facade, large windows, and a Drury Plaza sign on the top.

An indoor swimming pool area with clear signage indicating a depth of 3 feet and a no diving warning.

A buffet setup with various food items and a decorative vase of flowers.

19. Drury Plaza Hotel St. Louis Chesterfield

Chesterfield

Cassandra

RM530

RM614 total

includes taxes & fees

25 Oct - 26 Oct

A multi-story hotel with a stone facade and a covered entrance.

A modern living room with a blue accent wall, a gray sofa, a dining table with chairs, and a coffee table.

A compact living space with a kitchenette, a dining area, and a workspace.

A compact hotel room with two beds, a desk with a chair, a television, a microwave, and a refrigerator.

20. WoodSpring Suites St Peters-OFallon

St. Peters

Thomas

RM332

RM393 total

includes taxes & fees

28 Sept - 29 Sept

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Stay near popular Defiance attractions

A glass of red wine on a wooden table with a vineyard in the background.

Chandler Hill Vineyards

7.8/10 (7 reviews)

This elegant Missouri winery showcases local and California wines from its hillside setting. Savour varietals on the expansive terrace while enjoying vineyard views and seasonal cuisine from their full-service kitchen.

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A wooden dock extending into a pond with lily pads, surrounded by lush greenery and a clear blue sky.

August A. Busch Memorial Conservation Area

8.6/10 (7 reviews)

This sprawling conservation area features over 30 lakes and historic WWII bunkers amid diverse habitats. Explore well-maintained trails while watching for migratory birds and wildlife in their natural environment.

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Sugar Creek Winery

8.0/10 (1 review)

Sip award-winning Missouri wines at this hillside vineyard along the scenic Katy Trail. Relax on covered decks with your own picnic while enjoying live weekend music and panoramic countryside views.

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Historic Daniel Boone Home and Heritage Center

9.6/10 (4 reviews)

Step into the limestone home where Daniel Boone's son Nathan crafted a frontier masterpiece with seven fireplaces. Explore the surrounding historic village for an authentic glimpse into 19th-century pioneer life.

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Yellow Farmhouse Winery

This boutique winery in Defiance, Missouri was known for its distinctive unfiltered wines and relaxed atmosphere. Visitors could enjoy tastings with live music while picnicking on scenic grounds with vineyard views.

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Broemmelsiek Park

This 494-acre natural playground offers nine miles of trails through forests and around serene lakes. Attend a monthly stargazing event at the astronomy viewing area for a uniquely celestial park experience.

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Matson Hill Park Trailhead

Wander through 475 acres of rugged forest terrain with challenging hiking paths and gravity-flow mountain bike trails. The historic 1830s Hays Home offers a glimpse into pioneer life amid the natural splendour.

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Hamburg Trail Trailhead

This moderate 6.9-mile loop winds through the scenic Weldon Spring Conservation Area, connecting to the Katy Trail State Park. Spot native wildlife while traversing diverse landscapes of shaded woodlands and open fields.

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Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighbouring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

See all hotels in Defiance

Top Defiance Hotel Reviews

Hollywood Casino & Hotel St. Louis

10/10 Excellent

"Staff was helpful. Clean rooms. Very accommodating."

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

8/10 Good

"Staff was excellent, rooms are clean, bed and bedding excellent and comfortable, hallways showing a little wear, breakfast choices could offer more variety. Overall the stay was nice for our concert trip"

Wingate by Wyndham St. Louis/Fenton Route 66

8/10 Good

"The hotel and room were what you expect for the price. The enterance was not clearly marked and getting into the property could have had better signage."

Hampton Inn St. Charles St. Peters

10/10 Excellent

"Friendly and helpful staff. Very good breakfast and coffee. Clean rooms."

Country Inn & Suites by Radisson, St. Charles Historic District

10/10 Excellent

"Staff was welcoming and very helpful with a situation that occurred with our booking!"

Studio 6 Extended Stay - St Louis, MO - Westport/Craig Road

10/10 Excellent

"Muy bien"

Drury Plaza Hotel St. Louis Chesterfield

10/10 Excellent

"The hotel staff were friendly, breakfast and dinner were tasty, The 3 free beverages with dinner were an extra nice surprise. Having the option to decline housekeeping during my stay shows they are eco friendly."

Drury Inn & Suites Southwest St. Louis

10/10 Excellent

"Great place to stay!"

