Top 10 Texas Medical Center Hotels of 2026

Aerial view of Hermann park in Houston with Japanese Garden, zoo

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Compare popular hotels in Texas Medical Center

Property	Property class	Guest rating
Home2 Suites by Hilton Houston Medical Center, TX	3.0 star property	9.4 Exceptional 673 reviews	View
Residence Inn by Marriott Houston Medical Center/NRG Park	3.0 star property	9.4 Exceptional 551 reviews	View
The Westin Houston Medical Center/Museum District	4.0 star property	9.2 Wonderful 1,162 reviews	View
Hilton Garden Inn Houston Medical Center, TX	3.0 star property	9.2 Wonderful 1,016 reviews	View
InterContinental Houston by IHG	4.0 star property	9.2 Wonderful 1,015 reviews	View

Where to stay in Texas Medical Center

Find the best Texas Medical Center areas for the activities you enjoy most.

Downtown Houston

Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.

See properties

The Galleria

Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.

See properties

Montrose

Unique features of Montrose include the theatres and museums. Make a stop by Menil Collection or Rothko Chapel while you're exploring the area.

See properties

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Downtown Transit Center Station.

See properties

Southeast Houston

While you're in Southeast Houston, take in top sights like Fertitta Center or Houston Zoo, and hop on the metro to see more of the city at Palm Center Transit Center or MacGregor Park/Martin Luther King Jr. Station.

See properties

Top Texas Medical Center Hotel Reviews

Club Quarters Hotel Downtown, Houston

10/10 Excellent

"Hotel was perfectly in the middle of everything. Very clean, highly polished and very comfortable"

The Westin Houston Medical Center/Museum District

10/10 Excellent

"The room was very clean somewhat there was hai inside the bathtub so I wasn’t able to use it. Air conditioner didn’t get cold it took 1 hour before we feel the coldness. It was hard to find the parking we found the easiest parking valet when we were about to leave. But overall it was very neat and close to everything. I will stay longer so I can actually enjoy the amenities and we didn’t have a chance to check out the bar and the breakfast."

Blossom Hotel Houston, Curio Collection by Hilton

8/10 Good

"I selected this property because it looked nice and it was close to MDAnderson. They offered shuttle service which was big in making the decision to stay here. I love this beatifully decorated, clean, boutique hotel. The rooms are spacious and don't disappoint. Rooms stocked with an ESPRESSO machine - NOT a coffee machine. I dont like ESPRESSO so this was a bit disappointing not having coffee to drink IN ROOM. I didn't give it 5-stars because the hotel appears to be understaffed. All the staff seem to be working hard, but they need help......from the vallet team to the restaurant staff, to the housekeeping staff. Also, duriing my stay, shuttle service had constant issues and wasn't offering this service. Very disappointing. I dont' believe it's the fault of the staff, it's the lack of enough employees to get the job done and deliver a great service. Blossom Hotel almost got it right -- and I have no doubt that they will get it right in the future."

Frequently asked questions

What is Texas Medical Center like?

Texas Medical Center is a neighbourhood that travellers like for its museums, shopping and zoo. Consider a visit to Houston Zoo as part of your Texas Medical Center travel plans.

What's a favourite place to stay in Texas Medical Center?

Based on our traveller data, Blossom Hotel Houston, Curio Collection by Hilton is one of the top choices for your stay in Texas Medical Center. This hotel is a short 13-minute walk from MD Anderson Cancer Center, and it offers a full-service spa and 2 bars. Other good options for your stay in the area include Hilton Houston Plaza/Medical Center and Hyatt Place Houston Medical Center.

How many hotels can I expect to find in the Texas Medical Center area?

Expedia has 177 hotels and other accommodation options in Texas Medical Center to choose from, making this an ideal home base for exploring the greater Houston area.

If I need to cancel my hotel reservation in Texas Medical Center, will I receive a refund?

Yes, you'll find most hotel bookings are refundable if you cancel before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your scheduled arrival. If your reservation is non-refundable, you may still be able to cancel and receive a refund within 24 hours of your booking. Add your dates and click on "Search", then filter by "fully refundable" to view the best deals available in Texas Medical Center.

What can I see and do in this Houston neighbourhood?

Houston Zoo is an attraction you might want to check out while you're in Texas Medical Center. While you're out sightseeing, NRG Stadium and Reckling Park are a couple of additional sights to visit in Houston.

How can I get around Texas Medical Center and the greater Houston area?

For a quick way to explore the city, catch a ride on metro transit at TMC Transit Center, Dryden/TMC Station or Smith Lands Station.

Hotels in Texas Medical Center, Houston

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Our top choices for Texas Medical Center hotels

Hilton Houston Plaza/Medical Center

The Westin Houston Medical Center/Museum District

Luxury Med Center Fully Equipped King Sized Bed Condos

DoubleTree by Hilton Houston Medical Center Hotel & Suites

Hilton Garden Inn Houston Medical Center, TX

Blossom Hotel Houston, Curio Collection by Hilton

Home2 Suites by Hilton Houston Medical Center, TX

Hyatt House Houston Medical Center

Houston Marriott Medical Center/Museum District

InterContinental Houston by IHG

Hyatt Place Houston Medical Center

Extended Stay America Suites Houston Med Ctr Braeswood Bl

Residence Inn by Marriott Houston Medical Center/NRG Park

Hampton Inn & Suites Houston Medical Center NRG Park

Americas Best Value Inn NRG Park Medical Center

Palace Inn Blue 290 W 43rd & Bingle Rd

Studio 6 Houston, TX – Pearland/Medical Center

Doubletree by Hilton Houston Hobby Airport

Courtyard by Marriott Houston Intercontinental Airport

Best Western Plus Pearland/Houston Medical Center Hotel

Compare popular hotels in Texas Medical Center

Where to stay in Texas Medical Center

Downtown Houston

The Galleria

Montrose

Houston Central Business District

Southeast Houston

Top Texas Medical Center Hotel Reviews

Club Quarters Hotel Downtown, Houston

Frequently asked questions

Explore a world of travel with Expedia