Defiance hotels from RM320
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12 Aug - 13 AugTomorrow
13 Aug - 14 AugThis weekend
14 Aug - 16 AugNext weekend
21 Aug - 23 AugOur top choices for Defiance hotels
1. Holiday Inn Express St. Louis West - O'Fallon by IHG
Holiday Inn Express St. Louis West - O'Fallon by IHGO'Fallon
Sheria
RM430
RM507 total
includes taxes & fees
16 Aug - 17 Aug
2. TownePlace Suites by Marriott St. Louis Chesterfield
TownePlace Suites by Marriott St. Louis ChesterfieldChesterfield
Cindy
RM524
RM615 total
includes taxes & fees
28 Aug - 29 Aug
3. Sleep Inn & Suites O'Fallon MO - Technology Drive
Sleep Inn & Suites O'Fallon MO - Technology DriveO'Fallon
Josh
RM335
RM395 total
includes taxes & fees
1 Sept - 2 Sept
4. The Wildwood Hotel
The Wildwood HotelWildwood
Hailey
RM361
RM420 total
includes taxes & fees
24 Aug - 25 Aug
5. Residence Inn by Marriott O'Fallon
Residence Inn by Marriott O'FallonO'Fallon
Gerald
RM536
RM632 total
includes taxes & fees
28 Aug - 29 Aug
6. Comfort Inn & Suites Chesterfield - St. Louis
Comfort Inn & Suites Chesterfield - St. LouisChesterfield
Jessica
RM344
RM415 total
includes taxes & fees
23 Aug - 24 Aug
7. Hampton Inn & Suites St. Louis/Chesterfield
Hampton Inn & Suites St. Louis/ChesterfieldChesterfield
Karen E
RM449
RM523 total
includes taxes & fees
30 Aug - 31 Aug
8. Hilton Garden Inn St. Louis/O'Fallon MO
Hilton Garden Inn St. Louis/O'Fallon MOO'Fallon
Kassie
RM567
RM672 total
includes taxes & fees
24 Aug - 25 Aug
9. Staybridge Suites O'Fallon Chesterfield by IHG
Staybridge Suites O'Fallon Chesterfield by IHGO'Fallon
Norman
RM467
RM550 total
includes taxes & fees
7 Sept - 8 Sept
10. Courtyard by Marriott St. Louis Chesterfield
Courtyard by Marriott St. Louis ChesterfieldChesterfield
Steven
RM414
RM481 total
includes taxes & fees
29 Aug - 30 Aug
11. Holiday Inn Express & Suites St. Louis - Chesterfield by IHG
Holiday Inn Express & Suites St. Louis - Chesterfield by IHGChesterfield
NEBAHAT
RM466
RM543 total
includes taxes & fees
30 Aug - 31 Aug
12. Best Western Plus Washington Hotel
Best Western Plus Washington HotelWashington
Jimi
RM528
RM601 total
includes taxes & fees
13 Aug - 14 Aug
13. Quality Inn Near Six Flags St. Louis
Quality Inn Near Six Flags St. LouisPacific
Brent
RM385
RM440 total
includes taxes & fees
16 Aug - 17 Aug
14. Drury Plaza Hotel St. Louis Chesterfield
Drury Plaza Hotel St. Louis ChesterfieldChesterfield
Andrea T
RM532
RM617 total
includes taxes & fees
16 Aug - 17 Aug
15. Residence Inn by Marriott St. Louis Chesterfield
Residence Inn by Marriott St. Louis ChesterfieldChesterfield
Tenisha
RM773
RM904 total
includes taxes & fees
23 Aug - 24 Aug
16. Comfort Inn Near Six Flags St. Louis
Comfort Inn Near Six Flags St. LouisPacific
David
RM390
RM446 total
includes taxes & fees
1 Sept - 2 Sept
17. Hyatt Place St. Louis/Chesterfield
Hyatt Place St. Louis/ChesterfieldChesterfield
Taylor
RM530
RM615 total
includes taxes & fees
30 Aug - 31 Aug
18. Holiday Inn St. Louis West Six Flags by IHG
Holiday Inn St. Louis West Six Flags by IHGEureka
Samantha
RM430
RM501 total
includes taxes & fees
7 Sept - 8 Sept
19. Hampton Inn St. Louis Wentzville
Hampton Inn St. Louis WentzvilleWentzville
Julie
RM600
RM687 total
includes taxes & fees
23 Aug - 24 Aug
20. Super 8 by Wyndham O'Fallon MO/St. Louis Area
Super 8 by Wyndham O'Fallon MO/St. Louis AreaO'Fallon
Shelly
RM268
RM316 total
includes taxes & fees
30 Aug - 31 Aug
Stay near popular Defiance attractions
August A. Busch Memorial Conservation Area
8.6/10 (7 reviews)
This sprawling conservation area features over 30 lakes and historic WWII bunkers amid diverse habitats. Explore well-maintained trails while watching for migratory birds and wildlife in their natural environment.