Drury Plaza Hotel St. Louis Creve Coeur

10/10 Excellent

"Clean rooms, nice staff"

More cheap stays in Defiance

Sleep Inn & Suites O'Fallon MO - Technology Drive

1147 Technology Drive O'Fallon MO

RM323

RM381 total

27 Sept - 28 Sept

includes taxes & fees

Quality Inn Foristell

12 Highway W Foristell MO

RM348

RM393 total

27 Sept - 28 Sept

includes taxes & fees

8.2/10 Very good! (1,001 reviews)

Country Inn & Suites by Radisson, St. Peters, MO

3877 Veterans Memorial Pkwy St. Charles MO

RM346

RM398 total

27 Oct - 28 Oct

includes taxes & fees

8/10 Very good! (1,000 reviews)

Comfort Suites St Charles - St Louis

1400 S 5th St St. Charles MO

RM356

RM409 total

18 Oct - 19 Oct

includes taxes & fees

Hampton Inn St. Charles St. Peters

3720 W Clay St St. Charles MO

RM471

RM541 total

18 Oct - 19 Oct

includes taxes & fees

8.2/10 Very good! (1,004 reviews)

Country Inn & Suites by Radisson, St. Charles Historic District

1190 S Main St St. Charles MO

RM598

RM687 total

28 Sept - 29 Sept

includes taxes & fees

9.4/10 Exceptional! (1,097 reviews)

Frequently asked questions

What's the best place to stay in Defiance?

Hollywood Casino & Hotel St. Louis, located 18.1 mi (29.2 km) from the heart of Defiance, is a top choice for your stay, based on our traveller data. Two other options for your visit to the area are Sonesta ES Suites St. Louis - Chesterfield and Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham. See all available top hotels, or vacation rentals in Defiance.

If I need to cancel my hotel reservation in Defiance, will I receive a refund?

Yes! The majority of room reservations are fully refundable if you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you have a reservation that's non-refundable, you might be able to cancel it and receive a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Defiance.

What are some accommodation options with pools in Defiance?

Sonesta ES Suites St. Louis - Chesterfield: Offers daily, a seasonal outdoor pool and free self parking. Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham and Ameristar Casino Resort and Spa are two additional hotels with an on-site pool. View all hotels with pools in Defiance.

How is it staying in Defiance?

Visitors can enjoy all that Defiance has to offer, including the wineries and parks. Top sights in the area include St. Louis Union Station, Enterprise Center and St. Louis Zoo. In Defiance, there are 19 hotels and other accommodation options to choose from. Find out more about Defiance.

What should I do while I'm visiting Defiance?

Natural beauty is on display at August A. Busch Memorial Conservation Area, Missouri River and Matson Hill Park Trailhead. A couple of additional sights to add to your itinerary are Yellow Farmhouse Winery and Chandler Hill Vineyards. Take a look at what more there is to see and do in Expedia's Defiance guide.

What's the weather like in Defiance?

The hottest months are usually July and August, with an average temperature of 24°C, while the coldest months are January and February, with an average of 3°C. Average annual precipitation for Defiance is 1228 mm.

Defiance hotels from RM319

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in Defiance

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Defiance hotels

1. Sleep Inn & Suites O'Fallon MO - Technology Drive

2. Holiday Inn Express St. Louis West - O'Fallon by IHG

3. The Wildwood Hotel

4. Comfort Inn & Suites Chesterfield - St. Louis

5. TownePlace Suites by Marriott St. Louis Chesterfield

6. Staybridge Suites O'Fallon Chesterfield by IHG

7. Best Western Plus Washington Hotel

8. Residence Inn by Marriott St. Louis Chesterfield

9. Hilton Garden Inn St. Louis/O'Fallon MO

10. Hyatt Place St. Louis/Chesterfield

11. Holiday Inn St. Louis West Six Flags by IHG

12. Holiday Inn Express & Suites St. Louis - Chesterfield by IHG

13. Hampton Inn & Suites St. Louis/Chesterfield

14. Comfort Inn Near Six Flags St. Louis

15. Hampton Inn St. Louis Wentzville

16. Quality Inn Foristell

17. Courtyard by Marriott St. Louis Chesterfield

18. Residence Inn by Marriott O'Fallon

19. Drury Plaza Hotel St. Louis Chesterfield

20. WoodSpring Suites St Peters-OFallon

Stay near popular Defiance attractions

Chandler Hill Vineyards

August A. Busch Memorial Conservation Area

Sugar Creek Winery

Historic Daniel Boone Home and Heritage Center

Yellow Farmhouse Winery

Broemmelsiek Park

Matson Hill Park Trailhead

Hamburg Trail Trailhead

Learn more about Defiance

Top Defiance Hotel Reviews

Hollywood Casino & Hotel St. Louis

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

Wingate by Wyndham St. Louis/Fenton Route 66

Hampton Inn St. Charles St. Peters

Country Inn & Suites by Radisson, St. Charles Historic District

Studio 6 Extended Stay - St Louis, MO - Westport/Craig Road

Drury Plaza Hotel St. Louis Chesterfield

Drury Inn & Suites Southwest St. Louis

Drury Plaza Hotel St. Louis Creve Coeur

More cheap stays in Defiance

Sleep Inn & Suites O'Fallon MO - Technology Drive

Quality Inn Foristell

Country Inn & Suites by Radisson, St. Peters, MO

Comfort Suites St Charles - St Louis

Hampton Inn St. Charles St. Peters

Country Inn & Suites by Radisson, St. Charles Historic District

Frequently asked questions

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