Photo by Pages of Travel
Chandler Hill Vineyards
7.8/10 (7 reviews)
This elegant Missouri winery showcases local and California wines from its hillside setting. Savour varietals on the expansive terrace while enjoying vineyard views and seasonal cuisine from their full-service kitchen.
Historic Daniel Boone Home and Heritage Center
9.6/10 (4 reviews)
Step into the limestone home where Daniel Boone's son Nathan crafted a frontier masterpiece with seven fireplaces. Explore the surrounding historic village for an authentic glimpse into 19th-century pioneer life.
Sugar Creek Winery
8.0/10 (1 review)
Sip award-winning Missouri wines at this hillside vineyard along the scenic Katy Trail. Relax on covered decks with your own picnic while enjoying live weekend music and panoramic countryside views.
Yellow Farmhouse Winery
This boutique winery in Defiance, Missouri was known for its distinctive unfiltered wines and relaxed atmosphere. Visitors could enjoy tastings with live music while picnicking on scenic grounds with vineyard views.
Matson Hill Park Trailhead
Wander through 475 acres of rugged forest terrain with challenging hiking paths and gravity-flow mountain bike trails. The historic 1830s Hays Home offers a glimpse into pioneer life amid the natural splendour.
Broemmelsiek Park
This 494-acre natural playground offers nine miles of trails through forests and around serene lakes. Attend a monthly stargazing event at the astronomy viewing area for a uniquely celestial park experience.
Hamburg Trail Trailhead
This moderate 6.9-mile loop winds through the scenic Weldon Spring Conservation Area, connecting to the Katy Trail State Park. Spot native wildlife while traversing diverse landscapes of shaded woodlands and open fields.
Learn more about Defiance
Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighbouring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.
See all hotels in Defiance
Top Defiance Hotel Reviews
The Wildwood Hotel
10/10 Excellent
"Very nice and clean! LOVED the breakfast options! Warm up breakfast sandwiches, nutella, healthy oatmeal that passes the Yuka app, we were thrilled! The fair price of 150 per night for a king suite is what drew us to the property but we were happy with our stay!"
Hampton Inn St. Charles St. Peters
10/10 Excellent
"The hotel is in excellent condition. Itโs either new or newly remodeled. Bed was super comfortable and pillows awesome. The breakfast area offered a lot to choose from. I highly recommend this hotel at this location in St Charles MO and would definitely stay again. Hotel exit is right off the highway which was very convenient. We stayed in room 416 and it was very quiet!"
La Quinta Inn & Suites by Wyndham St. Louis Westport
8/10 Good
"Westport is a nice area and very convenient to airport and STL places of interest"
Sonesta ES Suites St. Louis - Chesterfield
8/10 Good
"Great place to stay. Room was comfortable and roomy. Definitely recommend staying here"
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
8/10 Good
"An old drury needs to be updated or is in the process"
Drury Plaza Hotel St. Louis Creve Coeur
10/10 Excellent
"Loved loved loved this hotel the staff were very inviting and helpful. I loved the 530 kickback and the free hot breakfast. The location was very convenient with many other restaurants and stores close. Overall Iโll stay here again and again 100/100!"
Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West
8/10 Good
"Missing shower curtain in one of the bathrooms , call the front desk multiple times was never able to get a hold of anybody, check out was 11. Our keys stopped working at nine difficult to load our cars when we kept getting locked out. .. hotel was very clean pool area very nice and clean front desk very helpful and nice."
Best Western Plus Fenton
8/10 Good
"Clean rooms, friendly staff, good breakfast, however workout room equipment was really dirty."
More cheap stays in Defiance
Days Inn and Suites by Wyndham St. Louis/Westport Plaza
1970 Craig Rd Maryland Heights MO
RM278
RM323 total
25 Aug - 26 Aug
includes taxes & fees
Sleep Inn & Suites O'Fallon MO - Technology Drive
1147 Technology Drive O'Fallon MO
RM335
RM395 total
1 Sept - 2 Sept
includes taxes & fees
9/10 Wonderful! (1,076 reviews)
Best Western Plus St. Louis West-Westport
12220 Dorsett Rd Maryland Heights MO
RM379
RM440 total
19 Aug - 20 Aug
includes taxes & fees
Hampton Inn St. Charles St. Peters
3720 W Clay St St. Charles MO
RM399
RM459 total
30 Aug - 31 Aug
includes taxes & fees
8/10 Very good! (1,000 reviews)
Best Western Plus Fenton
1680 Fenton Business Park Ct Fenton MO
RM424
RM489 total
17 Aug - 18 Aug
includes taxes & fees
9/10 Wonderful! (429 reviews)
Holiday Inn Express & Suites St. Louis - Chesterfield by IHG
11 Arnage Boulevard Chesterfield MO
RM466
RM543 total
30 Aug - 31 Aug
includes taxes & fees
9/10 Wonderful! (1,000 reviews)
